ATE493416T1 - Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten - Google Patents
Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiatenInfo
- Publication number
- ATE493416T1 ATE493416T1 AT08747498T AT08747498T ATE493416T1 AT E493416 T1 ATE493416 T1 AT E493416T1 AT 08747498 T AT08747498 T AT 08747498T AT 08747498 T AT08747498 T AT 08747498T AT E493416 T1 ATE493416 T1 AT E493416T1
- Authority
- AT
- Austria
- Prior art keywords
- alpha
- hydroxy
- producing
- improved method
- opiates
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940127240 opiate Drugs 0.000 title 1
- XUSCOHKHRDQKCI-ARFHVFGLSA-N (1S,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-13-one Chemical compound C1C(=O)CC[C@H]2[C@]3([H])NCC[C@@]21C1=CC=CC=C1C3 XUSCOHKHRDQKCI-ARFHVFGLSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000011982 enantioselective catalyst Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052741 iridium Inorganic materials 0.000 abstract 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91596207P | 2007-05-04 | 2007-05-04 | |
| US94905507P | 2007-07-11 | 2007-07-11 | |
| PCT/US2008/062413 WO2008137672A1 (en) | 2007-05-04 | 2008-05-02 | Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE493416T1 true ATE493416T1 (de) | 2011-01-15 |
Family
ID=39561936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08747498T ATE493416T1 (de) | 2007-05-04 | 2008-05-02 | Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7985858B2 (de) |
| EP (3) | EP2152715B1 (de) |
| JP (1) | JP2009534472A (de) |
| AT (1) | ATE493416T1 (de) |
| AU (3) | AU2008207580B2 (de) |
| CA (1) | CA2637610A1 (de) |
| DE (1) | DE602008004245D1 (de) |
| ES (2) | ES2468415T3 (de) |
| MX (1) | MX2008013842A (de) |
| WO (1) | WO2008137672A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9040726B2 (en) * | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| WO2010017573A1 (en) * | 2008-08-11 | 2010-02-18 | Tasmanian Alkaloids Pty Limited | PROCESS FOR MAKING MORPHINAN-6α-OLS |
| US8269006B2 (en) * | 2008-09-30 | 2012-09-18 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| CN102803267A (zh) * | 2009-06-11 | 2012-11-28 | 马林克罗特有限公司 | 通过催化氢转移的6-α-氨基N-取代的吗啡喃的制备 |
| CN102459274B (zh) * | 2009-06-11 | 2015-07-15 | 马林克罗特有限公司 | 6-酮基去甲吗啡喃通过催化氢转移的还原胺化 |
| WO2011009020A2 (en) | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| GB0914338D0 (en) | 2009-08-17 | 2009-09-30 | Johnson Matthey Plc | Improved process |
| JP5693590B2 (ja) | 2009-10-02 | 2015-04-01 | ダウ グローバル テクノロジーズ エルエルシー | 熱可塑性加硫物用途におけるブロック複合材料 |
| JP2013529595A (ja) | 2010-06-11 | 2013-07-22 | ローズ テクノロジーズ | 第３級アミンのｎ−脱アルキル化方法 |
| ES2645725T3 (es) | 2010-06-11 | 2017-12-07 | Rhodes Technologies | Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos |
| WO2012025944A2 (en) * | 2010-08-27 | 2012-03-01 | Usv Limited | Sitagliptin, salts and polymorphs thereof |
| JP5685046B2 (ja) * | 2010-10-14 | 2015-03-18 | 高砂香料工業株式会社 | 光学純度低下防止方法 |
| MX2013013634A (es) | 2011-06-09 | 2013-12-12 | Mallinckrodt Llc | Aminacion reductiva de 6-ceto-morfinanos por transfrencia catalitica de hidrogeno. |
| WO2013065189A1 (ja) | 2011-11-04 | 2013-05-10 | 高砂香料工業株式会社 | 光学純度低下防止方法 |
| US9012468B2 (en) | 2012-02-08 | 2015-04-21 | Mallinckrodt Llc | One pot process for producing 6-hydroxyl nal-opiate |
| ES2749157T3 (es) * | 2013-11-01 | 2020-03-19 | SpecGx LLC | Preparación conveniente de morfinan-6-oles N-sustituidos a partir de morfinan-6-ona |
| ES2741810T3 (es) | 2013-11-07 | 2020-02-12 | SpecGx LLC | Producción de 6-hidroximorfinanos sin el aislamiento de intermedios |
| US9701687B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| US9701688B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| GB201719667D0 (en) * | 2017-11-27 | 2018-01-10 | Johnson Matthey Plc | Process |
| BR112020010901A2 (pt) * | 2017-12-12 | 2020-11-17 | Xalud Therapeutics, Inc. | derivados halogenados de morfinanos e usos dos mesmos |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US182692A (en) * | 1876-09-26 | Improvement in washing-machines | ||
| US2772270A (en) | 1954-10-21 | 1956-11-27 | M J Lewenstein | 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone |
| US2722270A (en) * | 1954-12-13 | 1955-11-01 | Bongiorno Leonard | Spark responsive safety starting control for oil burners |
| US4089855A (en) | 1976-04-23 | 1978-05-16 | Cornell Research Foundation, Inc. | Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby |
| EP0034480A3 (de) | 1980-02-14 | 1982-01-13 | Grigg, Ronald Ernest | Alkylierung von Aminen |
| US4795813A (en) | 1981-08-17 | 1989-01-03 | The Florida Board Of Regents On Behalf Of The Florida State University | Synthesis of derivatives of codeine and other 3-O-alkylmorphines |
| US4443605A (en) | 1982-07-30 | 1984-04-17 | Miles Laboratories, Inc. | 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans |
| US4775759A (en) | 1984-11-27 | 1988-10-04 | The United States Of America As Represented By The Department Of Health And Human Services | Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT) |
| US4673679A (en) | 1986-05-14 | 1987-06-16 | E. I. Du Pont De Nemours And Company | Use of prodrugs of 3-hydroxymorphinans to prevent bitter taste upon buccal, nasal or sublingual administration |
| US5668285A (en) | 1986-10-31 | 1997-09-16 | The United States Of America As Represented By The Department Of Health And Human Services | Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates |
| US4912114A (en) | 1988-03-18 | 1990-03-27 | Sandoz Ltd. | Morphinan derivatives |
| US5208338A (en) | 1991-06-14 | 1993-05-04 | The United States Of America As Represented By The Department Of Health & Human Services. | Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans |
| DE4132159A1 (de) | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| US5808091A (en) * | 1991-10-29 | 1998-09-15 | Bracco International B.V. | Rhenium and technetium complexes containing a hypoxia localizing moiety |
| ATE176472T1 (de) | 1994-05-31 | 1999-02-15 | Mallinckrodt Chemical Inc | Verfahren zur herstellung von nalbuphin das wenig des 6-beta-epimers enthält |
| DE69634639T2 (de) | 1995-12-06 | 2006-03-02 | Japan Science And Technology Agency, Kawaguchi | Verfahren zur herstellung optische aktive verbindungen |
| DE19548399A1 (de) | 1995-12-22 | 1997-06-26 | Basf Ag | Rutheniumkomplexe mit einem chiralen, zweizähnigen Phosphinoxazolin-Liganden zur enantioselektiven Transferhydrierung von prochiralen Ketonen |
| GB9616253D0 (en) * | 1996-08-01 | 1996-09-11 | Johnson Matthey Plc | Preparation of narcotic analgesics |
| PT102006B (pt) | 1997-05-19 | 2000-06-30 | Hovione Sociedade Quimica S A | Novo processo de preparacao de azitromicina |
| GB9821067D0 (en) | 1998-09-29 | 1998-11-18 | Zeneca Ltd | Transfer hydrogenation process |
| BRPI0408680A (pt) | 2003-03-26 | 2006-03-28 | Pharmacia & Upjohn Co Llc | processo para produzir álcoois e aminas enantiomericamente enriquecidos |
| US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| SK286047B6 (sk) | 2004-04-13 | 2008-01-07 | Zentiva, A. S. | Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu |
| EP1781615A1 (de) | 2004-07-23 | 2007-05-09 | Pliva Istrazivanje i Razvoj d.o.o. | Neue form eines benzolsulfonamidderivats |
| GB0421687D0 (en) | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
| EP1817291A1 (de) | 2004-11-05 | 2007-08-15 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphane |
-
2008
- 2008-05-02 AU AU2008207580A patent/AU2008207580B2/en active Active
- 2008-05-02 US US12/444,421 patent/US7985858B2/en active Active
- 2008-05-02 CA CA002637610A patent/CA2637610A1/en not_active Abandoned
- 2008-05-02 MX MX2008013842A patent/MX2008013842A/es not_active Application Discontinuation
- 2008-05-02 ES ES10000185.8T patent/ES2468415T3/es active Active
- 2008-05-02 DE DE602008004245T patent/DE602008004245D1/de active Active
- 2008-05-02 EP EP08747498A patent/EP2152715B1/de active Active
- 2008-05-02 EP EP10000185.8A patent/EP2189460B1/de active Active
- 2008-05-02 JP JP2009513489A patent/JP2009534472A/ja not_active Withdrawn
- 2008-05-02 EP EP10000184A patent/EP2180000B1/de active Active
- 2008-05-02 WO PCT/US2008/062413 patent/WO2008137672A1/en not_active Ceased
- 2008-05-02 ES ES10000184T patent/ES2407033T3/es active Active
- 2008-05-02 AT AT08747498T patent/ATE493416T1/de not_active IP Right Cessation
-
2009
- 2009-12-03 US US12/630,192 patent/US8524904B2/en active Active
- 2009-12-03 US US12/630,171 patent/US8273888B2/en active Active
-
2010
- 2010-01-18 AU AU2010200188A patent/AU2010200188B2/en active Active
- 2010-01-18 AU AU2010200191A patent/AU2010200191B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US8524904B2 (en) | 2013-09-03 |
| JP2009534472A (ja) | 2009-09-24 |
| ES2407033T3 (es) | 2013-06-11 |
| EP2152715B1 (de) | 2010-12-29 |
| US20100113788A1 (en) | 2010-05-06 |
| AU2010200188A1 (en) | 2010-02-04 |
| WO2008137672A1 (en) | 2008-11-13 |
| EP2189460B1 (de) | 2014-04-23 |
| MX2008013842A (es) | 2009-03-06 |
| AU2008207580A1 (en) | 2009-11-19 |
| AU2010200191B2 (en) | 2012-02-09 |
| US8273888B2 (en) | 2012-09-25 |
| AU2010200188B2 (en) | 2012-02-02 |
| US20100041888A1 (en) | 2010-02-18 |
| US20100081818A1 (en) | 2010-04-01 |
| ES2468415T3 (es) | 2014-06-16 |
| EP2152715A1 (de) | 2010-02-17 |
| DE602008004245D1 (de) | 2011-02-10 |
| US7985858B2 (en) | 2011-07-26 |
| AU2010200191A1 (en) | 2010-02-04 |
| EP2180000B1 (de) | 2013-03-27 |
| EP2189460A1 (de) | 2010-05-26 |
| EP2180000A1 (de) | 2010-04-28 |
| AU2008207580B2 (en) | 2011-04-14 |
| CA2637610A1 (en) | 2008-11-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |