IT1234387B - Processo di purificazione di intermedi utili nella preparazione del diltiazem - Google Patents

Processo di purificazione di intermedi utili nella preparazione del diltiazem

Info

Publication number: IT1234387B
Authority: IT; Italy
Prior art keywords: diltiazem; preparation; purification process; useful intermediates; intermediates
Prior art date: 1989-07-12

Application number

IT8921166A

Other languages

English (en)

Other versions

IT8921166A0 (it

Inventor

Claudio Giordano

Dario Tentorio

Laura Russo

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-12

Filing date

1989-07-12

Publication date

1992-05-18

1989-07-12 Application filed by Zambon Spa filed Critical Zambon Spa

1989-07-12 Publication of IT8921166A0 publication Critical patent/IT8921166A0/it

1989-07-12 Priority to IT8921166A priority Critical patent/IT1234387B/it

1990-06-22 Priority to CH2086/90A priority patent/CH680219A5/it

1990-06-29 Priority to CA002020158A priority patent/CA2020158C/en

1990-07-03 Priority to NL9001515A priority patent/NL9001515A/nl

1990-07-03 Priority to FR9008374A priority patent/FR2649706B1/fr

1990-07-04 Priority to GB9014799A priority patent/GB2233646B/en

1990-07-04 Priority to JP2178494A priority patent/JP2979240B2/ja

1990-07-11 Priority to AT0147690A priority patent/AT401649B/de

1990-07-11 Priority to DE4021999A priority patent/DE4021999C2/de

1990-07-11 Priority to SE9002410A priority patent/SE509636C2/sv

1990-07-11 Priority to ES9001892A priority patent/ES2020722A6/es

1990-07-11 Priority to BE9000707A priority patent/BE1003313A3/fr

1992-05-18 Application granted granted Critical

1992-05-18 Publication of IT1234387B publication Critical patent/IT1234387B/it

1993-01-25 Priority to US08/008,892 priority patent/US5315005A/en

Links

HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title 1
229960004166 diltiazem Drugs 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT8921166A 1989-07-12 1989-07-12 Processo di purificazione di intermedi utili nella preparazione del diltiazem IT1234387B (it)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
IT8921166A IT1234387B (it)	1989-07-12	1989-07-12	Processo di purificazione di intermedi utili nella preparazione del diltiazem
CH2086/90A CH680219A5 (it)	1989-07-12	1990-06-22
CA002020158A CA2020158C (en)	1989-07-12	1990-06-29	Process for the purification of (25,35)-2,3-dihydro-3- hydroxy-2-(4-methoxy-phenyl)-1, 5-benzothiazepin-4(5h)-one
NL9001515A NL9001515A (nl)	1989-07-12	1990-07-03	Werkwijze voor de zuivering van tussenprodukten.
FR9008374A FR2649706B1 (fr)	1989-07-12	1990-07-03	Procede de purification de produits intermediaires pour la preparation du diltiazem
JP2178494A JP2979240B2 (ja)	1989-07-12	1990-07-04	（２ｓ，３ｓ）―２，３―ジヒドロ―３―ヒドロキシ―２―（４―メトキシフェニル）―１，５―ベンゾチアゼピン―４（５ｈ）―オンの精製方法
GB9014799A GB2233646B (en)	1989-07-12	1990-07-04	Process for the purification of benzothiazepinone intermediates
AT0147690A AT401649B (de)	1989-07-12	1990-07-11	Verfahren zur reinigung von zwischenprodukten
DE4021999A DE4021999C2 (de)	1989-07-12	1990-07-11	Reinigungsverfahren
SE9002410A SE509636C2 (sv)	1989-07-12	1990-07-11	Förfarande för optisk rening av (2S,3S)-2,3-diväte-3-hydroxi- 2-(4-metoxifenyl)-1,5-bensotiazepin-4(5H)-on
ES9001892A ES2020722A6 (es)	1989-07-12	1990-07-11	Procedimiento para la purificacion de intermedios para la preparacion de benzotiacepinas.
BE9000707A BE1003313A3 (fr)	1989-07-12	1990-07-11	Procede de purification de produits intermediaires pour la preparation du diltiazem.
US08/008,892 US5315005A (en)	1989-07-12	1993-01-25	Process for the single crystallization of enatiomeric ratio's (2S,3S):(2R,3R) of substituted 1,5-benzothiazepinone

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8921166A IT1234387B (it)	1989-07-12	1989-07-12	Processo di purificazione di intermedi utili nella preparazione del diltiazem

Publications (2)

Publication Number	Publication Date
IT8921166A0 IT8921166A0 (it)	1989-07-12
IT1234387B true IT1234387B (it)	1992-05-18

Family

ID=11177746

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8921166A IT1234387B (it)	1989-07-12	1989-07-12	Processo di purificazione di intermedi utili nella preparazione del diltiazem

Country Status (13)

Country	Link
US (1)	US5315005A (it)
JP (1)	JP2979240B2 (it)
AT (1)	AT401649B (it)
BE (1)	BE1003313A3 (it)
CA (1)	CA2020158C (it)
CH (1)	CH680219A5 (it)
DE (1)	DE4021999C2 (it)
ES (1)	ES2020722A6 (it)
FR (1)	FR2649706B1 (it)
GB (1)	GB2233646B (it)
IT (1)	IT1234387B (it)
NL (1)	NL9001515A (it)
SE (1)	SE509636C2 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5559229A (en) *	1995-06-01	1996-09-24	Acic (Canada) Inc.	Method for the manufacture of benzothiazepine
US7513937B2 (en)	2005-07-08	2009-04-07	Refined Global Solutions, Inc.	Oil reconditioning device and associated methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
FR2360124A1 (fr) *	1976-07-30	1978-02-24	Amiens Const Electro Mecan	Procede de controle de commutation de la puissance de chauffage dans un appareil electrodomestique a programmateur et dispositif pour la mise en oeuvre dudit procede
EP0059335B1 (en) *	1981-02-27	1985-05-15	Tanabe Seiyaku Co., Ltd.	Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
SE449611B (sv) *	1982-07-09	1987-05-11	Tanabe Seiyaku Co	Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) *	1982-10-15	1987-01-07	Luso Farmaco Inst	Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
IT1217988B (it) *	1988-01-28	1990-03-30	Ind Chimica Profarmaco Spa	Procedimento per la risoluzione ottica di un pacemo
ZA893392B (en) *	1988-05-24	1990-01-31	Hoffmann La Roche	Process for the manufacture of optically active naphthothiazepinones
FR2641535B1 (fr) *	1989-01-11	1991-03-15	Synthelabo	Procede de preparation de (+) - (2s, 3s)-hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4
FR2642425A1 (fr) *	1989-01-30	1990-08-03	Sanofi Sa	Procede de preparation de derives de benzothiazepine-1,5 one-4
IT1230057B (it) *	1989-04-13	1991-09-27	Zambon Spa	Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine
ATE116643T1 (de) *	1989-04-28	1995-01-15	Tanabe Seiyaku Co	Verfahren zur herstellung von 1,5- benzothiazepinderivaten.
JPH0798813B2 (ja) *	1989-04-28	1995-10-25	田辺製薬株式会社	１，５―ベンゾチアゼピン誘導体の製法

1989
- 1989-07-12 IT IT8921166A patent/IT1234387B/it active
1990
- 1990-06-22 CH CH2086/90A patent/CH680219A5/it not_active IP Right Cessation
- 1990-06-29 CA CA002020158A patent/CA2020158C/en not_active Expired - Lifetime
- 1990-07-03 FR FR9008374A patent/FR2649706B1/fr not_active Expired - Fee Related
- 1990-07-03 NL NL9001515A patent/NL9001515A/nl active Search and Examination
- 1990-07-04 JP JP2178494A patent/JP2979240B2/ja not_active Expired - Lifetime
- 1990-07-04 GB GB9014799A patent/GB2233646B/en not_active Expired - Fee Related
- 1990-07-11 AT AT0147690A patent/AT401649B/de not_active IP Right Cessation
- 1990-07-11 DE DE4021999A patent/DE4021999C2/de not_active Expired - Fee Related
- 1990-07-11 SE SE9002410A patent/SE509636C2/sv not_active IP Right Cessation
- 1990-07-11 BE BE9000707A patent/BE1003313A3/fr not_active IP Right Cessation
- 1990-07-11 ES ES9001892A patent/ES2020722A6/es not_active Expired - Fee Related
1993
- 1993-01-25 US US08/008,892 patent/US5315005A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
NL194274B (it)	2001-07-02
BE1003313A3 (fr)	1992-02-25
CA2020158C (en)	1997-03-04
JP2979240B2 (ja)	1999-11-15
SE509636C2 (sv)	1999-02-15
DE4021999A1 (de)	1991-01-17
GB2233646A (en)	1991-01-16
ES2020722A6 (es)	1991-09-01
AT401649B (de)	1996-10-25
DE4021999C2 (de)	2002-08-29
IT8921166A0 (it)	1989-07-12
CA2020158A1 (en)	1991-01-13
GB9014799D0 (en)	1990-08-22
JPH0348671A (ja)	1991-03-01
US5315005A (en)	1994-05-24
FR2649706B1 (fr)	1994-10-07
NL194274C (it)	2001-11-05
GB2233646B (en)	1993-01-27
FR2649706A1 (fr)	1991-01-18
NL9001515A (nl)	1991-02-01
SE9002410D0 (sv)	1990-07-11
ATA147690A (de)	1996-03-15
CH680219A5 (it)	1992-07-15
SE9002410L (sv)	1991-01-13

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970612

Publication	Publication Date	Title
ITMI930518A0 (it)	1993-03-19	Processo per la preparazione di apg
BR8705719A (pt)	1988-05-31	Processo de fabricar artigos descartaveis
BR8705718A (pt)	1988-05-31	Processo de fabricar artigos descartaveis
ITMI931295A0 (it)	1993-06-16	Processo per la preparazione di cumene
BR8801102A (pt)	1988-10-18	Processo para fabricacao de cimento
BR9007797A (pt)	1992-09-15	Processo para fabricacao de borracha de nitrila e borracha reduzida
BR8803210A (pt)	1989-01-17	Ferramenta e processo de perfilagem de poco para limitacao de fluxo
ITMI941013A0 (it)	1994-05-19	Processo per la preparazione di plimeri acrilici
IT1249777B (it)	1995-03-18	Processo per la preparazione di intermedi per la sintesi del diltiazem
ITMI921157A0 (it)	1992-05-15	Processo per la preparazione di alchilpoliglucosidi
ITMI920350A0 (it)	1992-02-18	Processo per la produzione di pezzi smaltati
IT1226300B (it)	1990-12-27	Processo per la preparazione di intermedi per la sintesi del diltiazem.
BR8904840A (pt)	1990-05-01	Processo para producao de n-fosfonometilglicina
IT1234387B (it)	1992-05-18	Processo di purificazione di intermedi utili nella preparazione del diltiazem
BR9001296A (pt)	1991-04-02	Processo para preparacao de o-carboxi-piridil-e o-carbo-xi-quinolil-imidazolinonas
BR9005109A (pt)	1991-09-17	Processo para producao de 2-piperazinonas e uso do produto
IT1232306B (it)	1992-01-28	Processo di risoluzione di intermedi utili per la preparazione del diltiazem
BR8900476A (pt)	1989-10-03	Processo para preparacao de alcanol-ou alquilfenol-oxetilatos sulfatados
ITMI931033A0 (it)	1993-05-20	Processo per la preparazione di gemfibrozil
IT8821479A0 (it)	1988-07-26	Processo per la preparazione di intermedi per la sintesi del diltiazem.
IT1250913B (it)	1995-04-21	Processo di sottomurazione
BR9001804A (pt)	1991-06-11	Processo para producao de difluorhalometoxibenzeno
ITMI921156A0 (it)	1992-05-15	Processo per la produzione di idrossialchil-glucosidi
BR8906394A (pt)	1990-08-21	Processo para obtencao de peroxidos alquilaromaticos terciarios
ITMI921348A0 (it)	1992-06-01	Processo per la preparazione di eseretolo