ATE186330T1 - Reagens und verfahren für den nachweis einer nukleotidischen sequenz mit signalamplifizierung - Google Patents
Reagens und verfahren für den nachweis einer nukleotidischen sequenz mit signalamplifizierungInfo
- Publication number
- ATE186330T1 ATE186330T1 AT94928418T AT94928418T ATE186330T1 AT E186330 T1 ATE186330 T1 AT E186330T1 AT 94928418 T AT94928418 T AT 94928418T AT 94928418 T AT94928418 T AT 94928418T AT E186330 T1 ATE186330 T1 AT E186330T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleotide
- pct
- nucleotide sequence
- units
- reagent
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title abstract 8
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 4
- 230000003321 amplification Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 title abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 238000001514 detection method Methods 0.000 abstract 2
- 230000003252 repetitive effect Effects 0.000 abstract 2
- 239000000523 sample Substances 0.000 abstract 2
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000016361 genetic disease Diseases 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000700 radioactive tracer Substances 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9311006A FR2710075B1 (fr) | 1993-09-15 | 1993-09-15 | Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE186330T1 true ATE186330T1 (de) | 1999-11-15 |
Family
ID=9450908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94928418T ATE186330T1 (de) | 1993-09-15 | 1994-09-15 | Reagens und verfahren für den nachweis einer nukleotidischen sequenz mit signalamplifizierung |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5695936A (de) |
| EP (1) | EP0669991B1 (de) |
| AT (1) | ATE186330T1 (de) |
| CA (1) | CA2149315C (de) |
| DE (1) | DE69421514T2 (de) |
| ES (1) | ES2140560T3 (de) |
| FR (1) | FR2710075B1 (de) |
| WO (1) | WO1995008000A2 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2710075B1 (fr) * | 1993-09-15 | 1995-10-27 | Bio Merieux | Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal. |
| US6306657B1 (en) * | 1994-06-28 | 2001-10-23 | Kalyx Biosciences, Inc. | Polynucleotide probe and kit for amplifying signal detection in hybridization assays |
| DE19537952A1 (de) | 1995-10-12 | 1997-04-17 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis eines Analyten |
| FR2746413B1 (fr) * | 1996-03-19 | 1998-04-24 | Bio Merieux | Detection d'une sequence nucleotidique avec amplification de signal |
| US5853993A (en) * | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
| FR2758884B1 (fr) * | 1997-01-30 | 1999-04-02 | Bio Merieux | Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu |
| US6558901B1 (en) * | 1997-05-02 | 2003-05-06 | Biomerieux Vitek | Nucleic acid assays |
| IL124275A (en) * | 1997-05-02 | 2002-03-10 | Bio Merieux Vitek Inc | A method to produce sequences of nucleic acids |
| FR2780059B1 (fr) | 1998-06-17 | 2002-10-11 | Bio Merieux | Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus |
| EP1112378A1 (de) * | 1998-07-17 | 2001-07-04 | GeneTag Technology, Inc. | Methoden zur detektion und kartierung von genen, mutationen und abweichender polynukleotidsequenzen |
| US6432642B1 (en) * | 1999-01-15 | 2002-08-13 | Pe Corporation (Ny) | Binary probe and clamp composition and methods for a target hybridization detection |
| CA2370687A1 (en) * | 1999-06-25 | 2001-01-04 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Nucleic acid binding of multi-zinc finger transcription factors |
| HK1050552A1 (zh) * | 1999-12-17 | 2003-06-27 | Bio Merieux | 标记核糖核酸的方法以及由此方法获得的标记的rna片段 |
| US6489114B2 (en) | 1999-12-17 | 2002-12-03 | Bio Merieux | Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby |
| US6902891B2 (en) | 1999-12-17 | 2005-06-07 | Bio Merieux | Process for labeling a nucleic acid |
| KR100446358B1 (ko) * | 2000-03-31 | 2004-09-01 | 산코 준야쿠 가부시키가이샤 | 프로우브 중합체 제작용 프로우브, 프로우브 중합체의 제작방법 및 그 이용 |
| AU2001274146A1 (en) * | 2000-05-29 | 2001-12-11 | Bio Merieux | Biocompatible polymer for fixing biological ligands |
| GB0016833D0 (en) * | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (2) |
| US20040161746A1 (en) * | 2000-12-21 | 2004-08-19 | Yoshiko Matsumoto | Method of testing allergic disease |
| EP1390530A2 (de) * | 2001-01-05 | 2004-02-25 | Genomicfx, Inc. | Verfahren zur relativen quantifizierung von immobilisierten nukleinsäuren |
| EP2295971B1 (de) * | 2001-03-09 | 2016-09-07 | TrovaGene, Inc. | Konjugatsonden und optische Erkennung von Analyten |
| US7060441B2 (en) | 2001-05-04 | 2006-06-13 | Biomerieux | Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling |
| US7338805B2 (en) | 2001-05-04 | 2008-03-04 | Bio Merieux | Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules |
| FR2829580B1 (fr) | 2001-09-07 | 2004-02-13 | Bio Merieux | Procede de lecture, de detection ou de quantification, hybrides ou complexes utilises dans ce procede et biopuce mettant en oeuvre ledit procede |
| SE0200531D0 (sv) * | 2002-02-22 | 2002-02-22 | Avaris Ab | Novel biomolecular complexes, method for their production and use |
| US20030175828A1 (en) * | 2002-03-15 | 2003-09-18 | Lazar James G. | Signal amplification by Hybrid Capture |
| US20040002095A1 (en) * | 2002-03-22 | 2004-01-01 | Bio-Rad Laboratories, Inc. | Universal signal amplification tail |
| FR2840687B1 (fr) | 2002-06-05 | 2008-01-25 | Bio Merieux | Procede de detection simultanee de reactions d'hybridation et immunologiques et ses utilisations en diagnostic |
| FR2846426B1 (fr) | 2002-10-28 | 2004-12-10 | Bio Merieux | Procede de dosage du ngf pour le diagnostic in vitro du cancer du sein et utilisation en therapie |
| AU2003298733B2 (en) * | 2002-11-27 | 2009-06-18 | Agena Bioscience, Inc. | Fragmentation-based methods and systems for sequence variation detection and discovery |
| FR2855832B1 (fr) | 2003-06-03 | 2007-09-14 | Biomerieux Sa | Procede de diagnostic et/ou de pronostic d'un syndrome septique |
| EP1687445A4 (de) * | 2003-09-23 | 2007-03-28 | Atom Sciences Inc | Polymere nukleinsäurehybridisierungssonden |
| EP1725572B1 (de) | 2003-11-05 | 2017-05-31 | AGCT GmbH | Makromolekulare nukleotidverbindungen und methoden zu deren anwendung |
| FR2868071B1 (fr) * | 2004-03-26 | 2006-06-09 | Biomerieux Sa | Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| FR2868433B1 (fr) | 2004-04-06 | 2008-01-18 | Biomerieux Sa | Procede pour le pronostic et/ou le diagnostic d'un cancer |
| JPWO2005100983A1 (ja) * | 2004-04-16 | 2008-03-06 | 英俊 岡部 | 悪性腫瘍の検査方法 |
| FR2873388B1 (fr) * | 2004-07-23 | 2012-04-06 | Biomerieux Sa | Procede de marquage et de purification d'acides nucleiques d'interet presents dans un echantillon biologique a traiter dans un unique recipient reactionnel |
| FR2886735B1 (fr) | 2005-06-01 | 2015-09-11 | Biomerieux Sa | Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques |
| US8778845B2 (en) | 2005-12-15 | 2014-07-15 | Genral Electric Company | Composition, device and associated method |
| US8741813B2 (en) | 2005-12-15 | 2014-06-03 | General Electric Company | Composition, device and associated method |
| FR2897062B1 (fr) | 2006-02-09 | 2011-11-04 | Biomerieux Sa | Domaine peptidique necessaire a l'interaction entre l'enveloppe d'un virus appartenant au groupe d'interference de herv-w et un recepteur asct |
| US8765643B2 (en) | 2006-12-04 | 2014-07-01 | General Electric Company | Composition, device and associated method |
| US8778846B2 (en) | 2006-12-04 | 2014-07-15 | General Electric Company | Composition, device and associated method |
| FR2917095B1 (fr) | 2007-06-07 | 2009-07-17 | Biomerieux Sa | Dispositif de lyse de microorganismes presents dans un echantillon environnemental ou clinique et d'extraction des acides nucleiques desdits microorganismes aux fins d'analyse. |
| FR2917090B1 (fr) | 2007-06-11 | 2012-06-15 | Biomerieux Sa | Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| CA2705985A1 (en) | 2007-11-28 | 2009-06-04 | Great Basin Scientific | Methods and compositions for signal enhancement using multivalent interactions |
| FR2934595B1 (fr) | 2008-07-29 | 2013-04-05 | Biomerieux Sa | Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques |
| FR2939445B1 (fr) | 2008-12-10 | 2013-05-03 | Biomerieux Sa | Systeme automatise de lyse de microorganismes presents dans un echantillon, d'extraction et de purification des acides nucleiques desdits microorganismes aux fins d'analyse. |
| EP2494073B1 (de) | 2009-10-26 | 2017-11-29 | AGCT GmbH | Konjugate von nukleotiden und methoden zu deren anwendung |
| US20120214187A1 (en) * | 2009-11-02 | 2012-08-23 | Ffina Biolutions, Llc | Method for Enhancing the Sensitivity of Antibody Based Assays |
| US9110079B2 (en) | 2010-09-29 | 2015-08-18 | Biomerieux | Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS |
| US20120258870A1 (en) | 2010-11-22 | 2012-10-11 | The University Of Chicago | Methods, Systems, and/or Use of Oligonucleotide Conjugates to Develop Panels for Use in Assays and Detections |
| FR2968767B1 (fr) | 2010-12-08 | 2012-12-21 | Biomerieux Sa | Procede et coffret pour le diagnostic in vitro du cancer de la prostate |
| DE102012008375A1 (de) | 2011-04-27 | 2012-10-31 | Genovoxx Gmbh | Methoden und Komponenten zur Detektion von Nukleinsäureketten |
| FR2980213B1 (fr) | 2011-09-16 | 2013-09-06 | Biomerieux Sa | Procede de caracterisation de bacteries, par detection de proteines non-structurales de bacteriophages |
| FR2987836A1 (fr) | 2012-03-09 | 2013-09-13 | Biomerieux Sa | Peptides d'interference et procede de detection de microorganismes |
| WO2013177046A1 (en) | 2012-05-21 | 2013-11-28 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for suppressing background due to cross-hybridization |
| FR2991777B1 (fr) | 2012-06-07 | 2015-08-21 | Biomerieux Sa | Procede de detection et/ou de dosage de l'annexine a3 d'un mammifere dans le sang ou au moins un de ses derives |
| FR2993281B1 (fr) | 2012-07-13 | 2014-07-18 | Biomerieux Sa | Systeme automatise de lyse de microorganismes presents dans un echantillon, d'extraction et de purification des acides nucleiques desdits microorganismes aux fins d'analyse |
| FR2999576B1 (fr) | 2012-12-13 | 2014-12-05 | Biomerieux Sa | Derives de testosterone |
| FR3000551B1 (fr) | 2012-12-27 | 2015-06-26 | Biomerieux Sa | Derives de folate, particulierement utiles dans le cadre du dosage de folate(s) |
| FR3001805B1 (fr) | 2013-02-01 | 2015-02-20 | Biomerieux Sa | Procede de detection d'un cancer colorectal |
| BR112016004161B1 (pt) | 2013-09-17 | 2023-01-17 | Biomerieux | Uso de pelo menos um tensoativo de fluoroalquila |
| FR3014446B1 (fr) | 2013-12-10 | 2017-05-26 | Biomerieux Sa | Stabilisation de la gdh en solution aqueuse |
| FR3027394B1 (fr) | 2014-10-17 | 2016-10-21 | Biomerieux Sa | Prediction de la susceptibilite, pour un patient a risque, de developper ou redevelopper une infection a clostridium difficile |
| EP3234606B1 (de) | 2014-12-16 | 2019-07-24 | Biomérieux | Verfahren und vorrichtung zur bestimmung der präsenz eines mikroorganismus in stuhl mit aktivkohlevorbehandlung |
| EP3233896A1 (de) | 2014-12-18 | 2017-10-25 | Biomérieux | Synthetische biepitopverbindung |
| FR3036188B1 (fr) | 2015-05-12 | 2019-06-07 | Biomerieux | Prediction du risque de developper, pour des patients admis en service de reanimation, une infection disseminee |
| FR3046847B1 (fr) | 2016-01-14 | 2018-02-09 | Biomerieux | Procede de determination d'une reponse humorale chez un sujet immunodeprime |
| FR3080185A1 (fr) | 2018-04-16 | 2019-10-18 | Biomerieux | Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux |
| US10876148B2 (en) | 2018-11-14 | 2020-12-29 | Element Biosciences, Inc. | De novo surface preparation and uses thereof |
| US10768173B1 (en) * | 2019-09-06 | 2020-09-08 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US10704094B1 (en) | 2018-11-14 | 2020-07-07 | Element Biosciences, Inc. | Multipart reagents having increased avidity for polymerase binding |
| US12313627B2 (en) | 2019-05-01 | 2025-05-27 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| AU2022316142A1 (en) | 2021-07-21 | 2024-02-22 | Element Biosciences, Inc. | Optical systems for nucleic acid sequencing and methods thereof |
| EP4573213A1 (de) | 2022-08-15 | 2025-06-25 | Element Biosciences, Inc. | Ortsaufgelöste oberflächenerfassung von nukleinsäuren |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4687732A (en) * | 1983-06-10 | 1987-08-18 | Yale University | Visualization polymers and their application to diagnostic medicine |
| FI71768C (fi) * | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
| GB8405437D0 (en) * | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
| CA1260372A (en) * | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
| US4755458A (en) * | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
| EP0204510B1 (de) * | 1985-05-31 | 1991-07-10 | Amoco Corporation | Verstärkung von Hybridisierungssignalen durch Verwendung von komplementarischen DNS-Strängen |
| US5273882A (en) * | 1985-06-13 | 1993-12-28 | Amgen | Method and kit for performing nucleic acid hybridization assays |
| US4868105A (en) * | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
| US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
| US4925785A (en) * | 1986-03-07 | 1990-05-15 | Biotechnica Diagnostics, Inc. | Nucleic acid hybridization assays |
| SE454781B (sv) * | 1986-10-17 | 1988-05-30 | Wallac Oy | Hybridiseringsforfarande for detektion av polynukleotidsekvens |
| FR2607607B1 (fr) * | 1986-12-01 | 1991-05-24 | Heudin Jean Claude | Machine informatique destinee a l'execution de traitements symboliques pour les applications de l'intelligence artificielle |
| FR2607507B1 (fr) * | 1986-12-02 | 1990-04-13 | Centre Nat Rech Scient | Nouveaux derives a-d-oligonucleotides, leur preparation et leur emploi |
| IL86164A0 (en) * | 1987-04-28 | 1988-11-15 | Tamir Biotechnology Ltd | Improved dna probes |
| CA1339351C (en) * | 1987-10-15 | 1997-08-26 | Michael S. Urdea | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| WO1989003849A1 (en) * | 1987-10-28 | 1989-05-05 | Howard Florey Institute Of Experimental Physiology | Oligonucleotide-polyamide conjugates |
| US5104791A (en) * | 1988-02-09 | 1992-04-14 | E. I. Du Pont De Nemours And Company | Particle counting nucleic acid hybridization assays |
| US5374524A (en) * | 1988-05-10 | 1994-12-20 | E. I. Du Pont De Nemours And Company | Solution sandwich hybridization, capture and detection of amplified nucleic acids |
| SE8802574D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Oligonucleotide hybridization probes and means for the synthesis of the most preferred probes |
| US5324829A (en) * | 1988-12-16 | 1994-06-28 | Ortho Diagnostic Systems, Inc. | High specific activity nucleic acid probes having target recognition and signal generating moieties |
| ATE152777T1 (de) * | 1989-12-04 | 1997-05-15 | Microprobe Corp | Verstärkter einfang von ziel-nukleinsäuren mittels verwendung von oligonukleotiden, die kovalent an polymere gebunden sind |
| CA2039517C (en) * | 1990-04-03 | 2006-11-07 | David Segev | Dna probe signal amplification |
| FR2663040B1 (fr) * | 1990-06-11 | 1995-09-15 | Bio Merieux | Procede de detection d'une sequence nucleotidique selon la technique d'hybridation sandwich. |
| US5387510A (en) * | 1991-10-02 | 1995-02-07 | Eastman Kodak Company | Detection of amplified nucleic acid using secondary capture oligonucleotides and test kit |
| FR2710075B1 (fr) * | 1993-09-15 | 1995-10-27 | Bio Merieux | Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal. |
-
1993
- 1993-09-15 FR FR9311006A patent/FR2710075B1/fr not_active Expired - Fee Related
-
1994
- 1994-09-15 US US08/433,505 patent/US5695936A/en not_active Expired - Lifetime
- 1994-09-15 EP EP94928418A patent/EP0669991B1/de not_active Expired - Lifetime
- 1994-09-15 ES ES94928418T patent/ES2140560T3/es not_active Expired - Lifetime
- 1994-09-15 DE DE69421514T patent/DE69421514T2/de not_active Expired - Lifetime
- 1994-09-15 AT AT94928418T patent/ATE186330T1/de not_active IP Right Cessation
- 1994-09-15 CA CA002149315A patent/CA2149315C/fr not_active Expired - Fee Related
- 1994-09-15 WO PCT/FR1994/001084 patent/WO1995008000A2/fr not_active Ceased
-
1997
- 1997-06-06 US US08/870,730 patent/US6017707A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0669991B1 (de) | 1999-11-03 |
| DE69421514D1 (de) | 1999-12-09 |
| ES2140560T3 (es) | 2000-03-01 |
| CA2149315C (fr) | 2002-04-16 |
| US5695936A (en) | 1997-12-09 |
| FR2710075B1 (fr) | 1995-10-27 |
| FR2710075A1 (fr) | 1995-03-24 |
| WO1995008000A3 (fr) | 1995-06-08 |
| WO1995008000A2 (fr) | 1995-03-23 |
| EP0669991A1 (de) | 1995-09-06 |
| US6017707A (en) | 2000-01-25 |
| DE69421514T2 (de) | 2000-07-06 |
| CA2149315A1 (fr) | 1995-03-23 |
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