ATE178492T1 - Gentechnologisch hergestellte lipasen für die therapeutische behandlung - Google Patents

Gentechnologisch hergestellte lipasen für die therapeutische behandlung

Info

Publication number
ATE178492T1
ATE178492T1 AT91910966T AT91910966T ATE178492T1 AT E178492 T1 ATE178492 T1 AT E178492T1 AT 91910966 T AT91910966 T AT 91910966T AT 91910966 T AT91910966 T AT 91910966T AT E178492 T1 ATE178492 T1 AT E178492T1
Authority
AT
Austria
Prior art keywords
therapeutic treatment
genetically produced
lipases
produced lipases
lipase
Prior art date
Application number
AT91910966T
Other languages
English (en)
Inventor
Birgitte Huge-Jensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK137990A external-priority patent/DK137990D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE178492T1 publication Critical patent/ATE178492T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT91910966T 1990-06-06 1991-06-04 Gentechnologisch hergestellte lipasen für die therapeutische behandlung ATE178492T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK137990A DK137990D0 (da) 1990-06-06 1990-06-06 Rekombinante terapeutiske lipaser
DK173590A DK173590D0 (da) 1990-06-06 1990-07-19 Rekombinante terapeutiske lipaser

Publications (1)

Publication Number Publication Date
ATE178492T1 true ATE178492T1 (de) 1999-04-15

Family

ID=26065679

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91910966T ATE178492T1 (de) 1990-06-06 1991-06-04 Gentechnologisch hergestellte lipasen für die therapeutische behandlung

Country Status (10)

Country Link
US (1) US5614189A (de)
EP (1) EP0600868B1 (de)
JP (1) JP3072853B2 (de)
AT (1) ATE178492T1 (de)
AU (1) AU645583B2 (de)
CA (1) CA2084184A1 (de)
DE (1) DE69131106T2 (de)
DK (1) DK173590D0 (de)
FI (1) FI925530L (de)
WO (1) WO1991018623A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
DE602005009677D1 (de) 2004-03-22 2008-10-23 Solvay Pharm Gmbh Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin, mit tensiden
BRPI0510817A (pt) * 2004-05-24 2007-11-20 Novozymes As protease, uso de uma protease, composição farmacêutica, e, método para o tratamento de uma doença
ES2352086T3 (es) 2004-10-14 2011-02-15 Cystic Fibrosis Foundation Therapeutics, Inc. Composiciones que contienen lipasa, proteasa y amilasa para el tratamiento de la insuficiencia pancreática.
AU2006261442A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Lipases for pharmaceutical use
KR20080017039A (ko) * 2005-06-24 2008-02-25 노보자임스 에이/에스 약학적 용도의 프로테아제
WO2006136161A2 (en) 2005-06-24 2006-12-28 Novozymes A/S Amylases for pharmaceutical use
RU2413532C2 (ru) * 2005-07-29 2011-03-10 Зольвай Фармасьютиклз Гмбх Способ получения стерилизованного порошкообразного панкреатина
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US20100196344A1 (en) * 2005-10-14 2010-08-05 Cystic Fibrosis Foundation Therapeutics, Inc. Compositions and methods for treating pancreatic insufficiency
US20070104805A1 (en) * 2005-11-01 2007-05-10 Udell Ronald G Compositions of Hoodia Gordonii and Pinolenic Acid Derivatives
US8071089B2 (en) 2005-11-01 2011-12-06 Bio-Cat, Inc. Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
EP2261328B1 (de) * 2006-12-21 2013-11-20 Novozymes A/S Lipase-varianten zur pharmazeutischen Verwendung
US20090130063A1 (en) * 2007-11-15 2009-05-21 Solvay Pharmaceuticals Gmbh Process for separating and determining the viral load in a pancreatin sample
WO2009071550A1 (en) * 2007-12-04 2009-06-11 Novozymes A/S Protease variants for pharmaceutical use
CA2711187A1 (en) * 2008-01-03 2009-07-09 George Shlieout Pharmaceutical compositions comprising granules of purified microbial lipase and methods for preventing or treating digestive disorders
EP2391382B1 (de) * 2009-01-29 2014-06-04 Nordmark Arzneimittel GmbH & Co.KG Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
CA2919114A1 (en) * 2013-07-22 2015-02-12 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions
JP2014193909A (ja) * 2014-06-04 2014-10-09 Nordmark Arzneimittel Gmbh & Co Kg 医薬調製物
GB201501081D0 (en) * 2015-01-22 2015-03-11 Cilian Ag Use of enzymes with a wide pH activity range as medicaments for promoting digestion
WO2016126970A1 (en) 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
DE102015114857A1 (de) * 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Getränk, enthaltend eine pharmazeutische Zusammensetzung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8421210D0 (en) * 1984-08-21 1984-09-26 Celltech Ltd Polypeptide and polypeptide composition
US4659667A (en) * 1985-02-26 1987-04-21 Miles Laboratories, Inc. Process to recover crystalline enzymes and crystalline enzymes produced thereby
US5108457A (en) * 1986-11-19 1992-04-28 The Clorox Company Enzymatic peracid bleaching system with modified enzyme
EP0305216B1 (de) * 1987-08-28 1995-08-02 Novo Nordisk A/S Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen
ATE94206T1 (de) * 1989-12-21 1993-09-15 Novo Nordisk As Enzymhaltige zubereitung und eine solche zubereitung enthaltendes detergens.

Also Published As

Publication number Publication date
EP0600868B1 (de) 1999-04-07
US5614189A (en) 1997-03-25
FI925530A0 (fi) 1992-12-04
DE69131106D1 (de) 1999-05-12
JP3072853B2 (ja) 2000-08-07
CA2084184A1 (en) 1991-12-07
WO1991018623A1 (en) 1991-12-12
EP0600868A1 (de) 1994-06-15
FI925530A7 (fi) 1992-12-04
AU645583B2 (en) 1994-01-20
FI925530L (fi) 1992-12-04
DE69131106T2 (de) 1999-11-18
JPH06501147A (ja) 1994-02-10
AU8096491A (en) 1991-12-31
DK173590D0 (da) 1990-07-19

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Legal Events

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