ATE185343T1 - Verfahren zur herstellung von 1,5- benzothiazepinen durch ringschluss von aminoestern - Google Patents

Verfahren zur herstellung von 1,5- benzothiazepinen durch ringschluss von aminoestern

Info

Publication number: ATE185343T1
Authority: AT; Austria
Prior art keywords: benzothiazepines; producing; ring closure; amino esters; formula
Prior art date: 1989-04-13

Application number

AT95103953T

Other languages

English (en)

Inventor

Dario Tentorio

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-13

Filing date

1990-04-12

Publication date

1999-10-15

1990-04-12 Application filed by Zambon Spa filed Critical Zambon Spa

1999-10-15 Application granted granted Critical

1999-10-15 Publication of ATE185343T1 publication Critical patent/ATE185343T1/de

Links

-1 AMINO ESTERS Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000006798 ring closing metathesis reaction Methods 0.000 title 1
JDRPDUXQDCDWHT-UHFFFAOYSA-N 2-(4-methoxyphenyl)-5h-1,5-benzothiazepin-4-one Chemical class C1=CC(OC)=CC=C1C1=CC(=O)NC2=CC=CC=C2S1 JDRPDUXQDCDWHT-UHFFFAOYSA-N 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Luminescent Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT95103953T 1989-04-13 1990-04-12 Verfahren zur herstellung von 1,5- benzothiazepinen durch ringschluss von aminoestern ATE185343T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8920134A IT1230057B (it)	1989-04-13	1989-04-13	Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine

Publications (1)

Publication Number	Publication Date
ATE185343T1 true ATE185343T1 (de)	1999-10-15

Family

ID=11164095

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT90107048T ATE156484T1 (de)	1989-04-13	1990-04-12	Verfahren für die racemattrennung von zwischenprodukten, die bei der herstellung von 1,5-benzothiazepinen verwendbar sind
AT95103953T ATE185343T1 (de)	1989-04-13	1990-04-12	Verfahren zur herstellung von 1,5- benzothiazepinen durch ringschluss von aminoestern

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT90107048T ATE156484T1 (de)	1989-04-13	1990-04-12	Verfahren für die racemattrennung von zwischenprodukten, die bei der herstellung von 1,5-benzothiazepinen verwendbar sind

Country Status (9)

Country	Link
US (1)	US5144025A (de)
EP (2)	EP0669327B1 (de)
JP (1)	JP2979237B2 (de)
AT (2)	ATE156484T1 (de)
DE (2)	DE69033315T2 (de)
DK (2)	DK0669327T3 (de)
ES (2)	ES2138100T3 (de)
GR (2)	GR3025188T3 (de)
IT (1)	IT1230057B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1234387B (it) *	1989-07-12	1992-05-18	Zambon Spa	Processo di purificazione di intermedi utili nella preparazione del diltiazem
US4963671A (en) *	1989-11-20	1990-10-16	E. R. Squibb & Sons, Inc.	Process for resolving chiral intermediates used in making calcium channel blockers
JPH085869B2 (ja) *	1990-03-08	1996-01-24	田辺製薬株式会社	１，５−ベンゾチアゼピン誘導体の製法
EP0778272B1 (de) *	1995-12-05	1998-12-23	Tanabe Seiyaku Co., Ltd.	Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung
IT1295376B1 (it) *	1997-10-22	1999-05-12	Zambon Spa	Processo per il riciclo di un sottoprodotto della sintesi del diltiazem
DE10142564A1 (de)	2000-09-30	2002-04-11	Zeiss Carl	Stativ
US20030119908A1 (en) *	2001-12-21	2003-06-26	Zambon Group S.P.A.	Stable gabapentin compositions
CN101532094B (zh) *	2008-03-11	2010-07-28	江西稀有稀土金属钨业集团有限公司	从钙和镁杂质含量高的酸性原料体系中全程萃取分离得到镍和钴的工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1236467A (en) *	1967-10-28	1971-06-23	Tanabe Seiyaku Co	Benzothiazepine derivatives
SE449611B (sv) *	1982-07-09	1987-05-11	Tanabe Seiyaku Co	Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) *	1982-10-15	1987-01-07	Luso Farmaco Inst	Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
US4567175A (en) *	1983-06-03	1986-01-28	Tanabe Seiyaku Co., Ltd.	8-Chloro-1,5-benzothiazepine derivatives
US4594342A (en) *	1984-04-10	1986-06-10	Tanabe Seiyaku Co., Ltd.	1,5-benzothiazepine derivative
GB2167063A (en) *	1984-11-17	1986-05-21	Tanabe Seiyaku Co	6 or 9-chloro-1, 5-benzothiazepine derivatives
EP0322779A3 (de) *	1987-12-29	1991-05-08	Yoshitomi Pharmaceutical Industries, Ltd.	Benzolaktam-Verbindungen und deren pharmazeutische Verwendungen
ZA893392B (en) *	1988-05-24	1990-01-31	Hoffmann La Roche	Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) *	1989-01-11	1991-03-15	Synthelabo	Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
DE69015682T2 (de) *	1989-04-28	1995-05-11	Tanabe Seiyaku Co	Verfahren zur Herstellung von 1,5-Benzothiazepinderivaten.
US4963671A (en) *	1989-11-20	1990-10-16	E. R. Squibb & Sons, Inc.	Process for resolving chiral intermediates used in making calcium channel blockers
JPH085869B2 (ja) *	1990-03-08	1996-01-24	田辺製薬株式会社	１，５−ベンゾチアゼピン誘導体の製法

1989
- 1989-04-13 IT IT8920134A patent/IT1230057B/it active
1990
- 1990-04-05 US US07/504,860 patent/US5144025A/en not_active Expired - Lifetime
- 1990-04-12 DE DE69033315T patent/DE69033315T2/de not_active Expired - Fee Related
- 1990-04-12 EP EP95103953A patent/EP0669327B1/de not_active Expired - Lifetime
- 1990-04-12 AT AT90107048T patent/ATE156484T1/de not_active IP Right Cessation
- 1990-04-12 ES ES95103953T patent/ES2138100T3/es not_active Expired - Lifetime
- 1990-04-12 DK DK95103953T patent/DK0669327T3/da active
- 1990-04-12 ES ES90107048T patent/ES2106724T3/es not_active Expired - Lifetime
- 1990-04-12 AT AT95103953T patent/ATE185343T1/de not_active IP Right Cessation
- 1990-04-12 DK DK90107048.2T patent/DK0392543T3/da active
- 1990-04-12 DE DE69031187T patent/DE69031187T2/de not_active Expired - Fee Related
- 1990-04-12 EP EP90107048A patent/EP0392543B1/de not_active Expired - Lifetime
- 1990-04-13 JP JP2099140A patent/JP2979237B2/ja not_active Expired - Lifetime
1997
- 1997-10-29 GR GR970402823T patent/GR3025188T3/el unknown
1999
- 1999-12-02 GR GR990403114T patent/GR3032027T3/el unknown

Also Published As

Publication number	Publication date
GR3025188T3 (en)	1998-02-27
JP2979237B2 (ja)	1999-11-15
EP0669327A1 (de)	1995-08-30
ATE156484T1 (de)	1997-08-15
DK0669327T3 (da)	2000-04-10
DE69031187D1 (de)	1997-09-11
ES2138100T3 (es)	2000-01-01
DE69031187T2 (de)	1998-01-22
ES2106724T3 (es)	1997-11-16
DK0392543T3 (da)	1997-09-15
EP0392543B1 (de)	1997-08-06
IT1230057B (it)	1991-09-27
IT8920134A0 (it)	1989-04-13
EP0669327B1 (de)	1999-10-06
JPH03115273A (ja)	1991-05-16
GR3032027T3 (en)	2000-03-31
DE69033315T2 (de)	2000-04-13
EP0392543A1 (de)	1990-10-17
US5144025A (en)	1992-09-01
DE69033315D1 (de)	1999-11-11

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Legal Events

Date	Code	Title	Description
2000-03-15	UEP	Publication of translation of european patent specification
2006-01-15	REN	Ceased due to non-payment of the annual fee