ATE183507T1 - Verfahren zur herstellung von 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)1-piperazin l)pyrimidin - Google Patents

Verfahren zur herstellung von 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)1-piperazin l)pyrimidin

Info

Publication number
ATE183507T1
ATE183507T1 AT94401018T AT94401018T ATE183507T1 AT E183507 T1 ATE183507 T1 AT E183507T1 AT 94401018 T AT94401018 T AT 94401018T AT 94401018 T AT94401018 T AT 94401018T AT E183507 T1 ATE183507 T1 AT E183507T1
Authority
AT
Austria
Prior art keywords
pyrimidine
pyrazolyl
chloro
butyl
piperazine
Prior art date
Application number
AT94401018T
Other languages
English (en)
Inventor
Ramon Merce-Vidal
Jordi Frigola-Constansa
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Application granted granted Critical
Publication of ATE183507T1 publication Critical patent/ATE183507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT94401018T 1993-05-10 1994-05-09 Verfahren zur herstellung von 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)1-piperazin l)pyrimidin ATE183507T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9305586A FR2705098B1 (fr) 1993-05-10 1993-05-10 Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Publications (1)

Publication Number Publication Date
ATE183507T1 true ATE183507T1 (de) 1999-09-15

Family

ID=9446957

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94401018T ATE183507T1 (de) 1993-05-10 1994-05-09 Verfahren zur herstellung von 2-(4-(4-(4-chloro-1-pyrazolyl)butyl)1-piperazin l)pyrimidin

Country Status (24)

Country Link
US (1) US5536836A (de)
EP (1) EP0624585B1 (de)
JP (1) JPH06329670A (de)
KR (1) KR100302383B1 (de)
CN (1) CN1053898C (de)
AT (1) ATE183507T1 (de)
AU (1) AU675513B2 (de)
BR (1) BR9401901A (de)
CA (1) CA2122885A1 (de)
DE (1) DE69420073T2 (de)
DK (1) DK0624585T3 (de)
EG (1) EG20804A (de)
ES (1) ES2089971B1 (de)
FI (1) FI942159A7 (de)
FR (1) FR2705098B1 (de)
GR (1) GR3031796T3 (de)
HU (1) HU217445B (de)
IS (1) IS1650B (de)
JO (1) JO1793B1 (de)
NO (1) NO303873B1 (de)
NZ (1) NZ260443A (de)
PH (1) PH30932A (de)
RU (1) RU2116305C1 (de)
ZA (1) ZA943141B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
FR2701260B1 (fr) * 1993-02-05 1995-05-05 Esteve Labor Dr Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.
ES2099031B1 (es) * 1995-05-31 1997-12-01 Esteve Labor Dr Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen.
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351939A (en) * 1980-10-16 1982-09-28 Mead Johnson & Company Spiro-quaternary ammonium halides and N-(2-pyrimidinyl)piperazinylalkylazaspiroalkanedione process
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4892943A (en) * 1985-10-16 1990-01-09 American Home Products Corporation Fused bicyclic imides with psychotropic activity
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.

Also Published As

Publication number Publication date
FR2705098A1 (fr) 1994-11-18
KR100302383B1 (ko) 2001-11-22
FI942159L (fi) 1994-11-11
EP0624585B1 (de) 1999-08-18
JO1793B1 (en) 1994-12-25
DE69420073T2 (de) 2000-01-05
DE69420073D1 (de) 1999-09-23
RU2116305C1 (ru) 1998-07-27
ES2089971A1 (es) 1996-10-01
NO941758D0 (no) 1994-05-10
NO303873B1 (no) 1998-09-14
FR2705098B1 (fr) 1995-08-04
DK0624585T3 (da) 1999-12-06
EG20804A (fr) 2000-03-29
GR3031796T3 (en) 2000-02-29
NO941758L (no) 1994-11-11
NZ260443A (en) 1995-04-27
ZA943141B (en) 1995-01-09
AU6184494A (en) 1994-11-17
HU217445B (hu) 2000-01-28
EP0624585A1 (de) 1994-11-17
PH30932A (en) 1997-12-23
IS4163A (is) 1994-11-11
US5536836A (en) 1996-07-16
HUT69706A (en) 1995-09-28
FI942159A0 (fi) 1994-05-10
HU9401501D0 (en) 1994-08-29
AU675513B2 (en) 1997-02-06
FI942159A7 (fi) 1994-11-11
CN1100096A (zh) 1995-03-15
CA2122885A1 (fr) 1994-11-11
CN1053898C (zh) 2000-06-28
ES2089971B1 (es) 1998-02-16
JPH06329670A (ja) 1994-11-29
IS1650B (is) 1997-03-25
BR9401901A (pt) 1994-12-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee