DK0646601T3 - Motilin-lignende polypeptider med gastrointestinal motorisk stimulerende aktivitet - Google Patents

Motilin-lignende polypeptider med gastrointestinal motorisk stimulerende aktivitet

Info

Publication number: DK0646601T3
Authority: DK; Denmark
Prior art keywords: glu; leu; lys; gln; arg
Prior art date: 1993-08-06

Application number

DK94305707T

Other languages

English (en)

Inventor

Mark J Macielag

Ramalinga Dharanipragada

James R Florance

Mary Sue Marvin

Alphonse Galdes

Original Assignee

Baxter Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-08-06

Filing date

1994-08-01

Publication date

2000-09-18

1994-08-01 Application filed by Baxter Int filed Critical Baxter Int

2000-09-18 Application granted granted Critical

2000-09-18 Publication of DK0646601T3 publication Critical patent/DK0646601T3/da

Links

229920001184 polypeptide Polymers 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
230000002496 gastric effect Effects 0.000 title abstract 2
230000004936 stimulating effect Effects 0.000 title abstract 2
-1 alicyclic amino acid Chemical class 0.000 abstract 6
QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Chemical group CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 4
QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Chemical group C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 4
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 4
229940024606 amino acid Drugs 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 3
USPFMEKVPDBMCG-LBPRGKRZSA-N N-benzyloxycarbonyl-L-leucine Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 USPFMEKVPDBMCG-LBPRGKRZSA-N 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical group C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 2
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract 2
229930182816 L-glutamine Natural products 0.000 abstract 2
229960003767 alanine Drugs 0.000 abstract 2
229960002989 glutamic acid Drugs 0.000 abstract 2
OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
QUOGESRFPZDMMT-RXMQYKEDSA-N (2r)-2-amino-6-(diaminomethylideneamino)hexanoic acid Chemical compound OC(=O)[C@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-RXMQYKEDSA-N 0.000 abstract 1
125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
LVRVABPNVHYXRT-BQWXUCBYSA-N 52906-92-0 Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 LVRVABPNVHYXRT-BQWXUCBYSA-N 0.000 abstract 1
239000004475 Arginine Substances 0.000 abstract 1
OGNSCSPNOLGXSM-GSVOUGTGSA-N D-2,4-diaminobutyric acid Chemical compound NCC[C@@H](N)C(O)=O OGNSCSPNOLGXSM-GSVOUGTGSA-N 0.000 abstract 1
DCXYFEDJOCDNAF-UWTATZPHSA-N D-Asparagine Chemical compound OC(=O)[C@H](N)CC(N)=O DCXYFEDJOCDNAF-UWTATZPHSA-N 0.000 abstract 1
AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 abstract 1
229930028154 D-arginine Natural products 0.000 abstract 1
229930182846 D-asparagine Natural products 0.000 abstract 1
ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 abstract 1
229930195715 D-glutamine Natural products 0.000 abstract 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
229930182821 L-proline Natural products 0.000 abstract 1
125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
102000002419 Motilin Human genes 0.000 abstract 1
101800002372 Motilin Proteins 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229960002743 glutamine Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229960002429 proline Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/63—Motilins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK94305707T 1993-08-06 1994-08-01 Motilin-lignende polypeptider med gastrointestinal motorisk stimulerende aktivitet DK0646601T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/103,490 US5422341A (en)	1993-08-06	1993-08-06	Motilin-like polypeptides with gastrointestinal motor stimulating activity

Publications (1)

Publication Number	Publication Date
DK0646601T3 true DK0646601T3 (da)	2000-09-18

Family

ID=22295474

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94305707T DK0646601T3 (da)	1993-08-06	1994-08-01	Motilin-lignende polypeptider med gastrointestinal motorisk stimulerende aktivitet

Country Status (15)

Country	Link
US (1)	US5422341A (da)
EP (1)	EP0646601B1 (da)
JP (1)	JP2949129B2 (da)
KR (1)	KR100360975B1 (da)
CN (1)	CN1054857C (da)
AT (1)	ATE194627T1 (da)
AU (1)	AU677324B2 (da)
CA (1)	CA2127330C (da)
DE (1)	DE69425212T2 (da)
DK (1)	DK0646601T3 (da)
ES (1)	ES2152293T3 (da)
FI (1)	FI111462B (da)
NO (1)	NO312299B1 (da)
TW (1)	TW434261B (da)
ZA (1)	ZA945436B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5734012A (en) *	1996-05-16	1998-03-31	Ohmeda Pharmaceutical Products Division Inc.	Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity
IL140993A0 (en) *	2000-05-15	2002-02-10	Bayer Ag	Trypsin substrate and diagnostic device, and method of using same
US20050009205A1 (en) *	2003-07-11	2005-01-13	Ye Fang	Fluorescent ligands for GPCR arrays
US7521420B2 (en)	2003-06-18	2009-04-21	Tranzyme Pharma, Inc.	Macrocyclic antagonists of the motilin receptor
US20060293243A1 (en) *	2005-06-17	2006-12-28	Navneet Puri	Stable, buffered, pharmaceutical compositions including motilin-like peptides
US20060287243A1 (en) *	2005-06-17	2006-12-21	Navneet Puri	Stable pharmaceutical compositions including motilin-like peptides
EP2054429B1 (en)	2006-09-11	2013-11-06	Tranzyme Pharma, Inc.	Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
US20080287371A1 (en) *	2007-05-17	2008-11-20	Tranzyme Pharma Inc.	Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
MY161842A (en)	2009-07-29	2017-05-15	Daiichi Sankyo Co Ltd	Motilin-like peptide compound having transmucosal absorbability imparted thereto
CN107383169A (zh) *	2017-04-24	2017-11-24	青岛大学	一种具有胃肠运动刺激活性的多肽

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2753274B2 (ja) *	1988-08-24	1998-05-18	株式会社三和化学研究所	モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド
EP0378078A1 (en) *	1989-01-06	1990-07-18	Sanwa Kagaku Kenkyusho Co., Ltd.	Motilin-like polypeptide and use thereof
JPH02311495A (ja) *	1989-05-24	1990-12-27	Sanwa Kagaku Kenkyusho Co Ltd	モチリン様活性を有するポリペプチド及びその用途
JPH04364131A (ja) *	1991-04-03	1992-12-16	Sanwa Kagaku Kenkyusho Co Ltd	易吸収性モチリン製剤

1993
- 1993-08-06 US US08/103,490 patent/US5422341A/en not_active Expired - Lifetime
1994
- 1994-06-24 AU AU65967/94A patent/AU677324B2/en not_active Ceased
- 1994-06-29 TW TW083105907A patent/TW434261B/zh not_active IP Right Cessation
- 1994-07-04 CA CA002127330A patent/CA2127330C/en not_active Expired - Fee Related
- 1994-07-18 NO NO19942690A patent/NO312299B1/no not_active IP Right Cessation
- 1994-07-22 ZA ZA945436A patent/ZA945436B/xx unknown
- 1994-08-01 DK DK94305707T patent/DK0646601T3/da active
- 1994-08-01 AT AT94305707T patent/ATE194627T1/de not_active IP Right Cessation
- 1994-08-01 DE DE69425212T patent/DE69425212T2/de not_active Expired - Lifetime
- 1994-08-01 EP EP94305707A patent/EP0646601B1/en not_active Expired - Lifetime
- 1994-08-01 ES ES94305707T patent/ES2152293T3/es not_active Expired - Lifetime
- 1994-08-04 JP JP6183351A patent/JP2949129B2/ja not_active Expired - Lifetime
- 1994-08-05 FI FI943651A patent/FI111462B/fi active
- 1994-08-05 CN CN94115025A patent/CN1054857C/zh not_active Expired - Fee Related
- 1994-08-05 KR KR1019940019380A patent/KR100360975B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2949129B2 (ja)	1999-09-13
ZA945436B (en)	1995-04-04
KR100360975B1 (ko)	2003-01-24
CA2127330A1 (en)	1995-02-07
CN1119650A (zh)	1996-04-03
NO312299B1 (no)	2002-04-22
DE69425212D1 (de)	2000-08-17
TW434261B (en)	2001-05-16
FI943651A0 (fi)	1994-08-05
ATE194627T1 (de)	2000-07-15
KR950005320A (ko)	1995-03-20
CN1054857C (zh)	2000-07-26
EP0646601B1 (en)	2000-07-12
FI111462B (fi)	2003-07-31
CA2127330C (en)	1998-07-14
DE69425212T2 (de)	2001-03-08
AU6596794A (en)	1995-02-16
US5422341A (en)	1995-06-06
ES2152293T3 (es)	2001-02-01
EP0646601A1 (en)	1995-04-05
NO942690D0 (no)	1994-07-18
JPH0770178A (ja)	1995-03-14
AU677324B2 (en)	1997-04-17
FI943651A7 (fi)	1995-02-07
NO942690L (no)	1995-02-07

Publication	Publication Date	Title
CA2127331A1 (en)	1995-02-07	Motilin-Like Polypeptides that Inhibit Gastrointestinal Motor Activity
DK0646601T3 (da)	2000-09-18	Motilin-lignende polypeptider med gastrointestinal motorisk stimulerende aktivitet
DE3784799D1 (de)	1993-04-22	Malonsaeurederivate und ihre synthesemethoden.
DE60012721D1 (de)	2004-09-09	Analoge des magensaft inhibierenden peptides und ihre verwendung für die behandlung von diabetes
EP0097534A3 (en)	1984-12-12	Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
SE448302B (sv)	1987-02-09	Tetra- eller pentapeptider och faramceutiska kompositioner innehallande desamma
EP0760368A4 (en)	1997-08-27	NEW PYRIMIDINE DERIVATIVE
ATE189685T1 (de)	2000-02-15	Zyklische motilin-ähnliche polypeptide mit die gastrointestinale motorik stimulierender aktivität
ATA137799A (de)	2002-07-15	Faktor x-analogon mit verbesserter aktivierbarkeit
OA09561A (en)	1993-01-31	Thioacylating reagents and intermediates thiopeptides and methods for preparing and using same
DK1127064T3 (da)	2006-05-22	Hidtil ukendte aminosyresekvenser, DNA, der koder for aminosyresekvenserme, antistoffer, der er rettet mod sådanne sekvenser, og forskellige anvendelser deraf
ATE97941T1 (de)	1993-12-15	Polyamidharz-zusammensetzung.
SE7704088L (sv)	1977-10-10	Sett att framstella dipeptidderivat
ATE190334T1 (de)	2000-03-15	Azlacton-derivatisierte polyamide
WO2001064715A3 (en)	2002-03-21	Memno peptides, a process for their preparation and their use
BG106117A (en)	2002-07-31	Novel 8a- and 9a-15-membered lactams
Georg et al.	1991	Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids
ES418929A1 (es)	1976-03-01	Procedimiento para la preparacion de polipeptidos.
PL366673A1 (en)	2005-10-03	New compounds, n-trianizyle ammonium salts and their application
SE9402253D0 (sv)	1994-06-27	Process
DE69925911D1 (de)	2005-07-28	Immunodiagnostischer wirkstoff zum nachweiss von maedi-visna virus und caev infektionen
DK0787137T3 (da)	2002-05-06	Fremgangsmåde til fremstilling af N-carboxyanhydridaminosyerer ud fra N-(N'-nitrosocarbamoyl)aminosyrer
AU1698283A (en)	1984-01-26	Derivatives of glycine and glycine esters
IL109978A (en)	1999-10-28	Cyclic ureas derived from alpha omega-diamino acids and their preparation
ATE473208T1 (de)	2010-07-15	Isodipeptid als syntheseeinheit zur herstellung von peptiden