BE904431A - Nouveaux derives morpholino de la daunorubicine et de la doxorubicine. - Google Patents

Nouveaux derives morpholino de la daunorubicine et de la doxorubicine.

Info

Publication number
BE904431A
BE904431A BE0/216422A BE216422A BE904431A BE 904431 A BE904431 A BE 904431A BE 0/216422 A BE0/216422 A BE 0/216422A BE 216422 A BE216422 A BE 216422A BE 904431 A BE904431 A BE 904431A
Authority
BE
Belgium
Prior art keywords
daunorubicin
doxorubicin
morpholino derivatives
novel morpholino
novel
Prior art date
Application number
BE0/216422A
Other languages
English (en)
Inventor
A Bargiotti
P Zini
S Penco
F Giuliani
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE904431A publication Critical patent/BE904431A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Glycosides d'anthracyclines utiles comme agents antitumeurs et répondant à la formule générale (A) : dans laquelle X représente un atome d'hydrogène ou un groupe hydroxy, tandis que R représente un atome d'hydrogène, un groupe méthyle ou un groupe hydroxy-méthyle; l'invention concerne également les sels pharmaceutiques acceptables de ces glycosides d'anthracyclines.
BE0/216422A 1985-03-22 1986-03-18 Nouveaux derives morpholino de la daunorubicine et de la doxorubicine. BE904431A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08507577A GB2172594B (en) 1985-03-22 1985-03-22 New morpholino derivatives of daunorubicin and doxorubicin

Publications (1)

Publication Number Publication Date
BE904431A true BE904431A (fr) 1986-07-16

Family

ID=10576503

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216422A BE904431A (fr) 1985-03-22 1986-03-18 Nouveaux derives morpholino de la daunorubicine et de la doxorubicine.

Country Status (10)

Country Link
US (1) US4672057A (fr)
JP (1) JPS61221194A (fr)
BE (1) BE904431A (fr)
BG (1) BG60535B2 (fr)
BR (1) BR1100255A (fr)
CZ (1) CZ419591A3 (fr)
DE (1) DE3609052C2 (fr)
GB (1) GB2172594B (fr)
HK (1) HK37392A (fr)
MX (1) MX9203114A (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823224A1 (de) * 1988-07-08 1990-01-11 Behringwerke Ag Morpholino-derivate der rhodomycine, verfahren zu ihrer herstellung und ihre verwendung
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives
US5304687A (en) * 1989-12-19 1994-04-19 Farmitalia Carlo Erba S.R.L. Morpholinyl derivatives of doxorubicin and process for their preparation
DK0434960T3 (da) * 1989-12-19 1996-10-14 Pharmacia Spa Chirale 1,5-diiod-2-methoxy- eller benzyloxymellemprodukter
GB9019934D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates
US5776458A (en) * 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9909925D0 (en) * 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives
AU767394C (en) * 1999-12-29 2005-04-21 Immunogen, Inc. Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
EP1603575A2 (fr) * 2003-03-18 2005-12-14 Pharmacia Italia S.p.A. Polytherapie contre des tumeurs comprenant l'administration de nemorubicine combinee a une radiotherapie
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
WO2006051549A2 (fr) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Therapie combinee
JP4513765B2 (ja) * 2005-04-15 2010-07-28 日本ビクター株式会社 電気音響変換器
US20100069317A1 (en) * 2006-07-12 2010-03-18 Nerviano Medical Sciences S.R.L. Crystalline nemorubicin hydrochloride
US20100104566A1 (en) * 2007-01-29 2010-04-29 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline and an antibody
JP5302300B2 (ja) 2007-05-11 2013-10-02 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ アンスラサイクリンの医薬組成物
WO2009016072A2 (fr) * 2007-08-02 2009-02-05 Nerviano Medical Sciences S.R.L. Dérivé de la morpholinyle anthracycline combiné à des inhibiteurs de protéine kinases
EP2240495B1 (fr) 2008-02-01 2015-07-15 Genentech, Inc. Métabolite de némorubicine et réactifs analogues, conjugués anticorps-médicament et procédés
US20110021517A1 (en) * 2008-02-26 2011-01-27 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
AU2009270988A1 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
JP2013530993A (ja) 2010-07-02 2013-08-01 アンジオケム インコーポレーテッド 治療用コンジュゲートのための短く且つｄ−アミノ酸を含有するポリペプチドおよびその使用
KR20190120439A (ko) 2010-11-08 2019-10-23 제넨테크, 인크. 피하 투여용 항―ｉｌ―6 수용체 항체
KR101897307B1 (ko) 2010-12-02 2018-09-10 네르비아노 메디칼 사이언시스 에스.알.엘. 모르폴리닐 안트라사이클린 유도체의 제조 방법
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
KR101640912B1 (ko) * 2014-07-03 2016-07-20 현대자동차주식회사 고온 저마찰성 코팅층 및 이의 제조방법
WO2016040825A1 (fr) 2014-09-12 2016-03-17 Genentech, Inc. Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés
EP4180061A1 (fr) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Réactifs de liaison dérivés d'anthracycline, conjugués anticorps-médicament et procédés
WO2025168481A1 (fr) 2024-02-05 2025-08-14 Nerviano Medical Sciences S.R.L. Dérivés d'imino-anthracycline et procédés

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639897A (fr) *
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
DE3609052A1 (de) 1986-09-25
JPH0482160B2 (fr) 1992-12-25
GB8507577D0 (en) 1985-05-01
MX9203114A (es) 1992-07-01
US4672057A (en) 1987-06-09
BR1100255A (pt) 2002-04-02
HK37392A (en) 1992-06-04
GB2172594A (en) 1986-09-24
GB2172594B (en) 1988-06-08
DE3609052C2 (de) 1994-10-27
CZ419591A3 (en) 1993-03-17
JPS61221194A (ja) 1986-10-01
BG60535B2 (bg) 1995-07-28

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *PHARMACIA & UPJOHN S.P.A.

Effective date: 20060318