ATE185555T1 - Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung - Google Patents

Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung

Info

Publication number
ATE185555T1
ATE185555T1 AT95907051T AT95907051T ATE185555T1 AT E185555 T1 ATE185555 T1 AT E185555T1 AT 95907051 T AT95907051 T AT 95907051T AT 95907051 T AT95907051 T AT 95907051T AT E185555 T1 ATE185555 T1 AT E185555T1
Authority
AT
Austria
Prior art keywords
group
pct
preparation
monoamin
oxydase
Prior art date
Application number
AT95907051T
Other languages
English (en)
Inventor
Michel Seman
Suzanne Bernard
Rene Milcent
Catherine Paillat
Original Assignee
Mayoly Spindler Lab
Michel Seman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayoly Spindler Lab, Michel Seman filed Critical Mayoly Spindler Lab
Application granted granted Critical
Publication of ATE185555T1 publication Critical patent/ATE185555T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02Compounds containing any of the groups, e.g. carbazates
    • C07C281/04Compounds containing any of the groups, e.g. carbazates the other nitrogen atom being further doubly-bound to a carbon atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones
    • C07C251/86Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/63Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/14Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95907051T 1994-01-19 1995-01-19 Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung ATE185555T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9400557A FR2715155B1 (fr) 1994-01-19 1994-01-19 Inhibiteurs de la monoamine oxydase B et leurs procédés de préparation.

Publications (1)

Publication Number Publication Date
ATE185555T1 true ATE185555T1 (de) 1999-10-15

Family

ID=9459190

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95907051T ATE185555T1 (de) 1994-01-19 1995-01-19 Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung

Country Status (8)

Country Link
US (1) US5811456A (de)
EP (1) EP0740654B1 (de)
JP (1) JPH09507673A (de)
AT (1) ATE185555T1 (de)
CA (1) CA2180956A1 (de)
DE (1) DE69512763D1 (de)
FR (1) FR2715155B1 (de)
WO (1) WO1995019960A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2137750C1 (ru) * 1998-05-19 1999-09-20 Институт органического синтеза Уральского отделения РАН Замещенные ди(формиларил)полиэфиры, или их координационные соединения, или их фармацевтически приемлемые аддитивные соли, способ их получения и фармацевтическая композиция на их основе
US6589504B1 (en) * 2000-09-22 2003-07-08 Pharmacia & Upjohn Company Compounds and methods for diagnosing and treating amyloid-related conditions
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US20040171075A1 (en) * 2002-12-31 2004-09-02 Flynn Daniel L Modulation of protein functionalities
US20080220497A1 (en) * 2003-12-24 2008-09-11 Flynn Daniel L Modulation of protein functionalities
JP5197016B2 (ja) 2004-12-23 2013-05-15 デシファラ ファーマスーティカルズ, エルエルシー 酵素モジュレータ及び治療
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
US7790756B2 (en) 2006-10-11 2010-09-07 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
US20080248548A1 (en) * 2007-04-09 2008-10-09 Flynn Daniel L Modulation of protein functionalities
AU2008242720A1 (en) * 2007-04-20 2008-10-30 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
US20110189167A1 (en) * 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
EP2365752B1 (de) * 2008-10-29 2014-09-24 Deciphera Pharmaceuticals, Llc Cyclopropanamide und analoge mit antikrebs-eigenschaften und antiproliferativen eigenschaften
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
MX2017003554A (es) 2014-09-16 2017-06-30 Brocia Robert Bebidas energeticas y otros adyuvantes nutricionales derivados de espiritus destilados a base de agave.
EA202091763A1 (ru) 2018-01-31 2020-12-14 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Комбинированная терапия для лечения мастоцитоза
SG11202007198WA (en) 2018-01-31 2020-08-28 Deciphera Pharmaceuticals Llc Combination therapy for the treatment of gastrointestinal stromal tumors
MX2021006062A (es) * 2018-11-26 2021-07-06 Roar Holding Llc Metodos para mejorar la calidad de las bebidas.
EP3938363A1 (de) 2019-03-11 2022-01-19 Teva Pharmaceuticals International GmbH Festkörperformen von ripretinib
JP7818502B2 (ja) 2019-08-12 2026-02-20 デシフェラ・ファーマシューティカルズ,エルエルシー 胃腸間質腫瘍を治療するためのリプレチニブ
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
SI4084778T1 (sl) 2019-12-30 2024-01-31 Deciphera Pharmaceuticals, Llc Formulacije inhibitorja amorfne kinaze in načini njihove uporabe
AU2020417282B2 (en) 2019-12-30 2023-08-31 Deciphera Pharmaceuticals, Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB839610A (en) * 1957-07-03 1960-06-29 Hoffmann La Roche Novel acid hydrazides and a process for the manufacture of same
DE1163847B (de) * 1958-12-23 1964-02-27 Ici Ltd Verfahren zur Herstellung von ª‡-Methylbenzylhydraziden
FR59M (de) * 1960-07-15 1961-01-09
US3177251A (en) * 1960-07-30 1965-04-06 Robert Et Carriere Lab Hydroxy benzoic acid hydrazides
US3419659A (en) * 1964-07-08 1968-12-31 Gaf Corp Sun screening methods
CH480790A (de) * 1966-12-16 1969-11-15 Agripat Sa Mittel zur Bekämpfung von Insekten, Spinnentieren und deren Entwicklungsstadien
US3753680A (en) * 1970-05-14 1973-08-21 Stauffer Chemical Co Arylidene semicarbazones and their utility as herbicides
BE795111A (fr) * 1972-02-09 1973-08-07 Philips Nv Composes de benzylidene-semicarbazide et leur activite insecticide
US3867425A (en) * 1974-01-09 1975-02-18 American Cyanamid Co Substituted benzyl carbazic acid esters
HU190795B (en) * 1982-05-04 1986-11-28 Egyt Gyogyszervegyeszeti Gyar,Hu Process for producing carbazinic derivatives and compositions containing them for increasing weight yield
DE3624349A1 (de) * 1986-07-17 1988-01-28 Schering Ag Substituierte hydrazone, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
FR2631827B1 (fr) * 1988-05-27 1992-03-27 Delalande Sa Nouveaux derives d'(hetero)aryl-5 tetrazole, leur procede de preparation et leur application en therapeutique
CA2019162A1 (en) * 1989-06-22 1990-12-22 Adam Chi-Tung Hsu Halopropargyl compounds, compositions, uses and processes of preparation
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
FR2655044B1 (fr) * 1989-11-24 1995-03-03 Delalande Sa Derives d'(hetero) arylmethyloxy-4 phenyl tetrazole et oxadiazole, leur procede de preparation et leur application en therapeutique.
US5120347A (en) * 1990-06-21 1992-06-09 Rohm And Haas Company Aryl triazole herbicides
FR2675504B1 (fr) * 1991-04-16 1995-01-27 Delalande Sa Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CA2180956A1 (fr) 1995-07-27
JPH09507673A (ja) 1997-08-05
US5811456A (en) 1998-09-22
EP0740654B1 (de) 1999-10-13
EP0740654A1 (de) 1996-11-06
FR2715155A1 (fr) 1995-07-21
FR2715155B1 (fr) 1996-07-26
WO1995019960A1 (fr) 1995-07-27
DE69512763D1 (de) 1999-11-18

Similar Documents

Publication Publication Date Title
ATE185555T1 (de) Monoamin oxydase b hemmende verbidungen verfahren zu ihrer herstellung un ihrer verwendung
ATE132848T1 (de) Verfahren zur herstellung von sertralin- zwischenprodukten
ATE225348T1 (de) Substituierte azaindolylidenderivate und verfahren zu ihrer herstellung
GB9416897D0 (en) Metalloproteinase inhibitors
HUT77220A (hu) Szubsztituált benzamidinek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
DE69231445D1 (de) Triazole enthaltende antifungizide mittel
DE69204840D1 (de) Verfahren zur Herstellung von Sertralin.
TW251285B (de)
AT397654B (de) Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
BR9507168A (pt) Composto e processo para a preparação do mesmo
DK0847384T3 (da) Carbamoylcarboxylsyreamider
UA72934C2 (uk) Феніл- і піридилтетрагідропіридини, що інгібують фактор некрозу пухлин, спосіб їх одержання та фармацевтична композиція
DE69412085D1 (de) Neues verfahren zur herstellung von beta-alkoxyacrylsäure
BR9811481B1 (pt) processo para a preparação de derivados de 1,3-diazo-spiro (4,4) non-1-en-4-ona e intermediários de 1-ciano-1-acil amino ciclopentano.
ATE5720T1 (de) 2-pyridyloxyacetanilid-verbindungen, verfahren zu ihrer herstellung und ihre verwendung.
PL324858A1 (en) Novel passive constituents of a coupling reaction, method of obtaining them and hair colouring agents
ATE172189T1 (de) 15-deoxyspergualin-analoge verbindungen, ihre verwendung als therapeutika und verfahren zu ihrer herstellung
JPH11322670A5 (de)
DE59309487D1 (de) Isoxazolcarbonsäureamide, verfahren zu ihrer herstellung und ihre verwendung
ATE206127T1 (de) Inhibitoren retroviraler proteasen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties