ATE190659T1 - Rekombinante immuntoxine - Google Patents

Rekombinante immuntoxine

Info

Publication number: ATE190659T1
Authority: AT; Austria
Prior art keywords: recombinant; immuntoxins; relates; immunotoxins; pe38kdel
Prior art date: 1991-09-30

Application number

AT92921866T

Other languages

English (en)

Inventor

Ira Pastan

Mark Willingham

David Fitzgerald

Uli Brinkmann

Lee Pai

Original Assignee

Us Health

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-30

Filing date

1992-09-29

Publication date

2000-04-15

1992-09-29 Application filed by Us Health filed Critical Us Health

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE190659T1 publication Critical patent/ATE190659T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92921866T 1991-09-30 1992-09-29 Rekombinante immuntoxine ATE190659T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76733191A	1991-09-30	1991-09-30
PCT/US1992/008257 WO1993007286A1 (en)	1991-09-30	1992-09-29	Recombinant immunotoxins

Publications (1)

Publication Number	Publication Date
ATE190659T1 true ATE190659T1 (de)	2000-04-15

Family

ID=25079156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92921866T ATE190659T1 (de)	1991-09-30	1992-09-29	Rekombinante immuntoxine

Country Status (8)

Country	Link
EP (1)	EP0610286B1 (de)
JP (1)	JP3512795B2 (de)
AT (1)	ATE190659T1 (de)
AU (1)	AU675413B2 (de)
CA (1)	CA2120153C (de)
DE (1)	DE69230798T2 (de)
DK (1)	DK0610286T3 (de)
WO (1)	WO1993007286A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5889157A (en) *	1990-10-12	1999-03-30	The United States Of America As Represented By The Department Of Health And Human Services	Humanized B3 antibody fragments, fusion proteins, and uses thereof
US5981726A (en) *	1990-10-12	1999-11-09	The United States Of America As Represented By The Department Of Health And Human Services	Chimeric and mutationally stabilized tumor-specific B1, B3 and B5 antibody fragments; immunotoxic fusion proteins; and uses thereof
US5608039A (en) *	1990-10-12	1997-03-04	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Single chain B3 antibody fusion proteins and their uses
DK0654085T3 (da) *	1992-01-23	1997-09-22	Merck Patent Gmbh	Monomere og dimere antistof-fragment-fusionsproteiner
EP0651805B1 (de) *	1992-07-17	2006-12-13	Dana Farber Cancer Institute	Method eder intrazellularen bindung von zielgerichteten molekülen
US5747654A (en)	1993-06-14	1998-05-05	The United States Of America As Represented By The Department Of Health And Human Services	Recombinant disulfide-stabilized polypeptide fragments having binding specificity
FR2706486B1 (fr) *	1993-06-16	1995-09-01	Rhone Poulenc Rorer Sa	Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques.
US5851829A (en) *	1993-07-16	1998-12-22	Dana-Farber Cancer Institute	Method of intracellular binding of target molecules
EP0796334A1 (de) *	1994-10-28	1997-09-24	THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES	Tumorspezifische antikörperfragmente, fusionsproteine, und deren verwendungen
AU5965296A (en) *	1995-05-31	1996-12-18	Regents Of The University Of Minnesota	Recombinant polypeptide cytotoxins for cancer treatment
EP0861091B1 (de) *	1995-10-13	2003-08-20	THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services	Immunotoxin enthaltend ein disulfid-stabilisiertes antikörperfragment
WO1997044461A2 (en)	1996-05-22	1997-11-27	Novopharm Biotech, Inc.	Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
CA2270898A1 (en)	1996-11-06	1998-05-14	The Regents Of The University Of California	Isolated tumor necrosis factor receptor releasing enzyme, compositions comprising the enzyme and methods of the use thereof
US7115722B1 (en)	1997-05-22	2006-10-03	Viventia Biotech, Inc.	Antigen binding fragments that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
WO1999060113A1 (en)	1998-05-20	1999-11-25	Chugai Seiyaku Kabushiki Kaisha	Novel method for isolating gene
US7030228B1 (en)	1999-11-15	2006-04-18	Miltenyi Biotec Gmbh	Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby
AU2006329208B2 (en) *	2005-12-23	2012-03-08	Viventia Bio Inc.	Methods for generating and screening fusion protein libraries and uses thereof
US8932586B2 (en)	2011-09-06	2015-01-13	Intrexon Corporation	Modified forms of Pseudomonas exotoxin A

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2053911C (en) *	1989-04-21	1999-11-02	Ira H. Pastan	Recombinant antibody-toxin fusion protein

1992
- 1992-09-29 CA CA002120153A patent/CA2120153C/en not_active Expired - Fee Related
- 1992-09-29 EP EP92921866A patent/EP0610286B1/de not_active Expired - Lifetime
- 1992-09-29 WO PCT/US1992/008257 patent/WO1993007286A1/en not_active Ceased
- 1992-09-29 JP JP50699493A patent/JP3512795B2/ja not_active Expired - Fee Related
- 1992-09-29 DE DE69230798T patent/DE69230798T2/de not_active Expired - Fee Related
- 1992-09-29 AT AT92921866T patent/ATE190659T1/de not_active IP Right Cessation
- 1992-09-29 DK DK92921866T patent/DK0610286T3/da active
- 1992-09-29 AU AU27798/92A patent/AU675413B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP0610286A1 (de)	1994-08-17
EP0610286B1 (de)	2000-03-15
JP3512795B2 (ja)	2004-03-31
JPH07502643A (ja)	1995-03-23
AU675413B2 (en)	1997-02-06
DE69230798T2 (de)	2000-08-03
EP0610286A4 (en)	1995-10-25
CA2120153A1 (en)	1993-04-15
WO1993007286A1 (en)	1993-04-15
AU2779892A (en)	1993-05-03
DE69230798D1 (de)	2000-04-20
CA2120153C (en)	2006-06-06
DK0610286T3 (da)	2000-07-17

Legal Events

Date	Code	Title	Description
2000-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE190659T1 (de)	2000-04-15	Rekombinante immuntoxine
GR3026658T3 (en)	1998-07-31	Hydrazino-type radionuclide chelators having an n 3?s configuration
FI844510A0 (fi)	1984-11-16	Ensym-resistenta immunsystemet modulerande peptider.
FR2657259B1 (de)	1994-08-19
BR0112111A (pt)	2003-05-06	Realce de respostas imunes mediadas por proteìna de fusão de anticorpo-citocina por tratamento combinado com agentes de realce de captação de imunocitocina
ES8602768A1 (es)	1985-11-16	Un procedimiento para la preparacion de nuevas n-(heterociclil biciclo)-4-piperidinaminas.
FI951138A7 (fi)	1995-04-13	Puuttellisia adenovirusvektoreita ja niiden käyttö geeniterapiassa
DE122006000010I2 (de)	2007-10-04	Benzocyclobutyl- oder Indanyl-Alkyl-Amino-Alkyl substituierte 3-Benzazepin-2-ones, verwendbar in derBehandlung von kardiovaskularen Krankheiten
DK0668769T3 (da)	2000-10-02	Egebarkekstrakt-relaterede syntetiske sammensætninger og fremgangsmåde til deres anvendelse
DE69131200D1 (en)	1999-06-10	Herpes simplex virus vp16 impfstoffe
GR3026219T3 (en)	1998-05-29	Mouse monoclonal antibodies
ATE296312T1 (de)	2005-06-15	Metalkomplexbildner
ATE199167T1 (de)	2001-02-15	Nichtglykosyliertes fgf-4 und dieses enthaltende präparate
DK0563085T3 (da)	1996-12-16	Hidtil ukendte præparater
ATE116135T1 (de)	1995-01-15	Einschlusskomplex von nimesulide mit cyclodextrinen.
KR890700353A (ko)	1989-04-24	면역독소의 면역억제 기저 사람치료법
EP0311616A4 (de)	1989-05-23	Kombination von gammainterferonen und antientzündungsmitteln oder antipyretischen mitteln zur behandlung von krankheiten.
BG101126A (en)	1997-09-30	The use of muramylpeptide compounds
DK1431391T3 (da)	2005-12-19	RANTES-mutanter og terapeutiske anvendelser heraf
DE69409961D1 (de)	1998-06-04	Triarylethylenderivate zur therapeutischen verwendung
ATE130304T1 (de)	1995-12-15	Neue alpha-glukosidaseinhibitoren.
ZA893310B (en)	1991-01-30	Novel strobilurine derivatives,their preparation and their use
SE8900564D0 (sv)	1989-02-17	Novel medicinal use
FI933386A7 (fi)	1993-07-28	Pienimolekyylisiä sulfatoituja poly-b-2,6-fruktofuranosaaneja ja niide n käyttö rappeuttavien nivelsairauksien hoitoon
ITMI911597A1 (it)	1992-12-10	Composizione di trattamento di acque di rifiuto da destinare al riciclo, e procedimento di riciclo di acque di rifiuto che utilizza questa composizione.