ATE176281T1 - Verfahren und zusammensetzungen für chromosomenspezifische färbung - Google Patents
Verfahren und zusammensetzungen für chromosomenspezifische färbungInfo
- Publication number
- ATE176281T1 ATE176281T1 AT90308718T AT90308718T ATE176281T1 AT E176281 T1 ATE176281 T1 AT E176281T1 AT 90308718 T AT90308718 T AT 90308718T AT 90308718 T AT90308718 T AT 90308718T AT E176281 T1 ATE176281 T1 AT E176281T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- nucleic acid
- probes
- cytogenetic
- acid probes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000004040 coloring Methods 0.000 title 1
- 230000002559 cytogenic effect Effects 0.000 abstract 4
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 3
- 239000002853 nucleic acid probe Substances 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002068 genetic effect Effects 0.000 abstract 2
- 230000008707 rearrangement Effects 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 238000010186 staining Methods 0.000 abstract 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003149 assay kit Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 238000004980 dosimetry Methods 0.000 abstract 1
- 238000007901 in situ hybridization Methods 0.000 abstract 1
- 230000016507 interphase Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000031864 metaphase Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/204—Modifications characterised by specific length of the oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/101—Temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2531/00—Reactions of nucleic acids characterised by
- C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
- C12Q2531/113—PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/601—Detection means characterised by use of a special device being a microscope, e.g. atomic force microscopy [AFM]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44466989A | 1989-12-01 | 1989-12-01 | |
| US49709890A | 1990-03-20 | 1990-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE176281T1 true ATE176281T1 (de) | 1999-02-15 |
Family
ID=27034011
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90308718T ATE176281T1 (de) | 1989-12-01 | 1990-08-08 | Verfahren und zusammensetzungen für chromosomenspezifische färbung |
| AT98202403T ATE366323T1 (de) | 1989-12-01 | 1990-08-08 | Verfahren und zusammensetzung für chromosomenspezifische färbung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98202403T ATE366323T1 (de) | 1989-12-01 | 1990-08-08 | Verfahren und zusammensetzung für chromosomenspezifische färbung |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0430402B2 (de) |
| JP (4) | JP3771934B2 (de) |
| KR (1) | KR910012263A (de) |
| AT (2) | ATE176281T1 (de) |
| AU (1) | AU647741B2 (de) |
| DE (2) | DE69034245T2 (de) |
| DK (1) | DK0885971T3 (de) |
| IE (2) | IE902727A1 (de) |
| NZ (1) | NZ234529A (de) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6344315B1 (en) | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| US6475720B1 (en) | 1986-01-16 | 2002-11-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
| US7115709B1 (en) | 1986-01-16 | 2006-10-03 | The Regents Of The University Of California | Methods of staining target chromosomal DNA employing high complexity nucleic acid probes |
| US5721098A (en) * | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
| US5756696A (en) * | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
| US6872817B1 (en) | 1986-01-16 | 2005-03-29 | The Regents Of The Univ. Of California | Method of staining target interphase chromosomal DNA |
| US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| US6280929B1 (en) | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
| ES2112833T3 (es) * | 1988-12-06 | 1998-04-16 | Flinders Technologies Pty Ltd | Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal. |
| US8592155B2 (en) | 1989-07-19 | 2013-11-26 | The Regents Of The University Of California | Method of detecting genetic deletions identified with chromosomal abnormalities |
| AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| US5491224A (en) * | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
| US5789161A (en) * | 1990-09-20 | 1998-08-04 | Amoco Corporation | Methods for genome identification using direct label probe composition |
| WO1992010566A1 (en) * | 1990-12-13 | 1992-06-25 | Board Of Regents, The University Of Texas System | In-situ hybridization probes for identification and banding of specific human chromosomes and regions |
| US5538869A (en) * | 1990-12-13 | 1996-07-23 | Board Of Regents, The University Of Texas System | In-situ hybridization probes for identification and banding of specific human chromosomes and regions |
| US6025126A (en) | 1991-10-28 | 2000-02-15 | Arch Development Corporation | Methods and compositions for the detection of chromosomal aberrations |
| GB9204610D0 (en) * | 1992-03-03 | 1992-04-15 | Lynxvale Ltd | Detection of trisomy 21;materials and methods |
| EP1134293A3 (de) * | 1992-03-04 | 2004-01-07 | The Regents of The University of California | Vergleichende Genomhybridisierung |
| US7534567B2 (en) | 1992-03-04 | 2009-05-19 | The Regents Of The University Of California | Detection of nucleic acid sequence differences by comparative genomic hybridization |
| US5976790A (en) * | 1992-03-04 | 1999-11-02 | The Regents Of The University Of California | Comparative Genomic Hybridization (CGH) |
| AU680412B2 (en) * | 1992-04-09 | 1997-07-31 | Ig Laboratories, Inc. | Probes for detecting common liveborn chromosomal aneuploidies |
| WO1994009022A1 (en) * | 1992-10-09 | 1994-04-28 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue |
| WO1994016104A1 (en) * | 1993-01-08 | 1994-07-21 | Ctrc Research Foundation | Color imaging system for use in molecular biology |
| US5597694A (en) * | 1993-10-07 | 1997-01-28 | Massachusetts Institute Of Technology | Interspersed repetitive element-bubble amplification of nucleic acids |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5814444A (en) * | 1995-06-07 | 1998-09-29 | University Of Washington | Methods for making and using single-chromosome amplfication libraries |
| WO1997008339A1 (en) * | 1995-08-25 | 1997-03-06 | Dade International Inc. | Chronic myelogenous leukemia diagnostic assay |
| US7455964B1 (en) | 1996-07-15 | 2008-11-25 | The Hospital For Sick Children | Genes from the 20q13 amplicon and their uses |
| US5801021A (en) | 1995-10-20 | 1998-09-01 | The Regents Of The University Of California | Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer |
| US5892010A (en) * | 1996-07-15 | 1999-04-06 | The Regents Of The University Of California | Genes from the 20Q13 amplicon and their uses |
| US7049424B2 (en) | 1996-07-15 | 2006-05-23 | The Regents Of The University Of California | Genes from the 20Q13 amplicon and their uses |
| US5776683A (en) * | 1996-07-11 | 1998-07-07 | California Pacific Medical Center | Methods for identifying genes amplified in cancer cells |
| IL129222A0 (en) | 1996-10-01 | 2000-02-17 | Geron Corp | Telomerase reverse transcriptase |
| EP2264427B1 (de) | 1997-01-31 | 2017-05-03 | Xy, Llc | Optisches Gerät mit fokussierendem Reflektor zur Konvergenz der Strahlung auf einen Partikelfluss, und zugehöriges Analyseverfahren |
| EP0878552A1 (de) * | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molekularer Nachweis von chromosomalen Veränderungen |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
| EP1092783A4 (de) * | 1998-02-25 | 2004-11-03 | Sumitomo Electric Industries | Verfahren zur krebsdiagnose auf basis des nachweises von chromosomenabnormalitäten |
| JP2002513587A (ja) | 1998-05-04 | 2002-05-14 | ダコ エー エス | 染色体異常を検出するための方法およびプローブ |
| US6414133B1 (en) | 1998-10-13 | 2002-07-02 | Ventana Medical Systems, Inc. | Multiple fusion probes |
| US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
| GB0009784D0 (en) | 2000-04-20 | 2000-06-07 | Simeg Limited | Methods for clinical diagnosis |
| GB0016742D0 (en) * | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
| US7083924B2 (en) | 2000-07-10 | 2006-08-01 | Btg International Limited | Diagnostic method for the identification of foetal DNA in a material sample |
| WO2002043486A1 (en) | 2000-11-29 | 2002-06-06 | Xy, Inc. | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
| US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
| US7585964B2 (en) | 2001-05-14 | 2009-09-08 | Cancer Genetics, Inc. | Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (FISH) |
| JP4595067B2 (ja) | 2002-08-01 | 2010-12-08 | エックスワイ,エルエルシー | 低圧精子細胞分離システム |
| US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
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| JP2004089046A (ja) * | 2002-08-30 | 2004-03-25 | Fuso Pharmaceutical Industries Ltd | カンジダアルビカンス菌の検出用プローブおよびそれを用いた方法 |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| EP2359689B1 (de) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben |
| BRPI0408857B1 (pt) | 2003-03-28 | 2018-09-11 | Inguran Llc | aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo |
| ES2541121T3 (es) | 2003-05-15 | 2015-07-16 | Xy, Llc | Clasificación eficiente de células haploides por sistemas de citometría de flujo |
| WO2005079474A2 (en) | 2004-02-17 | 2005-09-01 | The Regents Of The University Of California | Detection of nucleic acid sequence differences by comparative genomic hybridization |
| DK2801363T3 (en) | 2004-03-29 | 2018-05-28 | Inguran Llc | PROCEDURE FOR STORING SORTED SPERMATOZOES |
| US7306916B2 (en) * | 2004-05-04 | 2007-12-11 | Dako Denmark A/S | Methods for detecting chromosome aberrations |
| CA2574499C (en) | 2004-07-22 | 2016-11-29 | Monsanto Technology Llc | Process for enriching a population of sperm cells |
| US8409808B2 (en) | 2005-02-18 | 2013-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method for detecting risk of progression of low grade cervical dysplasia |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| EP2522746B1 (de) | 2006-03-02 | 2014-11-12 | The Ohio State University Research Foundation | Mikro-RNA-Expressionsprofil im Zusammenhang mit Bauchspeicheldrüsenkrebs |
| WO2008036851A2 (en) | 2006-09-20 | 2008-03-27 | Colorado State University Research Fondation | Detection of chromosomal inversions |
| AU2008239594B2 (en) | 2007-04-13 | 2013-10-24 | Beth Israel Deaconess Medical Center | Methods for treating cancer resistant to ErbB therapeutics |
| EP2255190A4 (de) * | 2008-02-12 | 2011-05-04 | Brigham & Womens Hospital | Fish-test für eml4-alk-fusion bei lungenkrebs |
| TWI518325B (zh) | 2010-02-04 | 2016-01-21 | 自治醫科大學 | 對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療 |
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| CA2815787A1 (en) | 2010-10-25 | 2012-05-10 | Massachusetts Institute Of Technology | Wound healing metakaryotic stem cells and methods of use thereof |
| KR20140049993A (ko) * | 2011-06-02 | 2014-04-28 | 메사추세츠 인스티튜트 오브 테크놀로지 | 메타핵 줄기 세포의 dsRNA/DNA 하이브리드 게놈 복제 중간체 |
| JP6117194B2 (ja) | 2011-06-17 | 2017-04-19 | ミリアド・ジェネティックス・インコーポレイテッド | アレル不均衡を評価するための方法および材料 |
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| BR112014004213A2 (pt) | 2011-08-23 | 2017-06-20 | Found Medicine Inc | novas moléculas de fusão kif5b-ret e usos das mesmas |
| WO2013056178A2 (en) | 2011-10-14 | 2013-04-18 | Foundation Medicine, Inc. | Novel estrogen receptor mutations and uses thereof |
| US10378060B2 (en) | 2011-10-14 | 2019-08-13 | Dana-Farber Cancer Institute, Inc. | ZNF365/ZFP365 biomarker predictive of anti-cancer response |
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| BR112014015152A2 (pt) | 2011-12-21 | 2017-07-04 | Myriad Genetics Inc | métodos e materiais para a avaliação da perda de heterozigosidade |
| CA2864481C (en) | 2012-02-23 | 2020-07-14 | Dana-Farber Cancer Institute, Inc. | Methods for predicting anti-cancer response |
| WO2013182645A1 (en) | 2012-06-07 | 2013-12-12 | Institut Curie | Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors |
| AU2013296237B2 (en) | 2012-08-03 | 2019-05-16 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
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| US4999290A (en) * | 1988-03-31 | 1991-03-12 | The Board Of Regents, The University Of Texas System | Detection of genomic abnormalities with unique aberrant gene transcripts |
| US4874853A (en) * | 1988-04-18 | 1989-10-17 | City Of Hope | Synthetic oligonucleotides useful in diagnosis of chronic myelogenous leukemia |
| ES2018959A6 (es) * | 1988-11-15 | 1991-05-16 | Univ Yale | Metodo de delineacion de cromosomas humanos individuales en celulas metafasicas e interfasicas mediante hibridacion de suspension in situ. |
| AU647741B2 (en) * | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| EP1134293A3 (de) * | 1992-03-04 | 2004-01-07 | The Regents of The University of California | Vergleichende Genomhybridisierung |
| US6590076B1 (en) * | 1999-04-02 | 2003-07-08 | Corixa Corporation | Compositions for the treatment and diagnosis of breast cancer and methods for their use |
| WO2000061814A1 (en) * | 1999-04-09 | 2000-10-19 | The Regents Of The University Of California | Detection of chromosome copy number changes to distinguish melanocytic nevi from malignant melanoma |
| JP2006094733A (ja) * | 2004-09-28 | 2006-04-13 | As One Corp | 癌の検出方法 |
| JP2008048668A (ja) * | 2006-08-24 | 2008-03-06 | Yamaguchi Univ | Dnaコピー数多型を用いた癌発症体質の判定方法 |
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- 1990-07-27 IE IE20070380A patent/IE20070380A1/en unknown
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- 1990-08-08 EP EP90308718A patent/EP0430402B2/de not_active Expired - Lifetime
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- 1990-08-21 JP JP22094690A patent/JP3771934B2/ja not_active Expired - Lifetime
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2005
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2008
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| IE20070380A1 (en) | 2007-06-27 |
| KR910012263A (ko) | 1991-08-07 |
| AU647741B2 (en) | 1994-03-31 |
| JP4517152B2 (ja) | 2010-08-04 |
| JP3771934B2 (ja) | 2006-05-10 |
| DE69032920D1 (de) | 1999-03-11 |
| EP0885971A3 (de) | 1999-11-10 |
| DE69034245D1 (de) | 2007-08-16 |
| DE69032920T4 (de) | 2009-11-05 |
| DE69032920T3 (de) | 2008-10-09 |
| IE902727A1 (en) | 1991-06-05 |
| EP0885971B1 (de) | 2007-07-04 |
| EP0430402A3 (en) | 1991-09-11 |
| ATE366323T1 (de) | 2007-07-15 |
| JP2008283989A (ja) | 2008-11-27 |
| EP0430402B1 (de) | 1999-01-27 |
| EP0885971A2 (de) | 1998-12-23 |
| DE69032920T2 (de) | 1999-09-09 |
| DK0885971T3 (da) | 2007-11-12 |
| JP2003199564A (ja) | 2003-07-15 |
| NZ234529A (en) | 1993-12-23 |
| JP2005304508A (ja) | 2005-11-04 |
| EP0430402B2 (de) | 2008-03-05 |
| DE69034245T2 (de) | 2008-03-13 |
| EP0430402A2 (de) | 1991-06-05 |
| AU5898790A (en) | 1991-06-06 |
| JPH03224499A (ja) | 1991-10-03 |
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