ATE184052T1 - Gdf-1 und uog1 proteine - Google Patents

Gdf-1 und uog1 proteine

Info

Publication number
ATE184052T1
ATE184052T1 AT91915864T AT91915864T ATE184052T1 AT E184052 T1 ATE184052 T1 AT E184052T1 AT 91915864 T AT91915864 T AT 91915864T AT 91915864 T AT91915864 T AT 91915864T AT E184052 T1 ATE184052 T1 AT E184052T1
Authority
AT
Austria
Prior art keywords
gdf
protein
uog1
proteins
mammalian
Prior art date
Application number
AT91915864T
Other languages
English (en)
Inventor
Se-Jin Lee
Original Assignee
Carnegie Inst Of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carnegie Inst Of Washington filed Critical Carnegie Inst Of Washington
Application granted granted Critical
Publication of ATE184052T1 publication Critical patent/ATE184052T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT91915864T 1990-06-15 1991-06-14 Gdf-1 und uog1 proteine ATE184052T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53837290A 1990-06-15 1990-06-15
US61445290A 1990-11-16 1990-11-16

Publications (1)

Publication Number Publication Date
ATE184052T1 true ATE184052T1 (de) 1999-09-15

Family

ID=27065793

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915864T ATE184052T1 (de) 1990-06-15 1991-06-14 Gdf-1 und uog1 proteine

Country Status (9)

Country Link
US (2) US20040039162A1 (de)
EP (1) EP0652951B1 (de)
JP (1) JPH06500466A (de)
AT (1) ATE184052T1 (de)
AU (1) AU666291B2 (de)
CA (1) CA2085134C (de)
DE (1) DE69131580T2 (de)
ES (1) ES2137931T3 (de)
WO (1) WO1992000382A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
EP1637156A1 (de) * 1991-08-30 2006-03-22 Curis, Inc. Systemische Gabe osteogener Proteine zur Behandlung metabolischer Knochenkrankheiten
AU681594B2 (en) * 1992-07-31 1997-09-04 Stryker Corporation Morphogen-induced nerve regeneration and repair
EP0690871A4 (de) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-5
US5821056A (en) 1993-01-12 1998-10-13 The Johns Hopkins University School Of Medicine Growth differentiation factor-9
JPH09503903A (ja) * 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−６
JPH09503904A (ja) * 1993-07-09 1997-04-22 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−７
DE69534468T2 (de) * 1994-07-08 2006-07-13 The Johns Hopkins University School Of Medicine Wachstums-differenzierungsfaktor-11
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
US5831054A (en) * 1994-07-13 1998-11-03 The Johns Hopkins University School Of Medicine Polynucleotide encoding growth differentiation factor-12
ATE493141T1 (de) 1996-03-22 2011-01-15 Stryker Corp Verfahren zur verbesserten funktionellen erholung der motorischen koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns
US6524802B1 (en) 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
AU6267798A (en) 1997-02-07 1998-08-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
JP2001526788A (ja) 1997-05-30 2001-12-18 クリエイティブ バイオモレキュールズ，インコーポレイテッド 組織形態形成および活性を評価するための方法
WO1999058671A2 (en) * 1998-05-08 1999-11-18 Research Corporation Technologies, Inc. Human and nematode homologues of the yeast longevity assurance gene lag1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6872698B2 (en) * 1998-07-06 2005-03-29 Scion Pharmaceuticals, Inc. Methods for treating neurological injuries and disorders
JP2002519394A (ja) * 1998-07-06 2002-07-02 スネス ファーマシューティカルズ インコーポレイテッド 神経損傷および障害を治療するための方法
WO2005089829A2 (en) 2004-03-10 2005-09-29 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
WO2005116052A2 (en) 2004-04-27 2005-12-08 Research Development Foundation ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING
CA2567405A1 (en) 2004-05-25 2005-12-08 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
US20090298761A1 (en) 2006-05-17 2009-12-03 Donald Engelman Methods of treating cartilage defects using a soluble morphogenic protein complex
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2120859B1 (de) 2006-12-21 2013-11-20 Stryker Corporation Formulierungen mit verzögerter freisetzung mit kristallen von bmp-7
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
AU2009214629A1 (en) 2008-02-13 2009-08-20 Eric T. Choi BMP-7 for use in treating vascular sclerosis
JP5599778B2 (ja) 2008-04-14 2014-10-01 デピュイ・シンセス・プロダクツ・エルエルシー 液体緩衝ｇｄｆ−５製剤
US20100204123A1 (en) 2009-02-12 2010-08-12 Mary Elizabeth Pecquet Goad Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
EP2352750B1 (de) 2009-09-17 2012-06-13 Stryker Corporation Puffer zur steuerung des ph-wertes knochenmorphogenetischer proteine
CA2785038A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
PH12013500294A1 (en) 2010-08-20 2017-08-23 Wyeth Llc Designer osteogenic proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses

Also Published As

Publication number Publication date
WO1992000382A1 (en) 1992-01-09
DE69131580D1 (de) 1999-10-07
EP0652951A4 (de) 1993-08-16
US20040039162A1 (en) 2004-02-26
JPH06500466A (ja) 1994-01-20
HK1013847A1 (en) 1999-12-10
EP0652951A1 (de) 1995-05-17
AU666291B2 (en) 1996-02-08
US20030040611A1 (en) 2003-02-27
AU8496491A (en) 1992-01-23
DE69131580T2 (de) 2000-01-13
ES2137931T3 (es) 2000-01-01
CA2085134C (en) 2003-03-18
EP0652951B1 (de) 1999-09-01
CA2085134A1 (en) 1991-12-16

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