ES2134758T3 - Derivados de nucleosidos de aciclopirimidina 6-sustituidos y agente antivirico que los contiene como su ingrediente activo. - Google Patents

Derivados de nucleosidos de aciclopirimidina 6-sustituidos y agente antivirico que los contiene como su ingrediente activo.

Info

Publication number
ES2134758T3
ES2134758T3 ES90402693T ES90402693T ES2134758T3 ES 2134758 T3 ES2134758 T3 ES 2134758T3 ES 90402693 T ES90402693 T ES 90402693T ES 90402693 T ES90402693 T ES 90402693T ES 2134758 T3 ES2134758 T3 ES 2134758T3
Authority
ES
Spain
Prior art keywords
alkyl
atom
group
hydrogen atom
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90402693T
Other languages
English (en)
Inventor
Tadashi Miyasaka
Hiromichi Tanaka
Clercq Erik Desire Alice De
Masanori Baba
Richard Thomas Walker
Masaru Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2200895A external-priority patent/JPH0751567B2/ja
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of ES2134758T3 publication Critical patent/ES2134758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBEN DICHOS DERIVADOS DE FORMULA (I): EN LA QUE R1 REPRESENTA UN ATOMO DE HIDROGENO, HALOGENO, O GRUPOS ALQUILO, CICLOALQUILO, ALQUENILO, ALQUINILO, ALQUIL CARBONILO, ARIL CARBONILO, ARILCARBONILALQUIL, TIOARILO O ARALQUILO; R (AL CUADRADO) REPRESENTA LOS GRUPOS TIOARILO, TIOALQUILO, TIOCICLOALQUILO, ARILSULFINILO, ALQUILSULFINILO, CICLOALQUILSULFINILO, ALQUENILO, ALQUINILO, ARALQUILO, ARILCARBONILO, ARILCARBONILALQUIL O ARILOXI, TODOS ELLOS SUSTITUIDOS POR UNO O MAS DE LOS SUSTITUYENTES ELEGIDOS DE UN ATOMO HALOGENO, GRUPOS ALQUILO (HALOGENADO O NO), ALCOXI, HIDROXILO, NITRO, AMINO, CIANO Y ACIL; R3 REPRESENTA A HIDROGENO, METILO, ALQUILO RAMIFICADO O -CH2-Z-(CH2)N-R5; R5 REPRESENTA A HIDROGENO, HALOGENO, HIDROXILO, HETEROCICLICO, CALBONILOXI, FORMILOXI, ALKILCARBONILOXI, CICLOALKILCARBONILOXI, ARALKILCARBONILOXI, N-ALKILTIOCARBAMOILOXI, N-ARILCARBAMOILOXI, N-ALKILTIOCARBAMOILOXI, N-ARILTIOCARBAMOILOXI, ALCOXI, ARALKILOXI, ALQUILO RAMIFICADO O ASUSTITUIDO UNA O VARIAS VECES, HALOGENO, ARIL, ALKIL, ALCOXI, ALQUILO HALOGENADO; Z REPRESENTA GRUPO OXIGENO, SULFURO O METILENO; N REPRESENTA 0 1 O 5; R4 REPRESENTA HIDROGENO, ALQUILO O ARALQUILO; X REPRESENTA OXIGENO O SULFURO; Y REPRESENTA OXIGENO O SULFURO. TAMBIEN DESCRIBE SALES ACEPTABLES FARMACEUTICAMENTE Y LOS DERIVADOS Y LAS SALES CONTIENEN AGENTES ANTIVIRALES.
ES90402693T 1989-09-29 1990-09-28 Derivados de nucleosidos de aciclopirimidina 6-sustituidos y agente antivirico que los contiene como su ingrediente activo. Expired - Lifetime ES2134758T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25453189 1989-09-29
JP5970090 1990-03-09
JP2200895A JPH0751567B2 (ja) 1989-09-29 1990-07-27 ６―置換アシクロピリミジンヌクレオシド誘導体及び該誘導体を有効成分とする抗ウイルス剤

Publications (1)

Publication Number Publication Date
ES2134758T3 true ES2134758T3 (es) 1999-10-16

Family

ID=27296972

Family Applications (2)

Application Number Title Priority Date Filing Date
ES90402693T Expired - Lifetime ES2134758T3 (es) 1989-09-29 1990-09-28 Derivados de nucleosidos de aciclopirimidina 6-sustituidos y agente antivirico que los contiene como su ingrediente activo.
ES97110658T Expired - Lifetime ES2177861T3 (es) 1989-09-29 1990-09-28 Derivados nucleosidicos de aciclopirimidina 6-sustituidos y agente antiviral que los contiene como ingrediente activo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97110658T Expired - Lifetime ES2177861T3 (es) 1989-09-29 1990-09-28 Derivados nucleosidicos de aciclopirimidina 6-sustituidos y agente antiviral que los contiene como ingrediente activo.

Country Status (10)

Country Link
EP (2) EP0829476B1 (es)
AT (2) ATE222891T1 (es)
CA (1) CA2026226C (es)
DD (1) DD299297A5 (es)
DE (2) DE69033223T2 (es)
DK (2) DK0420763T3 (es)
ES (2) ES2134758T3 (es)
GR (1) GR3031231T3 (es)
HU (1) HU205917B (es)
PH (1) PH30766A (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278167A (en) * 1992-05-13 1994-01-11 Brown University Research Foundation 6-pyridyl substituted pyrimidine derivatives
EP0631783A1 (en) * 1993-06-03 1995-01-04 Mitsubishi Chemical Corporation Antiviral combinations of 2',3'-di-deoxyribonucleosides with 6-benzyl-1-ethoxymethyl-5-substituted uracil derivatives
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
EP0748316B1 (en) * 1994-02-28 2002-05-08 Sunkyong Industries Co., Ltd. Pyrimidine acyclonucleoside derivatives
RU2138487C1 (ru) * 1996-02-22 1999-09-27 Самдзин Фармасьютикал Ко., Лтд. Новые противовирусные гомокарбоциклические нуклеозидные производные замещенных пиримидиндионов, способ их получения и композиция, содержащая их в качестве активных ингредиентов
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
FR2781219B1 (fr) 1998-07-16 2000-08-25 Synthelabo Procede pour la preparation de 5-(1-methylethyl)-6-(phenylmethyl)pyrimidine-2,4 (1h, 3h) -dione
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US6713486B1 (en) * 1999-03-04 2004-03-30 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
US6545152B1 (en) 2000-07-18 2003-04-08 Parker Hughes Institute R-isomers of nonnucleoside inhibitors
US6689793B2 (en) 2000-12-06 2004-02-10 Parker Hughes Institute Piperidinylethyl-, phenoxyethyl-, and β-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity
FR2820135B1 (fr) * 2001-01-29 2005-01-14 Univ Geneve Derives d'acyclonucleosides pyrimidiniques, leur procede de preparation et leur utilisation
ATE370127T1 (de) 2001-01-29 2007-09-15 Univ Geneve Pyrimidinische azyklonukleoside, verfahren zur ihrer herstellung und ihre verwendung
WO2003057677A1 (en) * 2002-01-11 2003-07-17 Syddansk Universitet Anti-retroviral 5,6-disubstituted acyclopyrimidine nucleoside derivatives
MXPA05001783A (es) 2002-08-13 2005-04-25 Warner Lambert Co Derivados de pirimidina-2,4-diona como inhibidores de las metaloproteinasas de matriz.
HRPK20090508B3 (hr) 2009-09-25 2012-12-31 Sveučilište u Zagrebu Novi 6-supstituirani derivati pirimidina
WO2023025319A1 (zh) * 2021-08-27 2023-03-02 南京知和医药科技有限公司 一种新型的胞苷衍生物及其药物组合物和用途
CN115554303B (zh) * 2021-09-18 2024-07-09 上海科技大学 一种三环类化合物、其制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3497515A (en) * 1966-02-04 1970-02-24 Du Pont 3,5,6-substituted uracils
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2142317A1 (de) * 1971-08-24 1973-03-01 Bayer Ag Hypnotisches mittel
DE3206197A1 (de) * 1982-02-20 1983-09-01 Henkel KGaA, 4000 Düsseldorf Uracil-derivate als antiseborrhoische zusaetze fuer kosmetische mittel
JPS61205261A (ja) * 1985-03-08 1986-09-11 Sagami Chem Res Center ６―置換―５―フルオロウラシル誘導体
CH676712A5 (es) * 1988-03-31 1991-02-28 Mitsubishi Chem Ind

Also Published As

Publication number Publication date
EP0829476A3 (en) 1999-02-24
EP0420763A3 (en) 1991-09-18
EP0420763B1 (en) 1999-07-28
HU906019D0 (en) 1991-03-28
AU6326290A (en) 1991-04-11
AU642906B2 (en) 1993-11-04
HUT55006A (en) 1991-04-29
DD299297A5 (de) 1992-04-09
CA2026226A1 (en) 1991-03-30
DE69033998D1 (de) 2002-10-02
EP0829476B1 (en) 2002-08-28
CA2026226C (en) 2003-08-19
PH30766A (en) 1997-10-17
DE69033998T2 (de) 2003-05-08
EP0420763A2 (en) 1991-04-03
DK0420763T3 (da) 2000-03-06
ATE222891T1 (de) 2002-09-15
DE69033223D1 (de) 1999-09-02
ATE182587T1 (de) 1999-08-15
ES2177861T3 (es) 2002-12-16
EP0829476A2 (en) 1998-03-18
GR3031231T3 (en) 1999-12-31
HU205917B (en) 1992-07-28
DK0829476T3 (da) 2002-11-11
DE69033223T2 (de) 1999-12-23

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