ATE176471T1 - Verfahren zu herstellung von areno(e>indole - Google Patents
Verfahren zu herstellung von areno(e>indoleInfo
- Publication number
- ATE176471T1 ATE176471T1 AT93920859T AT93920859T ATE176471T1 AT E176471 T1 ATE176471 T1 AT E176471T1 AT 93920859 T AT93920859 T AT 93920859T AT 93920859 T AT93920859 T AT 93920859T AT E176471 T1 ATE176471 T1 AT E176471T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- areno
- acyle
- viii
- vii
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000005627 indol-4-ones Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- -1 pyrolyl Chemical group 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES09201894A ES2059259B1 (es) | 1992-09-22 | 1992-09-22 | Procedimiento de obtencion de nuevos areno (e)indoles utiles como intermedios en la sintesis de productos con actividad antitumoral. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE176471T1 true ATE176471T1 (de) | 1999-02-15 |
Family
ID=8278210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93920859T ATE176471T1 (de) | 1992-09-22 | 1993-09-22 | Verfahren zu herstellung von areno(e>indole |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5571927A (de) |
| EP (1) | EP0623619B1 (de) |
| JP (1) | JP3338854B2 (de) |
| AT (1) | ATE176471T1 (de) |
| AU (1) | AU4820593A (de) |
| CA (1) | CA2124072A1 (de) |
| DE (1) | DE69323418T2 (de) |
| DK (1) | DK0623619T3 (de) |
| ES (2) | ES2059259B1 (de) |
| TW (1) | TW239128B (de) |
| WO (1) | WO1994006796A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4415463C2 (de) * | 1994-05-03 | 1996-09-26 | Lutz F Prof Dr Tietze | Acetale und Glykoside von 6-Hydroxy-2,3-dihydro-1H-indolen und 5-Hydroxy-1,2-dihydro-3H-pyrrolo(3,2-e)indolen, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| CN101211088B (zh) * | 2006-12-28 | 2011-08-10 | 中国科学院西安光学精密机械研究所 | 单晶体可调谐宽带非共线飞秒光参量放大方法及装置 |
| TWI807411B (zh) | 2017-04-27 | 2023-07-01 | 西班牙商瑪製藥股份有限公司 | 抗腫瘤化合物 |
-
1992
- 1992-09-22 ES ES09201894A patent/ES2059259B1/es not_active Expired - Lifetime
-
1993
- 1993-09-22 AU AU48205/93A patent/AU4820593A/en not_active Abandoned
- 1993-09-22 ES ES93920859T patent/ES2130283T3/es not_active Expired - Lifetime
- 1993-09-22 AT AT93920859T patent/ATE176471T1/de not_active IP Right Cessation
- 1993-09-22 WO PCT/ES1993/000078 patent/WO1994006796A1/es not_active Ceased
- 1993-09-22 CA CA002124072A patent/CA2124072A1/en not_active Abandoned
- 1993-09-22 DE DE69323418T patent/DE69323418T2/de not_active Expired - Fee Related
- 1993-09-22 EP EP93920859A patent/EP0623619B1/de not_active Expired - Lifetime
- 1993-09-22 JP JP50781894A patent/JP3338854B2/ja not_active Expired - Fee Related
- 1993-09-22 DK DK93920859T patent/DK0623619T3/da active
-
1994
- 1994-01-04 TW TW083100017A patent/TW239128B/zh active
- 1994-05-19 US US08/252,658 patent/US5571927A/en not_active Expired - Fee Related
-
1996
- 1996-07-03 US US08/674,863 patent/US5631384A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07501344A (ja) | 1995-02-09 |
| TW239128B (de) | 1995-01-21 |
| ES2130283T3 (es) | 1999-07-01 |
| DE69323418T2 (de) | 1999-09-09 |
| US5571927A (en) | 1996-11-05 |
| US5631384A (en) | 1997-05-20 |
| CA2124072A1 (en) | 1994-03-31 |
| EP0623619A1 (de) | 1994-11-09 |
| EP0623619B1 (de) | 1999-02-03 |
| AU4820593A (en) | 1994-04-12 |
| DE69323418D1 (de) | 1999-03-18 |
| WO1994006796A1 (es) | 1994-03-31 |
| JP3338854B2 (ja) | 2002-10-28 |
| DK0623619T3 (da) | 1999-09-20 |
| ES2059259A1 (es) | 1994-11-01 |
| ES2059259B1 (es) | 1995-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |