ATE184053T1 - Verfahren zur herstellung von indolopyrrolocarbazolderivaten - Google Patents

Verfahren zur herstellung von indolopyrrolocarbazolderivaten

Info

Publication number
ATE184053T1
ATE184053T1 AT93120137T AT93120137T ATE184053T1 AT E184053 T1 ATE184053 T1 AT E184053T1 AT 93120137 T AT93120137 T AT 93120137T AT 93120137 T AT93120137 T AT 93120137T AT E184053 T1 ATE184053 T1 AT E184053T1
Authority
AT
Austria
Prior art keywords
group
formula
compound
chem
mono
Prior art date
Application number
AT93120137T
Other languages
English (en)
Inventor
Katsuhisa Kojiri
Hajime Suzuki
Hisao Kondo
Hiroyuki Suda
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE184053T1 publication Critical patent/ATE184053T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93120137T 1992-12-14 1993-12-14 Verfahren zur herstellung von indolopyrrolocarbazolderivaten ATE184053T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35362392 1992-12-14
JP5303593 1993-02-18

Publications (1)

Publication Number Publication Date
ATE184053T1 true ATE184053T1 (de) 1999-09-15

Family

ID=26393744

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93120137T ATE184053T1 (de) 1992-12-14 1993-12-14 Verfahren zur herstellung von indolopyrrolocarbazolderivaten

Country Status (10)

Country Link
EP (1) EP0602597B1 (de)
JP (1) JP3603322B2 (de)
KR (1) KR100293578B1 (de)
AT (1) ATE184053T1 (de)
AU (1) AU669584B2 (de)
CA (1) CA2111283C (de)
DE (1) DE69326222T2 (de)
DK (1) DK0602597T3 (de)
ES (1) ES2135441T3 (de)
GR (1) GR3031359T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437992A (en) * 1994-04-28 1995-08-01 Genencor International, Inc. Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp
EP0760375B1 (de) * 1994-05-09 2003-11-26 Banyu Pharmaceutical Co., Ltd. Antitumor-indolopyrolocarbazolderivat
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
JP3707075B2 (ja) * 1994-06-13 2005-10-19 萬有製薬株式会社 グリコシルトランスフェラーゼをコードする遺伝子及びその用途
AU3086495A (en) * 1994-08-02 1996-03-04 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazoles
AU4485400A (en) * 1999-04-26 2000-11-10 Advanced Life Sciences Inc. Synthetic indolocarbazole regioisomers and uses thereof
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
JP2004534006A (ja) 2001-03-22 2004-11-11 ブリストル−マイヤーズ　スクイブ　カンパニー インドロピロロカルバゾール化合物のトポイソメラーゼｉ選択的細胞毒シュガー誘導体
US6559299B2 (en) * 2001-03-29 2003-05-06 Merck & Co., Inc. Preparation and isolation of indolocarbazole glycosides
CA2398828A1 (en) 2002-08-09 2004-02-09 Merck & Co., Inc. A pharmaceutical composition containing an indolopyrrolocarbazole derivative
EP1666485A1 (de) * 2003-09-16 2006-06-07 Banyu Pharmaceutical Co., Ltd. Neues indolopyrrolocarbazolderivat mit antitumorwirkung
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CN106432250B (zh) * 2016-09-07 2018-07-10 河南师范大学 具有抗癌活性的吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-缩氨基硫脲类化合物及其制备方法和应用
CN106478643B (zh) * 2016-09-07 2018-07-10 河南师范大学 吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-芳腙类化合物及其制备方法和在抗癌药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0602597A3 (de) 1995-04-19
CA2111283A1 (en) 1994-06-15
EP0602597B1 (de) 1999-09-01
GR3031359T3 (en) 2000-01-31
DK0602597T3 (da) 2000-02-28
CA2111283C (en) 2004-10-26
KR100293578B1 (ko) 2001-09-17
DE69326222T2 (de) 1999-12-30
JP3603322B2 (ja) 2004-12-22
KR940014800A (ko) 1994-07-19
AU669584B2 (en) 1996-06-13
EP0602597A2 (de) 1994-06-22
DE69326222D1 (de) 1999-10-07
ES2135441T3 (es) 1999-11-01
AU5235493A (en) 1994-06-23
JPH06296494A (ja) 1994-10-25

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee