BE904431A - Nouveaux derives morpholino de la daunorubicine et de la doxorubicine. - Google Patents

Nouveaux derives morpholino de la daunorubicine et de la doxorubicine.

Info

Publication number
BE904431A
BE904431A BE0/216422A BE216422A BE904431A BE 904431 A BE904431 A BE 904431A BE 0/216422 A BE0/216422 A BE 0/216422A BE 216422 A BE216422 A BE 216422A BE 904431 A BE904431 A BE 904431A
Authority
BE
Belgium
Prior art keywords
daunorubicin
doxorubicin
morpholino derivatives
novel morpholino
novel
Prior art date
Application number
BE0/216422A
Other languages
English (en)
Inventor
A Bargiotti
P Zini
S Penco
F Giuliani
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE904431A publication Critical patent/BE904431A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Glycosides d'anthracyclines utiles comme agents antitumeurs et répondant à la formule générale (A) : dans laquelle X représente un atome d'hydrogène ou un groupe hydroxy, tandis que R représente un atome d'hydrogène, un groupe méthyle ou un groupe hydroxy-méthyle; l'invention concerne également les sels pharmaceutiques acceptables de ces glycosides d'anthracyclines.
BE0/216422A 1985-03-22 1986-03-18 Nouveaux derives morpholino de la daunorubicine et de la doxorubicine. BE904431A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08507577A GB2172594B (en) 1985-03-22 1985-03-22 New morpholino derivatives of daunorubicin and doxorubicin

Publications (1)

Publication Number Publication Date
BE904431A true BE904431A (fr) 1986-07-16

Family

ID=10576503

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216422A BE904431A (fr) 1985-03-22 1986-03-18 Nouveaux derives morpholino de la daunorubicine et de la doxorubicine.

Country Status (10)

Country Link
US (1) US4672057A (fr)
JP (1) JPS61221194A (fr)
BE (1) BE904431A (fr)
BG (1) BG60535B2 (fr)
BR (1) BR1100255A (fr)
CZ (1) CZ419591A3 (fr)
DE (1) DE3609052C2 (fr)
GB (1) GB2172594B (fr)
HK (1) HK37392A (fr)
MX (1) MX9203114A (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823224A1 (de) * 1988-07-08 1990-01-11 Behringwerke Ag Morpholino-derivate der rhodomycine, verfahren zu ihrer herstellung und ihre verwendung
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives
US5304687A (en) * 1989-12-19 1994-04-19 Farmitalia Carlo Erba S.R.L. Morpholinyl derivatives of doxorubicin and process for their preparation
ES2094136T3 (es) * 1989-12-19 1997-01-16 Pharmacia Spa Intermediarios quirales de 1,5-diyodo-2-metoxi o benciloxi.
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
GB9019934D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
US5776458A (en) * 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9909925D0 (en) * 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives
EP1242438B1 (fr) * 1999-12-29 2006-11-08 Immunogen, Inc. Agents cytotoxiques comprenant des doxorubicines et des daunorubicines modifiees et utilisation therapeutique de ceux-ci
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
MXPA05009851A (es) * 2003-03-18 2005-12-06 Pharmacia Italia Spa Como radiosensibilizador en combinacion con terapia con radiacion contra tumores.
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
US20080058274A1 (en) * 2004-11-15 2008-03-06 Yechezkel Barenholz Combination Therapy
JP4513765B2 (ja) * 2005-04-15 2010-07-28 日本ビクター株式会社 電気音響変換器
EA200970116A1 (ru) * 2006-07-12 2009-08-28 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Кристаллический гидрохлорид неморубицина
US20100104566A1 (en) * 2007-01-29 2010-04-29 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline and an antibody
JP5302300B2 (ja) 2007-05-11 2013-10-02 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ アンスラサイクリンの医薬組成物
JP2010535169A (ja) * 2007-08-02 2010-11-18 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ プロテインキナーゼ阻害薬と組み合わせられたモルホリニルアントラサイクリン誘導体
ES2547552T3 (es) * 2008-02-01 2015-10-07 Genentech, Inc. Metabolito de nemorrubicina y reactivos análogos, conjugados anticuerpo-fármaco y métodos
EP2257310A2 (fr) * 2008-02-26 2010-12-08 Nerviano Medical Sciences S.r.l. Combinaison antitumorale comprenant un dérivé de morpholinyle anthracycline et des agents de déméthylation
JP6067222B2 (ja) * 2008-07-15 2017-01-25 ジェネンテック， インコーポレイテッド アントラサイクリン誘導体コンジュゲート、その調製方法及び抗腫瘍化合物としてのその用途
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
EP2638067A2 (fr) 2010-11-08 2013-09-18 Genentech, Inc. Anticorps anti-récepteur de l'il-6 administré par voie sous-cutanée
BR112013013127B1 (pt) 2010-12-02 2021-06-22 Nerviano Medical Sciences S.R.L. Processo para a preparação de derivados de morfolinil antraciclina, compostos derivados de morfolinil antraciclina e composição farmacêutica compreendendo estes compostos
CN104363924B (zh) 2012-03-16 2018-04-17 约翰霍普金斯大学 用于递送hif‑1抑制剂的控制释放调配物
KR101640912B1 (ko) * 2014-07-03 2016-07-20 현대자동차주식회사 고온 저마찰성 코팅층 및 이의 제조방법
US10149913B2 (en) 2014-09-12 2018-12-11 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (fr) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Réactifs de liaison dérivés d'anthracycline, conjugués anticorps-médicament et procédés
WO2025168481A1 (fr) 2024-02-05 2025-08-14 Nerviano Medical Sciences S.R.L. Dérivés d'imino-anthracycline et procédés

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639897A (fr) *
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
GB8507577D0 (en) 1985-05-01
GB2172594A (en) 1986-09-24
GB2172594B (en) 1988-06-08
BG60535B2 (bg) 1995-07-28
BR1100255A (pt) 2002-04-02
HK37392A (en) 1992-06-04
JPH0482160B2 (fr) 1992-12-25
US4672057A (en) 1987-06-09
JPS61221194A (ja) 1986-10-01
DE3609052C2 (de) 1994-10-27
DE3609052A1 (de) 1986-09-25
MX9203114A (es) 1992-07-01
CZ419591A3 (en) 1993-03-17

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *PHARMACIA & UPJOHN S.P.A.

Effective date: 20060318