NO894287L - 1,4-diazepinderivater og fremgangsmaate for deres fremstilling. - Google Patents

1,4-diazepinderivater og fremgangsmaate for deres fremstilling.

Info

Publication number
NO894287L
NO894287L NO89894287A NO894287A NO894287L NO 894287 L NO894287 L NO 894287L NO 89894287 A NO89894287 A NO 89894287A NO 894287 A NO894287 A NO 894287A NO 894287 L NO894287 L NO 894287L
Authority
NO
Norway
Prior art keywords
hydrogen
procedures
preparation
diazepine derivatives
alkyl
Prior art date
Application number
NO89894287A
Other languages
English (en)
Other versions
NO175259C (no
NO894287D0 (no
NO175259B (no
Inventor
Kazuo Okano
Shuhei Miyazawa
Richard Stephen John Clark
Shinya Abe
Tetsuya Kawahara
Naoyuki Shimomura
Osamu Asano
Hiroyuki Yoshimura
Mitsuaki Miyamoto
Yoshinori Sakuma
Kenzo Muramoto
Hiroshi Obaishi
Koukichi Harada
Hajime Tsunoda
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO894287D0 publication Critical patent/NO894287D0/no
Publication of NO894287L publication Critical patent/NO894287L/no
Priority to NO923459A priority Critical patent/NO301072B1/no
Publication of NO175259B publication Critical patent/NO175259B/no
Publication of NO175259C publication Critical patent/NO175259C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO894287A 1988-10-31 1989-10-27 Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser NO175259C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO923459A NO301072B1 (no) 1988-10-31 1992-09-04 Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP27546088 1988-10-31
JP29706888 1988-11-24
JP31801688 1988-12-16
JP33162288 1988-12-28

Publications (4)

Publication Number Publication Date
NO894287D0 NO894287D0 (no) 1989-10-27
NO894287L true NO894287L (no) 1990-05-02
NO175259B NO175259B (no) 1994-06-13
NO175259C NO175259C (no) 1994-09-21

Family

ID=27479049

Family Applications (1)

Application Number Title Priority Date Filing Date
NO894287A NO175259C (no) 1988-10-31 1989-10-27 Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser

Country Status (15)

Country Link
EP (3) EP0606103B1 (no)
JP (1) JP2756004B2 (no)
KR (1) KR910009332B1 (no)
CN (1) CN1036520C (no)
AT (3) ATE183187T1 (no)
AU (1) AU621413B2 (no)
CA (1) CA2000985C (no)
DE (3) DE68929372T2 (no)
DK (1) DK540689A (no)
FI (1) FI95708C (no)
HU (1) HU217127B (no)
NO (1) NO175259C (no)
NZ (1) NZ231188A (no)
PH (1) PH27461A (no)
PT (1) PT92153B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
GB8907256D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
GB8907257D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-paf and anti-ischemic agents
AT394563B (de) * 1990-05-09 1992-05-11 Scras Verfahren zur herstellung von thieno-triazolodiazepinderivaten
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4107521A1 (de) * 1991-03-08 1992-09-10 Boehringer Ingelheim Kg Neue acylaminosubstituierte hetrazepine
ES2143993T3 (es) * 1991-12-11 2000-06-01 Yoshitomi Pharmaceutical Farmaco para tratar una enfermedad autoinmune.
TW219935B (no) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
ATE196903T1 (de) 1992-07-13 2000-10-15 Cytomed Inc 2,5-diaryl tetrahydro-thiopene, -furane und analoge zur behandlung von entzündungs-und immunkrankheiten
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
ES2061406B1 (es) * 1993-05-07 1995-06-01 Uriach & Cia Sa J Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
JP2523259B2 (ja) * 1993-06-30 1996-08-07 エスオーエンジニアリング株式会社 フォ―ハ―ス内のガラス温度制御方法
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
CA2294139A1 (en) * 1997-06-25 1998-12-30 Nikken Chemicals Co., Ltd. Triazolo-1,4-diazepine compounds and medicinal composition containing the same
FR2779652B1 (fr) * 1998-06-15 2001-06-08 Sod Conseils Rech Applic Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
SG109000A1 (en) 2003-07-16 2005-02-28 Asml Netherlands Bv Lithographic apparatus and device manufacturing method
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
EP2705039B1 (en) 2011-05-04 2017-07-26 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9328117B2 (en) 2011-06-17 2016-05-03 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
PL3157928T3 (pl) 2014-06-20 2019-07-31 Constellation Pharmaceuticals, Inc. Krystaliczne postacie 2-((4S)-6-(4-chlorofenylo)-1-metylo-4H-benzo[ c]izoksazolo-[4,5-e]azepin-4-ylo)acetamidu

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
DE3778559D1 (de) 1986-01-21 1992-06-04 Boehringer Ingelheim Kg Thieno-1,4-diazepine.
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3724031A1 (de) * 1986-07-22 1988-01-28 Boehringer Ingelheim Kg Neue hetrazepine und verfahren zu ihrer herstellung
ES2039408T3 (es) * 1986-11-17 1993-10-01 Yoshitomi Pharmaceutical Industries, Ltd. Un procedimiento para preparar un compuesto de tienotriazolodiazepina.
EP0368175A1 (de) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
GB8911030D0 (en) * 1989-05-13 1989-06-28 Scras Hetrazepine derivatives
EP0407955A1 (de) * 1989-07-12 1991-01-16 Boehringer Ingelheim Kg Neue Hetrazepine mit PAF-antagonistischer Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AT394563B (de) * 1990-05-09 1992-05-11 Scras Verfahren zur herstellung von thieno-triazolodiazepinderivaten

Also Published As

Publication number Publication date
DE68929372D1 (de) 2002-03-21
FI95708B (fi) 1995-11-30
JP2756004B2 (ja) 1998-05-25
CA2000985C (en) 2000-01-18
DE68929049D1 (de) 1999-09-16
AU621413B2 (en) 1992-03-12
HU217127B (hu) 1999-11-29
ATE234306T1 (de) 2003-03-15
EP0367110A1 (en) 1990-05-09
DK540689A (da) 1990-05-01
DE68929049T2 (de) 2000-01-27
KR910009332B1 (ko) 1991-11-11
HU895609D0 (en) 1990-01-28
JPH02256682A (ja) 1990-10-17
PT92153A (pt) 1990-05-31
FI95708C (fi) 1996-03-11
CN1036520C (zh) 1997-11-26
NO175259C (no) 1994-09-21
EP0677524B1 (en) 2002-02-13
FI894867A0 (fi) 1989-10-13
ATE213247T1 (de) 2002-02-15
DE68929372T2 (de) 2002-10-02
CN1121076A (zh) 1996-04-24
EP0606103A1 (en) 1994-07-13
EP0606103B1 (en) 2003-03-12
EP0677524A1 (en) 1995-10-18
AU4376189A (en) 1990-05-03
HUT53106A (en) 1990-09-28
DE68929455D1 (de) 2003-04-17
ATE183187T1 (de) 1999-08-15
EP0367110B1 (en) 1999-08-11
KR900006342A (ko) 1990-05-08
DE68929455T2 (de) 2004-01-08
CA2000985A1 (en) 1990-04-30
DK540689D0 (da) 1989-10-30
NO894287D0 (no) 1989-10-27
PT92153B (pt) 1995-06-30
PH27461A (en) 1993-07-09
NO175259B (no) 1994-06-13
NZ231188A (en) 1991-06-25

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Legal Events

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MM1K Lapsed by not paying the annual fees