ATE176472T1 - Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält - Google Patents

Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält

Info

Publication number: ATE176472T1
Authority: AT; Austria
Prior art keywords: nalbuphine; pct; producing; containing little; epimer
Prior art date: 1994-05-31

Application number

AT95920456T

Other languages

English (en)

Inventor

Frank Kavka

Original Assignee

Mallinckrodt Chemical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-31

Filing date

1995-05-16

Publication date

1999-02-15

1995-05-16 Application filed by Mallinckrodt Chemical Inc filed Critical Mallinckrodt Chemical Inc

1999-02-15 Application granted granted Critical

1999-02-15 Publication of ATE176472T1 publication Critical patent/ATE176472T1/de

Links

NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 title abstract 2
229960000805 nalbuphine Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)

AT95920456T 1994-05-31 1995-05-16 Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält ATE176472T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25146094A	1994-05-31	1994-05-31

Publications (1)

Publication Number	Publication Date
ATE176472T1 true ATE176472T1 (de)	1999-02-15

Family

ID=22952064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95920456T ATE176472T1 (de)	1994-05-31	1995-05-16	Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält

Country Status (11)

Country	Link
US (1)	US5756745A (de)
EP (1)	EP0763038B1 (de)
JP (1)	JP4040673B2 (de)
AT (1)	ATE176472T1 (de)
AU (1)	AU699114B2 (de)
CA (1)	CA2191843C (de)
DE (1)	DE69507697T2 (de)
ES (1)	ES2127532T3 (de)
HU (1)	HU224914B1 (de)
NZ (1)	NZ287243A (de)
WO (1)	WO1995032973A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19622866C2 (de) *	1996-06-07	1998-12-24	Viva Diagnostika Diagnostische	Verwendung von Opiat-Antagonisten und -Agonisten enthaltende Präparationen zur Prophylaxe und therapeutischen Behandlung von Migräne und Migräne-verwandten Erkrankungen
GB9717629D0 (en) *	1997-08-21	1997-10-22	Johnson Matthey Plc	Removal of residual organic solvents
US6114370A (en) *	1998-09-28	2000-09-05	Wall, Jr.; William H.	Amnesic sedation composition and method of administering same
WO2006084389A1 (de) *	2005-02-11	2006-08-17	Cilag Ltd.	Verfahren zur reinigung von noroxymorphon-verbindungen
ES2357216T3 (es) *	2005-06-16	2011-04-20	Mallinckrodt, Inc.	Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
ES2629766T3 (es)	2006-04-21	2017-08-14	Nektar Therapeutics	Reducción estereoselectiva de una morfinona
ES2407033T3 (es)	2007-05-04	2013-06-11	Mallinckrodt Llc	Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
JP2010533719A (ja) *	2007-07-17	2010-10-28	マリンクロッド・インコーポレイテッド	還元的アミノ化によるｎ−アルキル化オピエートの調製
WO2010017573A1 (en) *	2008-08-11	2010-02-18	Tasmanian Alkaloids Pty Limited	PROCESS FOR MAKING MORPHINAN-6α-OLS
NZ607842A (en) *	2008-09-30	2013-12-20	Mallinckrodt Llc	Processes for the selective amination of ketomorphinans
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010121369A1 (en)	2009-04-24	2010-10-28	Brock University	Processes for the preparation of morphinane and morphinone compounds
US8519133B2 (en) *	2009-06-11	2013-08-27	Mallinckrodt Llc	Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
US8471023B2 (en) *	2009-06-11	2013-06-25	Mallinckrodt Llc	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
GB0914338D0 (en)	2009-08-17	2009-09-30	Johnson Matthey Plc	Improved process
PH12012501552A1 (en) *	2010-01-29	2017-04-26	Toray Industries	Therapeutic or prophylactic agent for biliary diseases
KR20140036215A (ko)	2011-06-09	2014-03-25	말린크로트 엘엘씨	촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화
MX2014002630A (es)	2011-09-08	2014-04-14	Mallinckrodt Llc	Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
WO2015066443A1 (en)	2013-11-01	2015-05-07	Mallinckrodt Llc	Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones
BR112016008459B1 (pt)	2013-11-07	2023-02-07	SpecGx LLC	Produção de morfinanos de 6-hidroxi sem isolamento de intermediários
CN110330500B (zh) *	2019-07-12	2021-11-23	宜昌人福药业有限责任公司	一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法
CN110305142B (zh) *	2019-07-12	2021-11-16	宜昌人福药业有限责任公司	一种6β-羟基吗啡衍生物的立体选择性合成方法
CN113845526B (zh) *	2021-01-18	2022-11-08	四川大学	一种蒂巴因衍生物及其制备方法和应用
CN112759596B (zh) *	2021-01-05	2022-03-15	宜昌人福药业有限责任公司	一种纳布啡的制备方法及其中间体
US12508259B2 (en)	2022-02-01	2025-12-30	HUMANWELL PHARMACEUTICAL US, Inc.	Pharmaceutical formulations containing Nalbuphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3332950A (en) *	1963-03-23	1967-07-25	Endo Lab	14-hydroxydihydronormorphinone derivatives
IL26896A (en) *	1966-01-19	1970-11-30	Endo Lab	14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) *	1984-03-27	1992-05-12	Mallinckrodt Specialty Chemicals Company	Preparation of noroxymorphone from morphine

1995
- 1995-05-16 HU HU9603289A patent/HU224914B1/hu not_active IP Right Cessation
- 1995-05-16 ES ES95920456T patent/ES2127532T3/es not_active Expired - Lifetime
- 1995-05-16 EP EP95920456A patent/EP0763038B1/de not_active Expired - Lifetime
- 1995-05-16 AT AT95920456T patent/ATE176472T1/de not_active IP Right Cessation
- 1995-05-16 WO PCT/US1995/006097 patent/WO1995032973A1/en not_active Ceased
- 1995-05-16 AU AU25902/95A patent/AU699114B2/en not_active Ceased
- 1995-05-16 NZ NZ287243A patent/NZ287243A/en not_active IP Right Cessation
- 1995-05-16 US US08/737,887 patent/US5756745A/en not_active Expired - Lifetime
- 1995-05-16 DE DE69507697T patent/DE69507697T2/de not_active Expired - Lifetime
- 1995-05-16 CA CA002191843A patent/CA2191843C/en not_active Expired - Fee Related
- 1995-05-16 JP JP50091596A patent/JP4040673B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0763038A1 (de)	1997-03-19
CA2191843A1 (en)	1995-12-07
HU9603289D0 (en)	1997-01-28
US5756745A (en)	1998-05-26
HUT77409A (hu)	1998-04-28
JPH10501223A (ja)	1998-02-03
AU699114B2 (en)	1998-11-19
NZ287243A (en)	1997-12-19
WO1995032973A1 (en)	1995-12-07
AU2590295A (en)	1995-12-21
HU224914B1 (en)	2006-04-28
DE69507697D1 (de)	1999-03-18
DE69507697T2 (de)	1999-06-10
CA2191843C (en)	2006-05-02
ES2127532T3 (es)	1999-04-16
JP4040673B2 (ja)	2008-01-30
EP0763038B1 (de)	1999-02-03

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Legal Events

Date	Code	Title	Description
1999-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties