ATE180477T1 - Verfahren und zubereitungen zur isolierung von taxanen - Google Patents
Verfahren und zubereitungen zur isolierung von taxanenInfo
- Publication number
- ATE180477T1 ATE180477T1 AT92911220T AT92911220T ATE180477T1 AT E180477 T1 ATE180477 T1 AT E180477T1 AT 92911220 T AT92911220 T AT 92911220T AT 92911220 T AT92911220 T AT 92911220T AT E180477 T1 ATE180477 T1 AT E180477T1
- Authority
- AT
- Austria
- Prior art keywords
- taxanes
- disclosed
- methods
- taxans
- preparations
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002955 isolation Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229940123237 Taxane Drugs 0.000 abstract 5
- 229930012538 Paclitaxel Natural products 0.000 abstract 2
- 229960001592 paclitaxel Drugs 0.000 abstract 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 2
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69080591A | 1991-04-19 | 1991-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE180477T1 true ATE180477T1 (de) | 1999-06-15 |
Family
ID=24774037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92911220T ATE180477T1 (de) | 1991-04-19 | 1992-04-14 | Verfahren und zubereitungen zur isolierung von taxanen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5480639A (de) |
| EP (1) | EP0580759B1 (de) |
| JP (1) | JP3222466B2 (de) |
| CN (1) | CN1069965A (de) |
| AT (1) | ATE180477T1 (de) |
| AU (1) | AU1888792A (de) |
| DE (1) | DE69229267T2 (de) |
| IE (1) | IE921251A1 (de) |
| IL (1) | IL101594A0 (de) |
| MX (1) | MX9201775A (de) |
| PT (1) | PT100401A (de) |
| SI (1) | SI9200054B (de) |
| WO (1) | WO1992018492A1 (de) |
| YU (1) | YU40892A (de) |
| ZA (1) | ZA922769B (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7264951B1 (en) | 1992-02-20 | 2007-09-04 | Phyton, Inc. | Enhanced production of taxol and taxanes by cell cultures of Taxus species |
| FR2696463B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| KR100371062B1 (ko) * | 1992-11-27 | 2003-04-21 | 에프.에이치.포울딩 앤드 컴퍼니 리미티드 | 안정성이향상된주사가능한택솔조성물및이를제형화하는방법 |
| CA2126698A1 (en) * | 1992-12-07 | 1994-06-23 | Muraleedharan G. Nair | Process for the isolation and purification of taxol and taxanes from taxus spp. |
| FR2714053B1 (fr) * | 1993-12-22 | 1996-03-08 | Pf Medicament | Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III. |
| CN1112433A (zh) * | 1994-05-24 | 1995-11-29 | 郭明 | 红豆杉属植物提取物及其应用 |
| CN1166780C (zh) * | 1995-04-29 | 2004-09-15 | (株)三养吉尼克斯 | 从紫杉属植物大量生产紫杉醇的方法 |
| US5654448A (en) * | 1995-10-02 | 1997-08-05 | Xechem International, Inc. | Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes |
| CN1054382C (zh) * | 1996-03-05 | 2000-07-12 | 核工业北京化工冶金研究院 | 用反相制备液相色谱法分离纯化紫杉醇的方法 |
| DK0954596T3 (da) | 1996-05-24 | 2006-05-15 | Phyton Inc | Foröget produktion af taxaner ved celledyrkning af Taxus-art |
| US5965752A (en) * | 1996-08-23 | 1999-10-12 | Institut National De La Recherche Scientifique | Preparative scale isolation and purification of taxanes |
| DK1068192T3 (da) | 1998-01-14 | 2002-10-14 | Bristol Myers Squibb Co | Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanol |
| DE19822881B4 (de) * | 1998-05-22 | 2004-03-11 | Institut für Bioanalytik Umwelt-Toxikologie & Biotechnologie Halle GmbH | Verfahren zur Herstellung von Baccatin-III durch enzymatische Synthese |
| US6136989A (en) * | 1998-12-30 | 2000-10-24 | Phytogen Life Sciences, Incorporated | Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material |
| US5969165A (en) * | 1999-01-07 | 1999-10-19 | 508037 (Nb) Inc. | Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| NZ538766A (en) | 2000-01-13 | 2006-09-29 | Purdue Research Foundation | A process to purify taxanes from plant biomass |
| US6452024B1 (en) | 2000-02-22 | 2002-09-17 | Chaichem Pharmaceuticals International | Process for extraction and purification of paclitaxel from natural sources |
| KR100666652B1 (ko) * | 2000-02-25 | 2007-01-09 | 한화석유화학 주식회사 | 식물 원료로부터 초임계 유체를 이용하여 탁솔을 제조하는방법 |
| EP1147764A3 (de) * | 2000-04-19 | 2002-03-20 | Nof Corporation | Kosmetische Zusammensetzung |
| EP1355708B1 (de) * | 2000-09-29 | 2008-04-30 | Regents Of The University Of Minnesota | Verfahren zum extrahieren von verbindungen aus pflanzen |
| US20020155177A1 (en) * | 2000-09-29 | 2002-10-24 | Krasutsky Pavel A. | Process for extracting compounds from plants |
| AU2002223319A1 (en) | 2000-11-08 | 2002-05-21 | Actipharm Inc. | Process for mass production of gmp paclitaxel and related taxanes |
| US6333419B1 (en) | 2000-11-28 | 2001-12-25 | Indena Spa | Chromatographic separation method of paclitaxel and cephalomannin |
| WO2004054959A1 (en) * | 2002-12-16 | 2004-07-01 | Council Of Scientific And Industrial Research | Process for isolating brevifoliol |
| US7579491B2 (en) | 2002-12-30 | 2009-08-25 | Council Of Scientific And Industrial Research | Process for preparing brevifoliol |
| US6759539B1 (en) | 2003-02-27 | 2004-07-06 | Chaichem Pharmaceuticals International | Process for isolation and purification of paclitaxel from natural sources |
| US20070129171A1 (en) * | 2005-10-12 | 2007-06-07 | Simonds Vincent J | Method for Manufacturing a Golf Product |
| DE602006018532D1 (de) * | 2006-03-24 | 2011-01-05 | Postech Acad Ind Found | Stationäre phase und säule unter verwendung von cucurbiturilgebundenem kieselgel, und verfahren zur abtrennung von taxol unter verwendung der säule |
| EP3252128B1 (de) | 2006-04-03 | 2019-01-02 | Pharmatherm Chemicals Inc. | Thermales extrationsverfahren zur herstellung eines taxanextrakts |
| US7905990B2 (en) | 2007-11-20 | 2011-03-15 | Ensyn Renewables, Inc. | Rapid thermal conversion of biomass |
| US20110284359A1 (en) | 2010-05-20 | 2011-11-24 | Uop Llc | Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas |
| US8499702B2 (en) | 2010-07-15 | 2013-08-06 | Ensyn Renewables, Inc. | Char-handling processes in a pyrolysis system |
| US9441887B2 (en) | 2011-02-22 | 2016-09-13 | Ensyn Renewables, Inc. | Heat removal and recovery in biomass pyrolysis |
| CN102219764B (zh) * | 2011-05-12 | 2013-06-26 | 河南省科学院化学研究所有限公司 | 一种工业化分离纯化紫杉醇的方法 |
| US9347005B2 (en) | 2011-09-13 | 2016-05-24 | Ensyn Renewables, Inc. | Methods and apparatuses for rapid thermal processing of carbonaceous material |
| US10041667B2 (en) | 2011-09-22 | 2018-08-07 | Ensyn Renewables, Inc. | Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same |
| US10400175B2 (en) | 2011-09-22 | 2019-09-03 | Ensyn Renewables, Inc. | Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material |
| US9044727B2 (en) | 2011-09-22 | 2015-06-02 | Ensyn Renewables, Inc. | Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material |
| US9109177B2 (en) | 2011-12-12 | 2015-08-18 | Ensyn Renewables, Inc. | Systems and methods for renewable fuel |
| US9670413B2 (en) | 2012-06-28 | 2017-06-06 | Ensyn Renewables, Inc. | Methods and apparatuses for thermally converting biomass |
| EP3492559A1 (de) | 2013-06-26 | 2019-06-05 | Ensyn Renewables, Inc. | Verfahren für erneuerbaren kraftstoff |
| EP3337966B1 (de) | 2015-08-21 | 2021-12-15 | Ensyn Renewables, Inc. | Flüssigbiomassenheizsystem |
| MY193949A (en) | 2016-12-29 | 2022-11-02 | Ensyn Renewables Inc | Demetallization Of Liquid Biomass |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206221A (en) | 1979-01-03 | 1980-06-03 | The United States Of America As Represented By The Secretary Of Agriculture | Cephalomannine and its use in treating leukemic tumors |
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| US5019504A (en) * | 1989-03-23 | 1991-05-28 | The United States Of America As Represented By The Secretary Of Agriculture | Production of taxol or taxol-like compounds in cell culture |
-
1992
- 1992-04-14 EP EP92911220A patent/EP0580759B1/de not_active Expired - Lifetime
- 1992-04-14 DE DE69229267T patent/DE69229267T2/de not_active Expired - Fee Related
- 1992-04-14 WO PCT/US1992/003088 patent/WO1992018492A1/en not_active Ceased
- 1992-04-14 JP JP51088992A patent/JP3222466B2/ja not_active Expired - Fee Related
- 1992-04-14 AU AU18887/92A patent/AU1888792A/en not_active Abandoned
- 1992-04-14 AT AT92911220T patent/ATE180477T1/de not_active IP Right Cessation
- 1992-04-15 IL IL101594A patent/IL101594A0/xx unknown
- 1992-04-15 MX MX9201775A patent/MX9201775A/es unknown
- 1992-04-15 ZA ZA922769A patent/ZA922769B/xx unknown
- 1992-04-16 SI SI9200054A patent/SI9200054B/sl not_active IP Right Cessation
- 1992-04-16 IE IE125192A patent/IE921251A1/en not_active Application Discontinuation
- 1992-04-16 PT PT100401A patent/PT100401A/pt not_active Application Discontinuation
- 1992-04-18 CN CN92102718A patent/CN1069965A/zh active Pending
- 1992-04-20 YU YU40892A patent/YU40892A/sh unknown
-
1993
- 1993-07-21 US US08/095,817 patent/US5480639A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/470,746 patent/US5618538A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0580759A1 (de) | 1994-02-02 |
| JPH06509560A (ja) | 1994-10-27 |
| US5480639A (en) | 1996-01-02 |
| IL101594A0 (en) | 1992-12-30 |
| CN1069965A (zh) | 1993-03-17 |
| IE921251A1 (en) | 1992-10-21 |
| EP0580759B1 (de) | 1999-05-26 |
| US5618538A (en) | 1997-04-08 |
| SI9200054B (en) | 2001-12-31 |
| YU40892A (sh) | 1994-06-24 |
| PT100401A (pt) | 1993-08-31 |
| DE69229267D1 (de) | 1999-07-01 |
| ZA922769B (en) | 1992-12-30 |
| WO1992018492A1 (en) | 1992-10-29 |
| JP3222466B2 (ja) | 2001-10-29 |
| SI9200054A (en) | 1992-11-27 |
| DE69229267T2 (de) | 1999-12-16 |
| AU1888792A (en) | 1992-11-17 |
| MX9201775A (es) | 1992-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |