ATE175110T1 - Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe - Google Patents

Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe

Info

Publication number: ATE175110T1
Authority: AT; Austria
Prior art keywords: fluidized bed; microsphares; producing; bed stage; stage
Prior art date: 1993-10-22

Application number

AT94931369T

Other languages

English (en)

Inventor

Jeffrey L Cleland

Andrew J Jones

Michael Frank Powell

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-13

Publication date

1999-01-15

1994-10-13 Application filed by Genentech Inc filed Critical Genentech Inc

1999-01-15 Application granted granted Critical

1999-01-15 Publication of ATE175110T1 publication Critical patent/ATE175110T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
239000004005 microsphere Substances 0.000 abstract 2
238000001035 drying Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Mycology (AREA)
Virology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94931369T 1993-10-22 1994-10-13 Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe ATE175110T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14225793A	1993-10-22	1993-10-22
US14331393A	1993-10-25	1993-10-25

Publications (1)

Publication Number	Publication Date
ATE175110T1 true ATE175110T1 (de)	1999-01-15

Family

ID=26839915

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94931369T ATE175110T1 (de)	1993-10-22	1994-10-13	Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe

Country Status (9)

Country	Link
EP (1)	EP0724433B1 (de)
JP (1)	JP3841309B2 (de)
AT (1)	ATE175110T1 (de)
AU (1)	AU8017494A (de)
CA (1)	CA2172508C (de)
DE (1)	DE69415684T2 (de)
DK (1)	DK0724433T3 (de)
UY (1)	UY23846A1 (de)
WO (1)	WO1995011009A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0686045T3 (da) *	1993-02-23	2001-03-05	Genentech Inc	Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof
ATE288270T1 (de)	1993-11-19	2005-02-15	Janssen Pharmaceutica Nv	Mikroverkapselte 1,2-benzazole
US6117455A (en) *	1994-09-30	2000-09-12	Takeda Chemical Industries, Ltd.	Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US6267958B1 (en)	1995-07-27	2001-07-31	Genentech, Inc.	Protein formulation
US6685940B2 (en)	1995-07-27	2004-02-03	Genentech, Inc.	Protein formulation
EP0765660A3 (de) *	1995-09-28	1998-09-23	Takeda Chemical Industries, Ltd.	Mikrokapseln enthaltend 2-Piperazinon-1-essigsäure Verbindungen
US6270795B1 (en)	1995-11-09	2001-08-07	Microbiological Research Authority	Method of making microencapsulated DNA for vaccination and gene therapy
EP0965336A1 (de)	1995-11-09	1999-12-22	Microbiological Research Authority	Mikroverkapselte DNA zur Gentherapie
DE19545257A1 (de) *	1995-11-24	1997-06-19	Schering Ag	Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
GB2310801A (en) *	1996-03-04	1997-09-10	Merck & Co Inc	Process for removing an organic solvent from lactide-glycoside copolymer microspheres
US6190702B1 (en)	1996-03-28	2001-02-20	Takeda Chemical Industries, Ltd.	Sustained-released material prepared by dispersing a lyophilized polypeptide in an oil phase
ES2183172T3 (es) *	1996-05-07	2003-03-16	Alkermes Inc	Procedimiento para la preparacion de microparticulas.
AU734180B2 (en) *	1997-08-29	2001-06-07	Antigenics Llc	Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient
US6573238B2 (en)	1997-11-07	2003-06-03	Chiron Corporation	Method for producing sustained-release formulations
SE9801288D0 (sv)	1998-04-14	1998-04-14	Astra Ab	Vaccine delivery system and metod of production
GB9810236D0 (en)	1998-05-13	1998-07-08	Microbiological Res Authority	Improvements relating to encapsulation of bioactive agents
WO2001030320A1 (en) *	1999-10-22	2001-05-03	Amgen Inc.	Biodegradable microparticles with novel erythropoietin stimulating protein
WO2006123359A2 (en) *	2005-03-01	2006-11-23	Sun Pharmaceutical Industries Limited	A process of making microspheres
US10391059B2 (en)	2009-11-11	2019-08-27	Rapamycin Holdings, Inc.	Oral rapamycin nanoparticle preparations and use
WO2015161139A1 (en)	2014-04-16	2015-10-22	Rapamycin Holdings, Llc	Oral rapamycin preparation and use for stomatitis
JP5791629B2 (ja) *	2009-12-22	2015-10-07	エボニックコーポレイションＥｖｏｎｉｋＣｏｒｐｏｒａｔｉｏｎ	微粒子を調製する乳剤基調プロセス、及び、プロセスで利用されるワークヘッド構造体
UA111162C2 (uk)	2010-08-04	2016-04-11	Флекшен Терап'Ютікс, Інк.	Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
EP2739287B1 (de) *	2011-08-04	2017-07-05	Flexion Therapeutics, Inc.	Corticosteroide zur behandlung von gelenkschmerzen
WO2023277051A1 (ja) *	2021-06-30	2023-01-05	国立大学法人大阪大学	免疫賦活剤

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en) *	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
IT1214629B (it) *	1985-08-29	1990-01-18	Formenti Farmaceutici Spa	Procedimento di microincapsulazione di un medicamento,medicamento cosi'preparato,e composizioni farmaceutiche che lo comprendono
IL84167A (en) *	1986-10-24	1991-04-15	Southern Res Inst	Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation
US5075109A (en) *	1986-10-24	1991-12-24	Southern Research Institute	Method of potentiating an immune response
ES2102347T3 (es) *	1987-02-20	1997-08-01	Genentech Inc	Metodos y composiciones para la utilizacion de polipeptidos env y anticuerpos anti-env de hiv.
JP2813630B2 (ja) *	1987-02-20	1998-10-22	ジェネンテク，インコーポレイテッド	ヒト免疫不全ウイルスのエンベロープポリペプチドおよびその抗体
DK171073B1 (da) *	1988-08-24	1996-05-28	Allied Colloids Ltd	Polymere sammensætninger og metoder til deres fremstilling
US5008116A (en) *	1988-11-14	1991-04-16	Frederick Cahn	Immunostimulatory microsphere
US4990336A (en) *	1989-02-08	1991-02-05	Biosearch, Inc.	Sustained release dosage form
US5126147A (en) *	1990-02-08	1992-06-30	Biosearch, Inc.	Sustained release dosage form
FR2658432B1 (fr) *	1990-02-22	1994-07-01	Medgenix Group Sa	Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation.
AU8303691A (en) *	1991-04-24	1992-12-21	United States Of America, As Represented By The Secretary Of The Army, The	Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres
US5429822A (en) *	1992-03-13	1995-07-04	Cambridge Scientific, Inc.	Biodegradable bursting release system
FR2703927B1 (fr) *	1993-04-13	1995-07-13	Coletica	Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées.
EP0724432B1 (de) *	1993-10-22	2002-09-18	Genentech, Inc.	Verfahren zur mikroverkapselung von antigenen und verwendung der zusammensetzungen als impfstoffe
WO1995011008A2 (en) *	1993-10-22	1995-04-27	Genentech, Inc.	Methods and compositions for microencapsulation of adjuvants

1994
- 1994-10-13 WO PCT/US1994/011678 patent/WO1995011009A1/en not_active Ceased
- 1994-10-13 DK DK94931369T patent/DK0724433T3/da active
- 1994-10-13 CA CA002172508A patent/CA2172508C/en not_active Expired - Lifetime
- 1994-10-13 AT AT94931369T patent/ATE175110T1/de active
- 1994-10-13 EP EP94931369A patent/EP0724433B1/de not_active Expired - Lifetime
- 1994-10-13 AU AU80174/94A patent/AU8017494A/en not_active Abandoned
- 1994-10-13 DE DE69415684T patent/DE69415684T2/de not_active Expired - Lifetime
- 1994-10-13 JP JP51207695A patent/JP3841309B2/ja not_active Expired - Lifetime
- 1994-10-21 UY UY23846A patent/UY23846A1/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
UY23846A1 (es)	1995-03-28
EP0724433B1 (de)	1998-12-30
JPH09504026A (ja)	1997-04-22
CA2172508C (en)	2005-08-23
AU8017494A (en)	1995-05-08
DE69415684T2 (de)	1999-06-10
DK0724433T3 (da)	1999-08-30
CA2172508A1 (en)	1995-04-27
DE69415684D1 (de)	1999-02-11
EP0724433A1 (de)	1996-08-07
JP3841309B2 (ja)	2006-11-01
WO1995011009A1 (en)	1995-04-27

Legal Events

Date	Code	Title	Description
1999-07-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69415684D1 (de)	1999-02-11	Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe
DE69230967D1 (de)	2000-05-31	Verfahren zur herstellung von 2,6-naphthalindicarbonsäure
DE68901889D1 (de)	1992-07-30	Verfahren zur herstellung von carnitin.
ATE162686T1 (de)	1998-02-15	Verfahren zur herstellung von getrockneten früchten
DE68907438D1 (de)	1993-08-12	Verfahren zur herstellung von waschmittelzusammensetzungen.
DE69107220D1 (de)	1995-03-16	Verfahren zur herstellung von fluoroaliphatischen aminocarboxyltensiden.
DE68908193D1 (de)	1993-09-16	Verfahren zur herstellung von fluorglimmer.
DE69231975D1 (de)	2001-09-06	Verfahren zur herstellung von polyolefinen
DE69425496D1 (de)	2000-09-14	Verfahren zur herstellung von 1,4-dienen
DE68901908D1 (de)	1992-07-30	Verfahren zur herstellung von mesophasepech.
DE58902890D1 (de)	1993-01-14	Verfahren zur herstellung von 2,5-diarylaminoterephthalsaeuren.
DE58902073D1 (de)	1992-09-24	Verfahren zur herstellung von organohalogensilanen.
DE68906500D1 (de)	1993-06-17	Verfahren zur herstellung von 2,6-dimethylnaphthalin.
DE58903458D1 (de)	1993-03-18	Verfahren zur herstellung von 1,5-dihydroxy- und 1,5 diaminonaphthalin.
ATA105992A (de)	1997-11-15	Verfahren zur herstellung von wasserlöslichen, trockenen leukoschwefelfarbstoffen
DE59207782D1 (de)	1997-02-06	Verfahren zur herstellung von 8,12-oxido-13,14,15,16-tetranorlabdan
DE68907180D1 (de)	1993-07-22	Verfahren zur herstellung von 2,3,5-trimethylbenzochinon.
DE69314480D1 (de)	1997-11-13	Verfahren zur herstellung von 1,1,1,2,2,4,4,5,5,5,-decafluorpentan
DE58901624D1 (de)	1992-07-16	Verfahren zur herstellung von fluorbenzolen.
DE68901576D1 (de)	1992-06-25	Verfahren zur herstellung von 2,3,5-trimethylbenzochinon.
DE68906078D1 (de)	1993-05-27	Verfahren zur herstellung von urandioxid-pastillen.
DE69107086D1 (de)	1995-03-09	Verfahren zur herstellung von glycosylphosphattriestern.
DE69418723D1 (de)	1999-07-01	Verfahren zur herstellung von 1,1,2,3,3-pentafluorpropan
DE68905103D1 (de)	1993-04-08	Verfahren zur herstellung von dihalogenobenzoldisulfonverbindungen.
DE59002140D1 (de)	1993-09-09	Verfahren zur herstellung von 2,3,5-trimethyl-p-benzochinon.