ATE193181T1 - Verfahren zur vorbereitung von organen auf langzeitkonservierung und transplantation - Google Patents

Verfahren zur vorbereitung von organen auf langzeitkonservierung und transplantation

Info

Publication number
ATE193181T1
ATE193181T1 AT97107891T AT97107891T ATE193181T1 AT E193181 T1 ATE193181 T1 AT E193181T1 AT 97107891 T AT97107891 T AT 97107891T AT 97107891 T AT97107891 T AT 97107891T AT E193181 T1 ATE193181 T1 AT E193181T1
Authority
AT
Austria
Prior art keywords
organ
cryoprotectant
concentration
buffering agent
osmotic
Prior art date
Application number
AT97107891T
Other languages
English (en)
Inventor
Gregory M Fahy
Bijan S Khirabadi
Original Assignee
American Nat Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Nat Red Cross filed Critical American Nat Red Cross
Application granted granted Critical
Publication of ATE193181T1 publication Critical patent/ATE193181T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
AT97107891T 1991-07-08 1992-07-07 Verfahren zur vorbereitung von organen auf langzeitkonservierung und transplantation ATE193181T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/725,054 US5217860A (en) 1991-07-08 1991-07-08 Method for preserving organs for transplantation by vitrification

Publications (1)

Publication Number Publication Date
ATE193181T1 true ATE193181T1 (de) 2000-06-15

Family

ID=24912973

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97107891T ATE193181T1 (de) 1991-07-08 1992-07-07 Verfahren zur vorbereitung von organen auf langzeitkonservierung und transplantation

Country Status (7)

Country Link
US (2) US5217860A (de)
EP (2) EP0800765B1 (de)
JP (1) JPH07500815A (de)
AT (1) ATE193181T1 (de)
CA (1) CA2113119C (de)
DE (1) DE69231106T2 (de)
WO (1) WO1993000808A1 (de)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827222A (en) * 1990-10-10 1998-10-27 Life Resuscitation Technologies, Inc. Method of treating at least one of brain and associated nervous tissue injury
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5723282A (en) * 1991-07-08 1998-03-03 The American National Red Cross Method of preparing organs for vitrification
US5856081A (en) * 1991-07-08 1999-01-05 The American National Red Cross Computer controlled cryoprotectant perfusion apparatus
US5338662A (en) * 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US6161543A (en) * 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
US5356771A (en) * 1993-03-11 1994-10-18 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation organ preservation apparatus
US5362622A (en) * 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
US7138500B1 (en) * 1993-05-07 2006-11-21 Immunex Corporation Antibodies to human 4-1BB
DE9422008U1 (de) * 1993-06-07 1997-08-28 Mayer, Berndt, Priv.-Doz. Dr.med., 10585 Berlin Vorrichtung zur Konservierung von Organen, Extremitäten und Gewebelappen
KR950030791A (ko) * 1994-01-25 1995-12-18 아키요 시게마주 생물조직 보존방법 및 그를 위한 관류액
EP0759692B1 (de) * 1994-05-20 2009-02-25 Breonics, Inc. Verfahren zur überwachung der lebensfähigkeit transplantabler organe
US6409722B1 (en) 1998-07-07 2002-06-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US5897553A (en) 1995-11-02 1999-04-27 Medtronic, Inc. Ball point fluid-assisted electrocautery device
WO1996029865A1 (en) * 1995-03-27 1996-10-03 Organ, Inc. Organ evaluation and resuscitation device and method
US5586438A (en) * 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
WO1996029866A1 (en) * 1995-03-31 1996-10-03 Organ, Inc. Histological processing device and method
USD391372S (en) 1995-04-17 1998-02-24 Joseph Scelza Continuous perfusion tissue culture apparatus
DE19527734A1 (de) * 1995-07-28 1997-01-30 Hubert Verhaag Verfahren und Vorrichtung zur Konservierung von Geweben und Organen, insbesondere von Transplantationsgeweben und -organen
WO1996039819A1 (en) * 1995-06-07 1996-12-19 St. Jude Medical, Inc. Cardiovascular bioreactor apparatus and method
EA001957B1 (ru) * 1995-12-15 2001-10-22 Вироден Фармасьютикал Холдингс (Проприетэри) Лимитед КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ СПИДа
NL1003024C2 (nl) 1996-05-03 1997-11-06 Tjong Hauw Sie Prikkelgeleidingsblokkeringsinstrument.
AU4252097A (en) * 1996-09-06 1998-03-26 Universal Preservation Technologies, Inc. Vitrification solutions for shelf preservation of cells, tissues, organs and organisms
WO1998019529A1 (en) * 1996-11-07 1998-05-14 21St Century Medicine, Inc. A method for rapid cooling and warming of biological materials
US6642045B1 (en) 1997-04-14 2003-11-04 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US5834178C1 (en) * 1997-07-09 2002-04-23 Univ Wayne State Flush-storage solution for donor organs
US6096037A (en) 1997-07-29 2000-08-01 Medtronic, Inc. Tissue sealing electrosurgery device and methods of sealing tissue
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6485450B1 (en) 1998-03-16 2002-11-26 Life Science Holdings, Inc. Brain resuscitation apparatus and method
US6673008B1 (en) 1998-04-28 2004-01-06 Ronald J. Thompson Fallopian tube and method of in vitro fertilization and embryo development
US6706039B2 (en) 1998-07-07 2004-03-16 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US6537248B2 (en) * 1998-07-07 2003-03-25 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
EP2308295A3 (de) 1998-09-29 2011-05-25 Organ Recovery Systems, Inc. Vorrichtung zum Transportieren von Organen
US6977140B1 (en) * 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
KR100873690B1 (ko) * 1999-01-19 2008-12-12 유니버시티 오브 노스캐롤라이나 앳 채플 힐 인간 간 전구세포
US6194137B1 (en) 1999-04-13 2001-02-27 Organ Recovery Systems, Inc. Method of cryopreservation of blood vessels by vitrification
CA2376607C (en) * 1999-04-14 2014-06-10 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US20070166292A1 (en) * 1999-04-14 2007-07-19 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US6582953B2 (en) 1999-04-14 2003-06-24 Breonics, Inc. Organ chamber for exsanguinous metabolic support system
US20030040665A1 (en) * 1999-05-28 2003-02-27 E-Monitors, Inc. Systems and methods of pH tissue monitoring
US6567679B1 (en) 1999-05-28 2003-05-20 E-Monitors, Inc. Method of using a pH tissue monitor
US20070048726A1 (en) * 2000-01-14 2007-03-01 Biolife Solutions, Inc. Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State
US8241274B2 (en) 2000-01-19 2012-08-14 Medtronic, Inc. Method for guiding a medical device
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6692450B1 (en) 2000-01-19 2004-02-17 Medtronic Xomed, Inc. Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US6447443B1 (en) 2001-01-13 2002-09-10 Medtronic, Inc. Method for organ positioning and stabilization
US8221402B2 (en) 2000-01-19 2012-07-17 Medtronic, Inc. Method for guiding a medical device
US8048070B2 (en) 2000-03-06 2011-11-01 Salient Surgical Technologies, Inc. Fluid-assisted medical devices, systems and methods
FR2807827B1 (fr) * 2000-04-12 2002-07-05 Technomed Medical Systems Systeme de manipulation de fluide pour appareil de therapie
US6488680B1 (en) 2000-04-27 2002-12-03 Medtronic, Inc. Variable length electrodes for delivery of irrigated ablation
US6514250B1 (en) 2000-04-27 2003-02-04 Medtronic, Inc. Suction stabilized epicardial ablation devices
WO2001082812A1 (en) 2000-04-27 2001-11-08 Medtronic, Inc. Vibration sensitive ablation apparatus and method
AU2001284968B2 (en) * 2000-08-16 2006-12-21 Duke University Decellularized tissue engineered constructs and tissues
JP2004507473A (ja) * 2000-08-25 2004-03-11 オルガン リカヴァリー システムス インコーポレイテッド 血栓溶解性器官処理および修復法
US6926669B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Heart wall ablation/mapping catheter and method
ATE330468T1 (de) 2000-11-03 2006-07-15 Vitrolife Ab Lösung zur evaluierung und konservierung
US20040138621A1 (en) 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US7628780B2 (en) 2001-01-13 2009-12-08 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7740623B2 (en) 2001-01-13 2010-06-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US7959626B2 (en) * 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US6648883B2 (en) 2001-04-26 2003-11-18 Medtronic, Inc. Ablation system and method of use
US6663627B2 (en) 2001-04-26 2003-12-16 Medtronic, Inc. Ablation system and method of use
US6699240B2 (en) 2001-04-26 2004-03-02 Medtronic, Inc. Method and apparatus for tissue ablation
US7250048B2 (en) 2001-04-26 2007-07-31 Medtronic, Inc. Ablation system and method of use
US6807968B2 (en) 2001-04-26 2004-10-26 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US8580487B2 (en) * 2001-05-29 2013-11-12 Core Dynamics Limited Methods of preserving functionality of an organ, preserving fertility of a patient undergoing a treatment expected to cause sterility and assuring a supply of viable gametes for future use
US20050053912A1 (en) * 2001-06-11 2005-03-10 Roth Mark B. Methods for inducing reversible stasis
EP2275050A1 (de) 2001-09-05 2011-01-19 Salient Surgical Technologies, Inc. Flüssigkeitsgestützte elektrochirurgische Vorrichtungen, Verfahren und Systeme
US6677150B2 (en) 2001-09-14 2004-01-13 Organ Transport Systems, Inc. Organ preservation apparatus and methods
US6656175B2 (en) 2001-12-11 2003-12-02 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US6827715B2 (en) 2002-01-25 2004-12-07 Medtronic, Inc. System and method of performing an electrosurgical procedure
US7118566B2 (en) 2002-05-16 2006-10-10 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US7294143B2 (en) 2002-05-16 2007-11-13 Medtronic, Inc. Device and method for ablation of cardiac tissue
US7572622B2 (en) * 2002-08-14 2009-08-11 Transmedic, Inc. Heart preservation chamber
US8361091B2 (en) * 2002-08-23 2013-01-29 Organ Recovery Systems, Inc. Cannulas, cannula mount assemblies, and clamping methods using such cannulas and cannula mount assemblies
AU2002330726A1 (en) * 2002-08-28 2004-03-19 I.M.T. Interface Multigrad Technology Ltd Methods of preserving the functionality of an organ.
US7083620B2 (en) 2002-10-30 2006-08-01 Medtronic, Inc. Electrosurgical hemostat
US6921633B2 (en) * 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
USD531320S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Cassette for organ transporter
USD531319S1 (en) 2003-04-04 2006-10-31 Organ Recovery Systems Tube frame for organ transporter
WO2004089085A2 (en) * 2003-04-04 2004-10-21 Organ Recovery Systems, Inc. Device for separating gas from a liquid path
WO2004089235A2 (en) 2003-04-04 2004-10-21 Organ Recovery Systems, Inc. Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US7897327B2 (en) * 2003-06-02 2011-03-01 Organ Recovery Systems, Inc. Method and apparatus for pressure control for maintaining viability of organs
AT414254B (de) * 2003-06-05 2006-10-15 Kaindl Flooring Gmbh Verkleidungsplatte
US7278278B2 (en) 2003-06-12 2007-10-09 21St Century Medicine, Inc. Cryogenic storage system
JP2007509163A (ja) 2003-10-22 2007-04-12 フレッド ハッチンソン キャンサー リサーチ センター 組織および臓器においてスタシスを誘導する方法、組成物、および装置
US7504201B2 (en) 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
US8333764B2 (en) 2004-05-12 2012-12-18 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
WO2005112812A1 (en) 2004-05-14 2005-12-01 Medtronic, Inc. Method and devices for treating atrial fibrillation by mass ablation
US8741555B2 (en) * 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
WO2005120377A1 (en) 2004-06-02 2005-12-22 Medtronic, Inc. Clamping ablation tool
WO2005120374A1 (en) 2004-06-02 2005-12-22 Medtronic, Inc. Compound bipolar ablation device and method
EP1750608B1 (de) 2004-06-02 2012-10-03 Medtronic, Inc. Ablationsvorrichtung mit backen
EP1750607A2 (de) 2004-06-02 2007-02-14 Medtronic, Inc. Schlaufenablationsgerät und verfahren
US8926635B2 (en) 2004-06-18 2015-01-06 Medtronic, Inc. Methods and devices for occlusion of an atrial appendage
US8409219B2 (en) 2004-06-18 2013-04-02 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US8663245B2 (en) 2004-06-18 2014-03-04 Medtronic, Inc. Device for occlusion of a left atrial appendage
US8028438B2 (en) * 2004-07-02 2011-10-04 Aqualizer, Llc Moisture condensation control system
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) * 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
NZ591524A (en) * 2004-10-07 2012-09-28 Transmedics Inc Method for timing pulsatile flow of normothermic perfusate to the heart in ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
WO2007093978A1 (en) * 2006-02-13 2007-08-23 I.M.T. Interface Multigrad Technology Ltd. Frozen viable solid organs and method for freezing same
EP3677118A1 (de) * 2006-04-19 2020-07-08 Transmedics, Inc. Systeme zur ex-vivo-organpflege
US20080039746A1 (en) 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
EP2131650B1 (de) 2007-03-01 2017-11-29 Lifeline Scientific, Inc. Perfusionsregulierung
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
US8765364B2 (en) * 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
WO2009003061A1 (en) 2007-06-25 2008-12-31 Fred Hutchinson Cancer Research Center Methods and compositions regarding polychalcogenide compositions
US7892724B2 (en) * 2007-07-12 2011-02-22 Warsaw Orthopedic, Inc Method for enhancing the viability of mammalian cells, tissues and organs using a solution comprising two low molecular weight PEGs
US7960098B2 (en) * 2007-07-12 2011-06-14 Warsaw Orthoperic, Inc. Methods and compositions for the preservation of cells and tissues
EP2227174B1 (de) 2007-12-28 2019-05-01 Salient Surgical Technologies, Inc. Flüssigkeitsgestützte elektrochirurgische vorrichtung
US8420380B2 (en) * 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
EP2303171A2 (de) 2008-05-13 2011-04-06 Medtronic, Inc. Untersuchung von gewebeläsionen
NZ590122A (en) 2008-07-02 2012-02-24 Otsuka Pharma Co Ltd Artificial kidney precursor comprising a non-human mammalian metanephros and process for the production thereof
US9254168B2 (en) 2009-02-02 2016-02-09 Medtronic Advanced Energy Llc Electro-thermotherapy of tissue using penetrating microelectrode array
US8632533B2 (en) 2009-02-23 2014-01-21 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical device
CN102438445B (zh) * 2009-02-23 2014-12-10 细胞与组织系统股份有限公司 组织的无冰低温贮藏法
IN2012DN01917A (de) 2009-09-08 2015-07-24 Salient Surgical Tech Inc
WO2011112991A1 (en) 2010-03-11 2011-09-15 Salient Surgical Technologies, Inc. Bipolar electrosurgical cutter with position insensitive return electrode contact
US20110295249A1 (en) * 2010-05-28 2011-12-01 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof
US9138289B2 (en) 2010-06-28 2015-09-22 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US8920417B2 (en) 2010-06-30 2014-12-30 Medtronic Advanced Energy Llc Electrosurgical devices and methods of use thereof
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
US12082575B2 (en) 2010-09-01 2024-09-10 Organ Transport Pty Ltd Perfusion solution
EP2611291B1 (de) 2010-09-01 2020-03-25 Perfusion Fluid Technologies, Inc. Perfusionszusammensetzung
US9023040B2 (en) 2010-10-26 2015-05-05 Medtronic Advanced Energy Llc Electrosurgical cutting devices
US20120148542A1 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
US9427281B2 (en) 2011-03-11 2016-08-30 Medtronic Advanced Energy Llc Bronchoscope-compatible catheter provided with electrosurgical device
EP2704560B1 (de) 2011-04-14 2022-04-06 Transmedics, Inc. Organpflegelösung zur maschinellen ex-vivo-perfusion von spenderlungen
US9642625B2 (en) 2011-04-29 2017-05-09 Lifeline Scientific, Inc. Cannula for a donor organ with or without an aortic cuff or patch
US8828034B2 (en) 2011-04-29 2014-09-09 Lifeline Scientific, Inc. Cannula
US9022978B2 (en) 2011-04-29 2015-05-05 Lifeline Scientific, Inc. Universal sealring cannula
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
US8870864B2 (en) 2011-10-28 2014-10-28 Medtronic Advanced Energy Llc Single instrument electrosurgery apparatus and its method of use
ES2946695T3 (es) 2012-01-17 2023-07-24 Tevosol Inc Aparato para prueba, evaluación, y mantenimiento de corazones extraídos para trasplante
US20140017666A1 (en) 2012-07-10 2014-01-16 Lifeline Scientific, Inc. Filtration in organ perfusion apparatus
US9565853B2 (en) * 2012-07-10 2017-02-14 Lifeline Scientific, Inc. Perfusion apparatus with reduced pressure fluctuations, and bubble trap
US9119393B2 (en) * 2012-07-10 2015-09-01 Lifeline Scientific, Inc. Organ transporter with tilt and/or shock sensing
US9259562B2 (en) 2012-07-10 2016-02-16 Lifeline Scientific, Inc. Cannula
BR112015032918B1 (pt) * 2013-07-02 2021-09-28 Austrianova Singapore Pte Ltd Métodos para preparação de células encapsuladas para liofilização, composição e seus usos
US10823743B1 (en) 2013-10-28 2020-11-03 Ifirst Medical Technologies, Inc. Methods of measuring coagulation of a biological sample
CN106659150B (zh) * 2014-03-26 2021-06-01 体沃索股份有限公司 用于维护被收获的待移植心脏的设备
US10076112B2 (en) 2014-06-02 2018-09-18 Transmedic, Inc. Ex vivo organ care system
US9974599B2 (en) 2014-08-15 2018-05-22 Medtronic Ps Medical, Inc. Multipurpose electrosurgical device
WO2016090498A1 (en) 2014-12-12 2016-06-16 Freed Darren Apparatus and method for organ perfusion
US11389227B2 (en) 2015-08-20 2022-07-19 Medtronic Advanced Energy Llc Electrosurgical device with multivariate control
US11051875B2 (en) 2015-08-24 2021-07-06 Medtronic Advanced Energy Llc Multipurpose electrosurgical device
EP3347084B1 (de) 2015-09-09 2020-11-11 Transmedics, Inc. Aortenkanüle für ex-vivo-organpflegesystem
US10716612B2 (en) 2015-12-18 2020-07-21 Medtronic Advanced Energy Llc Electrosurgical device with multiple monopolar electrode assembly
ES2968415T3 (es) * 2016-02-09 2024-05-09 Sun Pharmaceutical Ind Ltd Sistema de perfusión
CA3025673A1 (en) 2016-05-30 2017-12-07 Tevosol, Inc. Apparatus and method for ex vivo lung ventilation with a varying exterior pressure
US10194975B1 (en) 2017-07-11 2019-02-05 Medtronic Advanced Energy, Llc Illuminated and isolated electrosurgical apparatus
FR3069135B1 (fr) * 2017-07-20 2020-10-30 Centre De Rech Biologiques Et Dexperimentations Cutanees Dispositif de maintien en survie d'un explant
US12023082B2 (en) 2017-10-06 2024-07-02 Medtronic Advanced Energy Llc Hemostatic thermal sealer
JP7600110B2 (ja) * 2018-11-22 2024-12-16 ヴィトラフィー ライフ サイエンシズ リミテッド 生物学的製品を冷凍するための装置
US11596146B2 (en) * 2019-06-20 2023-03-07 Joseph Mario Bernaudo Speed controlled centrifugal pump embalming systems and method of using the same
WO2021154995A1 (en) 2020-01-29 2021-08-05 Ifirst Medical Technologies, Inc. Medical analyzer and diagnostic sample profiler
CN115769035A (zh) 2020-04-08 2023-03-07 维特拉菲生命科学有限公司 用于冷冻消耗品的方法和设备
US20240074433A1 (en) * 2021-01-14 2024-03-07 Vitrafy Life Sciences Limited Method and apparatus for preservation of biological material
WO2023286009A1 (en) * 2021-07-15 2023-01-19 Sorin Group Italia S.R.L. Organ perfusion and preservation system and method
US20240008475A1 (en) * 2022-07-11 2024-01-11 Nicholas J. Shea Organ procurement devices, systems, and methods

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3772153A (en) * 1969-04-02 1973-11-13 Air Liquide Apparatus for the preservation of animal or human organs in living condition
US3892628A (en) * 1969-10-06 1975-07-01 Baxter Laboratories Inc Preservation of organs
US3639084A (en) * 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
US3753865A (en) * 1971-03-12 1973-08-21 Univ California Method and apparatus for preserving human organs extracorporeally
DE2241698C2 (de) * 1971-09-02 1982-08-26 Roland Dr.med. Zürich Doerig Verfahren zur Organerhaltung sowie Vorrichtung zum Durchführen dieses Verfahrens
US3843455A (en) * 1972-09-13 1974-10-22 M Bier Apparatus and technique for preservation of isolated organs through perfusion
US3995444A (en) * 1974-11-08 1976-12-07 American Hospital Supply Corporation Organ perfusion system
US4186565A (en) * 1978-05-19 1980-02-05 Henry Ford Hospital Perfusion system for organ preservation
US4629686A (en) * 1982-02-19 1986-12-16 Endotronics, Inc. Apparatus for delivering a controlled dosage of a chemical substance
US4559298A (en) * 1982-11-23 1985-12-17 American National Red Cross Cryopreservation of biological materials in a non-frozen or vitreous state
US4618586A (en) * 1983-04-08 1986-10-21 Endotronics, Inc. Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber
US4837390A (en) * 1983-05-11 1989-06-06 Keyes Offshore, Inc. Hyperbaric organ preservation apparatus and method for preserving living organs
US4471629A (en) * 1983-05-31 1984-09-18 Mount Carmel Research And Education Corporation Method of freezing and transplant of kidneys and apparatus
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US4879283A (en) * 1985-10-03 1989-11-07 Wisconsin Alumni Research Foundation Solution for the preservation of organs
US4688387A (en) * 1985-11-12 1987-08-25 Vital Force, Inc. Method for preservation and storage of viable biological materials at cryogenic temperatures
US4704029A (en) * 1985-12-26 1987-11-03 Research Corporation Blood glucose monitor
US4745759A (en) * 1986-12-23 1988-05-24 Bauer Dan O Kidney preservation machine
WO1988005261A1 (en) * 1987-01-16 1988-07-28 Tops Systems, Inc. Total organ perfusion system
US5051352A (en) * 1987-10-07 1991-09-24 The Regents Of The University Of California Apparatus and method of preserving the viability of animal organs
JPH0653160B2 (ja) * 1989-08-18 1994-07-20 呉羽化学工業株式会社 拍動発生方法及び装置

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DE69231106T2 (de) 2001-02-01
US5472876A (en) 1995-12-05
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CA2113119A1 (en) 1993-01-21
JPH07500815A (ja) 1995-01-26
EP0594733A4 (de) 1994-11-30
US5217860A (en) 1993-06-08
EP0594733A1 (de) 1994-05-04
CA2113119C (en) 2003-05-06
DE69231106D1 (de) 2000-06-29
EP0800765A2 (de) 1997-10-15
WO1993000808A1 (en) 1993-01-21

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