ATE176472T1 - Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält - Google Patents

Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält

Info

Publication number: ATE176472T1
Authority: AT; Austria
Prior art keywords: nalbuphine; pct; producing; containing little; epimer
Prior art date: 1994-05-31

Application number

AT95920456T

Other languages

English (en)

Inventor

Frank Kavka

Original Assignee

Mallinckrodt Chemical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-31

Filing date

1995-05-16

Publication date

1999-02-15

1995-05-16 Application filed by Mallinckrodt Chemical Inc filed Critical Mallinckrodt Chemical Inc

1999-02-15 Application granted granted Critical

1999-02-15 Publication of ATE176472T1 publication Critical patent/ATE176472T1/de

Links

NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 title abstract 2
229960000805 nalbuphine Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 3
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)

AT95920456T 1994-05-31 1995-05-16 Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält ATE176472T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25146094A	1994-05-31	1994-05-31

Publications (1)

Publication Number	Publication Date
ATE176472T1 true ATE176472T1 (de)	1999-02-15

Family

ID=22952064

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95920456T ATE176472T1 (de)	1994-05-31	1995-05-16	Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält

Country Status (11)

Country	Link
US (1)	US5756745A (de)
EP (1)	EP0763038B1 (de)
JP (1)	JP4040673B2 (de)
AT (1)	ATE176472T1 (de)
AU (1)	AU699114B2 (de)
CA (1)	CA2191843C (de)
DE (1)	DE69507697T2 (de)
ES (1)	ES2127532T3 (de)
HU (1)	HU224914B1 (de)
NZ (1)	NZ287243A (de)
WO (1)	WO1995032973A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19622866C2 (de) *	1996-06-07	1998-12-24	Viva Diagnostika Diagnostische	Verwendung von Opiat-Antagonisten und -Agonisten enthaltende Präparationen zur Prophylaxe und therapeutischen Behandlung von Migräne und Migräne-verwandten Erkrankungen
GB9717629D0 (en) *	1997-08-21	1997-10-22	Johnson Matthey Plc	Removal of residual organic solvents
US6114370A (en) *	1998-09-28	2000-09-05	Wall, Jr.; William H.	Amnesic sedation composition and method of administering same
WO2006084389A1 (de) *	2005-02-11	2006-08-17	Cilag Ltd.	Verfahren zur reinigung von noroxymorphon-verbindungen
DE602006019246D1 (de) *	2005-06-16	2011-02-10	Mallinckrodt Inc	Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
ES2629766T3 (es)	2006-04-21	2017-08-14	Nektar Therapeutics	Reducción estereoselectiva de una morfinona
ATE493416T1 (de) *	2007-05-04	2011-01-15	Mallinckrodt Inc	Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten
JP2010533719A (ja) *	2007-07-17	2010-10-28	マリンクロッド・インコーポレイテッド	還元的アミノ化によるｎ−アルキル化オピエートの調製
EP2328900B1 (de) *	2008-08-11	2013-08-28	Tasmanian Alkaloids Pty. Ltd.	VERFAHREN ZUR HERSTELLUNG VON MORPHINAN-6 alpha-OLS
CA2738628C (en)	2008-09-30	2017-07-04	Mallinckrodt Inc.	Processes for the selective amination of ketomorphinans
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
AU2010239059B2 (en)	2009-04-24	2016-06-09	Brock University	Processes for the preparation of morphinane and morphinone compounds
CA2764915C (en) *	2009-06-11	2017-07-11	Mallinckrodt Llc	Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer
US8471023B2 (en) *	2009-06-11	2013-06-25	Mallinckrodt Llc	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
GB0914338D0 (en)	2009-08-17	2009-09-30	Johnson Matthey Plc	Improved process
PH12012501552A1 (en) *	2010-01-29	2017-04-26	Toray Industries	Therapeutic or prophylactic agent for biliary diseases
ES2698408T3 (es)	2011-06-09	2019-02-04	SpecGx LLC	Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico
KR20140063763A (ko)	2011-09-08	2014-05-27	말린크로트 엘엘씨	중간체를 단리하지 않는 알칼로이드의 제조 방법
MX370344B (es) *	2013-11-01	2019-12-10	SpecGx LLC	Preparacion conveniente de morfinan-6-oles n-sustituidos a partir de morfinan-6-onas.
US9193737B2 (en)	2013-11-07	2015-11-24	Mallinckrodt Llc	Production of 6-hydroxy morphinans without the isolation of intermediates
CN110305142B (zh) *	2019-07-12	2021-11-16	宜昌人福药业有限责任公司	一种6β-羟基吗啡衍生物的立体选择性合成方法
CN110330500B (zh) *	2019-07-12	2021-11-23	宜昌人福药业有限责任公司	一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法
CN113845526B (zh) *	2021-01-18	2022-11-08	四川大学	一种蒂巴因衍生物及其制备方法和应用
CN112759596B (zh) *	2021-01-05	2022-03-15	宜昌人福药业有限责任公司	一种纳布啡的制备方法及其中间体
US12508259B2 (en)	2022-02-01	2025-12-30	HUMANWELL PHARMACEUTICAL US, Inc.	Pharmaceutical formulations containing Nalbuphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3332950A (en) *	1963-03-23	1967-07-25	Endo Lab	14-hydroxydihydronormorphinone derivatives
IL26896A (en) *	1966-01-19	1970-11-30	Endo Lab	14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
US4795813A (en) *	1981-08-17	1989-01-03	The Florida Board Of Regents On Behalf Of The Florida State University	Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) *	1984-03-27	1992-05-12	Mallinckrodt Specialty Chemicals Company	Preparation of noroxymorphone from morphine

1995
- 1995-05-16 DE DE69507697T patent/DE69507697T2/de not_active Expired - Lifetime
- 1995-05-16 NZ NZ287243A patent/NZ287243A/en not_active IP Right Cessation
- 1995-05-16 ES ES95920456T patent/ES2127532T3/es not_active Expired - Lifetime
- 1995-05-16 WO PCT/US1995/006097 patent/WO1995032973A1/en not_active Ceased
- 1995-05-16 CA CA002191843A patent/CA2191843C/en not_active Expired - Fee Related
- 1995-05-16 HU HU9603289A patent/HU224914B1/hu not_active IP Right Cessation
- 1995-05-16 AU AU25902/95A patent/AU699114B2/en not_active Ceased
- 1995-05-16 US US08/737,887 patent/US5756745A/en not_active Expired - Lifetime
- 1995-05-16 AT AT95920456T patent/ATE176472T1/de not_active IP Right Cessation
- 1995-05-16 EP EP95920456A patent/EP0763038B1/de not_active Expired - Lifetime
- 1995-05-16 JP JP50091596A patent/JP4040673B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU699114B2 (en)	1998-11-19
JP4040673B2 (ja)	2008-01-30
DE69507697D1 (de)	1999-03-18
DE69507697T2 (de)	1999-06-10
NZ287243A (en)	1997-12-19
ES2127532T3 (es)	1999-04-16
WO1995032973A1 (en)	1995-12-07
AU2590295A (en)	1995-12-21
CA2191843C (en)	2006-05-02
EP0763038B1 (de)	1999-02-03
HU224914B1 (en)	2006-04-28
CA2191843A1 (en)	1995-12-07
US5756745A (en)	1998-05-26
JPH10501223A (ja)	1998-02-03
EP0763038A1 (de)	1997-03-19
HU9603289D0 (en)	1997-01-28
HUT77409A (hu)	1998-04-28

Legal Events

Date	Code	Title	Description
1999-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69507697D1 (de)	1999-03-18	Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält
ATE190222T1 (de)	2000-03-15	Verfahren zur herstellung von umhüllten tabletten
AU6124696A (en)	1997-01-09	Control method for processes of synthesis of chemical products
ATE149196T1 (de)	1997-03-15	Verfahren zur herstellung von olefinen
ATE190050T1 (de)	2000-03-15	Verfahren zur herstellung von 2-acetyl-1-pyrrolin in verkapselter form, zwischenprodukte und endprodukt
DE69022788D1 (de)	1995-11-09	Verfahren zur Herstellung von Polysiloxandichtungen.
GB9126725D0 (en)	1992-02-12	Process
DE69207696D1 (de)	1996-02-29	Einschritt-Verfahren zur Herstellung von Dirithromycin
DE68913030D1 (de)	1994-03-24	Verfahren zur Herstellung von Propylen.
DE69822663D1 (de)	2004-04-29	Invert- bohremulsion, die durch umwandlung von olefinen hergestellte mischungen von sekundären estern enthält, und verfahren zur herstellung
ATE200544T1 (de)	2001-04-15	Fachwerk und gefacheelement und verfarhren zur herstellung eines gefacheelements
HUP9601321A3 (en)	1998-04-28	Substituted (benzyloxy)-carbonyl-guanidine derivatives, process for producing them, pharmaceutical compositions containing them their use as pharmaceutical compositions or diagnostica, and the use of the said compds.
ATE152722T1 (de)	1997-05-15	Verfahren zur herstellung von 9-(2-hydroxy)- ethoxy-guanin
ATE108618T1 (de)	1994-08-15	Verfahren und vorrichtung zur herstellung von beta-kasein.
DE58900821D1 (de)	1992-03-19	Verfahren zur herstellung von phosphororganischen derivaten des 2,4-di-t-butylphenols, der 4,4'-dihalogenmagnesium-verbindungen des biphenyls und die verwendung der phosphororganischen derivate zur stabilisierung von kunststoffen, insbesondere in polyolefinformmassen.
DE69514122D1 (de)	2000-01-27	Lösungsmittelfreies verfahren zur herstellung von 2,6 difluorbenzonitril
DE59307795D1 (de)	1998-01-15	Verfahren zur herstellung von rückstandsfreiem 2,4/2,6-diaminotoluolgemisch
AU1237592A (en)	1992-09-07	Iloprost effective against cerebral malaria
DE69328043D1 (de)	2000-04-13	Verbessertes Verfahren zur Herstellung von 1,3-Butylenglykol
DE69009394D1 (de)	1994-07-07	Verfahren zur Herstellung von 3-Cyano-3,5,5-trimethyl-1-cyclohexanon.
DE69414586D1 (de)	1998-12-17	Verfahren zur herstellung von indolizinderivaten
DE59201325D1 (de)	1995-03-16	Verbessertes Verfahren zur Herstellung von Polyenen.
ATE198188T1 (de)	2001-01-15	Verfahren zur herstellung von beta-isophoron durch isomerisierung von alpha-isophoron (i)
ATE192437T1 (de)	2000-05-15	Verfahren zur herstellung von 3-amino-2-chlor-4- alkyl- bzw. 4-cycloalkyl-pyridine
DE68917284D1 (de)	1994-09-08	Verfahren zur Herstellung von Laminaten.