ATE180496T1 - Peptid zur beschleunigung der wirkung des proteins-c mit thrombin - Google Patents

Peptid zur beschleunigung der wirkung des proteins-c mit thrombin

Info

Publication number
ATE180496T1
ATE180496T1 AT88900790T AT88900790T ATE180496T1 AT E180496 T1 ATE180496 T1 AT E180496T1 AT 88900790 T AT88900790 T AT 88900790T AT 88900790 T AT88900790 T AT 88900790T AT E180496 T1 ATE180496 T1 AT E180496T1
Authority
AT
Austria
Prior art keywords
peptide
thrombin
protein
accelerate
action
Prior art date
Application number
AT88900790T
Other languages
English (en)
Inventor
Shuji Yamamoto
Koji Suzuki
Original Assignee
Asahi Chemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27547577&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE180496(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Asahi Chemical Ind filed Critical Asahi Chemical Ind
Application granted granted Critical
Publication of ATE180496T1 publication Critical patent/ATE180496T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88900790T 1987-01-08 1988-01-08 Peptid zur beschleunigung der wirkung des proteins-c mit thrombin ATE180496T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP106687 1987-01-08
JP106587 1987-01-08
JP14408187 1987-06-11
JP30587787 1987-12-04
JP30587887 1987-12-04
JP30587687 1987-12-04

Publications (1)

Publication Number Publication Date
ATE180496T1 true ATE180496T1 (de) 1999-06-15

Family

ID=27547577

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88900790T ATE180496T1 (de) 1987-01-08 1988-01-08 Peptid zur beschleunigung der wirkung des proteins-c mit thrombin

Country Status (5)

Country Link
US (1) US6034060A (de)
EP (4) EP0312598B1 (de)
AT (1) ATE180496T1 (de)
DE (1) DE3856335T2 (de)
WO (1) WO1988005053A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
CA2022713A1 (en) * 1989-08-11 1991-02-12 Nils U. Bang Human thrombomodulin derivatives
WO1991004276A1 (en) * 1989-09-25 1991-04-04 Asahi Kasei Kogyo Kabushiki Kaisha Isolated, physiologically active human thrombomodulin polypeptide
AU643306B2 (en) * 1990-06-27 1993-11-11 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
KR930008093B1 (ko) * 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
EP0689843B1 (de) * 1993-12-17 2003-09-10 Mochida Pharmaceutical Co., Ltd. Lösliches thrombomodulin enthaltende zubereitung
WO1995028953A1 (en) * 1994-04-20 1995-11-02 Asahi Kasei Kogyo Kabushiki Kaisha Hepatopathy remedy
US5916874A (en) * 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
EP0965597A4 (de) * 1996-12-27 2003-01-08 Mochida Pharm Co Ltd Zellmembran-wirksame medikamente
AU729876B2 (en) 1997-10-15 2001-02-15 Asahi Kasei Kabushiki Kaisha Method for maintaining the quality of aqueous injection preparation of thrombomodulin over its storage/transportation
CA2332571A1 (en) * 1998-06-30 2000-01-06 Mochida Pharmaceutical Co., Ltd. Novel sugar chain-bonded thrombomodulin-like peptide
US20060083733A1 (en) * 2002-01-18 2006-04-20 Fumihide Nishio High-concentration preparation of soluble thrombomodulin
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
CN101522206B (zh) * 2006-10-06 2013-03-27 旭化成制药株式会社 弥散性血管内凝血综合征的治疗剂和/或改善剂
EP2138505B1 (de) 2007-03-23 2014-08-06 Asahi Kasei Pharma Corporation Verfahren zur herstellung von hochreinem löslichen thrombomodulin
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
US20120270789A1 (en) 2009-06-12 2012-10-25 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
CN103037893A (zh) 2010-06-14 2013-04-10 帕昂德国有限公司 具有纤溶亢进的凝血病的治疗
AU2012337838B2 (en) 2011-11-15 2016-04-21 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
US10709767B2 (en) * 2012-05-31 2020-07-14 Kinki University Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
KR20210060574A (ko) 2018-10-22 2021-05-26 아사히 가세이 파마 가부시키가이샤 응고 이상을 수반하는 패혈증의 치료 및/또는 개선을 위한 의약
JP7541993B2 (ja) 2019-03-14 2024-08-29 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥用ローディングトレイ組立体、凍結乾燥システム及び凍結乾燥方法
CN117534731B (zh) * 2021-09-24 2024-10-29 深圳市海伦海生物科技有限公司 一种抗凝血肽及其在抗凝血产品上的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
WO1987000050A1 (fr) * 1985-06-28 1987-01-15 Asahi Kasei Kogyo Kabushiki Kaisha Nouvelle substance physiologiquement active limitant la coagulation du sang
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
US5466668A (en) * 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
AU643306B2 (en) * 1990-06-27 1993-11-11 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
US5583102A (en) * 1993-12-03 1996-12-10 University Of Iowa Research Foundation Human thrombomodulin in wound healing

Also Published As

Publication number Publication date
DE3856335D1 (de) 1999-07-01
WO1988005053A1 (fr) 1988-07-14
JPH11236335A (ja) 1999-08-31
US6034060A (en) 2000-03-07
EP0312598B1 (de) 1999-05-26
EP0312598A1 (de) 1989-04-26
EP0312598A4 (de) 1989-05-16
EP0816494A1 (de) 1998-01-07
HK1002591A1 (en) 1998-09-04
EP0816493A1 (de) 1998-01-07
EP0816495A1 (de) 1998-01-07
DE3856335T2 (de) 2000-01-27

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Legal Events

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EELA Cancelled due to lapse of time