ATE190654T1 - Verwendung von dna oligomeren zur hemmung von hiv durch reduktion ribosomaler leserasterverschichtung - Google Patents
Verwendung von dna oligomeren zur hemmung von hiv durch reduktion ribosomaler leserasterverschichtungInfo
- Publication number
- ATE190654T1 ATE190654T1 AT95912987T AT95912987T ATE190654T1 AT E190654 T1 ATE190654 T1 AT E190654T1 AT 95912987 T AT95912987 T AT 95912987T AT 95912987 T AT95912987 T AT 95912987T AT E190654 T1 ATE190654 T1 AT E190654T1
- Authority
- AT
- Austria
- Prior art keywords
- dna oligomers
- reading frame
- hiv
- inhibit hiv
- frame shifting
- Prior art date
Links
- 210000003705 ribosome Anatomy 0.000 title abstract 2
- 108020004491 Antisense DNA Proteins 0.000 abstract 2
- 239000003816 antisense DNA Substances 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000001812 small ribosome subunit Anatomy 0.000 abstract 1
- 210000002845 virion Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22060494A | 1994-03-30 | 1994-03-30 | |
| US40985295A | 1995-03-23 | 1995-03-23 | |
| PCT/CA1995/000169 WO1995027054A1 (en) | 1994-03-30 | 1995-03-28 | Use of dna oligomers for inhibition of hiv by decreasing ribosomal frameshifting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE190654T1 true ATE190654T1 (de) | 2000-04-15 |
Family
ID=26915017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95912987T ATE190654T1 (de) | 1994-03-30 | 1995-03-28 | Verwendung von dna oligomeren zur hemmung von hiv durch reduktion ribosomaler leserasterverschichtung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5707866A (de) |
| EP (1) | EP0753063B1 (de) |
| JP (1) | JPH09511142A (de) |
| AT (1) | ATE190654T1 (de) |
| AU (1) | AU694494B2 (de) |
| CA (1) | CA2186107A1 (de) |
| DE (1) | DE69515652D1 (de) |
| WO (1) | WO1995027054A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291438B1 (en) | 1993-02-24 | 2001-09-18 | Jui H. Wang | Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use |
| US5872210A (en) * | 1995-10-05 | 1999-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Transframe peptide inhibitor of viral protease |
| WO1997012617A1 (en) * | 1995-10-06 | 1997-04-10 | University Of Medicine And Dentistry Of New Jersey | Proteins involved in targeting of peptidyl transfer center, and corresponding therapeutic agents and methods |
| US6776986B1 (en) | 1996-06-06 | 2004-08-17 | Novartis Ag | Inhibition of HIV-1 replication by antisense RNA expression |
| AU4672097A (en) * | 1996-10-01 | 1998-04-24 | Advanced Research And Technology Institute, Inc. | Methods and compositions for inhibiting bacterial growth |
| CA2395852A1 (en) * | 1999-12-23 | 2001-06-28 | Concept Shopping, Inc. | Techniques for optimizing promotion delivery |
| RU2206326C2 (ru) * | 2001-04-10 | 2003-06-20 | Асафов Александр Виленович | Применение натрия нуклеоспермата для лечения вич-инфекции и способ лечения |
| JP4471648B2 (ja) * | 2001-05-30 | 2010-06-02 | バイオレックス・セラピューティクス インコーポレイテッド | 高スループットスクリーニングのためのプレートおよび方法 |
| US7339051B2 (en) | 2003-04-28 | 2008-03-04 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (SARS) |
| US20110046200A1 (en) * | 2004-08-03 | 2011-02-24 | Michael T Howard | Use of antisense oligonucleotides to effect translation modulation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006704A1 (en) * | 1988-01-11 | 1989-07-27 | Microprobe Corporation | Oligonucleotide probes for detection of periodontal pathogens |
| JP3015462B2 (ja) * | 1989-02-06 | 2000-03-06 | ジーン‐トラック・システムス | リステリア検出のためのプローブ類及び方法 |
-
1995
- 1995-03-28 DE DE69515652T patent/DE69515652D1/de not_active Expired - Lifetime
- 1995-03-28 EP EP95912987A patent/EP0753063B1/de not_active Expired - Lifetime
- 1995-03-28 JP JP7525315A patent/JPH09511142A/ja active Pending
- 1995-03-28 CA CA002186107A patent/CA2186107A1/en not_active Abandoned
- 1995-03-28 AU AU20644/95A patent/AU694494B2/en not_active Ceased
- 1995-03-28 WO PCT/CA1995/000169 patent/WO1995027054A1/en not_active Ceased
- 1995-03-28 AT AT95912987T patent/ATE190654T1/de not_active IP Right Cessation
-
1996
- 1996-05-21 US US08/651,835 patent/US5707866A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69515652D1 (de) | 2000-04-20 |
| EP0753063A1 (de) | 1997-01-15 |
| AU2064495A (en) | 1995-10-23 |
| CA2186107A1 (en) | 1995-10-12 |
| WO1995027054A1 (en) | 1995-10-12 |
| US5707866A (en) | 1998-01-13 |
| JPH09511142A (ja) | 1997-11-11 |
| AU694494B2 (en) | 1998-07-23 |
| EP0753063B1 (de) | 2000-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |