ATE192454T1 - Verfahren zur herstellung von (11beta,16beta)-21- (3-carboxy-3-oxopropoxy)-11-hydroxy-2'-methyl-5 h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione - Google Patents

Verfahren zur herstellung von (11beta,16beta)-21- (3-carboxy-3-oxopropoxy)-11-hydroxy-2'-methyl-5 h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione

Info

Publication number: ATE192454T1
Authority: AT; Austria
Prior art keywords: 16beta; dieno; 11beta; pregna; oxazole
Prior art date: 1995-12-13

Application number

AT96942324T

Other languages

English (en)

Inventor

Luigi Forte

Calogero Cancellieri

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-13

Filing date

1996-12-04

Publication date

2000-05-15

1996-12-04 Application filed by Lepetit Spa filed Critical Lepetit Spa

2000-05-15 Application granted granted Critical

2000-05-15 Publication of ATE192454T1 publication Critical patent/ATE192454T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
KENSGCYKTRNIST-RVUAFKSESA-N 13649-57-5 Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]([C@@H](O)C[C@]23C)[C@@H]1[C@@H]3C[C@@H]1[C@@]2(C(=O)CO)N=C(C)O1 KENSGCYKTRNIST-RVUAFKSESA-N 0.000 abstract 1
FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 abstract 1
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
229940014800 succinic anhydride Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0068—Nitrogen and oxygen at position 16(17)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT96942324T 1995-12-13 1996-12-04 Verfahren zur herstellung von (11beta,16beta)-21- (3-carboxy-3-oxopropoxy)-11-hydroxy-2'-methyl-5 h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione ATE192454T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95119627		1995-12-13
PCT/EP1996/005391 WO1997021723A1 (en)	1995-12-13	1996-12-04	PREPARATION OF (11β,16β)-21-(3-CARBOXY-3-OXOPROPOXY)-11-HYDROXY-2'-METHYL-5'H-PREGNA-1,4-DIENO[17,16-D]OXAZOLE-3,20-DIONE

Publications (1)

Publication Number	Publication Date
ATE192454T1 true ATE192454T1 (de)	2000-05-15

Family

ID=8219883

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96942324T ATE192454T1 (de)	1995-12-13	1996-12-04	Verfahren zur herstellung von (11beta,16beta)-21- (3-carboxy-3-oxopropoxy)-11-hydroxy-2'-methyl-5 h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione

Country Status (20)

Country	Link
US (1)	US6417350B1 (de)
EP (1)	EP0879242B1 (de)
JP (1)	JP4076097B2 (de)
KR (1)	KR100433566B1 (de)
CN (1)	CN100351266C (de)
AT (1)	ATE192454T1 (de)
AU (1)	AU707406B2 (de)
CA (1)	CA2238692C (de)
DE (1)	DE69608134T2 (de)
EA (1)	EA000731B1 (de)
ES (1)	ES2145507T3 (de)
GR (1)	GR3033940T3 (de)
HU (1)	HU226668B1 (de)
MX (1)	MX9804574A (de)
NO (1)	NO309094B1 (de)
NZ (1)	NZ324299A (de)
PT (1)	PT879242E (de)
SI (1)	SI0879242T1 (de)
WO (1)	WO1997021723A1 (de)
ZA (1)	ZA9610413B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT876394E (pt) *	1995-12-13	2001-08-30	Lepetit Spa	Preparacao de (11beta,16beta)-21-(acetiloxi)-11-hidroxi-2'-metil-5'h-pregna-1,4-dieno¬17,16-d\|-3,20-diona
CN118725004B (zh) *	2024-06-19	2026-06-26	湖南玉新药业有限公司	一种地夫可特的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1141930B (it) *	1980-04-28	1986-10-08	Lepetit Spa	Esteri idrosolubili di steroido-ossazoli e loro composizioni farmaceutiche
GB8730216D0 (en) *	1987-12-29	1988-02-03	Lepetit Spa	Process for preparation of pregnenooxazolines
CN1092066A (zh) *	1993-03-04	1994-09-14	商业部科学研究院	6-甲基-1，2，3-噁噻嗪-4(3h)-酮-2，2-二氧化物及其盐的合成方法
PT876394E (pt) *	1995-12-13	2001-08-30	Lepetit Spa	Preparacao de (11beta,16beta)-21-(acetiloxi)-11-hidroxi-2'-metil-5'h-pregna-1,4-dieno¬17,16-d\|-3,20-diona

1996
- 1996-12-04 EA EA199800551A patent/EA000731B1/ru not_active IP Right Cessation
- 1996-12-04 WO PCT/EP1996/005391 patent/WO1997021723A1/en not_active Ceased
- 1996-12-04 AU AU11757/97A patent/AU707406B2/en not_active Expired
- 1996-12-04 AT AT96942324T patent/ATE192454T1/de active
- 1996-12-04 NZ NZ324299A patent/NZ324299A/en not_active IP Right Cessation
- 1996-12-04 DE DE69608134T patent/DE69608134T2/de not_active Expired - Lifetime
- 1996-12-04 HU HU9903535A patent/HU226668B1/hu unknown
- 1996-12-04 CA CA002238692A patent/CA2238692C/en not_active Expired - Fee Related
- 1996-12-04 PT PT96942324T patent/PT879242E/pt unknown
- 1996-12-04 SI SI9630178T patent/SI0879242T1/xx unknown
- 1996-12-04 CN CNB961990147A patent/CN100351266C/zh not_active Expired - Lifetime
- 1996-12-04 KR KR10-1998-0704319A patent/KR100433566B1/ko not_active Expired - Lifetime
- 1996-12-04 EP EP96942324A patent/EP0879242B1/de not_active Expired - Lifetime
- 1996-12-04 JP JP52169897A patent/JP4076097B2/ja not_active Expired - Lifetime
- 1996-12-04 ES ES96942324T patent/ES2145507T3/es not_active Expired - Lifetime
- 1996-12-11 ZA ZA9610413A patent/ZA9610413B/xx unknown
1998
- 1998-05-27 NO NO982413A patent/NO309094B1/no not_active IP Right Cessation
- 1998-06-08 MX MX9804574A patent/MX9804574A/es unknown
2000
- 2000-01-20 US US09/488,035 patent/US6417350B1/en not_active Expired - Lifetime
- 2000-07-12 GR GR20000401625T patent/GR3033940T3/el unknown

Also Published As

Publication number	Publication date
KR100433566B1 (ko)	2004-07-16
AU707406B2 (en)	1999-07-08
GR3033940T3 (en)	2000-11-30
US6417350B1 (en)	2002-07-09
NZ324299A (en)	1999-04-29
CN100351266C (zh)	2007-11-28
PT879242E (pt)	2000-10-31
EP0879242A1 (de)	1998-11-25
NO309094B1 (no)	2000-12-11
HUP9903535A2 (hu)	2000-03-28
DE69608134T2 (de)	2001-01-11
HUP9903535A3 (en)	2000-04-28
ES2145507T3 (es)	2000-07-01
ZA9610413B (en)	1997-09-09
DE69608134D1 (de)	2000-06-08
CA2238692C (en)	2004-07-20
KR19990072025A (ko)	1999-09-27
NO982413L (no)	1998-05-27
EA199800551A1 (ru)	1998-12-24
EA000731B1 (ru)	2000-02-28
AU1175797A (en)	1997-07-03
MX9804574A (es)	1998-09-30
CN1204340A (zh)	1999-01-06
JP4076097B2 (ja)	2008-04-16
HU226668B1 (en)	2009-06-29
HK1017690A1 (en)	1999-11-26
NO982413D0 (no)	1998-05-27
JP2000503633A (ja)	2000-03-28
SI0879242T1 (en)	2000-08-31
CA2238692A1 (en)	1997-06-19
WO1997021723A1 (en)	1997-06-19
EP0879242B1 (de)	2000-05-03

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Legal Events

Date	Code	Title
2000-09-15	UEP	Publication of translation of european patent specification
2002-09-15	EEIH	Change in the person of patent owner
2007-10-15	EEIH	Change in the person of patent owner