ATE182587T1 - Derivate von 6-substituierten azyklischen pyrimidin-nukleosiden und diese als wirkstoff enthaltende antivirale mittel - Google Patents
Derivate von 6-substituierten azyklischen pyrimidin-nukleosiden und diese als wirkstoff enthaltende antivirale mittelInfo
- Publication number
- ATE182587T1 ATE182587T1 AT90402693T AT90402693T ATE182587T1 AT E182587 T1 ATE182587 T1 AT E182587T1 AT 90402693 T AT90402693 T AT 90402693T AT 90402693 T AT90402693 T AT 90402693T AT E182587 T1 ATE182587 T1 AT E182587T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- atom
- group
- hydrogen atom
- oxygen
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 239000002718 pyrimidine nucleoside Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- -1 arylcarbonylalkyl Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000004434 sulfur atom Chemical group 0.000 abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000005110 aryl thio group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005201 cycloalkylcarbonyloxy group Chemical group 0.000 abstract 1
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 abstract 1
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/58—Two sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25453189 | 1989-09-29 | ||
| JP5970090 | 1990-03-09 | ||
| JP2200895A JPH0751567B2 (ja) | 1989-09-29 | 1990-07-27 | ６―置換アシクロピリミジンヌクレオシド誘導体及び該誘導体を有効成分とする抗ウイルス剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE182587T1 true ATE182587T1 (de) | 1999-08-15 |
Family
ID=27296972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90402693T ATE182587T1 (de) | 1989-09-29 | 1990-09-28 | Derivate von 6-substituierten azyklischen pyrimidin-nukleosiden und diese als wirkstoff enthaltende antivirale mittel |
| AT97110658T ATE222891T1 (de) | 1989-09-29 | 1990-09-28 | 6-substituierte acylopyrimidin-nucleoside- derivate und diese als wirksamen stoff enthaltende antivirusmittel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97110658T ATE222891T1 (de) | 1989-09-29 | 1990-09-28 | 6-substituierte acylopyrimidin-nucleoside- derivate und diese als wirksamen stoff enthaltende antivirusmittel |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0829476B1 (de) |
| AT (2) | ATE182587T1 (de) |
| CA (1) | CA2026226C (de) |
| DD (1) | DD299297A5 (de) |
| DE (2) | DE69033998T2 (de) |
| DK (2) | DK0420763T3 (de) |
| ES (2) | ES2177861T3 (de) |
| GR (1) | GR3031231T3 (de) |
| HU (1) | HU205917B (de) |
| PH (1) | PH30766A (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5278167A (en) * | 1992-05-13 | 1994-01-11 | Brown University Research Foundation | 6-pyridyl substituted pyrimidine derivatives |
| EP0631783A1 (de) * | 1993-06-03 | 1995-01-04 | Mitsubishi Chemical Corporation | Antivirale Kombinationen von 2',3-Di-deoxyribonukleosiden mit 6-benzyl-1-ethoxy-methyl-5-substituierten Uracil-Derivaten |
| KR0151811B1 (ko) * | 1993-12-21 | 1998-10-15 | 강박광 | 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법 |
| BR9408370A (pt) * | 1994-02-28 | 1997-08-26 | Sunkyong Ind Ltd | Derivados aciclonucleosídeo de pirimidina |
| DE69628750T2 (de) * | 1996-02-22 | 2004-04-29 | Samjin Pharm, Co., Ltd. | Neue antivirale, homocarbozklische nukleosidderivate von substituierten pyrimidindionen, verfahren zu ihrer herstellung und zusammensetzungen, die diese als aktiven bestandteil enthalten |
| US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
| FR2781219B1 (fr) | 1998-07-16 | 2000-08-25 | Synthelabo | Procede pour la preparation de 5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4 (1h, 3h) -dione |
| US6136335A (en) | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
| ATE274500T1 (de) * | 1999-03-04 | 2004-09-15 | Korea Res Inst Chem Tech | Anivirale 2,4-pyrimidindion-derivate und ein verfahren zu ihrer herstellung |
| KR20000065885A (ko) * | 1999-04-10 | 2000-11-15 | 최승주 | 항바이러스성 피리미딘다이온 유도체 및 그 제조방법 |
| US6545152B1 (en) | 2000-07-18 | 2003-04-08 | Parker Hughes Institute | R-isomers of nonnucleoside inhibitors |
| US6689793B2 (en) | 2000-12-06 | 2004-02-10 | Parker Hughes Institute | Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity |
| FR2820135B1 (fr) * | 2001-01-29 | 2005-01-14 | Univ Geneve | Derives d'acyclonucleosides pyrimidiniques, leur procede de preparation et leur utilisation |
| ATE370127T1 (de) | 2001-01-29 | 2007-09-15 | Univ Geneve | Pyrimidinische azyklonukleoside, verfahren zur ihrer herstellung und ihre verwendung |
| AU2003205536A1 (en) * | 2002-01-11 | 2003-07-24 | Statens Serum Institut | Anti-retroviral 5,6-disubstituted acyclopyrimidine nucleoside derivatives |
| JP2006500351A (ja) * | 2002-08-13 | 2006-01-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | マトリックスメタロプロテアーゼ−１３阻害剤としてのピリミジン−２，４−ジオン誘導体 |
| HRPK20090508B3 (hr) | 2009-09-25 | 2012-12-31 | Sveučilište u Zagrebu | Novi 6-supstituirani derivati pirimidina |
| CN117886870A (zh) * | 2021-08-27 | 2024-04-16 | 南京知和医药科技有限公司 | 一种新型的胞苷衍生物及其药物组合物和用途 |
| CN115554303B (zh) * | 2021-09-18 | 2024-07-09 | 上海科技大学 | 一种三环类化合物、其制备方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3497515A (en) * | 1966-02-04 | 1970-02-24 | Du Pont | 3,5,6-substituted uracils |
| DE2126148A1 (en) * | 1971-05-26 | 1972-12-07 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Prepn of uracil derivs - useful as plant - protection agents and their inters |
| DE2142317A1 (de) * | 1971-08-24 | 1973-03-01 | Bayer Ag | Hypnotisches mittel |
| DE3206197A1 (de) * | 1982-02-20 | 1983-09-01 | Henkel KGaA, 4000 Düsseldorf | Uracil-derivate als antiseborrhoische zusaetze fuer kosmetische mittel |
| JPS61205261A (ja) * | 1985-03-08 | 1986-09-11 | Sagami Chem Res Center | ６―置換―５―フルオロウラシル誘導体 |
| KR950006713B1 (ko) * | 1988-03-31 | 1995-06-21 | 미쓰비시 가세이 가부시끼가이샤 | 6-치환 비환식 피리미딘뉴클레오시드 유도체 및 그 유도체를 유효성분으로 하는 항 비루스제 |
-
1990
- 1990-09-24 HU HU906019A patent/HU205917B/hu not_active IP Right Cessation
- 1990-09-26 PH PH41275A patent/PH30766A/en unknown
- 1990-09-26 CA CA002026226A patent/CA2026226C/en not_active Expired - Fee Related
- 1990-09-28 ES ES97110658T patent/ES2177861T3/es not_active Expired - Lifetime
- 1990-09-28 EP EP97110658A patent/EP0829476B1/de not_active Expired - Lifetime
- 1990-09-28 EP EP90402693A patent/EP0420763B1/de not_active Expired - Lifetime
- 1990-09-28 DK DK90402693T patent/DK0420763T3/da active
- 1990-09-28 DE DE69033998T patent/DE69033998T2/de not_active Expired - Fee Related
- 1990-09-28 AT AT90402693T patent/ATE182587T1/de not_active IP Right Cessation
- 1990-09-28 DK DK97110658T patent/DK0829476T3/da active
- 1990-09-28 DD DD90344301A patent/DD299297A5/de unknown
- 1990-09-28 ES ES90402693T patent/ES2134758T3/es not_active Expired - Lifetime
- 1990-09-28 DE DE69033223T patent/DE69033223T2/de not_active Expired - Fee Related
- 1990-09-28 AT AT97110658T patent/ATE222891T1/de not_active IP Right Cessation
-
1999
- 1999-09-16 GR GR990402322T patent/GR3031231T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0420763B1 (de) | 1999-07-28 |
| AU642906B2 (en) | 1993-11-04 |
| ES2134758T3 (es) | 1999-10-16 |
| DK0829476T3 (da) | 2002-11-11 |
| EP0829476A3 (de) | 1999-02-24 |
| EP0420763A2 (de) | 1991-04-03 |
| HUT55006A (en) | 1991-04-29 |
| DD299297A5 (de) | 1992-04-09 |
| HU205917B (en) | 1992-07-28 |
| CA2026226C (en) | 2003-08-19 |
| HU906019D0 (en) | 1991-03-28 |
| DE69033998D1 (de) | 2002-10-02 |
| CA2026226A1 (en) | 1991-03-30 |
| AU6326290A (en) | 1991-04-11 |
| ES2177861T3 (es) | 2002-12-16 |
| DE69033998T2 (de) | 2003-05-08 |
| EP0829476A2 (de) | 1998-03-18 |
| EP0829476B1 (de) | 2002-08-28 |
| PH30766A (en) | 1997-10-17 |
| EP0420763A3 (en) | 1991-09-18 |
| DK0420763T3 (da) | 2000-03-06 |
| DE69033223D1 (de) | 1999-09-02 |
| GR3031231T3 (en) | 1999-12-31 |
| ATE222891T1 (de) | 2002-09-15 |
| DE69033223T2 (de) | 1999-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |