ATE182795T1 - Technetium-99m markierte peptide zur bilderzeugung der entzuendung - Google Patents
Technetium-99m markierte peptide zur bilderzeugung der entzuendungInfo
- Publication number
- ATE182795T1 ATE182795T1 AT94919239T AT94919239T ATE182795T1 AT E182795 T1 ATE182795 T1 AT E182795T1 AT 94919239 T AT94919239 T AT 94919239T AT 94919239 T AT94919239 T AT 94919239T AT E182795 T1 ATE182795 T1 AT E182795T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- technetium
- methods
- radiolabel
- labeled peptides
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title abstract 2
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 230000004054 inflammatory process Effects 0.000 title abstract 2
- 229940056501 technetium 99m Drugs 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 3
- 150000001875 compounds Chemical group 0.000 abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 2
- 239000012216 imaging agent Substances 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/073,577 US5561220A (en) | 1991-02-08 | 1993-06-07 | Technetium-99m labeled peptides for imaging inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE182795T1 true ATE182795T1 (de) | 1999-08-15 |
Family
ID=22114537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94919239T ATE182795T1 (de) | 1993-06-07 | 1994-05-25 | Technetium-99m markierte peptide zur bilderzeugung der entzuendung |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5561220A (de) |
| EP (1) | EP0702570B1 (de) |
| JP (1) | JP2941060B2 (de) |
| AT (1) | ATE182795T1 (de) |
| AU (1) | AU684294B2 (de) |
| CA (1) | CA2164707C (de) |
| DE (1) | DE69419919T2 (de) |
| DK (1) | DK0702570T3 (de) |
| ES (1) | ES2135585T3 (de) |
| GR (1) | GR3031351T3 (de) |
| SG (1) | SG44702A1 (de) |
| WO (1) | WO1994028942A1 (de) |
| ZA (1) | ZA943984B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2774378B2 (ja) * | 1991-02-08 | 1998-07-09 | ダイアテク,インコーポレイテッド | 映像用テクネチウム−99m標識化ポリペプチド |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5993775A (en) * | 1991-11-27 | 1999-11-30 | Diatide, Inc. | Radioactively labeled peptides comprising a single thiol moiety |
| AU683015B2 (en) * | 1992-03-13 | 1997-10-30 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| CA2167807C (en) * | 1993-07-28 | 2001-05-01 | Diatide, Inc. | Radiolabeled glucans |
| WO1995012414A1 (en) * | 1993-11-05 | 1995-05-11 | Repligen Corporation | Novel modified pf4 compositions and methods of use |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
| US5753206A (en) * | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| EP0975374B1 (de) | 1996-07-12 | 2007-12-05 | Immunomedics, Inc. | Radiometall-bindende peptide analoge |
| US6314314B1 (en) | 1999-01-14 | 2001-11-06 | Seth J. Karp | Method for locating an internal bleeding site in a human body |
| US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
| US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
| HRP20050585A2 (en) * | 2002-11-25 | 2006-02-28 | Attenuon | Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof |
| KR20060130588A (ko) * | 2003-11-18 | 2006-12-19 | 아테뉴온, 엘엘씨 | 우로키나제의 아미노 말단 단편에 결합하는 항체 및/또는이의 접합체, 조성물 및 이의 용도 |
| US20060024229A1 (en) * | 2004-07-29 | 2006-02-02 | Seth Karp | Method and product for locating an internal bleeding site |
| NZ572601A (en) | 2006-03-29 | 2012-03-30 | Univ Wayne State | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
| US20080167544A1 (en) * | 2006-12-01 | 2008-07-10 | Cold Spring Diagnostics, Inc. | Compositions And Methods For Locating An Internal Bleeding Site |
| DK2117571T3 (en) * | 2006-12-08 | 2017-05-08 | Monopar Therapeutics Inc | Urokinase-type plasminogen activator receptor epitope |
| IL295232A (en) * | 2020-02-10 | 2022-10-01 | Univ Utah Res Found | High molecular weight heparin compositions and methods for diagnosing, treating and monitoring eosinophil mediated inflammatory diseases |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057617A (en) * | 1975-05-15 | 1977-11-08 | Abramovici J | Method of labeling proteins with technetium |
| US4385046A (en) * | 1980-12-15 | 1983-05-24 | Minnesota Mining And Manufacturing Company | Diagnostic radio-labeled polysaccharide derivatives |
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
| US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4434151A (en) * | 1982-11-08 | 1984-02-28 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| EP0188256B1 (de) * | 1985-01-14 | 1991-08-21 | NeoRx | Metall-Radionuklid markiertes Protein für Diagnose und Therapie |
| US4830847A (en) * | 1985-06-28 | 1989-05-16 | The Procter & Gamble Company | Diphosphonate-derivatized macromolecules |
| US4844895A (en) * | 1985-11-01 | 1989-07-04 | New York University | Composition containing a peptide fragment of platelet factor four and method for restoring suppressed immune responses |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US4729525A (en) * | 1986-12-12 | 1988-03-08 | Trw Vehicle Safety Systems Inc. | Seat belt retractor with electrically actuatable locking mechanism |
| ATE106898T1 (de) * | 1987-03-26 | 1994-06-15 | Neorx Corp | Metall-radionuklid-markierte proteine und glykoproteine zur diagnose und therapie. |
| US4952393A (en) * | 1987-04-02 | 1990-08-28 | The General Hospital Corporation | Organ infarct imaging with technetium labelled glucarate |
| DE3884703D1 (de) * | 1987-07-23 | 1993-11-11 | Bayer Ag | Halogenierte Thiadiazolyl-oxyessig-säureamide, Verfahren und Zwischenprodukte zu ihrer Herstellung und ihre Verwendung als Herbizide. |
| US5266562A (en) * | 1987-11-19 | 1993-11-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Anti-inflammatory agents |
| US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
| AU639409B2 (en) * | 1987-12-10 | 1993-07-29 | La Jolla Cancer Research Foundation | Conformationally stabilized cell adhesion peptides |
| EP0381713B1 (de) * | 1988-04-29 | 1994-01-19 | Mallinckrodt, Inc. | Diaminedithiol-chelatierungsmittel für radioarzneimittel |
| US4935223A (en) * | 1988-08-04 | 1990-06-19 | Board Of Regents, The University Of Texas System | Labeled cells for use in imaging |
| US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
| US5198424A (en) * | 1989-03-08 | 1993-03-30 | Board Of Regents Of The University Of Oklahoma | Functionally active selectin-derived peptides |
| US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
| US5376356A (en) * | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
| DE3914703A1 (de) * | 1989-05-04 | 1990-11-08 | Steinhardt Lothar | Abflussmengenregler |
| NZ233601A (en) * | 1989-05-09 | 1997-06-24 | Gen Hospital Corp | N-terminal acylated peptides having an initial sequence met (or nle) -leu-phe and having a detectable label bound through dtpa or edta to a c-terminal lys or pu residue |
| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
| CA2021951A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
| EP0410539A1 (de) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogenrezeptorantagonisten |
| EP0410537A1 (de) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogen-Rezeptor-Antagonisten |
| EP0410541A1 (de) * | 1989-07-28 | 1991-01-30 | Merck & Co. Inc. | Fibrinogenrezeptorantagonisten |
| NZ235563A (en) * | 1989-10-13 | 1993-04-28 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical composition |
| NZ235564A (en) * | 1989-10-13 | 1993-10-26 | Merck & Co Inc | Fibrinogen receptor antagonist and pharmaceutical compositions |
| CA2027936C (en) * | 1989-10-23 | 2001-07-24 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
| US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
| IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
| US5011676A (en) * | 1990-03-27 | 1991-04-30 | Thomas Jefferson University | Method to directly radiolabel antibodies for diagnostic imaging and therapy |
| WO1991015515A1 (en) * | 1990-04-06 | 1991-10-17 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| JP2774378B2 (ja) * | 1991-02-08 | 1998-07-09 | ダイアテク,インコーポレイテッド | 映像用テクネチウム−99m標識化ポリペプチド |
| AU683015B2 (en) * | 1992-03-13 | 1997-10-30 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
-
1993
- 1993-06-07 US US08/073,577 patent/US5561220A/en not_active Expired - Fee Related
-
1994
- 1994-05-25 WO PCT/US1994/005895 patent/WO1994028942A1/en not_active Ceased
- 1994-05-25 DE DE69419919T patent/DE69419919T2/de not_active Expired - Fee Related
- 1994-05-25 JP JP7501848A patent/JP2941060B2/ja not_active Expired - Lifetime
- 1994-05-25 ES ES94919239T patent/ES2135585T3/es not_active Expired - Lifetime
- 1994-05-25 DK DK94919239T patent/DK0702570T3/da active
- 1994-05-25 EP EP94919239A patent/EP0702570B1/de not_active Expired - Lifetime
- 1994-05-25 AU AU70453/94A patent/AU684294B2/en not_active Ceased
- 1994-05-25 CA CA002164707A patent/CA2164707C/en not_active Expired - Fee Related
- 1994-05-25 SG SG1996005922A patent/SG44702A1/en unknown
- 1994-05-25 AT AT94919239T patent/ATE182795T1/de not_active IP Right Cessation
- 1994-06-07 ZA ZA943984A patent/ZA943984B/xx unknown
-
1995
- 1995-06-05 US US08/462,784 patent/US5714579A/en not_active Expired - Fee Related
-
1999
- 1999-09-29 GR GR990402444T patent/GR3031351T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG44702A1 (en) | 1997-12-19 |
| AU7045394A (en) | 1995-01-03 |
| DE69419919D1 (de) | 1999-09-09 |
| EP0702570B1 (de) | 1999-08-04 |
| AU684294B2 (en) | 1997-12-11 |
| US5714579A (en) | 1998-02-03 |
| JPH08509001A (ja) | 1996-09-24 |
| ES2135585T3 (es) | 1999-11-01 |
| ZA943984B (en) | 1995-01-16 |
| CA2164707A1 (en) | 1994-12-22 |
| CA2164707C (en) | 2001-01-16 |
| US5561220A (en) | 1996-10-01 |
| DE69419919T2 (de) | 2000-04-20 |
| JP2941060B2 (ja) | 1999-08-25 |
| DK0702570T3 (da) | 2000-03-06 |
| WO1994028942A1 (en) | 1994-12-22 |
| EP0702570A1 (de) | 1996-03-27 |
| GR3031351T3 (en) | 2000-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |