ATE185970T1 - Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel - Google Patents

Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel

Info

Publication number: ATE185970T1
Authority: AT; Austria
Prior art keywords: polyalkylene glycol; medicinal products; containing medicinal; staurosporine derivatives; glycerides containing
Prior art date: 1993-12-11

Application number

AT94308954T

Other languages

English (en)

Inventor

Roy Lindsay Allen Henry

Graham Paul Matthews

Original Assignee

Novartis Erfind Verwalt Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-11

Filing date

1994-12-02

Publication date

1999-11-15

1994-12-02 Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh

1999-11-15 Application granted granted Critical

1999-11-15 Publication of ATE185970T1 publication Critical patent/ATE185970T1/de

Links

229920001515 polyalkylene glycol Polymers 0.000 title abstract 2
HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
239000006185 dispersion Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000002202 Polyethylene glycol Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005456 glyceride group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
235000003441 saturated fatty acids Nutrition 0.000 abstract 1
150000004671 saturated fatty acids Chemical class 0.000 abstract 1
CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Compositions Of Macromolecular Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94308954T 1993-12-11 1994-12-02 Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel ATE185970T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939325395A GB9325395D0 (en)	1993-12-11	1993-12-11	Compositions

Publications (1)

Publication Number	Publication Date
ATE185970T1 true ATE185970T1 (de)	1999-11-15

Family

ID=10746475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94308954T ATE185970T1 (de)	1993-12-11	1994-12-02	Staurosporinderivate und polyalkylenglykol- glyceride enthaltende arzneimittel

Country Status (17)

Country	Link
US (1)	US5736542A (de)
EP (1)	EP0657164B1 (de)
JP (1)	JPH07196512A (de)
KR (1)	KR100366176B1 (de)
AT (1)	ATE185970T1 (de)
AU (1)	AU692801B2 (de)
CA (1)	CA2137764C (de)
DE (1)	DE69421366T2 (de)
DK (1)	DK0657164T3 (de)
ES (1)	ES2140512T3 (de)
GB (1)	GB9325395D0 (de)
GR (1)	GR3032368T3 (de)
IL (1)	IL111872A (de)
NZ (1)	NZ270109A (de)
PH (1)	PH31454A (de)
PT (1)	PT657164E (de)
ZA (1)	ZA949824B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7795246B2 (en)	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US6200968B1 (en) *	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US6242473B1 (en) *	1999-01-08	2001-06-05	Maxim Pharmaceuticals, Inc.	Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
GB9903547D0 (en) *	1999-02-16	1999-04-07	Novartis Ag	Organic compounds
DE19917990A1 (de) *	1999-04-20	2000-11-02	Florian Lang	Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk
WO2001004125A1 (en)	1999-07-13	2001-01-18	Kyowa Hakko Kogyo Co., Ltd.	Staurosporin derivatives
DE10042137A1 (de) *	2000-08-28	2002-03-14	Florian Lang	sgk2 und sgk3 als diagnostische und therapeutische Targets
PT1372611E (pt) *	2001-03-26	2006-08-31	Novartis Ag	Composicao farmaceutica compreendendo uma estaurosporina francamente soluvel em agua, um tensioactivo et um polimero soluvel em agua
KR101032281B1 (ko) *	2003-03-03	2011-05-06	플로리안 랑	진단 및 치료 표적으로서의 ｓｇｋ１
US20040246627A1 (en) *	2003-06-06	2004-12-09	Durrum Thomas M.	Disc drive pivot bearing assembly
EP1653973A1 (de)	2003-08-08	2006-05-10	Novartis AG	Kombinationen mit staurosporinen
AU2004264958B2 (en)	2003-08-13	2010-04-15	Biocon, Ltd	Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
AU2006210994A1 (en) *	2005-02-07	2006-08-10	Topotarget Uk Limited	Assays for agents with selective cytotoxicty to HDAC resistant cell lines
US9994585B2 (en)	2007-12-31	2018-06-12	Aphios Corporation	Transplantation therapies
US20100168219A1 (en) *	2008-12-31	2010-07-01	Jonathan Steven Alexander	Chronic inflammation and transplantation
US9034347B2 (en)	2011-12-19	2015-05-19	Arphios Corporation	Drug delivery system and method for the treatment of neuro-degenerative disease
CN105228614A (zh)	2012-11-28	2016-01-06	阿菲欧斯公司	用于治疗神经退化疾病和其它疾病的组合治疗剂和方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60185719A (ja) *	1984-03-06	1985-09-21	Ajinomoto Co Inc	抗腫瘍剤
JPH0699311B2 (ja) *	1986-11-06	1994-12-07	旭化成工業株式会社	抗血管レン縮剤および血管弛緩剤
US5093330A (en) *	1987-06-15	1992-03-03	Ciba-Geigy Corporation	Staurosporine derivatives substituted at methylamino nitrogen
IL86632A0 (en) *	1987-06-15	1988-11-30	Ciba Geigy Ag	Derivatives substituted at methyl-amino nitrogen
JPH01143877A (ja) *	1987-11-30	1989-06-06	Asahi Chem Ind Co Ltd	スタウロスポリン誘導体
EP0383919A4 (en) *	1988-02-04	1992-08-05	Kyowa Hakko Kogyo Co., Ltd.	Staurosporin derivatives
JPH0725786A (ja) *	1990-05-16	1995-01-27	Univ Rockefeller	アルツハイマー病を伴うアミロイドーシスの治療
WO1992017181A1 (en) *	1991-03-29	1992-10-15	The United States Of America, Represented By The Secretary, United States Department Of Commerce	Pharmaceutical compositions and methods for preventing skin tumor formation and causing regression of existing tumors
JPH0597708A (ja) *	1991-10-02	1993-04-20	Lion Corp	歯周病治療剤
WO1993007153A1 (en) *	1991-10-10	1993-04-15	Schering Corporation	4'-(n-substituted-n-oxide)staurosporine derivatives
JPH05247055A (ja) *	1992-03-03	1993-09-24	Meiji Seika Kaisha Ltd	スタウロスポリン誘導体及びそれを含有する抗腫瘍効果増強剤

1993
- 1993-12-11 GB GB939325395A patent/GB9325395D0/en active Pending
1994
- 1994-11-18 PH PH49409A patent/PH31454A/en unknown
- 1994-11-22 US US08/343,404 patent/US5736542A/en not_active Expired - Fee Related
- 1994-12-02 DK DK94308954T patent/DK0657164T3/da active
- 1994-12-02 PT PT94308954T patent/PT657164E/pt unknown
- 1994-12-02 AT AT94308954T patent/ATE185970T1/de active
- 1994-12-02 ES ES94308954T patent/ES2140512T3/es not_active Expired - Lifetime
- 1994-12-02 DE DE69421366T patent/DE69421366T2/de not_active Expired - Lifetime
- 1994-12-02 EP EP94308954A patent/EP0657164B1/de not_active Expired - Lifetime
- 1994-12-05 IL IL111872A patent/IL111872A/en not_active IP Right Cessation
- 1994-12-08 AU AU80308/94A patent/AU692801B2/en not_active Ceased
- 1994-12-09 CA CA002137764A patent/CA2137764C/en not_active Expired - Fee Related
- 1994-12-09 ZA ZA949824A patent/ZA949824B/xx unknown
- 1994-12-09 NZ NZ270109A patent/NZ270109A/en not_active IP Right Cessation
- 1994-12-09 KR KR1019940033397A patent/KR100366176B1/ko not_active Expired - Fee Related
- 1994-12-12 JP JP6307534A patent/JPH07196512A/ja active Pending
2000
- 2000-01-14 GR GR20000400066T patent/GR3032368T3/el unknown

Also Published As

Publication number	Publication date
GB9325395D0 (en)	1994-02-16
EP0657164A1 (de)	1995-06-14
PT657164E (pt)	2000-04-28
ZA949824B (en)	1995-07-13
PH31454A (en)	1998-11-03
KR960021018A (ko)	1996-07-18
AU692801B2 (en)	1998-06-18
CA2137764A1 (en)	1995-06-12
CA2137764C (en)	2006-02-07
US5736542A (en)	1998-04-07
AU8030894A (en)	1995-06-22
IL111872A (en)	1998-02-08
NZ270109A (en)	1996-11-26
EP0657164B1 (de)	1999-10-27
JPH07196512A (ja)	1995-08-01
GR3032368T3 (en)	2000-04-27
IL111872A0 (en)	1995-06-29
DE69421366D1 (de)	1999-12-02
KR100366176B1 (ko)	2003-03-03
DE69421366T2 (de)	2000-03-23
DK0657164T3 (da)	2000-04-17
ES2140512T3 (es)	2000-03-01

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Legal Events

Date	Code	Title	Description
2000-05-15	UEP	Publication of translation of european patent specification