ATE189685T1 - Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität - Google Patents

Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität

Info

Publication number: ATE189685T1
Authority: AT; Austria
Prior art keywords: acid; lysine; group; ornithine; cyclic
Prior art date: 1996-05-16

Application number

AT97303251T

Other languages

English (en)

Inventor

Ramalinga Dharanipragada

Mark J Macielag

Jung Kim-Dettelback

James Florance

Original Assignee

Baxter Pharmaceutical Products

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-16

Filing date

1997-05-13

Publication date

2000-02-15

1997-05-13 Application filed by Baxter Pharmaceutical Products filed Critical Baxter Pharmaceutical Products

2000-02-15 Application granted granted Critical

2000-02-15 Publication of ATE189685T1 publication Critical patent/ATE189685T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
230000002496 gastric effect Effects 0.000 title abstract 2
230000004936 stimulating effect Effects 0.000 title abstract 2
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 8
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 8
OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 4
CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 abstract 4
OGNSCSPNOLGXSM-VKHMYHEASA-N L-2,4-diaminobutyric acid Chemical compound NCC[C@H](N)C(O)=O OGNSCSPNOLGXSM-VKHMYHEASA-N 0.000 abstract 4
CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 abstract 4
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 4
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 4
229960005261 aspartic acid Drugs 0.000 abstract 4
229960002989 glutamic acid Drugs 0.000 abstract 4
229960003104 ornithine Drugs 0.000 abstract 4
WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004122 cyclic group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
229930028154 D-arginine Natural products 0.000 abstract 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-Lysine Natural products NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
235000019766 L-Lysine Nutrition 0.000 abstract 1
125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
229930064664 L-arginine Natural products 0.000 abstract 1
235000014852 L-arginine Nutrition 0.000 abstract 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical group OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 1
229930182816 L-glutamine Chemical group 0.000 abstract 1
125000001176 L-lysyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C([H])([H])C([H])([H])C(N([H])[H])([H])[H] 0.000 abstract 1
239000004472 Lysine Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229960003767 alanine Drugs 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/63—Motilins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT97303251T 1996-05-16 1997-05-13 Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität ATE189685T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/648,644 US5734012A (en)	1996-05-16	1996-05-16	Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity

Publications (1)

Publication Number	Publication Date
ATE189685T1 true ATE189685T1 (de)	2000-02-15

Family

ID=24601620

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97303251T ATE189685T1 (de)	1996-05-16	1997-05-13	Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität

Country Status (8)

Country	Link
US (1)	US5734012A (de)
EP (1)	EP0807639B1 (de)
JP (1)	JPH1053599A (de)
KR (1)	KR970073603A (de)
AT (1)	ATE189685T1 (de)
CA (1)	CA2200935C (de)
DE (1)	DE69701269T2 (de)
ES (1)	ES2144826T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6265495B1 (en)	1998-09-22	2001-07-24	Nippon Shokubai Co., Ltd.	Method for production of esterified product
DK1633774T3 (da)	2003-06-18	2010-05-25	Tranzyme Pharma Inc	Makrocykliske motilinreceptorantagonister
US20060287243A1 (en) *	2005-06-17	2006-12-21	Navneet Puri	Stable pharmaceutical compositions including motilin-like peptides
US20060293243A1 (en) *	2005-06-17	2006-12-28	Navneet Puri	Stable, buffered, pharmaceutical compositions including motilin-like peptides
EP1902022A1 (de)	2005-07-12	2008-03-26	Glaxo Group Limited	Piperazinheteroarylderivate als gpr38-agonisten
SI1907374T1 (sl) *	2005-07-26	2012-11-30	Glaxo Group Ltd	Derivati benzilpiperazina uporabni za zdravljenje gastrointestinalnih motenj
EP2431380A3 (de)	2006-09-11	2013-07-03	Tranzyme Pharma, Inc.	Makrozyklischer Antagonist des Motilinrezeptors zur Behandlung von Magen-Darm-Motilitätsstörungen
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
KR101575703B1 (ko)	2009-02-27	2015-12-10	라퀄리아 파마 인코포레이티드	모틸린 수용체에 대해 작용제 활성을 가진 옥시인돌 유도체
ES2530519T3 (es) *	2009-08-05	2015-03-03	Polyphor Ag	Compuestos macrocíclicos completamente sintéticos, con conformación restringida
CN105294732B (zh) *	2009-08-05	2018-09-25	波利弗尔股份公司	构象受限的完全合成的大环化合物
TWI662967B (zh) *	2013-03-25	2019-06-21	日商志瑞亞新藥工業股份有限公司	食後期之胃運動亢進劑
CN104861045A (zh) *	2014-02-20	2015-08-26	复旦大学	环肽化合物gg6f及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5084442A (en) *	1988-09-06	1992-01-28	Hoffmann-La Roche Inc.	Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
EP0378078A1 (de) *	1989-01-06	1990-07-18	Sanwa Kagaku Kenkyusho Co., Ltd.	Dem Motilin ähnliches Polypeptid und seine Verwendung
US5422341A (en) *	1993-08-06	1995-06-06	Ohmeda Pharmaceutical Products Division Inc.	Motilin-like polypeptides with gastrointestinal motor stimulating activity
US5470830A (en) *	1993-08-06	1995-11-28	Ohmeda Pharmaceutical Products Division Inc.	Motilin-like polypeptides that inhibit gastrointestinal motor activity

1996
- 1996-05-16 US US08/648,644 patent/US5734012A/en not_active Expired - Lifetime
1997
- 1997-03-25 CA CA002200935A patent/CA2200935C/en not_active Expired - Fee Related
- 1997-05-13 ES ES97303251T patent/ES2144826T3/es not_active Expired - Lifetime
- 1997-05-13 AT AT97303251T patent/ATE189685T1/de not_active IP Right Cessation
- 1997-05-13 DE DE69701269T patent/DE69701269T2/de not_active Expired - Fee Related
- 1997-05-13 EP EP97303251A patent/EP0807639B1/de not_active Expired - Lifetime
- 1997-05-16 KR KR1019970018893A patent/KR970073603A/ko not_active Ceased
- 1997-05-16 JP JP9126736A patent/JPH1053599A/ja not_active Abandoned

Also Published As

Publication number	Publication date
JPH1053599A (ja)	1998-02-24
DE69701269D1 (de)	2000-03-16
KR970073603A (ko)	1997-12-10
EP0807639A3 (de)	1997-11-26
ES2144826T3 (es)	2000-06-16
EP0807639B1 (de)	2000-02-09
EP0807639A2 (de)	1997-11-19
CA2200935C (en)	2005-05-24
US5734012A (en)	1998-03-31
CA2200935A1 (en)	1997-11-16
DE69701269T2 (de)	2000-09-14

Legal Events

Date	Code	Title
2001-12-15	EEIH	Change in the person of patent owner
2002-01-15	UEP	Publication of translation of european patent specification
2011-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69701269D1 (de)	2000-03-16	Zyklische Motilin-ähnliche Polypeptide mit die gastrointestinale Motorik stimulierender Aktivität
NZ272015A (en)	1999-07-29	Treatment of insufficiency of central choline functions using a cyclic amide (substituted 1,3-benzoxazin-2-one derivative)
ATE86964T1 (de)	1993-04-15	Malonsaeurederivate und ihre synthesemethoden.
CA2127331A1 (en)	1995-02-07	Motilin-Like Polypeptides that Inhibit Gastrointestinal Motor Activity
RU2009103623A (ru)	2010-08-10	Производные теанина, их применение и способы их получения
FI906296A0 (fi)	1990-12-20	Nya metylenbisfosfonsyrederivat.
EP1156031A4 (de)	2004-09-15	Verbindungen, aus der verbindung hergestelltes polymer und das polymer enthaltende mischung
AU5371186A (en)	1986-08-21	Amides of n-acylated amino acids as anticonvulsants
DK0646601T3 (da)	2000-09-18	Motilin-lignende polypeptider med gastrointestinal motorisk stimulerende aktivitet
DE69841852D1 (de)	2010-09-30	Verfahren zur Herstellung von monofunktionalisiertem 1,4,7,10-Tetraazacyclododecan
DK498889D0 (da)	1989-10-09	Substituerede aromatiske forbindelser med virkning paa centralnervesystemet
DK0953563T3 (da)	2003-07-28	Fremgangsmåde til fremstilling af depsipeptidderivater samt hidtil ukendte intermediater derfor
NO984206L (no)	1998-09-11	Fremgangsmaate for fremstilling av N-beskyttende D-prolinderivater
EP1020465A4 (de)	2004-09-15	Stereoisomere indolderivate, verfahren zu ihrer herstellung und ihre verwendung
ATE252558T1 (de)	2003-11-15	1-aza-2-alkyl-6-aryl-cycloalkanen zur verbesserung des gedächtnisses
ATE293950T1 (de)	2005-05-15	Kosmetische aufhellung mit einem hydroxyphenyloxim-derivat
NZ337221A (en)	2001-01-26	Imino-aza-anthracyclinone derivatives for the treatment of amyloidosis
PL366673A1 (en)	2005-10-03	New compounds, n-trianizyle ammonium salts and their application
BR0009783A (pt)	2002-01-08	Sais de ácido fosfórico de uma diamina aromática
ATE229495T1 (de)	2002-12-15	Verfahren zur herstellung von n-acyl- aminosäureestern und n-acyl-aminoacetalen
ATE58720T1 (de)	1990-12-15	Verfahren zur herstellung von alpha-amino-alphawasserstoff-carbons\|ureamiden.
MXPA05013239A (es)	2006-03-09	Compuestos de amida y metodos para controlar enfermedades vegetales con los mismos.
ATE253048T1 (de)	2003-11-15	Verfahren zur herstellung von piperidincarbonsäureamiden
TH17166A (th)	1995-12-14	ฟีนิลอมิโนซัลโฟนิลยูเรียที่ถูกแทนที่สำหรับฆ่าวัชพืช