ATE184275T1 - Verfahren zur epoxidierung von carbonylverbindungen unter verwendung von sulfonium oder sulfoxoniumyliden und zwischenprodukte - Google Patents
Verfahren zur epoxidierung von carbonylverbindungen unter verwendung von sulfonium oder sulfoxoniumyliden und zwischenprodukteInfo
- Publication number
- ATE184275T1 ATE184275T1 AT92904637T AT92904637T ATE184275T1 AT E184275 T1 ATE184275 T1 AT E184275T1 AT 92904637 T AT92904637 T AT 92904637T AT 92904637 T AT92904637 T AT 92904637T AT E184275 T1 ATE184275 T1 AT E184275T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- mylides
- sulfoxonium
- epoxidation
- sulfonium
- Prior art date
Links
- 150000001728 carbonyl compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000006735 epoxidation reaction Methods 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 title 1
- RDVHBXWMOHJTPY-UHFFFAOYSA-M [keto(dimethyl)sulfuraniumyl]methane;bisulfate Chemical compound C[S+](C)(C)=O.OS([O-])(=O)=O RDVHBXWMOHJTPY-UHFFFAOYSA-M 0.000 abstract 1
- OQGMDCQKKHVSLZ-UHFFFAOYSA-L [keto(dimethyl)sulfuraniumyl]methane;sulfate Chemical compound C[S+](C)(C)=O.C[S+](C)(C)=O.[O-]S([O-])(=O)=O OQGMDCQKKHVSLZ-UHFFFAOYSA-L 0.000 abstract 1
- 150000002118 epoxides Chemical class 0.000 abstract 1
- ALALNHBRSNEZAC-UHFFFAOYSA-M hydron;trimethylsulfanium;sulfate Chemical compound C[S+](C)C.OS([O-])(=O)=O ALALNHBRSNEZAC-UHFFFAOYSA-M 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- MJZACYWTDBYPTO-UHFFFAOYSA-L trimethylsulfanium;sulfate Chemical compound C[S+](C)C.C[S+](C)C.[O-]S([O-])(=O)=O MJZACYWTDBYPTO-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
- C07C317/04—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
- C07C381/12—Sulfonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919103260A GB9103260D0 (en) | 1991-02-15 | 1991-02-15 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE184275T1 true ATE184275T1 (de) | 1999-09-15 |
Family
ID=10690099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92904637T ATE184275T1 (de) | 1991-02-15 | 1992-02-12 | Verfahren zur epoxidierung von carbonylverbindungen unter verwendung von sulfonium oder sulfoxoniumyliden und zwischenprodukte |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5637727A (de) |
| EP (1) | EP0636120B1 (de) |
| JP (1) | JP3418194B2 (de) |
| AT (1) | ATE184275T1 (de) |
| DE (1) | DE69229958T2 (de) |
| ES (1) | ES2138593T3 (de) |
| GB (1) | GB9103260D0 (de) |
| WO (1) | WO1992014703A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648511A (en) * | 1990-11-19 | 1997-07-15 | G.D. Searle & Co. | Method for making intermediates useful in the synthesis of retroviral protease inhibitors |
| US5583238A (en) * | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
| US5482947A (en) | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
| US6743929B1 (en) | 1992-08-25 | 2004-06-01 | G. D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| EP0724569B1 (de) * | 1993-10-22 | 2003-03-12 | Avecia Limited | Verfahren zur herstellung eines oxiranes aziridins oder cyclopropans |
| PT855388E (pt) * | 1993-11-23 | 2002-07-31 | Searle & Co | Metodo para fazer intermediarios uteis na sintese de inibidores de protease retroviral |
| KR20010052811A (ko) * | 1998-10-07 | 2001-06-25 | 미우라 아끼라 | 1,2-이치환-2,3-에폭시프로판류의 광학이성체 혼합물과 그제조법 및 이것을 유효성분으로 하는 농약, 그리고 중간체 |
| JP5080974B2 (ja) | 2004-07-08 | 2012-11-21 | チバ ホールディング インコーポレーテッド | α−ヒドロキシ及びα−アミノケトンの製造 |
| CN102850378B (zh) * | 2012-09-27 | 2013-12-11 | 山东诚创医药技术开发有限公司 | 一种芬司匹利的制备方法 |
| CN103724298A (zh) * | 2012-10-15 | 2014-04-16 | 天津药物研究院 | 一种1-苯基-1-环戊基环氧乙烷的制备方法 |
| CN103288780A (zh) * | 2013-05-10 | 2013-09-11 | 重庆先洋医药科技有限公司 | 1-苯基-1-环戊基环氧乙烷的制备方法 |
| CN110997646B (zh) * | 2017-08-10 | 2023-06-20 | 住友化学株式会社 | 环氧醇化合物的制造方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR840778A (fr) * | 1937-07-21 | 1939-05-03 | Bataafsche Petroleum | Procédé pour la préparation de produits ayant des propriétés forma trices de mousse, émulsifiantes et mouillantes |
| US2316152A (en) * | 1940-05-16 | 1943-04-13 | Battelle Memorial Institute | Process of preparing sulphonium compounds |
| CH312958A (de) * | 1951-07-25 | 1956-03-15 | Directie Staatsmijnen Nl | Verfahren zur Entfernung von Anionen aus flüssigen Medien |
| BE620775A (de) * | 1961-07-27 | |||
| US3442912A (en) * | 1965-09-23 | 1969-05-06 | Dow Chemical Co | Synthesis of aromatic epoxides from trialkylsulfonium salts |
| US3455967A (en) * | 1965-09-23 | 1969-07-15 | Dow Chemical Co | Synthesis of aromatic epoxides from benzylic sulfonium salts |
| US3426046A (en) * | 1965-10-22 | 1969-02-04 | Dow Chemical Co | Synthesis of epoxides from allylic sulfonium salts |
| US3998856A (en) * | 1975-04-10 | 1976-12-21 | Hoffmann-La Roche Inc. | Preparation of epoxides |
| JPS5268111A (en) * | 1975-12-05 | 1977-06-06 | Ota Pharma | Method of producing oxirane derivatives |
| JPS6028828B2 (ja) * | 1976-12-29 | 1985-07-06 | 太田製薬株式会社 | 新規オキシラン化合物およびその製造法 |
| US4654332A (en) * | 1979-03-07 | 1987-03-31 | Imperial Chemical Industries Plc | Heterocyclic compounds |
| FR2526796B1 (fr) * | 1982-05-14 | 1987-08-14 | Agrifurane Sa | Procede de transformation d'un aldehyde ou d'une cetone en epoxyde correspondant, en particulier de furfural en furyloxirannes, et nouveaux epoxydes obtenus a partir du furfural |
| KR890005170B1 (ko) * | 1983-02-01 | 1989-12-16 | 롱-쁠랑 아그로시미 | 유기인 유도체의 염의 제조방법 |
| DE3315524A1 (de) * | 1983-04-29 | 1984-10-31 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von oxiranen |
| DE3315510A1 (de) * | 1983-04-29 | 1984-10-31 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von oxiranen |
| DE3315681A1 (de) * | 1983-04-29 | 1984-10-31 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von oxiranen |
| DE3315619A1 (de) * | 1983-04-29 | 1984-10-31 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von oxiranen |
| EP0205400A3 (de) * | 1985-06-03 | 1987-10-14 | Ciba-Geigy Ag | Verfahren zur Herstellung von Alkyloxiranen |
| GB8520027D0 (en) * | 1985-08-09 | 1985-09-18 | Ici Plc | Insecticidal ethers |
| DE3537817A1 (de) * | 1985-10-24 | 1987-04-30 | Bayer Ag | Verfahren zur herstellung von oxiranen |
| DE3733755A1 (de) * | 1987-10-06 | 1989-04-20 | Bayer Ag | Verfahren zur herstellung von 2-(4-chlorphenyl-ethyl)-2-tert.-butyl-oxiran |
| DE3824457C2 (de) * | 1988-07-19 | 1995-07-27 | Bayer Ag | Verfahren zur Herstellung von 2- (4-Chlorphenyl-ethyl) -2- tert.-butyl-oxiran |
| US5256802A (en) * | 1990-04-03 | 1993-10-26 | Miles Inc. | Process for the production of oxiranes |
-
1991
- 1991-02-15 GB GB919103260A patent/GB9103260D0/en active Pending
-
1992
- 1992-02-12 US US08/098,379 patent/US5637727A/en not_active Expired - Lifetime
- 1992-02-12 DE DE69229958T patent/DE69229958T2/de not_active Expired - Lifetime
- 1992-02-12 JP JP50417192A patent/JP3418194B2/ja not_active Expired - Lifetime
- 1992-02-12 WO PCT/GB1992/000248 patent/WO1992014703A1/en not_active Ceased
- 1992-02-12 ES ES92904637T patent/ES2138593T3/es not_active Expired - Lifetime
- 1992-02-12 AT AT92904637T patent/ATE184275T1/de active
- 1992-02-12 EP EP92904637A patent/EP0636120B1/de not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/451,936 patent/US5750740A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB9103260D0 (en) | 1991-04-03 |
| ES2138593T3 (es) | 2000-01-16 |
| JP3418194B2 (ja) | 2003-06-16 |
| DE69229958T2 (de) | 2000-03-30 |
| EP0636120A1 (de) | 1995-02-01 |
| EP0636120B1 (de) | 1999-09-08 |
| US5750740A (en) | 1998-05-12 |
| JPH07500569A (ja) | 1995-01-19 |
| US5637727A (en) | 1997-06-10 |
| WO1992014703A1 (en) | 1992-09-03 |
| DE69229958D1 (de) | 1999-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |