ATE493416T1 - Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten - Google Patents

Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten

Info

Publication number: ATE493416T1
Authority: AT; Austria
Prior art keywords: alpha; hydroxy; producing; improved method; opiates
Prior art date: 2007-05-04

Application number

AT08747498T

Other languages

English (en)

Inventor

Christopher Grote

Peter Wang

Tao Jiang

Gary Cantrell

Frank Moser

Catherine Thomasson

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-04

Filing date

2008-05-02

Publication date

2011-01-15

2008-05-02 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE493416T1 publication Critical patent/ATE493416T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
229940127240 opiate Drugs 0.000 title 1
XUSCOHKHRDQKCI-ARFHVFGLSA-N (1S,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-one Chemical compound C1C(=O)CC[C@H]2[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 XUSCOHKHRDQKCI-ARFHVFGLSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000011982 enantioselective catalyst Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052741 iridium Inorganic materials 0.000 abstract 1
GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 abstract 1
229910052703 rhodium Inorganic materials 0.000 abstract 1
239000010948 rhodium Substances 0.000 abstract 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
229910052707 ruthenium Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)

AT08747498T 2007-05-04 2008-05-02 Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten ATE493416T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US91596207P	2007-05-04	2007-05-04
US94905507P	2007-07-11	2007-07-11
PCT/US2008/062413 WO2008137672A1 (en)	2007-05-04	2008-05-02	Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates

Publications (1)

Publication Number	Publication Date
ATE493416T1 true ATE493416T1 (de)	2011-01-15

Family

ID=39561936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08747498T ATE493416T1 (de)	2007-05-04	2008-05-02	Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten

Country Status (10)

Country	Link
US (3)	US7985858B2 (de)
EP (3)	EP2180000B1 (de)
JP (1)	JP2009534472A (de)
AT (1)	ATE493416T1 (de)
AU (3)	AU2008207580B2 (de)
CA (1)	CA2637610A1 (de)
DE (1)	DE602008004245D1 (de)
ES (2)	ES2407033T3 (de)
MX (1)	MX2008013842A (de)
WO (1)	WO2008137672A1 (de)

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WO2010017573A1 (en) *	2008-08-11	2010-02-18	Tasmanian Alkaloids Pty Limited	PROCESS FOR MAKING MORPHINAN-6α-OLS
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US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8519133B2 (en) *	2009-06-11	2013-08-27	Mallinckrodt Llc	Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
US8471023B2 (en) *	2009-06-11	2013-06-25	Mallinckrodt Llc	Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
US8829020B2 (en)	2009-07-16	2014-09-09	Mallinckrodt Llc	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
GB0914338D0 (en)	2009-08-17	2009-09-30	Johnson Matthey Plc	Improved process
CN102770487B (zh)	2009-10-02	2014-10-01	陶氏环球技术有限责任公司	热塑性硫化材料应用中的嵌段复合材料
EP2580201B1 (de)	2010-06-11	2017-08-02	Rhodes Technologies	Übergangsmetallkatalysierte verfahren zur herstellung von n-allyl-verbindungen und ihre verwendung
CA2802294C (en)	2010-06-11	2016-05-10	Rhodes Technologies	Process for n-dealkylation of tertiary amines
US20130158265A1 (en) *	2010-08-27	2013-06-20	Dhananjay Govind Sathe	Sitagliptin, salts and polymorphs thereof
JP5685046B2 (ja) *	2010-10-14	2015-03-18	高砂香料工業株式会社	光学純度低下防止方法
KR20140036215A (ko)	2011-06-09	2014-03-25	말린크로트 엘엘씨	촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화
US9896402B2 (en)	2011-11-04	2018-02-20	Takasago International Corporation	Method for preventing decrease in optical purity
PL2812336T3 (pl) *	2012-02-08	2017-07-31	Mallinckrodt Llc	Sposób wytwarzania 6-hydroksyIowej pochodnej opiatu nal w jednym naczyniu
WO2015066443A1 (en) *	2013-11-01	2015-05-07	Mallinckrodt Llc	Convenient preparation of n-substituted morphinan-6-ols from morphinan-6-ones
BR112016008459B1 (pt)	2013-11-07	2023-02-07	SpecGx LLC	Produção de morfinanos de 6-hidroxi sem isolamento de intermediários
US9701687B2 (en)	2014-05-05	2017-07-11	Noramco, Inc.	Process for the preparation of opioid compounds
US9701688B2 (en) *	2014-05-05	2017-07-11	Noramco, Inc.	Process for the preparation of opioid compounds
GB201719667D0 (en) *	2017-11-27	2018-01-10	Johnson Matthey Plc	Process
AU2018383773A1 (en)	2017-12-12	2020-06-11	Xalud Therapeutics, Inc.	Halogenated derivatives of morphinans and uses thereof

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CA2520030A1 (en) *	2003-03-26	2004-10-07	Pharmacia & Upjohn Company Llc	Process to produce enantiomerically enriched alcohols and amines
US20060182692A1 (en) *	2003-12-16	2006-08-17	Fishburn C S	Chemically modified small molecules
SK286047B6 (sk) *	2004-04-13	2008-01-07	Zentiva, A. S.	Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
EP1781615A1 (de)	2004-07-23	2007-05-09	Pliva Istrazivanje i Razvoj d.o.o.	Neue form eines benzolsulfonamidderivats
GB0421687D0 (en)	2004-09-30	2004-11-03	Johnson Matthey Plc	Preparation of opiate analgesics
PT2251330E (pt)	2004-11-05	2012-07-20	Rensselaer Polytech Inst	4-hidroxibenzomorfanos

2008
- 2008-05-02 ES ES10000184T patent/ES2407033T3/es active Active
- 2008-05-02 DE DE602008004245T patent/DE602008004245D1/de active Active
- 2008-05-02 EP EP10000184A patent/EP2180000B1/de active Active
- 2008-05-02 WO PCT/US2008/062413 patent/WO2008137672A1/en not_active Ceased
- 2008-05-02 CA CA002637610A patent/CA2637610A1/en not_active Abandoned
- 2008-05-02 EP EP10000185.8A patent/EP2189460B1/de active Active
- 2008-05-02 US US12/444,421 patent/US7985858B2/en active Active
- 2008-05-02 MX MX2008013842A patent/MX2008013842A/es not_active Application Discontinuation
- 2008-05-02 ES ES10000185.8T patent/ES2468415T3/es active Active
- 2008-05-02 JP JP2009513489A patent/JP2009534472A/ja not_active Withdrawn
- 2008-05-02 AU AU2008207580A patent/AU2008207580B2/en active Active
- 2008-05-02 EP EP08747498A patent/EP2152715B1/de active Active
- 2008-05-02 AT AT08747498T patent/ATE493416T1/de not_active IP Right Cessation
2009
- 2009-12-03 US US12/630,171 patent/US8273888B2/en active Active
- 2009-12-03 US US12/630,192 patent/US8524904B2/en active Active
2010
- 2010-01-18 AU AU2010200191A patent/AU2010200191B2/en active Active
- 2010-01-18 AU AU2010200188A patent/AU2010200188B2/en active Active

Also Published As

Publication number	Publication date
AU2008207580B2 (en)	2011-04-14
AU2008207580A1 (en)	2009-11-19
CA2637610A1 (en)	2008-11-04
US8273888B2 (en)	2012-09-25
AU2010200191B2 (en)	2012-02-09
US7985858B2 (en)	2011-07-26
EP2152715B1 (de)	2010-12-29
EP2189460A1 (de)	2010-05-26
ES2407033T3 (es)	2013-06-11
EP2189460B1 (de)	2014-04-23
EP2180000A1 (de)	2010-04-28
US20100041888A1 (en)	2010-02-18
WO2008137672A1 (en)	2008-11-13
US20100113788A1 (en)	2010-05-06
EP2180000B1 (de)	2013-03-27
AU2010200191A1 (en)	2010-02-04
DE602008004245D1 (de)	2011-02-10
MX2008013842A (es)	2009-03-06
AU2010200188B2 (en)	2012-02-02
ES2468415T3 (es)	2014-06-16
US20100081818A1 (en)	2010-04-01
JP2009534472A (ja)	2009-09-24
US8524904B2 (en)	2013-09-03
AU2010200188A1 (en)	2010-02-04
EP2152715A1 (de)	2010-02-17

Legal Events

Date	Code	Title	Description
2011-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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