ATE182797T1 - Neuartige materialien enthaltend achirale analoge des glyceryl-phosphatidylcholins - Google Patents

Neuartige materialien enthaltend achirale analoge des glyceryl-phosphatidylcholins

Info

Publication number: ATE182797T1
Authority: AT; Austria
Prior art keywords: groups; pct; achiral; same; glyceryl
Prior art date: 1993-01-28

Application number

AT94905185T

Other languages

English (en)

Inventor

Jeremy Russell

Uxbridge Lane

Stephen Alexander Charles

Richard Neil Freeman

Judith Elizabeth Browne

Kingston Lane Park

Original Assignee

Biocompatibles Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-01-28

Filing date

1994-01-28

Publication date

1999-08-15

1994-01-28 Application filed by Biocompatibles Ltd filed Critical Biocompatibles Ltd

1999-08-15 Application granted granted Critical

1999-08-15 Publication of ATE182797T1 publication Critical patent/ATE182797T1/de

Links

239000000463 material Substances 0.000 title abstract 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 title 1
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
102000008946 Fibrinogen Human genes 0.000 abstract 1
108010049003 Fibrinogen Proteins 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
210000001124 body fluid Anatomy 0.000 abstract 1
239000010839 body fluid Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229940012952 fibrinogen Drugs 0.000 abstract 1
-1 glyceryl phosphatidyl choline analogues Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000007943 implant Substances 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
230000010118 platelet activation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
- C08G63/692—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus
- C08G63/6924—Polyesters containing atoms other than carbon, hydrogen and oxygen containing phosphorus derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/6926—Dicarboxylic acids and dihydroxy compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0076—Chemical modification of the substrate
- A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0076—Chemical modification of the substrate
- A61L33/0088—Chemical modification of the substrate by grafting of a monomer onto the substrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L33/066—Rubbers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/0804—Manufacture of polymers containing ionic or ionogenic groups
- C08G18/0833—Manufacture of polymers containing ionic or ionogenic groups containing cationic or cationogenic groups together with anionic or anionogenic groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Surgery (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Dermatology (AREA)
Manufacturing & Machinery (AREA)
Materials For Medical Uses (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT94905185T 1993-01-28 1994-01-28 Neuartige materialien enthaltend achirale analoge des glyceryl-phosphatidylcholins ATE182797T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939301702A GB9301702D0 (en)	1993-01-28	1993-01-28	New materials

Publications (1)

Publication Number	Publication Date
ATE182797T1 true ATE182797T1 (de)	1999-08-15

Family

ID=10729480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94905185T ATE182797T1 (de)	1993-01-28	1994-01-28	Neuartige materialien enthaltend achirale analoge des glyceryl-phosphatidylcholins

Country Status (7)

Country	Link
US (1)	US5717047A (de)
EP (1)	EP0682535B1 (de)
JP (1)	JPH08507293A (de)
AT (1)	ATE182797T1 (de)
DE (1)	DE69419902D1 (de)
GB (1)	GB9301702D0 (de)
WO (1)	WO1994016748A1 (de)

Families Citing this family (26)

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GB9415926D0 (en) *	1994-08-04	1994-09-28	Biocompatibles Ltd	New materials
EP0928604A1 (de)	1997-12-12	1999-07-14	Biocompatibles Limited	Stent
WO1999052574A1 (en) *	1998-04-10	1999-10-21	Massachusetts Institute Of Technology	Biopolymers resistant coatings
US6346594B1 (en) *	1998-09-21	2002-02-12	Menicon Co., Ltd.	Ocular lens material and process for producing same
EP1255761B1 (de)	2000-02-07	2005-08-31	Biocompatibles UK Limited	Silizium enthaltende verbindungen hergestellt durch michael -ähnliche additionsreaktionen als monomere und makromere
EP1122258B1 (de)	2000-02-07	2004-05-12	Biocompatibles UK Limited	Silizium enthaltende Verbindungen hergestellt durch Michael Addition als Monomere und Macromere
AU2001269961A1 (en) *	2000-07-06	2002-01-21	Guilford Pharmaceuticals	Improved polymers and polymerization processes
GB0100761D0 (en)	2001-01-11	2001-02-21	Biocompatibles Ltd	Drug delivery from stents
JP3922648B2 (ja) *	2004-05-24	2007-05-30	株式会社資生堂	アフィニティー粒子及びアフィニティー分離方法
EP3085361A1 (de)	2004-09-07	2016-10-26	Biocompatibles UK Limited	Zusammensetzungen mit camptothecinen in mikrosphären
EP2520287B1 (de)	2006-02-10	2025-03-26	Boston Scientific Medical Device Limited	Beladung von hydrophoben arzneimitteln in hydrophile polymer-abgabesysteme
US7713541B1 (en) *	2006-11-21	2010-05-11	Abbott Cardiovascular Systems Inc.	Zwitterionic terpolymers, method of making and use on medical devices
JP2008189589A (ja) *	2007-02-05	2008-08-21	Nof Corp	ホスホリルコリン基含有環状ケタール化合物、その製造方法及びホスファチジルコリン基含有ジオール化合物の製造方法
US20080286332A1 (en) *	2007-05-14	2008-11-20	Pacetti Stephen D	Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
JP5347303B2 (ja) *	2008-03-31	2013-11-20	日油株式会社	カーボネート化合物、中間体、その製造方法および用途
EP3181123A1 (de)	2008-12-02	2017-06-21	Biocompatibles Uk Ltd.	Pankreastumorbehandlung
WO2011075185A1 (en)	2009-12-18	2011-06-23	Oligasis	Targeted drug phosphorylcholine polymer conjugates
BR112012026118B1 (pt)	2010-04-15	2021-01-05	Oligasis	polímeros de alto peso molecular contendo zwitterion
WO2013176084A1 (ja) *	2012-05-22	2013-11-28	日産化学工業株式会社	シリルアルキルホスホラミダード化合物を含むシランカップリング剤
WO2015035342A2 (en)	2013-09-08	2015-03-12	Oligasis Llc	Factor viii zwitterionic polymer conjugates
US9840553B2 (en)	2014-06-28	2017-12-12	Kodiak Sciences Inc.	Dual PDGF/VEGF antagonists
KR20210013299A (ko)	2014-10-17	2021-02-03	코디악 사이언시스 인코포레이티드	부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트
KR20250057128A (ko)	2015-12-30	2025-04-28	코디악 사이언시스 인코포레이티드	항체 및 이의 접합체
CA3059938A1 (en)	2017-04-14	2018-10-18	Kodiak Sciences Inc.	Complement factor d antagonist antibodies and conjugates thereof
EP3758737A4 (de)	2018-03-02	2022-10-12	Kodiak Sciences Inc.	Il-6-antikörper und fusionskonstrukte und konjugate davon
CA3157509A1 (en)	2019-10-10	2021-04-15	Kodiak Sciences Inc.	Methods of treating an eye disorder

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EP0032622B1 (de) *	1979-12-20	1985-08-14	Dennis Chapman	Polymerisationsfähige Phospholipide und deren Polymere, Verfahren zu deren Herstellung, Verfahren zu deren Verwendung für die Bildung von Überzugschichten auf Substraten und zum Bilden von Liposomen und die daraus entstehenden Liposomzusammensetzungen und Substrate mit Überzugschichten
DE3307925A1 (de) *	1983-03-05	1984-09-06	A. Nattermann & Cie GmbH, 5000 Köln	Neue 0-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
GB8407557D0 (en) *	1984-03-23	1984-05-02	Hayward J A	Polymeric lipsomes
GB8428109D0 (en) *	1984-11-07	1984-12-12	Biocompatibles Ltd	Biocompatible surfaces
GB8527071D0 (en) *	1985-11-04	1985-12-11	Biocompatibles Ltd	Plastics
GB8618334D0 (en) *	1986-07-28	1986-09-03	Biocompatibles Ltd	Polyesters
JPS638391A (ja) *	1986-06-27	1988-01-14	Terumo Corp	重合性β−グリセロリン脂質およびその製造方法
DE3817425A1 (de) *	1988-05-21	1989-11-23	Cassella Ag	Alkenyl-phosphon- und -phosphin-saeureester, verfahren zu ihrer herstellung sowie unter deren verwendung hergestellte hydrogele und deren verwendung
GB9004881D0 (en) *	1990-03-05	1990-05-02	Biocompatibles Ltd	Method of improving the ocular of synthetic polymers haemo and biocompatibility
GB9022938D0 (en) *	1990-10-22	1990-12-05	Biocompatibles Ltd	Non-thrombogenic surfaces
GB9023498D0 (en) *	1990-10-29	1990-12-12	Biocompatibles Ltd	Soft contact lens material
DE69126440T2 (de) *	1990-11-05	1997-09-18	Biocompatibles Ltd	Phosphorsäureester und ihre verwendung zur herstellung biokompatibler oberflächen
GB9112267D0 (en) *	1991-06-07	1991-07-24	Biocompatibles Ltd	Polymeric coating
WO1993001221A1 (en) *	1991-07-05	1993-01-21	Biocompatibles Limited	Polymeric surface coatings
GB9118597D0 (en) *	1991-08-30	1991-10-16	Biocompatibles Ltd	Polymer treatments

1993
- 1993-01-28 GB GB939301702A patent/GB9301702D0/en active Pending
1994
- 1994-01-28 JP JP6516842A patent/JPH08507293A/ja active Pending
- 1994-01-28 EP EP94905185A patent/EP0682535B1/de not_active Expired - Lifetime
- 1994-01-28 DE DE69419902T patent/DE69419902D1/de not_active Expired - Lifetime
- 1994-01-28 WO PCT/GB1994/000177 patent/WO1994016748A1/en not_active Ceased
- 1994-01-28 AT AT94905185T patent/ATE182797T1/de active
- 1994-01-28 US US08/464,692 patent/US5717047A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1994016748A1 (en)	1994-08-04
EP0682535B1 (de)	1999-08-04
DE69419902D1 (de)	1999-09-09
GB9301702D0 (en)	1993-03-17
JPH08507293A (ja)	1996-08-06
US5717047A (en)	1998-02-10
EP0682535A1 (de)	1995-11-22

Publication	Publication Date	Title
ATE182797T1 (de)	1999-08-15	Neuartige materialien enthaltend achirale analoge des glyceryl-phosphatidylcholins
NO931809D0 (no)	1993-05-19	Hemofilter
FI921802A0 (fi)	1992-04-23	Uusia bioaktiivisia pinnotteita ja niiden valmistus ja käyttö
MY118508A (en)	2004-11-30	Antigestagenically active steroids with a fluorinated 17(alfa)- alkyl chain.
ATE129155T1 (de)	1995-11-15	Verwendung von phosphatidylglycerol(dic 18:10) zur behandlung obstruktiver atemwegserkrankungen.
AR010809A1 (es)	2000-07-12	Compuestos derivados de aminofosfonatos, un procedimiento para su preparacion, composicion farmaceutica que los comprenden, uso de los mismospara la fabricacion de un medicamento util en el tratamiento de arterioesclerosis
TR199701121T1 (xx)	1998-03-21	Benazepril veya benazeprilat ve valsartan i�eren kombinasyon bile�imleri.
ES2150907T3 (es)	2000-12-16	Derivados de aminoacidos.
ATE232387T1 (de)	2003-02-15	Verwendung eines inositoltriphosphatester, zur herstellung eines medikamentes
DE3473597D1 (en)	1988-09-29	Benzothiazine derivatives, processes for their preparation, medicaments containing them, and their use
FI925875A0 (fi)	1992-12-23	Foerfarande foer framstaellning av nya som inhibitorer av proteolytiska enzymer anvaendbara 2-sackarinylmetyl- och 4,5,6,7-tetrahydro-2-sackarinylmetylfosfater, -fosfonater och -fosfinater
ATE247474T1 (de)	2003-09-15	Verwendung von inosittriphosphat zur herstellung von arzneimitteln
NO177675C (no)	1995-11-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive P-substituerte propan-fosfinsyre forbindelser
HU9403100D0 (en)	1994-12-28	Lineare adhesive inhibitors and pharmaceutical compositions containing them
FI903741A0 (fi)	1990-07-26	Arylpyrazolderivat, som foerhindrar aggregation av blodplaettar.
ATE99164T1 (de)	1994-01-15	Zahnbehandlung durch freisetzung von vesikeln.
HU9501691D0 (en)	1995-08-28	New triazoloquinazolines, their production and their use
ZA936603B (en)	1994-03-29	Ureidoacetamide derivatives their preparation and medicaments containing them
DE69301662D1 (de)	1996-04-04	Optisch aktives hydrochinin (amino-3-phenyl)-1-ethansulfonat, deren herstellung und verwendung
HUP0003500A2 (hu)	2001-02-28	Adhézió inhibitor ciklopeptidszármazékok, azokat tartalmazó gyógyszerkészítmények, eljárás előállításukra, és alkalmazásuk