ATE176904T1 - Verfahren zur herstellung von phenylalanin- derivaten oder homologen, die eine guanidin- oder modifizierte guanidin-gruppe enthalten, verwendbar für die herstellung von gnrh antagonistisch wirksamen peptiden - Google Patents
Verfahren zur herstellung von phenylalanin- derivaten oder homologen, die eine guanidin- oder modifizierte guanidin-gruppe enthalten, verwendbar für die herstellung von gnrh antagonistisch wirksamen peptidenInfo
- Publication number
- ATE176904T1 ATE176904T1 AT94919491T AT94919491T ATE176904T1 AT E176904 T1 ATE176904 T1 AT E176904T1 AT 94919491 T AT94919491 T AT 94919491T AT 94919491 T AT94919491 T AT 94919491T AT E176904 T1 ATE176904 T1 AT E176904T1
- Authority
- AT
- Austria
- Prior art keywords
- guanidine
- production
- peptides
- modified
- unnatural amino
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 3
- 238000004519 manufacturing process Methods 0.000 title 2
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 title 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 title 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 title 1
- 150000002993 phenylalanine derivatives Chemical class 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 206010062767 Hypophysitis Diseases 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000002149 gonad Anatomy 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 229940094892 gonadotropins Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000006384 methylpyridyl group Chemical group 0.000 abstract 1
- 210000003635 pituitary gland Anatomy 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/08—Sulfenic acids; Derivatives thereof
- C07C313/18—Sulfenamides
- C07C313/26—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C313/30—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/078,965 US5352796A (en) | 1989-10-30 | 1993-06-17 | Amino acids useful in making GnRH analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE176904T1 true ATE176904T1 (de) | 1999-03-15 |
Family
ID=22147289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94919491T ATE176904T1 (de) | 1993-06-17 | 1994-06-13 | Verfahren zur herstellung von phenylalanin- derivaten oder homologen, die eine guanidin- oder modifizierte guanidin-gruppe enthalten, verwendbar für die herstellung von gnrh antagonistisch wirksamen peptiden |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US5352796A (de) |
| EP (1) | EP0703900B1 (de) |
| JP (1) | JPH09500110A (de) |
| KR (1) | KR100308361B1 (de) |
| AT (1) | ATE176904T1 (de) |
| AU (1) | AU682702B2 (de) |
| CA (1) | CA2165469A1 (de) |
| DE (1) | DE69416676T2 (de) |
| IL (1) | IL110032A (de) |
| NZ (1) | NZ267921A (de) |
| PH (1) | PH31215A (de) |
| WO (1) | WO1995000474A1 (de) |
| ZA (1) | ZA944345B (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
| US6469158B1 (en) * | 1992-05-14 | 2002-10-22 | Ribozyme Pharmaceuticals, Incorporated | Synthesis, deprotection, analysis and purification of RNA and ribozymes |
| GB9312761D0 (en) * | 1993-06-21 | 1993-08-04 | Wellcome Found | Amino acid derivatives |
| US5843901A (en) * | 1995-06-07 | 1998-12-01 | Advanced Research & Technology Institute | LHRH antagonist peptides |
| CA2235510A1 (en) * | 1995-10-27 | 1997-05-01 | Merck & Co., Inc. | Gnrh/reduced pseudomonas exotoxin conjugates |
| US5912872A (en) * | 1996-09-27 | 1999-06-15 | Digital Optics Corporation | Integrated optical apparatus providing separated beams on a detector and associated methods |
| US5928727A (en) * | 1997-06-02 | 1999-07-27 | Lacks Industries, Inc. | Method for electroplating elastomer-modified polyphthalamide articles |
| WO1999026964A1 (en) * | 1997-11-20 | 1999-06-03 | Ortho-Mcneil Pharmaceutical, Inc. | LIQUID PHASE PROCESS FOR THE PREPARATION OF GnRH PEPTIDES |
| WO1999044987A1 (en) | 1998-03-05 | 1999-09-10 | Agouron Pharmaceuticals, Inc. | NON-PEPTIDE GnRH AGENTS |
| US6455499B1 (en) | 1999-02-23 | 2002-09-24 | Indiana University Foundation | Methods for treating disorders associated with LHRH activity |
| US6638950B2 (en) | 2000-06-21 | 2003-10-28 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
| US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US8858961B2 (en) * | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| CA2402405C (en) | 2000-07-14 | 2008-02-12 | Allergan Sales, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| US20040214829A1 (en) * | 2000-07-14 | 2004-10-28 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
| IL153322A0 (en) | 2000-07-14 | 2003-07-06 | Allergan Inc | Compositions containing therapeutically active components having enhanced solubility |
| US6598784B2 (en) * | 2000-12-20 | 2003-07-29 | Meadwestvaco Packaging Syatens, Llc | Beverage carton with strap type carrying handle |
| AU2005303610B2 (en) * | 2004-11-12 | 2011-07-21 | Ucl Business Plc | Guanidine derivatives as inhibitors of DDAH |
| EP2118123B1 (de) | 2007-01-31 | 2015-10-14 | Dana-Farber Cancer Institute, Inc. | Stabilisierte p53-peptide und deren verwendungen |
| EP2508531B1 (de) | 2007-03-28 | 2016-10-19 | President and Fellows of Harvard College | Geheftete Polypeptide |
| MX355543B (es) | 2010-08-13 | 2018-04-20 | Aileron Therapeutics Inc Star | Macrociclos peptidomiméticos. |
| MX358886B (es) | 2011-10-18 | 2018-08-31 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos. |
| CN104144695A (zh) | 2012-02-15 | 2014-11-12 | 爱勒让治疗公司 | 三唑交联的和硫醚交联的拟肽大环化合物 |
| CN107216380A (zh) | 2012-02-15 | 2017-09-29 | 爱勒让治疗公司 | 拟肽大环化合物 |
| JP6526563B2 (ja) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス，インコーポレイテッド | 二置換アミノ酸ならびにその調製および使用の方法 |
| HUE034308T2 (en) | 2013-03-21 | 2018-02-28 | Sanofi Aventis Deutschland | Preparation of hydantoin-containing peptide products |
| CN105102427B (zh) | 2013-03-21 | 2018-09-07 | 赛诺菲-安万特德国有限公司 | 含有环状酰亚胺的肽产物的合成 |
| AU2015320549A1 (en) | 2014-09-24 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK558181A (da) * | 1981-01-30 | 1982-07-31 | Smithkline Corp | Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler |
| DE3271043D1 (en) * | 1981-11-09 | 1986-06-12 | Merck & Co Inc | N-carboxymethyl(amidino)lysyl-proline antihypertensive agents |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| US5352796A (en) * | 1989-10-30 | 1994-10-04 | The Salk Institute For Biological Studies | Amino acids useful in making GnRH analogs |
| IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
-
1993
- 1993-06-17 US US08/078,965 patent/US5352796A/en not_active Expired - Fee Related
-
1994
- 1994-06-13 EP EP94919491A patent/EP0703900B1/de not_active Expired - Lifetime
- 1994-06-13 AU AU70611/94A patent/AU682702B2/en not_active Ceased
- 1994-06-13 WO PCT/US1994/006726 patent/WO1995000474A1/en not_active Ceased
- 1994-06-13 KR KR1019950705738A patent/KR100308361B1/ko not_active Expired - Fee Related
- 1994-06-13 NZ NZ267921A patent/NZ267921A/en unknown
- 1994-06-13 JP JP7502914A patent/JPH09500110A/ja not_active Ceased
- 1994-06-13 CA CA002165469A patent/CA2165469A1/en not_active Abandoned
- 1994-06-13 AT AT94919491T patent/ATE176904T1/de not_active IP Right Cessation
- 1994-06-13 DE DE69416676T patent/DE69416676T2/de not_active Expired - Fee Related
- 1994-06-16 IL IL11003294A patent/IL110032A/xx not_active IP Right Cessation
- 1994-06-17 PH PH48477A patent/PH31215A/en unknown
- 1994-06-17 ZA ZA944345A patent/ZA944345B/xx unknown
- 1994-08-11 US US08/289,103 patent/US5565574A/en not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/465,854 patent/US5710249A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL110032A (en) | 1999-09-22 |
| WO1995000474A1 (en) | 1995-01-05 |
| US5352796A (en) | 1994-10-04 |
| PH31215A (en) | 1998-05-05 |
| ZA944345B (en) | 1995-04-03 |
| AU7061194A (en) | 1995-01-17 |
| EP0703900A1 (de) | 1996-04-03 |
| DE69416676D1 (de) | 1999-04-01 |
| KR100308361B1 (ko) | 2001-11-30 |
| DE69416676T2 (de) | 1999-09-16 |
| KR960703110A (ko) | 1996-06-19 |
| US5565574A (en) | 1996-10-15 |
| US5710249A (en) | 1998-01-20 |
| CA2165469A1 (en) | 1995-01-05 |
| EP0703900B1 (de) | 1999-02-24 |
| NZ267921A (en) | 1997-12-19 |
| JPH09500110A (ja) | 1997-01-07 |
| IL110032A0 (en) | 1994-10-07 |
| AU682702B2 (en) | 1997-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |