ATE169023T1 - 2-spirocyclopropyl 4-acylcephalosporine und verfahren zu ihrer herstellung - Google Patents

2-spirocyclopropyl 4-acylcephalosporine und verfahren zu ihrer herstellung

Info

Publication number
ATE169023T1
ATE169023T1 AT92907957T AT92907957T ATE169023T1 AT E169023 T1 ATE169023 T1 AT E169023T1 AT 92907957 T AT92907957 T AT 92907957T AT 92907957 T AT92907957 T AT 92907957T AT E169023 T1 ATE169023 T1 AT E169023T1
Authority
AT
Austria
Prior art keywords
spirocyclopropyl
acylcephalosporins
production
useful
acylcephem
Prior art date
Application number
AT92907957T
Other languages
English (en)
Inventor
Samarendra N Maiti
Narender A V Reddy
David Czajkowski
Paul Spevak
Charles Fiakpui
Ronald G Micetich
Original Assignee
Synphar Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synphar Lab Inc filed Critical Synphar Lab Inc
Application granted granted Critical
Publication of ATE169023T1 publication Critical patent/ATE169023T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Detergent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Cephalosporin Compounds (AREA)
AT92907957T 1991-04-08 1992-04-07 2-spirocyclopropyl 4-acylcephalosporine und verfahren zu ihrer herstellung ATE169023T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/681,680 US5258377A (en) 1991-04-08 1991-04-08 2-spirocyclopropyl 4-acylcephems

Publications (1)

Publication Number Publication Date
ATE169023T1 true ATE169023T1 (de) 1998-08-15

Family

ID=24736298

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92907957T ATE169023T1 (de) 1991-04-08 1992-04-07 2-spirocyclopropyl 4-acylcephalosporine und verfahren zu ihrer herstellung

Country Status (10)

Country Link
US (1) US5258377A (de)
EP (1) EP0580650B1 (de)
JP (1) JPH06506207A (de)
AT (1) ATE169023T1 (de)
CA (1) CA2107892A1 (de)
DE (1) DE69226432D1 (de)
FI (1) FI934395L (de)
HU (1) HUT66046A (de)
WO (1) WO1992017482A1 (de)
ZA (1) ZA922504B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
GB8928373D0 (en) * 1989-12-15 1990-02-21 Erba Carlo Spa Beta-lactam derivatives
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
MXPA06002125A (es) * 2003-08-25 2006-05-31 Revaax Pharmaceuticals Llc Composiciones orales de cefazolin neuroterapeutico.
KR102665710B1 (ko) 2017-08-24 2024-05-14 노보 노르디스크 에이/에스 Glp-1 조성물 및 그 용도
JP7761567B2 (ja) 2020-02-18 2025-10-28 ノヴォ ノルディスク アー／エス 医薬製剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH563396A5 (de) * 1970-06-05 1975-06-30 Ciba Geigy Ag
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
US4717722A (en) * 1984-05-07 1988-01-05 Merck & Co., Inc. Substituted 1-oxa-dethiacephalosporins as anti-inflammatory and antidegenerative agents
DE3751700D1 (de) * 1986-11-12 1996-03-21 Merck & Co Inc Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel
JPH01226887A (ja) * 1988-03-07 1989-09-11 Takeda Chem Ind Ltd ３環性セファムまたはイソセファム化合物，その製造法およびエラスターゼ阻害剤
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
ZA907976B (en) * 1989-10-06 1991-09-25 Synphar Lab Inc Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
US5258377A (en) 1993-11-02
ZA922504B (en) 1993-12-07
EP0580650A1 (de) 1994-02-02
JPH06506207A (ja) 1994-07-14
FI934395A0 (fi) 1993-10-06
AU1556092A (en) 1992-11-02
CA2107892A1 (en) 1992-10-09
HU9302717D0 (en) 1993-12-28
DE69226432D1 (de) 1998-09-03
AU668503B2 (en) 1996-05-09
EP0580650B1 (de) 1998-07-29
FI934395A7 (fi) 1993-10-21
FI934395L (fi) 1993-10-21
WO1992017482A1 (en) 1992-10-15
HUT66046A (en) 1994-09-28

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