ATE178905T1 - Peptidische neurotensin-antagonisten - Google Patents

Peptidische neurotensin-antagonisten

Info

Publication number: ATE178905T1
Authority: AT; Austria
Prior art keywords: pct; compound; radical; date nov; arg
Prior art date: 1994-05-20

Application number

AT95920949T

Other languages

English (en)

Inventor

Francois-Frederic Clerc

Marie-Christine Dubroeucq

Gerard Helynck

Jean Leboul

Jean-Paul Martin

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-20

Filing date

1995-05-17

Publication date

1999-04-15

1995-05-17 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1999-04-15 Application granted granted Critical

1999-04-15 Publication of ATE178905T1 publication Critical patent/ATE178905T1/de

Links

102000050267 Neurotensin Human genes 0.000 title 1
101800001814 Neurotensin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
-1 nicotinoyl Chemical group 0.000 abstract 3
125000000539 amino acid group Chemical group 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical group O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
229910052740 iodine Chemical group 0.000 abstract 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C27/00—Processes involving the simultaneous production of more than one class of oxygen-containing compounds
- C07C27/20—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction
- C07C27/22—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction with the use of catalysts which are specific for this process
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Zoology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT95920949T 1994-05-20 1995-05-17 Peptidische neurotensin-antagonisten ATE178905T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9406167A FR2720066B1 (fr)	1994-05-20	1994-05-20	Peptides antagonistes de la neurotensine.

Publications (1)

Publication Number	Publication Date
ATE178905T1 true ATE178905T1 (de)	1999-04-15

Family

ID=9463378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95920949T ATE178905T1 (de)	1994-05-20	1995-05-17	Peptidische neurotensin-antagonisten

Country Status (13)

Country	Link
US (1)	US5840682A (de)
EP (1)	EP0759934B1 (de)
JP (1)	JPH10500424A (de)
AT (1)	ATE178905T1 (de)
AU (1)	AU2619595A (de)
DE (1)	DE69509084T2 (de)
DK (1)	DK0759934T3 (de)
ES (1)	ES2132671T3 (de)
FR (1)	FR2720066B1 (de)
GR (1)	GR3029950T3 (de)
IL (1)	IL113767A (de)
WO (1)	WO1995032218A1 (de)
ZA (1)	ZA954026B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU728712C (en) *	1997-02-03	2001-07-19	Mallinckrodt, Inc.	Method for the detection and localization of malignant human tumours
DE10226921A1 (de) *	2002-06-17	2003-12-24	Bayer Ag	Antibakterielle Amid-Makrozyklen
DE10358824A1 (de) *	2003-12-16	2005-07-21	Bayer Healthcare Ag	Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014247A1 (de) *	2005-03-30	2006-10-05	Aicuris Gmbh & Co. Kg	Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) *	2005-03-30	2006-10-05	Aicuris Gmbh & Co. Kg	Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) *	2005-07-14	2007-01-18	Aicuris Gmbh & Co. Kg	Antibakterielle Amid-Markozyklen VII
WO2010079158A1 (en)	2009-01-07	2010-07-15	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for the treatment, the prognostic assessment and the detection of breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4439359A (en) *	1982-07-02	1984-03-27	Merck & Co., Inc.	Cyclic octapeptide analogs of neurotensin
US5162497A (en) *	1987-09-24	1992-11-10	The Administrators Of The Tulane Educational Fund	Bradykinin analogs with non-peptide bond
US5430047A (en) *	1994-04-07	1995-07-04	Warner-Lambert Company	Neurotensin antagonists
FR2720065B1 (fr) *	1994-05-20	1996-06-28	Rhone Poulenc Rorer Sa	Métabolite de fermentation d'actinomycètes A 9738 intermédiaire pour la préparation d'antagonistes de la neurotensine.

1994
- 1994-05-20 FR FR9406167A patent/FR2720066B1/fr not_active Expired - Lifetime
1995
- 1995-05-17 ZA ZA954026A patent/ZA954026B/xx unknown
- 1995-05-17 DE DE69509084T patent/DE69509084T2/de not_active Expired - Fee Related
- 1995-05-17 ES ES95920949T patent/ES2132671T3/es not_active Expired - Lifetime
- 1995-05-17 US US08/737,695 patent/US5840682A/en not_active Expired - Fee Related
- 1995-05-17 JP JP7530094A patent/JPH10500424A/ja active Pending
- 1995-05-17 EP EP95920949A patent/EP0759934B1/de not_active Expired - Lifetime
- 1995-05-17 DK DK95920949T patent/DK0759934T3/da active
- 1995-05-17 AT AT95920949T patent/ATE178905T1/de not_active IP Right Cessation
- 1995-05-17 WO PCT/FR1995/000643 patent/WO1995032218A1/fr not_active Ceased
- 1995-05-17 AU AU26195/95A patent/AU2619595A/en not_active Abandoned
- 1995-05-17 IL IL11376795A patent/IL113767A/xx active IP Right Grant
1999
- 1999-04-15 GR GR980400478T patent/GR3029950T3/el unknown

Also Published As

Publication number	Publication date
US5840682A (en)	1998-11-24
ZA954026B (en)	1996-03-06
EP0759934A1 (de)	1997-03-05
DE69509084D1 (de)	1999-05-20
JPH10500424A (ja)	1998-01-13
EP0759934B1 (de)	1999-04-14
IL113767A (en)	1999-04-11
ES2132671T3 (es)	1999-08-16
WO1995032218A1 (fr)	1995-11-30
DE69509084T2 (de)	1999-08-12
FR2720066B1 (fr)	1996-06-28
GR3029950T3 (en)	1999-07-30
DK0759934T3 (da)	1999-08-02
AU2619595A (en)	1995-12-18
IL113767A0 (en)	1995-08-31
FR2720066A1 (fr)	1995-11-24

Legal Events

Date	Code	Title	Description
2000-01-15	UEP	Publication of translation of european patent specification
2002-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
CO4480109A1 (es)	1997-07-09	Analogos, composiciones y procedimientos de uso de peptidos insulinotropicos similares al glucagon
FR2364948A1 (fr)	1978-04-14	Systemes adhesifs comprenant un polyamide contenant une bisamino piperazine
TR200101398T2 (tr)	2001-09-21	Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
JP2012512903A5 (de)	2013-02-21
HUP0204272A2 (hu)	2003-03-28	Kortikotropin-felszabadító faktor antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ATE116638T1 (de)	1995-01-15	N-substituierte lactame als cholecystokinin- antagonisten.
ATE184022T1 (de)	1999-09-15	Neuropeptide y antagoniste
DE69833654D1 (de)	2006-04-27	Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
DK1326634T3 (da)	2006-08-14	Vaccinepræparat der omfatter et antigen og et peptid med adjuvansegenskaber
BR9509665A (pt)	1997-10-28	Composto composições e métodos
DE3875538D1 (de)	1992-12-03	Aminoluciferine, verfahren zu deren herstellung und ihre verwendung.
ATE178905T1 (de)	1999-04-15	Peptidische neurotensin-antagonisten
EP0831938A4 (de)	2001-12-05	Mittel auf basis radiomarkierter peptide zur ortsspezifischen verabreichung
JP2021513990A5 (de)	2022-03-01
ATE489462T1 (de)	2010-12-15	Antimikrobielles polypeptid und nutzung davon
MX9801987A (es)	1998-08-30	Nuevos derivados de aminoacido, su obtencion y su uso.
ATE254121T1 (de)	2003-11-15	Heterocyclische verbindungen als bradykinin antagonisten
IL117209A0 (en)	1996-06-18	1-aryl-2-acylamino-ethane compounds and pharmaceutical compositions containing them
ATE384078T1 (de)	2008-02-15	Paralytisches peptide von der spitzmaus sowie dessen nutzung in der therapie von neuromuskulären krankheiten
AU2865801A (en)	2001-08-07	Therapeutic peptides
ATE137764T1 (de)	1996-05-15	Vasoaktive derivate des vasotocins
ATE45165T1 (de)	1989-08-15	Reduzierte peptide, hemmungsstoffe gastrischer ausscheidung, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE224724T1 (de)	2002-10-15	Pharmazeutische zusammensetzung enthaltend peptide für die inhibierung der immunoglobulin- rezeptor interaktion
ATE283276T1 (de)	2004-12-15	Deoxyhypusin reagenz und peptide