ATE176482T1 - Asp-b28-insulinkristalle - Google Patents

Asp-b28-insulinkristalle

Info

Publication number
ATE176482T1
ATE176482T1 AT94918771T AT94918771T ATE176482T1 AT E176482 T1 ATE176482 T1 AT E176482T1 AT 94918771 T AT94918771 T AT 94918771T AT 94918771 T AT94918771 T AT 94918771T AT E176482 T1 ATE176482 T1 AT E176482T1
Authority
AT
Austria
Prior art keywords
asp
insulin crystals
crystals
insulin
protamine
Prior art date
Application number
AT94918771T
Other languages
English (en)
Inventor
Per Balschmidt
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK93727A external-priority patent/DK72793D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE176482T1 publication Critical patent/ATE176482T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94918771T 1993-06-21 1994-06-21 Asp-b28-insulinkristalle ATE176482T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK93727A DK72793D0 (da) 1993-06-21 1993-06-21 Nyt produkt
US08/127,672 US5547930A (en) 1993-06-21 1993-09-28 AspB28 insulin crystals

Publications (1)

Publication Number Publication Date
ATE176482T1 true ATE176482T1 (de) 1999-02-15

Family

ID=26064536

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94918771T ATE176482T1 (de) 1993-06-21 1994-06-21 Asp-b28-insulinkristalle

Country Status (10)

Country Link
EP (1) EP0705275B1 (de)
JP (1) JP2837956B2 (de)
AT (1) ATE176482T1 (de)
AU (1) AU6995794A (de)
DE (4) DE10199011I2 (de)
DK (1) DK0705275T3 (de)
ES (1) ES2130428T3 (de)
GR (1) GR3030130T3 (de)
NL (3) NL300021I2 (de)
WO (1) WO1995000550A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
AU711428B2 (en) * 1994-06-16 1999-10-14 Eli Lilly And Company Monomeric insulin analog formulations
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
GB2327424B (en) * 1994-06-16 1999-03-31 Lilly Co Eli Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US5866538A (en) * 1996-06-20 1999-02-02 Novo Nordisk A/S Insulin preparations containing NaCl
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
WO1997048413A1 (en) * 1996-06-20 1997-12-24 Novo Nordisk A/S Insulin preparations containing carbohydrates
PT921812E (pt) * 1996-06-20 2002-04-29 Novo Nordisk As Preparacoes de insulina contendo um halogenuro
BE1013507A5 (fr) * 1996-11-22 2002-03-05 Lilly Co Eli Formulations d'analogues de l'insuline.
JP2001518915A (ja) * 1997-03-20 2001-10-16 ノボ ノルディスク アクティーゼルスカブ インシュリンと吸収増強剤の共沈殿による治療用粉末の調整法
SV1998000125A (es) 1997-10-24 1999-05-24 Lilly Co Eli Composiciones de insulina insoluble ref. x-11232
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
US20010053761A1 (en) * 1998-01-08 2001-12-20 Dimarchi Richard Dennis Method for administering aspb28-human insulin
EP1044016B1 (de) 1998-01-09 2005-03-16 Novo Nordisk A/S Stabilisierte insulin-zubereitungen
DE19825447A1 (de) * 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
EP1444219A1 (de) 2001-10-12 2004-08-11 Novo Nordisk A/S Substituierte piperidine und deren verwendung zur behandlung von krankheiten, die mit dem histamin-h3-rezeptor in zusammenhang stehen
EP1618090A1 (de) 2003-04-11 2006-01-25 Novo Nordisk A/S 11 beta-hydroxysteroiddehydrogenase-typ-1-aktive verbindungen
DK3300721T4 (da) 2003-11-20 2025-03-03 Novo Nordisk As Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
MX2007015675A (es) 2005-07-04 2008-02-20 Novo Nordisk As Antagonistas del receptor de histamina h3.
WO2007015805A1 (en) 2005-07-20 2007-02-08 Eli Lilly And Company 1-amino linked compounds
WO2007123581A1 (en) 2005-11-17 2007-11-01 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
ES2397659T3 (es) 2006-03-15 2013-03-08 Novo Nordisk A/S Mezclas de amilina e insulina
CN101410385B (zh) 2006-03-28 2011-08-24 高点制药有限责任公司 具有组胺h3受体活性的苯并噻唑类
JP5118692B2 (ja) 2006-04-24 2013-01-16 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロヘキシル置換ピロリジノン
KR20090040259A (ko) 2006-05-29 2009-04-23 하이 포인트 파마슈티칼스, 엘엘씨 3-(1,3-벤조디옥솔-5-일)-6-(4-시클로프로필피페라진-1-일)-피리다진, 그것의 염과 용매화합물 및 그것의 히스타민 ｈ3 수용체 안타고니스트로서의 용도
EP2164466A1 (de) 2007-06-01 2010-03-24 Novo Nordisk A/S Spontan dispergierbare vorkonzentrate mit einem peptidwirkstoff in einem festen oder halbfesten träger
US20100190706A1 (en) 2007-06-01 2010-07-29 Novo Nordisk A/S Stable Non-Aqueous Pharmaceutical Compositions
EP3228320B1 (de) 2008-10-17 2019-12-18 Sanofi-Aventis Deutschland GmbH Kombination von einem insulin und einem glp-1-agonisten
MX2011005037A (es) 2008-11-21 2011-06-16 High Point Pharmaceuticals Llc Compuestos de adamantilo benzamida.
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
PT2554183T (pt) 2009-11-13 2018-07-09 Sanofi Aventis Deutschland Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
US20140148384A1 (en) 2010-08-30 2014-05-29 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
EP2670368A4 (de) 2011-02-03 2015-04-15 Pharmedica Ltd Neue im mund zersetzbare filme zur insulinverabreichung zwecks behandlung von diabetes
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh) 2011-08-29 2018-05-29 赛诺菲-安万特德国有限公司 用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI641381B (zh) * 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
CN105899191B (zh) 2014-01-09 2020-06-16 赛诺菲 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
RU2016132340A (ru) * 2014-01-09 2018-02-14 Санофи Стабилизированные фармацевтические составы на основе инсулина аспарта
KR20160104724A (ko) 2014-01-09 2016-09-05 사노피 인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
JP2020143105A (ja) * 2014-01-09 2020-09-10 サノフイＳａｎｏｆｉ インスリンアスパルトの安定化された医薬製剤
TWI758239B (zh) 2014-12-12 2022-03-21 德商賽諾菲阿凡提斯德意志有限公司 甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2017163159A1 (en) * 2016-03-21 2017-09-28 Wockhardt Limited Biphasic pharmaceutical composition of insulin human

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
WO1995000550A1 (en) 1995-01-05
DE122006000017I1 (de) 2006-06-29
EP0705275A1 (de) 1996-04-10
DE69416409D1 (de) 1999-03-18
EP0705275B1 (de) 1999-02-03
NL300211I1 (nl) 2006-02-01
NL300021I1 (nl) 2000-12-01
NL300212I1 (nl) 2006-02-01
DE10199011I1 (de) 2001-04-12
DE122006000015I1 (de) 2006-06-29
DE10199011I2 (de) 2004-10-14
AU6995794A (en) 1995-01-17
NL300021I2 (nl) 2006-05-01
DE69416409T2 (de) 1999-09-16
DK0705275T3 (da) 1999-09-20
JP2837956B2 (ja) 1998-12-16
GR3030130T3 (en) 1999-07-30
JPH08511779A (ja) 1996-12-10
ES2130428T3 (es) 1999-07-01

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