ATE176481T1 - Synthese von 17-(3-pyridyl) steroiden - Google Patents

Synthese von 17-(3-pyridyl) steroiden

Info

Publication number: ATE176481T1
Authority: AT; Austria
Prior art keywords: beta; steroid; hydroxy; group; pyridyl
Prior art date: 1993-09-30

Application number

AT94927003T

Other languages

English (en)

Inventor

Gerard Andrew Potter

Ian Robert Hardcastle

Original Assignee

Btg Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-30

Filing date

1994-09-22

Publication date

1999-02-15

1993-09-30 Priority claimed from GB939320132A external-priority patent/GB9320132D0/en

1994-07-14 Priority claimed from GB9414192A external-priority patent/GB9414192D0/en

1994-09-22 Application filed by Btg Int Ltd filed Critical Btg Int Ltd

1999-02-15 Application granted granted Critical

1999-02-15 Publication of ATE176481T1 publication Critical patent/ATE176481T1/de

Links

150000003431 steroids Chemical class 0.000 title abstract 5
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
125000004423 acyloxy group Chemical group 0.000 abstract 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
229910000085 borane Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
239000007795 chemical reaction product Substances 0.000 abstract 2
238000006880 cross-coupling reaction Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
230000003637 steroidlike Effects 0.000 abstract 2
-1 (3-pyridyl)-substituted borane Chemical class 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)

AT94927003T 1993-09-30 1994-09-22 Synthese von 17-(3-pyridyl) steroiden ATE176481T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939320132A GB9320132D0 (en)	1993-09-30	1993-09-30	Synthesis of 17-(-3-pyridyl)steroids
GB9414192A GB9414192D0 (en)	1994-07-14	1994-07-14	Synthesis of 17-(3-pyridyl) steroids

Publications (1)

Publication Number	Publication Date
ATE176481T1 true ATE176481T1 (de)	1999-02-15

Family

ID=26303602

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94927003T ATE176481T1 (de)	1993-09-30	1994-09-22	Synthese von 17-(3-pyridyl) steroiden

Country Status (13)

Country	Link
EP (1)	EP0721461B1 (de)
JP (1)	JP3722835B2 (de)
AT (1)	ATE176481T1 (de)
AU (1)	AU676088B2 (de)
CA (1)	CA2170286C (de)
DE (1)	DE69416419T2 (de)
DK (1)	DK0721461T3 (de)
ES (1)	ES2127413T3 (de)
GB (1)	GB2282377B (de)
GR (1)	GR3029601T3 (de)
NZ (1)	NZ273367A (de)
SG (1)	SG49321A1 (de)
WO (1)	WO1995009178A1 (de)

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US8569275B2 (en)	2002-08-28	2013-10-29	Harbor Therapeutics, Inc.	Steroids having 7-oxgen and 17-heteroaryl substitution
GB0418900D0 (en)	2004-08-24	2004-09-29	Btg Int Ltd	Novel salt forms
EP2428519B1 (de)	2004-08-24	2015-01-21	BTG International Limited	Zusammenstellung zur Herstellung von 17-Vinyl-Triflate als Zwischenprodukte
US20080051380A1 (en)	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
WO2010149755A1 (en)	2009-06-26	2010-12-29	Novartis Ag	1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17
JP2013537210A (ja)	2010-09-16	2013-09-30	ノバルティスアーゲー	１７α−ヒドロキシラーゼ／Ｃ１７，２０−リアーゼ阻害剤
CN102558274B (zh) *	2010-12-08	2014-10-15	深圳万乐药业有限公司	一种适合工业化生产醋酸阿比特龙的合成方法
CN102558275A (zh) *	2010-12-20	2012-07-11	天津药物研究院	α型多晶型醋酸阿比特龙结晶、其制备方法、用途和药物组合物
US9029399B2 (en)	2011-04-28	2015-05-12	Novartis Ag	17α-hydroxylase/C17,20-lyase inhibitors
CN104066744B (zh)	2011-10-10	2017-03-22	扎克系统公司	用于制备17‑取代的甾体的方法
CN103059090B (zh) *	2011-10-20	2016-06-22	连云港润众制药有限公司	醋酸阿比特龙草酸盐以及醋酸阿比特龙的纯化方法
CN102336801B (zh) *	2011-10-31	2013-05-15	南京卡文迪许生物工程技术有限公司	醋酸阿比特龙多晶型物和药用组合物
EP2607371A1 (de)	2011-12-23	2013-06-26	Crystal Pharma, S.A.U.	Verfahren zur Herstellung von Abirateron und verwandten Verbindungen
CN103193849B (zh) *	2012-01-04	2016-05-04	连云港润众制药有限公司	一种高纯度醋酸阿比特龙的制备方法
CN103254265B (zh)	2012-02-21	2016-07-13	上海希迈医药科技有限公司	醋酸阿比特龙三氟乙酸盐及其制备方法和应用
CN102627681B (zh) *	2012-03-23	2016-04-13	山东新时代药业有限公司	一种醋酸阿比特龙的制备方法
EP2841444A4 (de) *	2012-04-23	2015-11-04	Alphora Res Inc	Verfahren zur herstellung von 17-substituierten steroiden
CN102731605B (zh) *	2012-06-19	2016-04-13	鲁南制药集团股份有限公司	一种醋酸阿比特龙的纯化方法
WO2014009434A1 (en)	2012-07-11	2014-01-16	Sandoz Ag	Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate
WO2014009437A1 (en)	2012-07-11	2014-01-16	Sandoz Ag	Oxidation stability of abiraterone acetate
WO2014009436A1 (en)	2012-07-11	2014-01-16	Sandoz Ag	Nanosuspension of abiraterone acetate
CN102816199B (zh) *	2012-08-15	2015-04-08	武汉长联来福制药股份有限公司	醋酸阿比特龙二聚体化合物的制备及检测方法
CN102816200B (zh) *	2012-09-05	2015-04-15	中山大学	一种醋酸阿比特龙的制备方法
CN103665085B (zh) *	2012-09-24	2016-04-20	成都伊诺达博医药科技有限公司	一种改进的乙酸阿比特龙酯合成方法
CN102816201A (zh) *	2012-09-25	2012-12-12	成都伊诺达博医药科技有限公司	一种阿比特龙的纯化方法
WO2014058785A1 (en)	2012-10-10	2014-04-17	Novartis Ag	Combination therapy
ITMI20121788A1 (it) *	2012-10-22	2014-04-23	Olon Spa	Procedimento per la purificazione di abiraterone acetato
WO2014071983A1 (en)	2012-11-09	2014-05-15	Synthon Bv	Process for making the 17-triflate intermediate of abiraterone-3-acetate
EP2917225A1 (de)	2012-11-09	2015-09-16	Synthon BV	Verfahren zur herstellung von abirateron-3-acetat
WO2014075978A1 (en)	2012-11-16	2014-05-22	Synthon B.V.	Process for the production of abiraterone-3-acetate involving an enol trliflation reaction in the presence of an alkoxy-pyridine compound
CN103059091B (zh) *	2012-11-22	2017-04-19	常州靶点医药科技有限公司	一种避免重金属残留的醋酸阿比特龙的制备方法
WO2014083512A1 (en) *	2012-11-28	2014-06-05	Dr. Reddy's Laboratories Limited	Process for preparation of abiraterone acetate
PL2792682T3 (pl)	2013-04-19	2017-04-28	Zach System	Sposób wytwarzania stałej postaci octanu abirateronu
WO2014188445A1 (en) *	2013-04-26	2014-11-27	Srinivasan Thirumalai Rajan	PROCESS FOR THE PREPARATION OF (3β)-17-(3-PYRIDINYL)ANDROSTA-5,16-DIEN-3-YL ACETATE AND POLYMORPH THEREOF
CN103387597B (zh) *	2013-08-21	2015-03-25	苏州明锐医药科技有限公司	阿比特龙醋酸酯的制备方法
CN104558090A (zh) *	2013-10-28	2015-04-29	重庆医药工业研究院有限责任公司	醋酸阿比特龙杂质及其测定方法
WO2015102022A2 (en) *	2013-12-31	2015-07-09	Laurus Labs Private Limited	An improved process for the preparation of abiraterone acetate
WO2015114518A2 (en)	2014-01-28	2015-08-06	Olon S.P.A.	Procedure for the preparation of abiraterone acetate and intermediates thereof
CN103965282B (zh)	2014-04-21	2016-01-20	武汉百科药物开发有限公司	一种醋酸阿比特龙的制备方法
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CZ2014475A3 (cs)	2014-07-09	2016-01-20	Zentiva, K.S.	Způsob přípravy Abirateron acetátu o vysoké čistotě aplikovatelný v průmyslovém měřítku
CN105622703B (zh) *	2014-11-05	2019-09-27	兰州大学	一种制备醋酸阿比特龙的方法
UA124972C2 (uk)	2016-07-29	2021-12-22	Янссен Фармацевтика Нв	Способи лікування раку передміхурової залози
CN107056871A (zh) *	2017-06-28	2017-08-18	李建恒	一种阿比特龙醋酸酯的合成方法
HU231297B1 (hu)	2018-07-31	2022-09-28	Richter Gedeon Nyrt	Stabil gyógyszerkészítmények és eljárás az előállításukra
CN109134571B (zh) *	2018-09-13	2020-10-02	浙江工业大学	一种17-碘-雄甾-5,16-二烯-3β-醇的制备方法
EP3944860A1 (de)	2020-07-30	2022-02-02	Galenicum Health S.L.U.	Abirateron zur verwendung in einem verfahren zur behandlung von krebs
CN112125942B (zh) *	2020-09-28	2021-12-14	湖南新合新生物医药有限公司	醋酸阿比特龙及其中间体的合成方法
CN112940065A (zh) *	2021-02-03	2021-06-11	山东大学	三氟甲磺酸盐在制备醋酸阿比特龙中的应用及合成方法
CN114709557B (zh) *	2022-04-13	2023-10-27	南京工业大学	一种后修饰碳硼烷的共价有机框架材料的设计合成及其在锂硫电池隔膜中的应用
US20250296952A1 (en)	2022-05-06	2025-09-25	Aurisco Pharmaceutical Co., Ltd.	Method for preparing abiraterone acetate and intermediate thereof

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CA2132449C (en) *	1992-03-31	2002-09-10	Susan E. Barrie	17 - substituted steroids useful in cancer treatment

1994
- 1994-09-22 AU AU76618/94A patent/AU676088B2/en not_active Expired
- 1994-09-22 JP JP51016395A patent/JP3722835B2/ja not_active Expired - Lifetime
- 1994-09-22 DE DE69416419T patent/DE69416419T2/de not_active Expired - Lifetime
- 1994-09-22 SG SG1996009266A patent/SG49321A1/en unknown
- 1994-09-22 EP EP94927003A patent/EP0721461B1/de not_active Expired - Lifetime
- 1994-09-22 ES ES94927003T patent/ES2127413T3/es not_active Expired - Lifetime
- 1994-09-22 NZ NZ273367A patent/NZ273367A/en not_active IP Right Cessation
- 1994-09-22 AT AT94927003T patent/ATE176481T1/de active
- 1994-09-22 GB GB9419139A patent/GB2282377B/en not_active Expired - Lifetime
- 1994-09-22 WO PCT/GB1994/002054 patent/WO1995009178A1/en not_active Ceased
- 1994-09-22 CA CA002170286A patent/CA2170286C/en not_active Expired - Lifetime
- 1994-09-22 DK DK94927003T patent/DK0721461T3/da active
1999
- 1999-03-08 GR GR990400688T patent/GR3029601T3/el unknown

Also Published As

Publication number	Publication date
CA2170286C (en)	2005-04-05
DE69416419T2 (de)	1999-06-10
DK0721461T3 (da)	1999-09-20
JPH09502994A (ja)	1997-03-25
JP3722835B2 (ja)	2005-11-30
ES2127413T3 (es)	1999-04-16
SG49321A1 (en)	1998-05-18
AU7661894A (en)	1995-04-18
GR3029601T3 (en)	1999-06-30
GB2282377B (en)	1997-09-03
GB2282377A (en)	1995-04-05
DE69416419D1 (de)	1999-03-18
GB9419139D0 (en)	1994-11-09
HK1002634A1 (en)	1998-09-04
WO1995009178A1 (en)	1995-04-06
AU676088B2 (en)	1997-02-27
EP0721461B1 (de)	1999-02-03
CA2170286A1 (en)	1995-04-06
NZ273367A (en)	1997-07-27
EP0721461A1 (de)	1996-07-17

Legal Events

Date	Code	Title	Description
1999-08-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69416419D1 (de)	1999-03-18	Synthese von 17-(3-pyridyl) steroiden
Bovicelli et al.	1992	Oxidation of natural targets by dioxiranes. Oxyfunctionalization of steroids
MacKay et al.	1961	Reactions of Atomic Carbon with Simple Hydrocarbons: Evidence for CH Bond INSERTION1
NO146865B (no)	1982-09-13	Analogifremgangsmaate for fremstilling av terapeutisk aktive 16-dehydro-androstanderivater
Jigajinni et al.	1982	Hydrogenolysis of enol triflates; A new method for the reduction of ketones to methylene compounds
DE59401321D1 (de)	1997-01-30	Verfahren zur Gewinnung von pharmakologisch wirksamen Verbindungen aus komplexen Stoffgemischen
Caballero et al.	1995	Cleavage of acetals promoted by copper (II) sulphate adsorbed on silica gel
Nahar et al.	2003	Synthesis of ester-linked lithocholic acid dimers
Grishko et al.	2014	Chemical conversions of betulone produced by biotransformation
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Fried et al.	1960	Alkylated Adrenal Hormones. The Synthesis of 5α-Methylated Androstanes
Aranda et al.	1997	Practical and efficient 1α-hydroxylation of 4, 4-dimethyl-2-ene derivatives in terpenic series
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US3004045A (en)	1961-10-10	delta5(10)-3,6-diketo androstenes
KADOTA et al.	1987	Studies on the Constituents of Orchidaceous Plants. VII. The C-24 Stereochemistry of Cyclohomonervilol and 24-Isopropenylcholesterol, Non-conventional Side Chain Triterpene and Sterol, from Nervilia purpurea SCHLECHTER
Piórko et al.	1996	Metal-marked steroids of the estrane group from the reaction of steroidal functional groups with arene-iron (Cp) complexes
DE1568702B2 (de)	1976-05-06	Verfahren zur herstellung von 11 beta-fluor-19-nor-steroiden, einige dieser verbindungen und diese enthaltende pharmazeutische zusammensetzungen
US3845040A (en)	1974-10-29	Protection of steroid carbonyl group by enolisation
Masamune et al.	1966	The Synthesis of an Etiojervane Analog of Progesterone
US3257427A (en)	1966-06-21	3-desoxy-delta-estratrienes and processes for the preparation thereof
US2859223A (en)	1958-11-04	delta4, 7-3, 20-diketo-17-hydroxy-11, 21-bis-oxygenated pregnadienes and processes of preparing the same
US2844605A (en)	1958-07-22	Organic compounds and process
US3311645A (en)	1967-03-28	4-methyl-17alpha-ethinyl estra-1, 3, 5(10)-triene compounds
US3476746A (en)	1969-11-04	11-oxygenated-10alpha-steroids
GB1151209A (en)	1969-05-07	Pentacyclic Steroid Intermediates and Method of Preparing the same