ATE179426T1 - Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten - Google Patents

Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten

Info

Publication number: ATE179426T1
Authority: AT; Austria
Prior art keywords: anthracycline derivatives; anticancer; formula; trifluoromethylated; daunomycin
Prior art date: 1994-03-11

Application number

AT95910796T

Other languages

English (en)

Inventor

Tomio New Fuji Mansio Takeuchi

Sumio Umezawa

Tsutomu Tsuchiya

Yasushi Takagi

Original Assignee

Zaidan Hojin Biseibutsu

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-11

Filing date

1995-03-10

Publication date

1999-05-15

1995-03-10 Application filed by Zaidan Hojin Biseibutsu filed Critical Zaidan Hojin Biseibutsu

1999-05-15 Application granted granted Critical

1999-05-15 Publication of ATE179426T1 publication Critical patent/ATE179426T1/de

Links

229940045799 anthracyclines and related substance Drugs 0.000 title abstract 3
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 4
IBZGBXXTIGCACK-CWKPULSASA-N Adriamycinone Chemical class C1[C@@](O)(C(=O)CO)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O IBZGBXXTIGCACK-CWKPULSASA-N 0.000 abstract 3
239000002246 antineoplastic agent Substances 0.000 abstract 3
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 2
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
229940009456 adriamycin Drugs 0.000 abstract 2
230000001093 anti-cancer Effects 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 2
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 2
YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 abstract 1
YOFDHOWPGULAQF-UHFFFAOYSA-N Daunomycin-Aglycone Natural products C1C(O)(C(C)=O)CC(O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
231100000053 low toxicity Toxicity 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/34—Halogenated alcohols
- C07C31/42—Polyhydroxylic acyclic alcohols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT95910796T 1994-03-11 1995-03-10 Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten ATE179426T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP6771494		1994-03-11

Publications (1)

Publication Number	Publication Date
ATE179426T1 true ATE179426T1 (de)	1999-05-15

Family

ID=13352911

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95910796T ATE179426T1 (de)	1994-03-11	1995-03-10	Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten

Country Status (7)

Country	Link
US (2)	US5719130A (de)
EP (1)	EP0749976B1 (de)
AT (1)	ATE179426T1 (de)
CA (1)	CA2185247A1 (de)
DE (1)	DE69509377T2 (de)
ES (1)	ES2131819T3 (de)
WO (1)	WO1995024412A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0912590A (ja) *	1995-06-23	1997-01-14	Microbial Chem Res Found	４−アミノ−２，４，６−トリデオキシ−２−フルオロ−マンノピラノシル基を有する新規アンスラサイクリン誘導体
JPH10175992A (ja) *	1996-12-16	1998-06-30	Microbial Chem Res Found	４−アミノ−２，４，６−トリデオキシ−２−フルオロ−α−Ｌ−タロピラノシル基を有する新規アンスラサイクリン誘導体
US6197809B1 (en)	1998-12-23	2001-03-06	Ardenia Investments Ltd.	Compounds for the treatment of cancer
US20040254099A1 (en) *	1999-04-21	2004-12-16	Adherex Technologies, Inc.	Compounds and methods for modulating beta-catenin mediated gene expression
US6303576B1 (en) *	1999-04-21	2001-10-16	Adherex Technologies Inc.	Compounds and methods for modulating β-catenin mediated gene expression
US20040038904A1 (en) *	2002-05-21	2004-02-26	Angela Ogden	Method of treating multiple sclerosis
US8962577B2 (en)	2012-03-16	2015-02-24	The Johns Hopkins University	Controlled release formulations for the delivery of HIF-1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0631298B2 (ja) *	1985-12-18	1994-04-27	財団法人微生物化学研究会	新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法
JPH0742304B2 (ja) *	1986-12-05	1995-05-10	財団法人微生物化学研究会	新規なアンスラサイクリン誘導体およびその製造法
JPH06797B2 (ja) *	1987-01-30	1994-01-05	財団法人相模中央化学研究所	１４−フルオロダウノルビシン誘導体
KR100211417B1 (ko) *	1990-11-30	1999-10-01	유충식	L-탈로피라노시드 유도체 및 그의 제조방법

1995
- 1995-03-10 CA CA002185247A patent/CA2185247A1/en not_active Abandoned
- 1995-03-10 DE DE69509377T patent/DE69509377T2/de not_active Expired - Fee Related
- 1995-03-10 WO PCT/JP1995/000407 patent/WO1995024412A1/ja not_active Ceased
- 1995-03-10 EP EP95910796A patent/EP0749976B1/de not_active Expired - Lifetime
- 1995-03-10 AT AT95910796T patent/ATE179426T1/de not_active IP Right Cessation
- 1995-03-10 US US08/714,050 patent/US5719130A/en not_active Expired - Fee Related
- 1995-03-10 ES ES95910796T patent/ES2131819T3/es not_active Expired - Lifetime
1997
- 1997-10-20 US US08/954,519 patent/US5801257A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0749976A1 (de)	1996-12-27
CA2185247A1 (en)	1995-09-14
US5719130A (en)	1998-02-17
EP0749976B1 (de)	1999-04-28
DE69509377T2 (de)	1999-11-18
ES2131819T3 (es)	1999-08-01
DE69509377D1 (de)	1999-06-02
WO1995024412A1 (en)	1995-09-14
EP0749976A4 (de)	1997-03-19
US5801257A (en)	1998-09-01

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Legal Events

Date	Code	Title	Description
1999-12-15	UEP	Publication of translation of european patent specification
2004-12-15	REN	Ceased due to non-payment of the annual fee