ATE183187T1 - 1,4-diazepin-derivate und deren pharmazeutische verwendung - Google Patents

1,4-diazepin-derivate und deren pharmazeutische verwendung

Info

Publication number: ATE183187T1
Authority: AT; Austria
Prior art keywords: hydrogen; pharmaceutical use; diazepine derivatives; alkyl; diazepine
Prior art date: 1988-10-31

Application number

AT89119910T

Other languages

English (en)

Inventor

Kazuo Okano

Shuhei Miyazawa

Richard Stephen John Clark

Shinya Abe

Tetsuya Kawahara

Naoyuki Shimomura

Osamu Asano

Hiroyuki Yoshimura

Mitsuaki Miyamoto

Yoshinori Sakuma

Kenzo Muramoto

Hiroshi Obaishi

Koukichi Harada

Hajime Tsunoda

Satoshi Katayama

Kouji Yamada

Shigeru Souda

Yoshimasa Machida

Kouichi Katayama

Isao Yamatsu

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-31

Filing date

1989-10-26

Publication date

1999-08-15

1989-10-26 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1999-08-15 Application granted granted Critical

1999-08-15 Publication of ATE183187T1 publication Critical patent/ATE183187T1/de

Links

150000004911 1,4-diazepines Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Immunology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT89119910T 1988-10-31 1989-10-26 1,4-diazepin-derivate und deren pharmazeutische verwendung ATE183187T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP27546088		1988-10-31
JP29706888		1988-11-24
JP31801688		1988-12-16
JP33162288		1988-12-28

Publications (1)

Publication Number	Publication Date
ATE183187T1 true ATE183187T1 (de)	1999-08-15

Family

ID=27479049

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT95111206T ATE213247T1 (de)	1988-10-31	1989-10-26	Thieno(3,2-f) (1,2,4- triazolo)(4,3-a) 1,4- diazepinderivate als paf-antagonisten
AT94101416T ATE234306T1 (de)	1988-10-31	1989-10-26	Thieno 3,2-f 1,2,4 triazolo 4,3-a 1,4 diazepinderivate als paf-antagonisten
AT89119910T ATE183187T1 (de)	1988-10-31	1989-10-26	1,4-diazepin-derivate und deren pharmazeutische verwendung

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT95111206T ATE213247T1 (de)	1988-10-31	1989-10-26	Thieno(3,2-f) (1,2,4- triazolo)(4,3-a) 1,4- diazepinderivate als paf-antagonisten
AT94101416T ATE234306T1 (de)	1988-10-31	1989-10-26	Thieno 3,2-f 1,2,4 triazolo 4,3-a 1,4 diazepinderivate als paf-antagonisten

Country Status (15)

Country	Link
EP (3)	EP0606103B1 (de)
JP (1)	JP2756004B2 (de)
KR (1)	KR910009332B1 (de)
CN (1)	CN1036520C (de)
AT (3)	ATE213247T1 (de)
AU (1)	AU621413B2 (de)
CA (1)	CA2000985C (de)
DE (3)	DE68929049T2 (de)
DK (1)	DK540689A (de)
FI (1)	FI95708C (de)
HU (1)	HU217127B (de)
NO (1)	NO175259C (de)
NZ (1)	NZ231188A (de)
PH (1)	PH27461A (de)
PT (1)	PT92153B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH30676A (en) *	1986-07-22	1997-09-16	Boehringer Ingelhein Kg	Hetrazepine compounds which have useful pharmaceutical utility
GB8907257D0 (en) *	1989-03-31	1989-05-17	Rech Et D Applic Scient Scras	New derivatives of hetrazepine as anti-paf and anti-ischemic agents
GB8907256D0 (en) *	1989-03-31	1989-05-17	Rech Et D Applic Scient Scras	New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
AT394563B (de) *	1990-05-09	1992-05-11	Scras	Verfahren zur herstellung von thieno-triazolodiazepinderivaten
DE4027470A1 (de) *	1990-08-30	1992-03-05	Boehringer Ingelheim Kg	Neue hetrazepinoide amide
DE4107521A1 (de) *	1991-03-08	1992-09-10	Boehringer Ingelheim Kg	Neue acylaminosubstituierte hetrazepine
US5686479A (en) *	1991-12-11	1997-11-11	Yoshitomi Pharmaceutical Industries, Ltd.	Immunosuppressive drug
TW219935B (de) *	1991-12-25	1994-02-01	Mitsubishi Chemicals Co Ltd
US5530141A (en) *	1992-03-04	1996-06-25	Center For Innovative Technology	2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) *	1992-03-04	1997-06-17	Center For Innovative Technology	Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5434151A (en) *	1992-08-24	1995-07-18	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5358938A (en) *	1992-07-13	1994-10-25	Cytomed, Inc.	Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5648486A (en) *	1992-07-13	1997-07-15	Cytomed, Inc.	Compounds and methods for the treatment of inflammatory and immune disorders
US5463083A (en)	1992-07-13	1995-10-31	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
HUT72601A (en)	1992-07-13	1996-05-28	Cytomed Inc	2,5-diaryl tetrahydro-thiophenes-furans and analogs for the treatment of inflammatory and immune disorders
ES2061406B1 (es) *	1993-05-07	1995-06-01	Uriach & Cia Sa J	Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
JP2523259B2 (ja) *	1993-06-30	1996-08-07	エスオーエンジニアリング株式会社	フォ―ハ―ス内のガラス温度制御方法
US5750565A (en)	1995-05-25	1998-05-12	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) *	1994-06-27	1998-08-11	Cytomed, Inc.,	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) *	1995-05-31	1997-12-30	Cytomed, Inc.	Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
CA2294139A1 (en) *	1997-06-25	1998-12-30	Nikken Chemicals Co., Ltd.	Triazolo-1,4-diazepine compounds and medicinal composition containing the same
FR2779652B1 (fr) *	1998-06-15	2001-06-08	Sod Conseils Rech Applic	Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
US7738074B2 (en)	2003-07-16	2010-06-15	Asml Netherlands B.V.	Lithographic apparatus and device manufacturing method
US7977336B2 (en)	2006-12-28	2011-07-12	Banyu Pharmaceutical Co. Ltd	Aminopyrimidine derivatives as PLK1 inhibitors
WO2012075456A1 (en)	2010-12-02	2012-06-07	Constellation Pharmaceuticals	Bromodomain inhibitors and uses thereof
AR084070A1 (es)	2010-12-02	2013-04-17	Constellation Pharmaceuticals Inc	Inhibidores del bromodominio y usos de los mismos
WO2012151512A2 (en)	2011-05-04	2012-11-08	Constellation Pharmaceuticals, Inc.	Bromodomain inhibitors and uses thereof
EP2721031B1 (de)	2011-06-17	2016-01-20	Constellation Pharmaceuticals, Inc.	Bromodomainhemmer und ihre verwendungen
TWI602820B (zh)	2012-06-06	2017-10-21	星宿藥物公司	溴域抑制劑及其用途
EP2864336B1 (de)	2012-06-06	2016-11-23	Constellation Pharmaceuticals, Inc.	Benzo[b]isoxazolazepinbromdomänenhemmer und verwendungen davon
US10092574B2 (en)	2012-09-26	2018-10-09	Valorisation-Recherche, Limited Partnership	Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
TR201906788T4 (tr)	2014-06-20	2019-05-21	Constellation Pharmaceuticals Inc	2-((4s)-6-(4-klorofenil)-1-metil-4h-benzo[c]izoksazolo[4,5-e]azepın-4-il)asetamidin kristal formları.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3435973A1 (de) *	1984-10-01	1986-04-10	Boehringer Ingelheim KG, 6507 Ingelheim	Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) *	1985-01-25	1986-07-31	Boehringer Ingelheim KG, 6507 Ingelheim	Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
DE3778559D1 (de) *	1986-01-21	1992-06-04	Boehringer Ingelheim Kg	Thieno-1,4-diazepine.
PH30676A (en)	1986-07-22	1997-09-16	Boehringer Ingelhein Kg	Hetrazepine compounds which have useful pharmaceutical utility
DE3724031A1 (de)	1986-07-22	1988-01-28	Boehringer Ingelheim Kg	Neue hetrazepine und verfahren zu ihrer herstellung
ES2039408T3 (es) *	1986-11-17	1993-10-01	Yoshitomi Pharmaceutical Industries, Ltd.	Un procedimiento para preparar un compuesto de tienotriazolodiazepina.
EP0368175A1 (de) *	1988-11-06	1990-05-16	Boehringer Ingelheim Kg	3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
GB8911030D0 (en) *	1989-05-13	1989-06-28	Scras	Hetrazepine derivatives
CA2020806A1 (en) *	1989-07-12	1991-01-13	Karl-Heinz Weber	Thienodiazepine derivatives
AT394563B (de) *	1990-05-09	1992-05-11	Scras	Verfahren zur herstellung von thieno-triazolodiazepinderivaten

1989
- 1989-10-13 FI FI894867A patent/FI95708C/fi not_active IP Right Cessation
- 1989-10-18 CA CA002000985A patent/CA2000985C/en not_active Expired - Fee Related
- 1989-10-18 PH PH39380A patent/PH27461A/en unknown
- 1989-10-26 AT AT95111206T patent/ATE213247T1/de not_active IP Right Cessation
- 1989-10-26 AU AU43761/89A patent/AU621413B2/en not_active Ceased
- 1989-10-26 DE DE68929049T patent/DE68929049T2/de not_active Expired - Fee Related
- 1989-10-26 DE DE68929455T patent/DE68929455T2/de not_active Expired - Fee Related
- 1989-10-26 AT AT94101416T patent/ATE234306T1/de not_active IP Right Cessation
- 1989-10-26 EP EP94101416A patent/EP0606103B1/de not_active Expired - Lifetime
- 1989-10-26 EP EP89119910A patent/EP0367110B1/de not_active Expired - Lifetime
- 1989-10-26 EP EP95111206A patent/EP0677524B1/de not_active Expired - Lifetime
- 1989-10-26 DE DE68929372T patent/DE68929372T2/de not_active Expired - Fee Related
- 1989-10-26 AT AT89119910T patent/ATE183187T1/de active
- 1989-10-27 NO NO894287A patent/NO175259C/no not_active IP Right Cessation
- 1989-10-27 JP JP1281300A patent/JP2756004B2/ja not_active Expired - Lifetime
- 1989-10-27 NZ NZ231188A patent/NZ231188A/xx unknown
- 1989-10-30 HU HU895609A patent/HU217127B/hu not_active IP Right Cessation
- 1989-10-30 PT PT92153A patent/PT92153B/pt not_active IP Right Cessation
- 1989-10-30 DK DK540689A patent/DK540689A/da not_active Application Discontinuation
- 1989-10-31 KR KR1019890015723A patent/KR910009332B1/ko not_active Expired
1994
- 1994-01-17 CN CN94100504A patent/CN1036520C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0606103B1 (de)	2003-03-12
FI894867A0 (fi)	1989-10-13
DE68929455T2 (de)	2004-01-08
DE68929372D1 (de)	2002-03-21
AU4376189A (en)	1990-05-03
NO894287L (no)	1990-05-02
DE68929049T2 (de)	2000-01-27
JP2756004B2 (ja)	1998-05-25
ATE234306T1 (de)	2003-03-15
DK540689D0 (da)	1989-10-30
EP0367110A1 (de)	1990-05-09
DK540689A (da)	1990-05-01
DE68929372T2 (de)	2002-10-02
EP0606103A1 (de)	1994-07-13
CA2000985C (en)	2000-01-18
NO175259C (no)	1994-09-21
PH27461A (en)	1993-07-09
NO175259B (no)	1994-06-13
NO894287D0 (no)	1989-10-27
FI95708C (fi)	1996-03-11
NZ231188A (en)	1991-06-25
HU895609D0 (en)	1990-01-28
HUT53106A (en)	1990-09-28
FI95708B (fi)	1995-11-30
DE68929049D1 (de)	1999-09-16
KR900006342A (ko)	1990-05-08
PT92153A (pt)	1990-05-31
PT92153B (pt)	1995-06-30
DE68929455D1 (de)	2003-04-17
JPH02256682A (ja)	1990-10-17
HU217127B (hu)	1999-11-29
EP0367110B1 (de)	1999-08-11
CN1121076A (zh)	1996-04-24
CA2000985A1 (en)	1990-04-30
KR910009332B1 (ko)	1991-11-11
AU621413B2 (en)	1992-03-12
EP0677524A1 (de)	1995-10-18
EP0677524B1 (de)	2002-02-13
CN1036520C (zh)	1997-11-26
ATE213247T1 (de)	2002-02-15

Publication	Publication Date	Title
ATE183187T1 (de)	1999-08-15	1,4-diazepin-derivate und deren pharmazeutische verwendung
ATE206119T1 (de)	2001-10-15	Thiacyclische piperidinylderivate
DE69525354D1 (de)	2002-03-21	Eine neuartige medizinische verwendung eines 5ht 3-antagonisten
NO305315B1 (no)	1999-05-10	Vitamin D-amid-derivater
DE69122812D1 (de)	1996-11-28	Glutathionderivat
DE69108067D1 (de)	1995-04-20	Thiazolidin-Derivate mit antihypertensiver Aktivität und deren therapeutische Anwendung.
ATE90346T1 (de)	1993-06-15	Analgetische phenothiazinderivate.
ATE120734T1 (de)	1995-04-15	Glyzerin-derivat und dessen pharmazeutische verwendung.
BG106922A (bg)	2003-03-31	Хетероциклeни амидни производни
SE9601708D0 (sv)	1996-05-06	Pyridyl- and pyrimidyl-piperazines in the treatment of substance abuse disorders
ATE131172T1 (de)	1995-12-15	Heterocyclische nmda antagonisten.
IT1213219B (it)	1989-12-14	Derivati amminoalchilnaftalenici ad attivita' farmacologica.
ATE123025T1 (de)	1995-06-15	2-amino-n-(((4-(aminocarbonyl)pyrimidin-2- yl>amino>alkyl>-pyrimidin-4- carbonsäureamidderivate, ihre herstellung und ihre anwendung in der therapeutica.
DE68906827D1 (de)	1993-07-08	Phenothiazinderivate, deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ES2122982T3 (es)	1999-01-01	Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.