ATE184203T1 - Technetium-99m-markierte peptide zur bilderzeugung - Google Patents
Technetium-99m-markierte peptide zur bilderzeugungInfo
- Publication number
- ATE184203T1 ATE184203T1 AT93910660T AT93910660T ATE184203T1 AT E184203 T1 ATE184203 T1 AT E184203T1 AT 93910660 T AT93910660 T AT 93910660T AT 93910660 T AT93910660 T AT 93910660T AT E184203 T1 ATE184203 T1 AT E184203T1
- Authority
- AT
- Austria
- Prior art keywords
- peptides
- pct
- technetium
- methods
- imaging
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 229940056501 technetium 99m Drugs 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 230000007935 neutral effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/871,282 US5965107A (en) | 1992-03-13 | 1992-04-30 | Technetium-99m labeled peptides for imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE184203T1 true ATE184203T1 (de) | 1999-09-15 |
Family
ID=25357111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93910660T ATE184203T1 (de) | 1992-04-30 | 1993-04-19 | Technetium-99m-markierte peptide zur bilderzeugung |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US5965107A (de) |
| EP (1) | EP0637968B2 (de) |
| JP (1) | JPH07506111A (de) |
| KR (1) | KR100320629B1 (de) |
| AT (1) | ATE184203T1 (de) |
| AU (1) | AU681080B2 (de) |
| CA (1) | CA2111863C (de) |
| DE (1) | DE69326335T3 (de) |
| WO (1) | WO1993021962A1 (de) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| EP0570493B1 (de) * | 1991-02-08 | 2000-01-05 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| JPH07504902A (ja) * | 1992-03-13 | 1995-06-01 | ダイアタイド・インコーポレイテッド | 炎症造影用のテクネチウム−99m標識ペプチド |
| AU687080B2 (en) * | 1993-04-08 | 1998-02-19 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| AU709306B2 (en) * | 1992-04-30 | 1999-08-26 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| ATE196094T1 (de) * | 1992-05-21 | 2000-09-15 | Diatide Inc | Technetium-99m markierte peptide zur bilderzeugung von thrombus |
| US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
| US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| EP0720621B1 (de) * | 1993-06-23 | 2001-02-07 | Diatide, Inc. | Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung |
| DE69426035T2 (de) * | 1993-07-28 | 2001-05-17 | Diatide, Inc. | Radiomarkierte glukane |
| US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| US5753206A (en) | 1995-06-07 | 1998-05-19 | Immunomedics, Inc. | Radiometal-binding analogues of luteinizing hormone releasing hormone |
| US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
| JP3647881B2 (ja) * | 1996-07-12 | 2005-05-18 | イムノメディクス,インコーポレイテッド | 放射性金属元素結合ペプチドの類似化合物 |
| US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
| WO2001009188A1 (en) * | 1999-07-29 | 2001-02-08 | Dyax Corp. | Binding moieties for fibrin |
| KR100864069B1 (ko) | 2000-12-12 | 2008-10-16 | 피브렉스 메디칼 리서치 앤드 디벨롭먼트 게엠베하 | 펩타이드 및/또는 단백질, 및 치료제 및 예방제의 제조를위한 그들의 용도 |
| US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
| US6984373B2 (en) * | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| ES2719088T3 (es) * | 2001-07-10 | 2019-07-08 | Ge Healthcare Ltd | Compuestos con base peptídica para localizar receptores de integrina |
| RU2004115104A (ru) * | 2001-10-19 | 2005-02-20 | Томас Джефферсон Юниверсити (Us) | Расар-композиции и способы визуализации злокачественных опухолей, а также их терапия |
| WO2003074005A2 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) * | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US20050214859A1 (en) | 2003-03-03 | 2005-09-29 | Dyax Corp. | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
| JP5139678B2 (ja) * | 2003-07-24 | 2013-02-06 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 安定な放射性医薬品組成物およびその製法 |
| WO2005123761A1 (en) * | 2004-06-21 | 2005-12-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION |
| ES2331958T3 (es) * | 2004-06-25 | 2010-01-21 | FIBREX MEDICAL RESEARCH & DEVELOPMENT GMBH | Uso de peptidos derivados de la cadena b beta de fibrinogeno humano para el tratamiento del choque. |
| EP1700608A1 (de) | 2005-03-10 | 2006-09-13 | Schering AG | Chelate für radioaktiv markierte Konjugate mit einer stabilisierenden Seitenkette |
| CN1314456C (zh) * | 2005-09-27 | 2007-05-09 | 江苏省原子医学研究所 | 2β-[N,N'-双(2-巯乙基)乙撑二胺]甲基-3β-(4-氯苯基)托烷的药盒 |
| WO2007095659A1 (de) * | 2006-02-23 | 2007-08-30 | Fibrex Medical Research & Development Gmbh | Peptide und peptid-derivate, herstellun derselben sowie deren verwendung zur herstellung eines therapeutisch und/oder präventiv wirkenden arzneimittels |
| PT1987063E (pt) | 2006-02-23 | 2009-12-15 | Fibrex Medical Res & Dev Gmbh | Péptidos e derivados peptídicos, a produção destes bem como a sua utilização para a preparação de uma composição farmacêutica terapeuticamente e/ou preventivamente activa |
| RU2008137796A (ru) * | 2006-02-23 | 2010-03-27 | Фибрекс Медикал Рисерч Энд Девелопмент Гмбх (At) | Пептиды и производные пептидов, а также содержащие их фармацевтические композиции |
| JP5345945B2 (ja) | 2006-12-11 | 2013-11-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | フィブリン結合ペプチドおよびそのコンジュゲート |
| EP2100900A1 (de) | 2008-03-07 | 2009-09-16 | Universitätsspital Basel | Bombesin-analoge Peptid-antagonistische Konjugate |
| WO2009124265A1 (en) * | 2008-04-03 | 2009-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Probes for in vivo targeting of active cysteine proteases |
| US8110402B2 (en) | 2008-05-13 | 2012-02-07 | University Of Kansas | Metal abstraction peptide (MAP) tag and associated methods |
| EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
| US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
| WO2010108063A1 (en) | 2009-03-19 | 2010-09-23 | Wyeth Llc | Methods for the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof |
| WO2010121133A2 (en) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
| KR101200049B1 (ko) * | 2012-05-14 | 2012-11-13 | 한국원자력연구원 | 테크네튬-99엠 트리카보닐 표지 글리신 단량체 또는 올리고머 활용 생리활성분자를 이용한 프로브의 제조방법 및 이를 포함하는 영상제 조성물 |
| US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| EP2740726A1 (de) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin-Rezeptorligande |
| WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
| EP2954933A1 (de) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Konjugat mit einem Neurotensinrezptorligand |
| EP2954934A1 (de) | 2014-06-11 | 2015-12-16 | 3B Pharmaceuticals GmbH | Konjugat aus einem Neurotensinrezeptorliganden und Verwendung davon |
| AU2015273934B2 (en) | 2014-06-10 | 2020-08-20 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| WO2017011769A2 (en) | 2015-07-15 | 2017-01-19 | California Institute Of Technology | Il-17f-specific capture agents, compositions, and methods of using and making |
| JP6991148B2 (ja) | 2016-02-09 | 2022-01-12 | ブラッコ・スイス・ソシエテ・アノニム | セレクチン標的化のための組み換えキメラタンパク質 |
| US20170319722A1 (en) | 2016-04-04 | 2017-11-09 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
| EP3279197A1 (de) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Diagnose, behandlung und vorbeugung von zuständen, die mit dem neurotensin-rezeptor verbunden sind |
| WO2018064597A1 (en) | 2016-09-29 | 2018-04-05 | Indi Molecular, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same |
| WO2018085375A1 (en) | 2016-11-01 | 2018-05-11 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
| WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
| WO2020097531A1 (en) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
| US20200291391A1 (en) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
| US12216122B2 (en) | 2019-05-20 | 2025-02-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1) |
| US20220218834A1 (en) | 2019-05-20 | 2022-07-14 | Ohio State Innovation Foundation | Apohemoglobin-haptoglobin complexes and methods of using thereof |
| EP3763726A1 (de) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Verbindungen mit fibroblasten-aktivierendem proteinligand und deren verwendung |
| KR20220032078A (ko) | 2019-07-08 | 2022-03-15 | 쓰리비 파마슈티컬스 게엠베하 | 섬유모세포 활성화 단백질 리간드를 포함하는 화합물 및 그의 용도 |
| US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
| WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
| WO2022123462A1 (en) | 2020-12-09 | 2022-06-16 | 3B Pharmaceuticals Gmbh | Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof |
| EP4050018A1 (de) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Verbindungen mit fibroblasten-aktivierendem proteinligand und deren verwendung |
| EP4122499A1 (de) | 2021-07-23 | 2023-01-25 | 3B Pharmaceuticals GmbH | Inhibitoren des fibroblastenaktivierungsproteins und verwendung davon |
| CA3227425A1 (en) | 2021-07-26 | 2023-02-02 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound |
| AR128023A1 (es) | 2021-12-17 | 2024-03-20 | 3B Pharmaceuticals Gmbh | Ligandos de anhidrasa carbónica ix |
| EP4282438A1 (de) | 2022-05-23 | 2023-11-29 | ABX Advanced Biochemical Compounds GmbH | Funktionalisierte bisaminothiolderivate, komplexe mit diesen bisaminothiolderivaten und verwendung dieser komplexe als diagnostika und therapeutika |
| EP4583917A1 (de) | 2022-09-07 | 2025-07-16 | 3B Pharmaceuticals GmbH | Liganden des prostataspezifischen membranantigens (psma) und verwendung davon |
| EP4455159A1 (de) | 2023-04-25 | 2024-10-30 | 3B Pharmaceuticals GmbH | Magenhemmende peptidrezeptorliganden mit bioverteilungsmodifikator |
| WO2025055942A1 (en) | 2023-09-12 | 2025-03-20 | Shanghai Sinotau Biotech. Co., Ltd | Inhibitors of prostate specific membrane antigen and use thereof |
| EP4590664A1 (de) | 2023-09-12 | 2025-07-30 | Shanghai Sinotau Biotech. Co., Ltd | Inhibitoren des prostataspezifischen membranantigens und verwendung davon |
| WO2025245032A1 (en) | 2024-05-20 | 2025-11-27 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
| US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4434151A (en) * | 1982-11-08 | 1984-02-28 | Medi-Physics, Inc. | Bifunctional chelating agents |
| US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
| US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
| US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
| US4575506A (en) * | 1983-11-03 | 1986-03-11 | Zambon S.P.A. | Method of treatment for inhibiting the tolerance onset while treating painful syndromes with central analgesics |
| US4638051A (en) * | 1984-04-30 | 1987-01-20 | The Johns Hopkins University | Brain imaging radiopharmaceuticals |
| SE442486B (sv) * | 1984-05-22 | 1986-01-13 | Kloster Speedsteel Ab | Sett att pulvermetallurgiskt framstella snabbstalsprodukter |
| US4837003A (en) * | 1984-09-13 | 1989-06-06 | Mallinckrodt, Inc. | Radiolabeled antibody fragments |
| US5242679A (en) * | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| EP0188256B1 (de) * | 1985-01-14 | 1991-08-21 | NeoRx | Metall-Radionuklid markiertes Protein für Diagnose und Therapie |
| EP0200211A1 (de) * | 1985-05-01 | 1986-11-05 | The Research Foundation Of State University Of New York | Radiopharmazeutische Verbindungen zur Diagnose |
| GB8525974D0 (en) * | 1985-10-22 | 1985-11-27 | Nyegaard & Co As | Chemical substance |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US5279811A (en) * | 1987-02-18 | 1994-01-18 | The Du Pont Merck Pharmaceutical Company | Ester-substituted diaminedithiols and radiolabeled complexes thereof |
| US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
| AU2258788A (en) * | 1987-07-07 | 1989-01-30 | Cytrx Biopool Ltd. | Fibrin-binding compound and method |
| CA1335725C (en) * | 1987-09-25 | 1995-05-30 | Stephen W. Hadley | Method of diagnosing blood clots using fibrin-binding proteins |
| WO1989007456A1 (en) * | 1988-02-09 | 1989-08-24 | Mallinckrodt, Inc. | Method of preparing a metal-radionuclide-labelled protein |
| US5061641A (en) * | 1988-04-01 | 1991-10-29 | Immunomedics, Inc. | Method for radiolabeling proteins |
| AU3778989A (en) * | 1988-04-29 | 1989-11-29 | Mallinckrodt, Inc. | Diaminedithiol chelating agents for radiopharmaceuticals |
| JPH03505094A (ja) * | 1988-05-02 | 1991-11-07 | ニュー イングランド ディーコネス ホスピタル コーポレイション | 動脈映像のための合成ペプチド |
| US4988496A (en) * | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5218128A (en) * | 1988-06-15 | 1993-06-08 | Centocor, Inc. | Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom |
| WO1989012680A1 (en) * | 1988-06-20 | 1989-12-28 | Washington University | USE OF MODIFIED tPA TO DETECT BLOOD CLOTS |
| AU616284B2 (en) * | 1988-06-23 | 1991-10-24 | E.I. Du Pont De Nemours And Company | Catalyzed hydrofluorination process |
| US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
| US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
| US5376356A (en) * | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
| NZ314680A (en) * | 1989-05-09 | 2000-08-25 | Ortho Pharma Corp | Treating localised infection or inflammation with a therapeutically conjugated chemotactic peptide |
| DE69023394T2 (de) * | 1989-06-16 | 1996-07-04 | Merck Frosst Canada Inc | Chelat-Derivate von atrialnatriurethischem Faktor (ANF). |
| US5248764A (en) * | 1989-06-16 | 1993-09-28 | Merck Frosst Canada, Inc. | Chelate derivatives of atrial natriuretic factor (ANF) |
| GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
| DK0436005T3 (da) * | 1989-07-20 | 1995-07-03 | Sandoz Ltd | Mærkede polypeptidderivater |
| FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
| US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
| EP0412201B1 (de) * | 1989-08-11 | 1993-10-27 | Siemens Aktiengesellschaft | Einphasen-Asynchronmotor |
| US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
| AU663291B2 (en) * | 1990-05-03 | 1995-10-05 | New England Deaconess Hospital Corporation | Synthetic peptides for arterial imaging |
| US5382654A (en) * | 1992-02-05 | 1995-01-17 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
| US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
| US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
| US7238340B1 (en) * | 1991-11-27 | 2007-07-03 | Cis Bio International | Monoamine, diamide, thiol-containing metal chelating agents |
| US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
| US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| EP0570493B1 (de) * | 1991-02-08 | 2000-01-05 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
| US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
| US5371184A (en) * | 1992-02-05 | 1994-12-06 | Mallinckrodt Medical, Inc. | Radiolabelled peptide compounds |
| JPH07504902A (ja) * | 1992-03-13 | 1995-06-01 | ダイアタイド・インコーポレイテッド | 炎症造影用のテクネチウム−99m標識ペプチド |
| US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| AU687080B2 (en) * | 1993-04-08 | 1998-02-19 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| ATE196094T1 (de) * | 1992-05-21 | 2000-09-15 | Diatide Inc | Technetium-99m markierte peptide zur bilderzeugung von thrombus |
| US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
| US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
| EP0720621B1 (de) * | 1993-06-23 | 2001-02-07 | Diatide, Inc. | Radiomarkierte somatostatin derivate zur abbildung und zur therapeutischen verwendung |
| US5480970A (en) * | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
| PT772459E (pt) * | 1994-05-02 | 2003-06-30 | Diatide Inc | Agentes de imagem marcados tecnecio-99m |
-
1992
- 1992-04-30 US US07/871,282 patent/US5965107A/en not_active Expired - Fee Related
-
1993
- 1993-04-19 CA CA002111863A patent/CA2111863C/en not_active Expired - Fee Related
- 1993-04-19 AT AT93910660T patent/ATE184203T1/de not_active IP Right Cessation
- 1993-04-19 EP EP93910660A patent/EP0637968B2/de not_active Expired - Lifetime
- 1993-04-19 US US08/170,299 patent/US6086849A/en not_active Expired - Fee Related
- 1993-04-19 DE DE69326335T patent/DE69326335T3/de not_active Expired - Fee Related
- 1993-04-19 KR KR1019930703989A patent/KR100320629B1/ko not_active Expired - Fee Related
- 1993-04-19 AU AU41076/93A patent/AU681080B2/en not_active Ceased
- 1993-04-19 JP JP5519337A patent/JPH07506111A/ja active Pending
- 1993-04-19 WO PCT/US1993/003687 patent/WO1993021962A1/en not_active Ceased
-
1995
- 1995-06-06 US US08/467,791 patent/US6093383A/en not_active Expired - Fee Related
- 1995-06-06 US US08/470,152 patent/US5780007A/en not_active Expired - Fee Related
- 1995-06-06 US US08/468,975 patent/US5776428A/en not_active Expired - Fee Related
- 1995-06-06 US US08/468,964 patent/US5922303A/en not_active Expired - Fee Related
- 1995-06-06 US US08/486,135 patent/US5720934A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU4107693A (en) | 1993-11-29 |
| CA2111863C (en) | 2001-04-24 |
| KR100320629B1 (ko) | 2002-06-20 |
| US6093383A (en) | 2000-07-25 |
| CA2111863A1 (en) | 1993-11-11 |
| DE69326335T3 (de) | 2007-03-29 |
| EP0637968B2 (de) | 2006-07-26 |
| KR940701275A (ko) | 1994-05-28 |
| US6086849A (en) | 2000-07-11 |
| EP0637968B1 (de) | 1999-09-08 |
| WO1993021962A1 (en) | 1993-11-11 |
| US5965107A (en) | 1999-10-12 |
| US5922303A (en) | 1999-07-13 |
| JPH07506111A (ja) | 1995-07-06 |
| DE69326335D1 (de) | 1999-10-14 |
| DE69326335T2 (de) | 2000-02-03 |
| US5720934A (en) | 1998-02-24 |
| AU681080B2 (en) | 1997-08-21 |
| EP0637968A1 (de) | 1995-02-15 |
| US5776428A (en) | 1998-07-07 |
| US5780007A (en) | 1998-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |