NL300021I2 - ASP-B28 insulinekristallen. - Google Patents

ASP-B28 insulinekristallen.

Info

Publication number: NL300021I2
Authority: NL; Netherlands
Prior art keywords: asp; insulin crystals; crystals; insulin; protamine
Prior art date: 1993-06-21

Application number

NL300021C

Other languages

English (en)

Dutch (nl)

Other versions

NL300021I1 (nl

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-21

Filing date

2000-10-16

Publication date

2006-05-01

1993-06-21 Priority claimed from DK93727A external-priority patent/DK72793D0/da

2000-10-16 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2000-12-01 Publication of NL300021I1 publication Critical patent/NL300021I1/nl

2006-05-01 Publication of NL300021I2 publication Critical patent/NL300021I2/nl

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
239000013078 crystal Substances 0.000 title abstract 3
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
102000007327 Protamines Human genes 0.000 abstract 1
108010007568 Protamines Proteins 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000002035 prolonged effect Effects 0.000 abstract 1
229940048914 protamine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NL300021C 1993-06-21 2000-10-16 ASP-B28 insulinekristallen. NL300021I2 (nl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK93727A DK72793D0 (da)	1993-06-21	1993-06-21	Nyt produkt
US08/127,672 US5547930A (en)	1993-06-21	1993-09-28	AspB28 insulin crystals
PCT/DK1994/000246 WO1995000550A1 (en)	1993-06-21	1994-06-21	Aspb28 insulin crystals

Publications (2)

Publication Number	Publication Date
NL300021I1 NL300021I1 (nl)	2000-12-01
NL300021I2 true NL300021I2 (nl)	2006-05-01

Family

ID=26064536

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NL300021C NL300021I2 (nl)	1993-06-21	2000-10-16	ASP-B28 insulinekristallen.
NL300212C NL300212I1 (nl)	1993-06-21	2005-12-02	ASP-B28 insulinekristallen.
NL300211C NL300211I1 (nl)	1993-06-21	2005-12-02	ASP-B28 insulinekristallen.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
NL300212C NL300212I1 (nl)	1993-06-21	2005-12-02	ASP-B28 insulinekristallen.
NL300211C NL300211I1 (nl)	1993-06-21	2005-12-02	ASP-B28 insulinekristallen.

Country Status (10)

Country	Link
EP (1)	EP0705275B1 (de)
JP (1)	JP2837956B2 (de)
AT (1)	ATE176482T1 (de)
AU (1)	AU6995794A (de)
DE (4)	DE122006000015I1 (de)
DK (1)	DK0705275T3 (de)
ES (1)	ES2130428T3 (de)
GR (1)	GR3030130T3 (de)
NL (3)	NL300021I2 (de)
WO (1)	WO1995000550A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK72793D0 (da) *	1993-06-21	1993-06-21	Novo Nordisk As	Nyt produkt
US5461031A (en) *	1994-06-16	1995-10-24	Eli Lilly And Company	Monomeric insulin analog formulations
GB2327424B (en) *	1994-06-16	1999-03-31	Lilly Co Eli	Monomeric insulin analog formulations
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
AU711428B2 (en) *	1994-06-16	1999-10-14	Eli Lilly And Company	Monomeric insulin analog formulations
US5547929A (en) *	1994-09-12	1996-08-20	Eli Lilly And Company	Insulin analog formulations
US5948751A (en) *	1996-06-20	1999-09-07	Novo Nordisk A/S	X14-mannitol
US5866538A (en) *	1996-06-20	1999-02-02	Novo Nordisk A/S	Insulin preparations containing NaCl
ATE369146T1 (de) *	1996-06-20	2007-08-15	Novo Nordisk As	Insulinpreparation mit mannitol
DK0921812T4 (da) *	1996-06-20	2012-04-02	Novo Nordisk As	Insulinpræparater, som indeholder et halogenid
BE1013507A5 (fr) *	1996-11-22	2002-03-05	Lilly Co Eli	Formulations d'analogues de l'insuline.
JP2001518915A (ja) *	1997-03-20	2001-10-16	ノボノルディスクアクティーゼルスカブ	インシュリンと吸収増強剤の共沈殿による治療用粉末の調整法
JP2001521004A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	脂肪酸−アシル化インスリン類似体
CO4970787A1 (es)	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US20010007853A1 (en) *	1998-01-08	2001-07-12	Dimarchi Richard Dennis	Method for administering monomeric insulin analogs
DE69924232D1 (de)	1998-01-09	2005-04-21	Novo Nordisk As	Stabilisierte insulin-zubereitungen
DE19825447A1 (de) *	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
EP2243776A1 (de)	2001-10-12	2010-10-27	High Point Pharmaceuticals, LLC	Substituierte Piperidine und ihre Verwendung zur Behandlung von Histamine H3 Rezeptor bedingten Erkrankungen
ATE482747T1 (de)	2003-04-11	2010-10-15	High Point Pharmaceuticals Llc	Neue amide derivate und deren pharmazeutische verwendungen
PT1687019T (pt)	2003-11-20	2018-02-26	Novo Nordisk As	Formulações de péptidos que contêm polietileno glicol que são ótimas para produção e para utilização em dispositivos de injeção
EP2386554A1 (de)	2005-07-04	2011-11-16	High Point Pharmaceuticals, LLC	Histamine H3 Rezeptor aktive Verbindungen
US8106090B2 (en)	2005-07-20	2012-01-31	Eli Lilly And Company	1-amino linked compounds
DK1951658T3 (da)	2005-11-17	2012-10-15	Lilly Co Eli	Glucagonreceptorantagonister, fremstilling og terapeutiske anvendelser
US20090054305A1 (en)	2006-03-15	2009-02-26	Novo Nordisk A/S	Mixtures of Amylin and Insulin
US8394842B2 (en)	2006-03-28	2013-03-12	High Point Pharmaceuticals, Llc	Benzothiazoles having histamine H3 receptor activity
EA016415B1 (ru)	2006-04-24	2012-04-30	Эли Лилли Энд Компани	Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1
EP2079732B9 (de)	2006-05-29	2012-03-21	High Point Pharmaceuticals, LLC	3-(1,3-benyodioxol-5-yl)-6- (4-cyclopropylpiperazin-1-yl)-pyridazin, dessen salze und solvate und dessen verwendung als histamin-h3-rezeptorantagonist
US20110144010A1 (en)	2007-06-01	2011-06-16	Novo Nordisk A/S	Spontaneously Dispersible Preconcentrates Including a Peptide Drug in a Solid or Semisolid Carrier
US20100190706A1 (en)	2007-06-01	2010-07-29	Novo Nordisk A/S	Stable Non-Aqueous Pharmaceutical Compositions
PT3228320T (pt)	2008-10-17	2020-03-26	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
MX2011005037A (es)	2008-11-21	2011-06-16	High Point Pharmaceuticals Llc	Compuestos de adamantilo benzamida.
DK2498802T3 (en)	2009-11-13	2015-04-13	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a GLP-1 agonist, insulin and a methionine
KR101337322B1 (ko)	2009-11-13	2013-12-06	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
ES2606554T3 (es)	2010-08-30	2017-03-24	Sanofi-Aventis Deutschland Gmbh	Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
EP2670368A4 (de)	2011-02-03	2015-04-15	Pharmedica Ltd	Neue im mund zersetzbare filme zur insulinverabreichung zwecks behandlung von diabetes
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl)	2011-08-29	2015-12-31	Sanofi Aventis Deutschland	Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
TWI641381B (zh) *	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
SG11201604706TA (en) *	2014-01-09	2016-07-28	Sanofi Sa	Stabilized pharmaceutical formulations of insulin aspart
JP2020143105A (ja) *	2014-01-09	2020-09-10	サノフイＳａｎｏｆｉ	インスリンアスパルトの安定化された医薬製剤
EP3091965A1 (de) *	2014-01-09	2016-11-16	Sanofi	Stabilisierte glycerinfreie pharmazeutische formulierungen von insulinanaloga und/oder insulinderivaten
CN112957455A (zh)	2014-01-09	2021-06-15	赛诺菲	胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂
AU2015359376B2 (en)	2014-12-12	2021-09-09	Sanofi-Aventis Deutschland Gmbh	Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
WO2017163159A1 (en) *	2016-03-21	2017-09-28	Wockhardt Limited	Biphasic pharmaceutical composition of insulin human

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3327709A1 (de)	1983-07-29	1985-02-07	Hoechst Ag, 6230 Frankfurt	Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
PH25772A (en) *	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation

1994
- 1994-06-21 DE DE200612000015 patent/DE122006000015I1/de active Pending
- 1994-06-21 WO PCT/DK1994/000246 patent/WO1995000550A1/en not_active Ceased
- 1994-06-21 DE DE200612000017 patent/DE122006000017I1/de active Pending
- 1994-06-21 DE DE69416409T patent/DE69416409T2/de not_active Expired - Lifetime
- 1994-06-21 DK DK94918771T patent/DK0705275T3/da active
- 1994-06-21 AU AU69957/94A patent/AU6995794A/en not_active Abandoned
- 1994-06-21 DE DE2001199011 patent/DE10199011I2/de active Active
- 1994-06-21 AT AT94918771T patent/ATE176482T1/de active
- 1994-06-21 ES ES94918771T patent/ES2130428T3/es not_active Expired - Lifetime
- 1994-06-21 JP JP7502347A patent/JP2837956B2/ja not_active Expired - Lifetime
- 1994-06-21 EP EP94918771A patent/EP0705275B1/de not_active Expired - Lifetime
1999
- 1999-04-30 GR GR990401212T patent/GR3030130T3/el unknown
2000
- 2000-10-16 NL NL300021C patent/NL300021I2/nl unknown
2005
- 2005-12-02 NL NL300212C patent/NL300212I1/nl unknown
- 2005-12-02 NL NL300211C patent/NL300211I1/nl unknown

Also Published As

Publication number	Publication date
EP0705275B1 (de)	1999-02-03
DE69416409D1 (de)	1999-03-18
AU6995794A (en)	1995-01-17
DE10199011I2 (de)	2004-10-14
GR3030130T3 (en)	1999-07-30
JPH08511779A (ja)	1996-12-10
DE122006000017I1 (de)	2006-06-29
DE122006000015I1 (de)	2006-06-29
ATE176482T1 (de)	1999-02-15
DE69416409T2 (de)	1999-09-16
DK0705275T3 (da)	1999-09-20
DE10199011I1 (de)	2001-04-12
ES2130428T3 (es)	1999-07-01
JP2837956B2 (ja)	1998-12-16
NL300212I1 (nl)	2006-02-01
NL300021I1 (nl)	2000-12-01
WO1995000550A1 (en)	1995-01-05
EP0705275A1 (de)	1996-04-10
NL300211I1 (nl)	2006-02-01

Publication	Publication Date	Title
DK0705275T3 (da)	1999-09-20	AspB28-insulin-krystaller
UA66417C2 (en)	2004-05-17	Recombinant adenovirus affecting canines, pharmaceutical composition
WO2000030622A3 (de)	2000-11-02	Verwendung von dialkylfumaraten zur behandlung von host-versus-graft reaktionen und von autoimmunerkrankungen
FI883055A7 (fi)	1988-12-25	Deodoroiva ja antimikrobinen koostumus käytettäväksi kosmeettisissa tai paikallisesti käytettävissä valmisteissa.
PL350658A1 (en)	2003-01-27	Medical preparations for the treatment of alpha−galactosidase a deficiency
AU4513093A (en)	1994-01-31	Looped, hairpin ribozyme
NO931919L (no)	1993-05-26	Optisk aktivt 5h-pyrrolo(3,4-b)pyrazinderivat, dets fremstilling samt farmasoeytiske preparater inneholdende derivatet
EE04021B1 (et)	2003-04-15	7a-( -aminoalküül)östratrieenid, nende valmistamise meetod, 7a-( -aminoalküül)östratrieene sisaldavad farmatseutilised preparaadid ja nende kasutamine ravimite valmistamiseks
DE3875108D1 (de)	1992-11-05	Physiologisch aktives polypeptid und pharmazeutische komposition.
FI954111A7 (fi)	1995-09-01	Uudet taksoidit, niiden valmistus ja niitä sisältävät farmaseuttiset v almisteet
DE59407457D1 (de)	1999-01-21	Blockierung der anlagerung von keimen an menschliche zellen
TR199903192T2 (xx)	2000-05-22	Eritropoetin, de�i�tirilmi� hemoglobin i�eren farmasotik kombine m�stahzarlar.
IT1274241B (it)	1997-07-15	Complessi agente terapeutico/matrice polimerica dotati di migliorate caratteristiche di sapore e composizioni farmaceutiche che li contengono
DE69013557D1 (de)	1994-12-01	An Liposome gekuppelte bioaktive Verbindungen und ihre Verwendung in pharmazeutischen Zubereitungen.
DE69724453D1 (de)	2003-10-02	Camptothecine analoga, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen
FI961938A7 (fi)	1996-05-07	Uudet taksoidit, niiden valmistus ja niitä sisältävät farmaseuttiset v almisteet
DE68902300D1 (de)	1992-09-03	Pharmazeutische loesung enthaltend salbutamol und cromoglycinsaeure.
FI930293A7 (fi)	1993-01-25	Uusia heteroaryylioksi-b-karboliineja, niiden valmistus ja käyttö lääk keissä
FI956353L (fi)	1995-12-29	Farmaseuttiset valmisteet ja niiden käyttö etenkin neurodegeneratiivisten sairauksien hoidossa
DK578589D0 (da)	1989-11-17	Farmaceutisk praeparat indeholdende labdanterpenoidderivater og pyrimido(6,1-a)isoquinolin-4-onderivater, dets fremstilling og anvendelse
AU1251192A (en)	1992-10-06	Use of tricyclic isoindolinones as antiviral drugs, and new, optically active isoindolinones
AU1447892A (en)	1992-10-06	Pharmaceutical preparations for the therapy of tumors containing colchicine as the active principle and methods for the use of the same
WO1999003509A3 (de)	1999-05-14	Pharmazeutische mittel enthaltend perfluoralkylgruppenhaltige trijodaromaten und ihre verwendung in der tumortherapie und interventionellen radiologie
CA2247998A1 (en)	1997-09-04	Fragments of cr1 and their use
IT9048026A0 (it)	1990-06-04	Preparato farmaceutico e/o cosmetico.