ATE185970T1 - Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel - Google Patents

Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel

Info

Publication number: ATE185970T1
Authority: AT; Austria
Prior art keywords: polyalkylene glycol; medicinal products; containing medicinal; staurosporine derivatives; glycerides containing
Prior art date: 1993-12-11

Application number

AT94308954T

Other languages

English (en)

Inventor

Roy Lindsay Allen Henry

Graham Paul Matthews

Original Assignee

Novartis Erfind Verwalt Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-11

Filing date

1994-12-02

Publication date

1999-11-15

1994-12-02 Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh

1999-11-15 Application granted granted Critical

1999-11-15 Publication of ATE185970T1 publication Critical patent/ATE185970T1/de

Links

229920001515 polyalkylene glycol Polymers 0.000 title abstract 2
HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
239000006185 dispersion Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000002202 Polyethylene glycol Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005456 glyceride group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
235000003441 saturated fatty acids Nutrition 0.000 abstract 1
150000004671 saturated fatty acids Chemical class 0.000 abstract 1
CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compositions Of Macromolecular Compounds (AREA)

AT94308954T 1993-12-11 1994-12-02 Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel ATE185970T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939325395A GB9325395D0 (en)	1993-12-11	1993-12-11	Compositions

Publications (1)

Publication Number	Publication Date
ATE185970T1 true ATE185970T1 (de)	1999-11-15

Family

ID=10746475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94308954T ATE185970T1 (de)	1993-12-11	1994-12-02	Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel

Country Status (17)

Country	Link
US (1)	US5736542A (de)
EP (1)	EP0657164B1 (de)
JP (1)	JPH07196512A (de)
KR (1)	KR100366176B1 (de)
AT (1)	ATE185970T1 (de)
AU (1)	AU692801B2 (de)
CA (1)	CA2137764C (de)
DE (1)	DE69421366T2 (de)
DK (1)	DK0657164T3 (de)
ES (1)	ES2140512T3 (de)
GB (1)	GB9325395D0 (de)
GR (1)	GR3032368T3 (de)
IL (1)	IL111872A (de)
NZ (1)	NZ270109A (de)
PH (1)	PH31454A (de)
PT (1)	PT657164E (de)
ZA (1)	ZA949824B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7795246B2 (en)	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) *	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US6242473B1 (en) *	1999-01-08	2001-06-05	Maxim Pharmaceuticals, Inc.	Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
GB9903547D0 (en) *	1999-02-16	1999-04-07	Novartis Ag	Organic compounds
DE19917990A1 (de) *	1999-04-20	2000-11-02	Florian Lang	Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk
US6806266B1 (en)	1999-07-13	2004-10-19	Kyowa Hakko Kogyo Co., Ltd.	Staurosporin derivatives
DE10042137A1 (de) *	2000-08-28	2002-03-14	Florian Lang	sgk2 und sgk3 als diagnostische und therapeutische Targets
DE60211494T2 (de) *	2001-03-26	2006-10-12	Novartis Ag	Pharmazeutische zusammensetzung enthaltend ein schlecht wasserlösliches staurosporin, eine oberflächenaktive substanz und ein wasserlösliches polymer
KR20110005747A (ko) *	2003-03-03	2011-01-18	플로리안 랑	진단 및 치료 표적으로서의 ｓｇｋ１
US20040246627A1 (en) *	2003-06-06	2004-12-09	Durrum Thomas M.	Disc drive pivot bearing assembly
JP2007501774A (ja)	2003-08-08	2007-02-01	ノバルティスアクチエンゲゼルシャフト	スタウロスポリンを含む組み合わせ
EP1660047B1 (de)	2003-08-13	2013-11-27	Biocon Limited	Mikroteilchenförmige fettsäure-salz-festdosis-formulierungen für therapeutische mittel
CA2596405A1 (en) *	2005-02-07	2006-08-10	Topotarget Uk Limited	Assays for agents with selective cytotoxicty to hdac resistant cell lines
US9994585B2 (en)	2007-12-31	2018-06-12	Aphios Corporation	Transplantation therapies
US20100168219A1 (en) *	2008-12-31	2010-07-01	Jonathan Steven Alexander	Chronic inflammation and transplantation
US9034347B2 (en)	2011-12-19	2015-05-19	Arphios Corporation	Drug delivery system and method for the treatment of neuro-degenerative disease
HK1218882A1 (zh)	2012-11-28	2017-03-17	Aphios Corporation	用於治疗神经退化疾病和其它疾病的组合治疗剂和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60185719A (ja) *	1984-03-06	1985-09-21	Ajinomoto Co Inc	抗腫瘍剤
JPH0699311B2 (ja) *	1986-11-06	1994-12-07	旭化成工業株式会社	抗血管レン縮剤および血管弛緩剤
US5093330A (en) *	1987-06-15	1992-03-03	Ciba-Geigy Corporation	Staurosporine derivatives substituted at methylamino nitrogen
IL86632A0 (en) *	1987-06-15	1988-11-30	Ciba Geigy Ag	Derivatives substituted at methyl-amino nitrogen
JPH01143877A (ja) *	1987-11-30	1989-06-06	Asahi Chem Ind Co Ltd	スタウロスポリン誘導体
JP2766360B2 (ja) *	1988-02-04	1998-06-18	協和醗酵工業株式会社	スタウロスポリン誘導体
JPH0725786A (ja) *	1990-05-16	1995-01-27	Univ Rockefeller	アルツハイマー病を伴うアミロイドーシスの治療
EP0577769A4 (en) *	1991-03-29	1994-06-01	Us Commerce	Pharmaceutical compositions and methods for preventing skin tumor formation and causing regression of existing tumors
JPH0597708A (ja) *	1991-10-02	1993-04-20	Lion Corp	歯周病治療剤
EP0540185A1 (de) *	1991-10-10	1993-05-05	Schering Corporation	N-substituierte Staurosporin-N-oxid-Derivate
JPH05247055A (ja) *	1992-03-03	1993-09-24	Meiji Seika Kaisha Ltd	スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤

1993
- 1993-12-11 GB GB939325395A patent/GB9325395D0/en active Pending
1994
- 1994-11-18 PH PH49409A patent/PH31454A/en unknown
- 1994-11-22 US US08/343,404 patent/US5736542A/en not_active Expired - Fee Related
- 1994-12-02 DE DE69421366T patent/DE69421366T2/de not_active Expired - Lifetime
- 1994-12-02 PT PT94308954T patent/PT657164E/pt unknown
- 1994-12-02 AT AT94308954T patent/ATE185970T1/de active
- 1994-12-02 EP EP94308954A patent/EP0657164B1/de not_active Expired - Lifetime
- 1994-12-02 DK DK94308954T patent/DK0657164T3/da active
- 1994-12-02 ES ES94308954T patent/ES2140512T3/es not_active Expired - Lifetime
- 1994-12-05 IL IL111872A patent/IL111872A/en not_active IP Right Cessation
- 1994-12-08 AU AU80308/94A patent/AU692801B2/en not_active Ceased
- 1994-12-09 ZA ZA949824A patent/ZA949824B/xx unknown
- 1994-12-09 CA CA002137764A patent/CA2137764C/en not_active Expired - Fee Related
- 1994-12-09 NZ NZ270109A patent/NZ270109A/en not_active IP Right Cessation
- 1994-12-09 KR KR1019940033397A patent/KR100366176B1/ko not_active Expired - Fee Related
- 1994-12-12 JP JP6307534A patent/JPH07196512A/ja active Pending
2000
- 2000-01-14 GR GR20000400066T patent/GR3032368T3/el unknown

Also Published As

Publication number	Publication date
KR960021018A (ko)	1996-07-18
JPH07196512A (ja)	1995-08-01
PH31454A (en)	1998-11-03
DE69421366D1 (de)	1999-12-02
CA2137764C (en)	2006-02-07
DK0657164T3 (da)	2000-04-17
DE69421366T2 (de)	2000-03-23
IL111872A (en)	1998-02-08
CA2137764A1 (en)	1995-06-12
ES2140512T3 (es)	2000-03-01
KR100366176B1 (ko)	2003-03-03
EP0657164B1 (de)	1999-10-27
AU692801B2 (en)	1998-06-18
ZA949824B (en)	1995-07-13
AU8030894A (en)	1995-06-22
GR3032368T3 (en)	2000-04-27
IL111872A0 (en)	1995-06-29
NZ270109A (en)	1996-11-26
PT657164E (pt)	2000-04-28
US5736542A (en)	1998-04-07
EP0657164A1 (de)	1995-06-14
GB9325395D0 (en)	1994-02-16

Legal Events

Date	Code	Title	Description
2000-05-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69421366D1 (de)	1999-12-02	Staurosporinderivate und Polyalkylenglykol-Glyceride enthaltende Arzneimittel
ES2186715T3 (es)	2003-05-16	Uso de un tensioactivo lipofilico en una composicion farmaceutica.
DE69506642D1 (de)	1999-01-28	Pharmazeutische Zubereitungen enthaltend mehrfach ungesättigte Fettsäuren zusammen mit antioxydativen Vitaminen und Provitaminen
SE8004938L (sv)	1981-01-06	Farmaceutisk kompositon av fast lekemedel med fordrojd frigoring
LV11884A (lv)	1997-12-20	Ciklosporina oralas arstnieciskas formas ar augstu biopieejamibu
ES2174814T3 (es)	2002-11-16	Acidos grasos esenciales destinados en la prevencion de accidentes cardio-vasculares.
WO2006096806A3 (en)	2007-10-25	Treatment with statin and omega-3 fatty acids and a combination product thereof
AU601176B2 (en)	1990-09-06	Benzodiazepine aerosols
ES2101574T3 (es)	1997-07-01	Composicion administrable por via oral apta para formar una microemulsion.
DK0904064T3 (da)	2001-12-17	Orale farmaceutiske præparater indeholdende kønshormoner
DE3780222D1 (de)	1992-08-13	Pharmazeutische zusammensetzung mit kontrollierter wirkstofffreisetzung.
DE58905028D1 (de)	1993-09-02	Pharmazeutische kombinationspraeparate und deren verwendung als antineoplastische arzneimittel.
ATE339952T1 (de)	2006-10-15	Fluorchlorkohlenwasserstofffreie aerosolformulierungen
ATE219940T1 (de)	2002-07-15	Arzneimittel enthaltende cyclosporinderivate
ATE301989T1 (de)	2005-09-15	Orale pharmazeutische zusammensetzung mit einem wirkstoff, der bei seiner ersten darmpassage starken wirkungen ausgesetzt werden kann
KR950010875A (ko)	1995-05-15	피부외용제
ATE59291T1 (de)	1991-01-15	2-(2-fluor-4-biphenylyl)propionsaeure oder deren salze enthaltende arzneimittel.
UY26303A1 (es)	2001-03-16	Composiciones farmacéuticas para administración oral y tópica
MY120521A (en)	2005-11-30	Pharmaceutical microspheres of valproic acid for oral administration.
NO932236L (no)	1993-06-17	Farmasoeytisk preparat inneholdende probukol med forhoeyet biotilgjengelighet
BE1002024A6 (fr)	1990-05-22	Preparation medicamenteuse a base de derives d'esters d'hecogenine et leur utilisation pour le traitement de l'hyperplasie prostatique benigne.
WO1999008666A3 (en)	1999-04-15	Pharmaceutical composition comprising an azateroid
SE8600496L (sv)	1986-08-06	Farmaceutiska kompositioner innehallande 9,10-dihydroergotalkaloider
DE69803772D1 (de)	2002-03-21	Oral anzuwendende feste arzneizubereitungen mit modulierter wirkstoffabgabe enthaltend nicorandil und verfahren zu deren herstellung
NO155620C (no)	1987-04-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive dibenzo(a,d)-cyklohepten-derivater.