ATE250664T1 - In vitro reifen von oozyten mit inhibitin/activin kombinationen - Google Patents
In vitro reifen von oozyten mit inhibitin/activin kombinationenInfo
- Publication number
- ATE250664T1 ATE250664T1 AT94909788T AT94909788T ATE250664T1 AT E250664 T1 ATE250664 T1 AT E250664T1 AT 94909788 T AT94909788 T AT 94909788T AT 94909788 T AT94909788 T AT 94909788T AT E250664 T1 ATE250664 T1 AT E250664T1
- Authority
- AT
- Austria
- Prior art keywords
- oocytes
- activin
- inhibitin
- combinations
- vitro
- Prior art date
Links
- 210000000287 oocyte Anatomy 0.000 title abstract 6
- 102000005606 Activins Human genes 0.000 title abstract 3
- 108010059616 Activins Proteins 0.000 title abstract 3
- 239000000488 activin Substances 0.000 title abstract 3
- 238000000338 in vitro Methods 0.000 title abstract 2
- 108010080511 serum sodium transport inhibitor Proteins 0.000 title 1
- 238000012258 culturing Methods 0.000 abstract 3
- 239000000893 inhibin Substances 0.000 abstract 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 abstract 2
- 230000004720 fertilization Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0608—Germ cells
- C12N5/0609—Oocytes, oogonia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/02—Atmosphere, e.g. low oxygen conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ink Jet (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/021,404 US5563059A (en) | 1993-02-23 | 1993-02-23 | Use of human inhibin and human activin to increase the number of mature primate oocytes |
| PCT/US1994/002008 WO1994019455A1 (en) | 1993-02-23 | 1994-02-18 | In vitro maturation of oocytes with inhibin, activin or inhibin/activin combinations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250664T1 true ATE250664T1 (de) | 2003-10-15 |
Family
ID=21804022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94909788T ATE250664T1 (de) | 1993-02-23 | 1994-02-18 | In vitro reifen von oozyten mit inhibitin/activin kombinationen |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5563059A (de) |
| EP (1) | EP0686192B1 (de) |
| JP (1) | JPH08507211A (de) |
| AT (1) | ATE250664T1 (de) |
| AU (1) | AU672103B2 (de) |
| CA (1) | CA2154447C (de) |
| DE (1) | DE69433174T2 (de) |
| DK (1) | DK0686192T3 (de) |
| ES (1) | ES2208655T3 (de) |
| PT (1) | PT686192E (de) |
| WO (1) | WO1994019455A1 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5545616A (en) * | 1994-09-22 | 1996-08-13 | Genentech, Inc. | Method for predicting and/or preventing preterm labor |
| EP2264427B1 (de) | 1997-01-31 | 2017-05-03 | Xy, Llc | Optisches Gerät mit fokussierendem Reflektor zur Konvergenz der Strahlung auf einen Partikelfluss, und zugehöriges Analyseverfahren |
| WO1999031977A1 (en) * | 1997-12-22 | 1999-07-01 | President And Fellows Of Harvard College | Method for cryopreserving oocytes |
| US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| US6300311B1 (en) | 1998-04-14 | 2001-10-09 | Texas Tech University | Regulation of vertebrate ovarian maturation and function using growth factors |
| US6143564A (en) * | 1998-07-07 | 2000-11-07 | University Of Hawaii | Use of the polar body chromosomes for the production of embryos and normal offspring |
| JP2002521025A (ja) * | 1998-07-24 | 2002-07-16 | ザ カーネギー インスチチューション オブ ワシントン | 増殖因子のTGF−βファミリーのメンバーを使用する、生殖系列幹細胞の維持および増殖のための方法。 |
| PT1917974E (pt) | 1998-07-30 | 2011-02-22 | Xy Llc | Sistema de inseminação artificial não cirúrgica em equinos |
| US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
| EP1124840A4 (de) * | 1998-10-28 | 2002-07-17 | Baylor College Medicine | Ovarspezifische gene und proteine |
| US6995251B1 (en) | 1999-10-28 | 2006-02-07 | Baylor | Ovary-specific genes and proteins |
| US20060079674A1 (en) * | 1998-10-28 | 2006-04-13 | Baylor College Of Medicine Wyeth | Contraceptive targets |
| US20020042926A1 (en) * | 1998-10-28 | 2002-04-11 | Matzuk Martin M. | Ovary-specific genes and proteins |
| US7335737B2 (en) * | 1998-10-28 | 2008-02-26 | Baylor College Of Medicine | Ovary-specific genes and proteins |
| CN1353617A (zh) * | 1999-02-24 | 2002-06-12 | 诺沃挪第克公司 | 不孕症的治疗 |
| AU2794000A (en) | 1999-02-24 | 2000-09-14 | Novo Nordisk A/S | Treatment of infertility |
| CZ20012671A3 (cs) * | 1999-02-26 | 2002-01-16 | Novo Nordisk A/S | Způsob in vitro oplodnění s pouľitím kultivačního média obsahujícího sterol aktivující meiosu |
| DE19910394A1 (de) * | 1999-03-03 | 2000-09-07 | Schering Ag | Substanzen für die Fertilitätskontrolle |
| AU777783B2 (en) * | 1999-04-19 | 2004-10-28 | Kyowa Hakko Kogyo Co. Ltd. | Proliferation inhibitor for androgen-independent tumor |
| EP1224276A4 (de) * | 1999-10-29 | 2004-04-07 | Nexia Biotech Inc | Herstellung von transgenen tieren mittels durch lopu erhaltende oocyten |
| US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
| EP1241935A2 (de) * | 1999-12-17 | 2002-09-25 | Gerald Schatten | Verfahren zur erzeugung transgener tiere |
| US7250292B2 (en) * | 2000-01-26 | 2007-07-31 | 21St Century Medicine | Hypertonic reduction of chilling injury |
| IL152714A (en) | 2000-05-09 | 2014-03-31 | Xy Llc | High-purity spermatozoa populations carrying chromosome-x and chromosome-y |
| RU2193777C2 (ru) * | 2000-06-15 | 2002-11-27 | Ростовский НИИ акушерства и педиатрии | Способ прогнозирования исходов программы эко и пэ |
| US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
| WO2002043486A1 (en) * | 2000-11-29 | 2002-06-06 | Xy, Inc. | System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations |
| US20030135876A1 (en) * | 2002-01-16 | 2003-07-17 | Larry Mobraaten | Maintenance of genetic lines using cryopreserved sperm |
| US6849394B2 (en) * | 2002-02-21 | 2005-02-01 | Minitube Of America | Compositions comprising reproductive cell media and methods for using such compositions |
| WO2003076600A2 (en) * | 2002-03-08 | 2003-09-18 | Mcgill University | In vitro maturation of immature human oocytes |
| AU2012203441B2 (en) * | 2002-05-17 | 2015-01-29 | Mount Sinai School Of Medicine Of New York University | Mesoderm and definitive endoderm cell populations |
| EP1543110A4 (de) | 2002-05-17 | 2006-09-06 | Sinai School Medicine | Mesoderm- und definitive endoderm-zellpopulationen |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
| JP4595067B2 (ja) | 2002-08-01 | 2010-12-08 | エックスワイ,エルエルシー | 低圧精子細胞分離システム |
| CA2534394C (en) | 2002-08-15 | 2013-01-08 | Xy, Inc. | High resolution flow cytometer |
| US20040105858A1 (en) * | 2002-08-29 | 2004-06-03 | Kim Joanne Young Hee Kwak | Diagnosis and treatment of infertility |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| BRPI0408857B1 (pt) | 2003-03-28 | 2018-09-11 | Inguran Llc | aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo |
| ES2541121T3 (es) | 2003-05-15 | 2015-07-16 | Xy, Llc | Clasificación eficiente de células haploides por sistemas de citometría de flujo |
| HUE031978T2 (en) | 2003-11-26 | 2017-08-28 | Merck Serono Sa | Use of IL-6 type cytokines for egg cell aging |
| JP2007528226A (ja) * | 2004-03-10 | 2007-10-11 | リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア | 胚幹細胞の増殖用組成物および方法 |
| DK2801363T3 (en) | 2004-03-29 | 2018-05-28 | Inguran Llc | PROCEDURE FOR STORING SORTED SPERMATOZOES |
| EP1765983A4 (de) | 2004-05-17 | 2008-10-22 | Gen Hospital Corp | Verfahren und zusammensetzungen zur herstellung von stammzellen aus von knochenmark abgeleiteten keimbahn-stammzellen |
| CA2574499C (en) | 2004-07-22 | 2016-11-29 | Monsanto Technology Llc | Process for enriching a population of sperm cells |
| RU2281777C1 (ru) * | 2005-04-21 | 2006-08-20 | Мария Львовна Семенова | Способ управления качеством ооцитов и композиция для добавления в среду культивирования ооцитов |
| RU2281778C1 (ru) * | 2005-04-21 | 2006-08-20 | Мария Львовна Семенова | Способ культивирования зиготы и/или эмбриона и композиция для добавления в среду культивирования зигот и/или эмбрионов |
| US7618770B2 (en) | 2005-07-29 | 2009-11-17 | Xy, Inc. | Methods and apparatus for reducing protein content in sperm cell extenders |
| US8874380B2 (en) | 2010-12-09 | 2014-10-28 | Rutgers, The State University Of New Jersey | Method of overcoming therapeutic limitations of nonuniform distribution of radiopharmaceuticals and chemotherapy drugs |
| US20080113432A1 (en) * | 2006-11-15 | 2008-05-15 | Mariposa Biotechnology, Inc. | Methods and compositions for reanimating cryopreserved oocytes |
| US20080113431A1 (en) * | 2006-11-15 | 2008-05-15 | Mariposa Biotechnology, Inc. | Methods and compositions for cryopreserving oocytes |
| US8903660B2 (en) | 2010-06-24 | 2014-12-02 | The Invention Science Fund I, Llc | Rejuvenation or preservation of germ cells |
| CN106350479A (zh) | 2011-04-14 | 2017-01-25 | 通用医疗公司 | 用于自体种系线粒体能量转移的组合物和方法 |
| EA201490050A1 (ru) | 2011-06-29 | 2014-07-30 | Зе Дженерэл Хоспитэл Корпорейшн | Композиции и способы повышения биоэнергетического состояния женских зародышевых клеток |
| BR112020010343A2 (pt) | 2017-11-23 | 2020-11-10 | Biosearch, S.A. | método para aumentar taxa de implantação de embrião em um paciente feminino sofrendo de síndrome de ovário policístico |
| CA3200577A1 (en) * | 2020-11-02 | 2022-05-05 | Conception Biosciences, Inc. | In vitro derivation of gonadal somatic cells |
| CN114913972B (zh) * | 2021-12-10 | 2023-12-01 | 北京大学第三医院(北京大学第三临床医学院) | 预测受试者卵巢刺激过程中获得的卵母细胞数量的系统 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845077A (en) * | 1984-04-03 | 1989-07-04 | Serono Laboratories, Inc. | Method of inducing ovulation |
| IE881133L (en) * | 1988-04-14 | 1989-10-14 | Univ Dublin | In-vitro culture of bovine embryos |
| IL94184A0 (en) * | 1989-05-01 | 1991-01-31 | Granada Biosciences Inc | In vitro maturation of bovine oocytes |
| JPH03173805A (ja) * | 1989-09-11 | 1991-07-29 | Ajinomoto Co Inc | 卵分割促進剤 |
| US5102868A (en) * | 1990-01-08 | 1992-04-07 | Genentech, Inc. | Method for inhibiting follicular maturation |
| US5166190A (en) * | 1990-01-08 | 1992-11-24 | Genentech, Inc. | Method for increasing fertility in males |
| CA2069755A1 (en) * | 1990-01-08 | 1991-07-09 | Jennie P. Mather | Method for increasing fertility in females |
| CA2072475A1 (en) * | 1991-07-01 | 1993-01-02 | Tanja Dominko | In vitro maturation of denuded bovine oocytes |
-
1993
- 1993-02-23 US US08/021,404 patent/US5563059A/en not_active Expired - Lifetime
-
1994
- 1994-02-18 AT AT94909788T patent/ATE250664T1/de active
- 1994-02-18 AU AU62497/94A patent/AU672103B2/en not_active Expired
- 1994-02-18 CA CA002154447A patent/CA2154447C/en not_active Expired - Lifetime
- 1994-02-18 JP JP6519269A patent/JPH08507211A/ja active Pending
- 1994-02-18 WO PCT/US1994/002008 patent/WO1994019455A1/en not_active Ceased
- 1994-02-18 ES ES94909788T patent/ES2208655T3/es not_active Expired - Lifetime
- 1994-02-18 EP EP94909788A patent/EP0686192B1/de not_active Expired - Lifetime
- 1994-02-18 DE DE69433174T patent/DE69433174T2/de not_active Expired - Lifetime
- 1994-02-18 DK DK94909788T patent/DK0686192T3/da active
- 1994-02-18 PT PT94909788T patent/PT686192E/pt unknown
-
1995
- 1995-06-05 US US08/463,370 patent/US5693534A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0686192A1 (de) | 1995-12-13 |
| US5563059A (en) | 1996-10-08 |
| JPH08507211A (ja) | 1996-08-06 |
| CA2154447C (en) | 2005-04-19 |
| WO1994019455A1 (en) | 1994-09-01 |
| CA2154447A1 (en) | 1994-09-01 |
| EP0686192B1 (de) | 2003-09-24 |
| DK0686192T3 (da) | 2004-02-02 |
| DE69433174T2 (de) | 2004-07-01 |
| AU6249794A (en) | 1994-09-14 |
| DE69433174D1 (de) | 2003-10-30 |
| PT686192E (pt) | 2004-02-27 |
| US5693534A (en) | 1997-12-02 |
| AU672103B2 (en) | 1996-09-19 |
| ES2208655T3 (es) | 2004-06-16 |
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