ATE194166T1 - Verfahren zur gewinnung fötaler zellen - Google Patents

Verfahren zur gewinnung fötaler zellen

Info

Publication number
ATE194166T1
ATE194166T1 AT91906073T AT91906073T ATE194166T1 AT E194166 T1 ATE194166 T1 AT E194166T1 AT 91906073 T AT91906073 T AT 91906073T AT 91906073 T AT91906073 T AT 91906073T AT E194166 T1 ATE194166 T1 AT E194166T1
Authority
AT
Austria
Prior art keywords
cells
pct
cell surface
maternal
fetal
Prior art date
Application number
AT91906073T
Other languages
English (en)
Inventor
Malcolm J Simons
Original Assignee
Genetype Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetype Ag filed Critical Genetype Ag
Application granted granted Critical
Publication of ATE194166T1 publication Critical patent/ATE194166T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
AT91906073T 1990-03-27 1991-03-27 Verfahren zur gewinnung fötaler zellen ATE194166T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/499,932 US5153117A (en) 1990-03-27 1990-03-27 Fetal cell recovery method
PCT/AU1991/000115 WO1991014768A1 (en) 1990-03-27 1991-03-27 Fetal cell recovery method

Publications (1)

Publication Number Publication Date
ATE194166T1 true ATE194166T1 (de) 2000-07-15

Family

ID=23987348

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91906073T ATE194166T1 (de) 1990-03-27 1991-03-27 Verfahren zur gewinnung fötaler zellen

Country Status (16)

Country Link
US (2) US5153117A (de)
EP (1) EP0521909B1 (de)
JP (1) JP2965699B2 (de)
AT (1) ATE194166T1 (de)
AU (1) AU649027B2 (de)
CA (1) CA2059554C (de)
DE (1) DE69132269T2 (de)
DK (1) DK0521909T3 (de)
ES (1) ES2149760T3 (de)
GR (1) GR3034487T3 (de)
IE (1) IE910996A1 (de)
IL (1) IL97677A (de)
NZ (1) NZ237589A (de)
SG (1) SG79188A1 (de)
WO (1) WO1991014768A1 (de)
ZA (1) ZA912317B (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05501612A (ja) * 1989-11-13 1993-03-25 チルドレンズ・メデイカル・センター・コーポレーシヨン 胎児ｄｎａ単離および検出のための非侵入性方法
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5627029A (en) * 1991-05-03 1997-05-06 Genzyme Corporation Method for obtaining informative cells
AU680412B2 (en) * 1992-04-09 1997-07-31 Ig Laboratories, Inc. Probes for detecting common liveborn chromosomal aneuploidies
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
BR9306867A (pt) * 1992-07-17 1998-12-08 Aprogenex Inc Enriquecimento e identificação de células fetais do sangue materno para a hibridização in situ
US5275933A (en) * 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood
EP0690927A4 (de) * 1993-01-06 2002-02-13 Boehringer Mannheim Corp Nachweis nicht lebender zellen mittels fluoreszenz
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
AU7921194A (en) * 1993-09-27 1995-04-18 Oncor, Inc. Methods for detecting and analyzing individual rare cells in a population
US6136540A (en) * 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US5352613A (en) * 1993-10-07 1994-10-04 Tafas Triantafillos P Cytological screening method
GB9422504D0 (en) * 1994-11-08 1995-01-04 Robertson Patricia M B Blood testing
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
CN1153064C (zh) * 1996-04-05 2004-06-09 约翰斯·霍普金斯大学 富集稀少细胞的方法
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
EP2264427B1 (de) 1997-01-31 2017-05-03 Xy, Llc Optisches Gerät mit fokussierendem Reflektor zur Konvergenz der Strahlung auf einen Partikelfluss, und zugehöriges Analyseverfahren
JP2001514751A (ja) * 1997-03-08 2001-09-11 ザ・ユニバーシティー・オブ・ダンディー 胎児診断方法
US6890755B1 (en) * 1997-12-08 2005-05-10 The Trustees Of Columbia University In The City Of New York Recovery of fetal cells from maternal blood using chaotic advection
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6210889B1 (en) * 1998-01-28 2001-04-03 The Universite Laval Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
US6733967B1 (en) 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
PT1917974E (pt) 1998-07-30 2011-02-22 Xy Llc Sistema de inseminação artificial não cirúrgica em equinos
AU2686100A (en) * 1999-02-18 2000-09-04 Bio-View Ltd. System and method for identifying and analyzing rare cell types in a mixed population of cells
WO2000071987A2 (en) * 1999-05-25 2000-11-30 John Philip Isolation and culturing of fetal cells
EP1283904A2 (de) * 1999-11-03 2003-02-19 Oncotech, Inc. Diagnose von krebs mit zellsortierung und genexpressionsprofilen
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
AU2001277635A1 (en) * 2000-03-14 2001-10-08 Exiqon A/S New methods for separation and isolation of subpopulations of cells in biological samples
IL152714A (en) 2000-05-09 2014-03-31 Xy Llc High-purity spermatozoa populations carrying chromosome-x and chromosome-y
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002074055A2 (en) * 2001-03-19 2002-09-26 Ikonisys, Inc. Epifluorecence microscope with improved image contrast
US20040214314A1 (en) * 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
WO2003040064A2 (en) * 2001-11-07 2003-05-15 Bioview Ltd. Kits and methods for preparing cell samples optimized for dual staining
IL163600A0 (en) * 2002-03-01 2005-12-18 Ravgen Inc Methods for detection of genetic disorders
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
EP1532453B1 (de) * 2002-05-31 2013-08-21 Genetic Technologies Limited Maternale antikörper als marker für fötale zellen zur identifizierung und anreicherung fötaler zellen aus maternalem blut
EP1533616A4 (de) * 2002-06-07 2007-01-17 Towa Kagaku Co Ltd Detektionskitt, darin zu verwendende assay-platte, detektionsverfahren, auswertungsverfahren, polyklonalantikörper von frosch-vitellogenin und prozess zur herstellung davon
WO2003106623A2 (en) * 2002-06-13 2003-12-24 New York University Early noninvasive prenatal test for aneuploidies and heritable conditions
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
JP4595067B2 (ja) 2002-08-01 2010-12-08 エックスワイ，エルエルシー 低圧精子細胞分離システム
CA2534394C (en) 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
CA2445204C (en) 2002-10-16 2014-08-12 Streck Laboratories, Inc. Method and device for collecting and preserving cells for analysis
EP1599608A4 (de) * 2003-03-05 2007-07-18 Genetic Technologies Ltd Identifizierung fötaler dna und fötaler zellmarker im mütterlichen plasma oder serum
BRPI0408857B1 (pt) 2003-03-28 2018-09-11 Inguran Llc aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo
ES2541121T3 (es) 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
DK2801363T3 (en) 2004-03-29 2018-05-28 Inguran Llc PROCEDURE FOR STORING SORTED SPERMATOZOES
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
US7527978B2 (en) * 2004-10-07 2009-05-05 Children's Hospital & Research Center At Oakland Flow cytometry based micronucleus assays and kits
US7439062B2 (en) * 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
EP1874920A4 (de) * 2005-04-05 2009-11-04 Cellpoint Diagnostics Vorrichtungen und verfahren zur anreicherung und veränderung zirkulierender tumorzellen und anderer partikel
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
GB0509500D0 (en) * 2005-05-10 2005-06-15 Revealcyte Method of fetal cell enrichment
EP1886138A4 (de) * 2005-05-11 2009-04-15 Genetic Technologies Ltd Verfahren zur anreicherung fötaler zellen
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
WO2007062486A1 (en) * 2005-12-02 2007-06-07 Simons Haplomics Limited Methods for gene mapping and haplotyping
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
GB0616045D0 (en) * 2006-08-11 2006-09-20 Univ Bristol Blood cell separation
DE102006062619B4 (de) * 2006-12-29 2012-04-26 Medion Diagnostics Ag Verfahren zur Bestimmung von minoren Zellpopulationen in heterogenen Zellpopulationen
CA2752838A1 (en) * 2008-02-18 2009-08-27 Genetic Technologies Limited Cell processing and/or enrichment methods
EP2265942B1 (de) 2008-03-12 2017-10-18 University Of Virginia Patent Foundation Nachweis polymerer analyten
US20120149587A1 (en) * 2008-03-12 2012-06-14 University Of Virginia Patent Foundation Method for detecting nucleated cells
EP2321642B1 (de) 2008-08-04 2017-01-11 Natera, Inc. Verfahren für allelzuordnung und ploidiezuordnung
CA3069082C (en) 2008-09-20 2022-03-22 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
WO2010078194A1 (en) * 2008-12-30 2010-07-08 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018561U1 (de) 2009-01-21 2017-08-28 Streck Inc. Blutsammelröhrchen
NO2398912T3 (de) 2009-02-18 2018-02-10
WO2010121294A1 (en) 2009-04-21 2010-10-28 Genetic Technologies Limited Methods for obtaining fetal genetic material
WO2011041485A1 (en) 2009-09-30 2011-04-07 Gene Security Network, Inc. Methods for non-invasive prenatal ploidy calling
US20110111410A1 (en) * 2009-11-09 2011-05-12 Streck, Inc. Stabilization of rna in intact cells within a blood sample
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
US9956281B2 (en) 2011-05-04 2018-05-01 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
US10091984B2 (en) 2013-07-24 2018-10-09 Streck, Inc. Compositions and methods for stabilizing circulating tumor cells
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
JP2017521091A (ja) * 2014-05-15 2017-08-03 ケルベンクス インコーポレイテッド 診断試験用の胎児有核赤血球（ｎｒｂｃ）の調製
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2018022991A1 (en) 2016-07-29 2018-02-01 Streck, Inc. Suspension composition for hematology analysis control
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CN115119829B (zh) 2017-10-19 2024-07-12 斯特雷克股份有限公司 用于胞外囊泡的溶血和凝血调节以及稳定化的组合物
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675286A (en) * 1985-01-28 1987-06-23 Aspen Diagnostics, Inc. Fetal cell separation and testing
US4835098A (en) * 1985-09-04 1989-05-30 Regents Of University Of Minnesota Characterization of HLA alleles with locus-specific DNA probes
US4987086A (en) * 1987-11-30 1991-01-22 Becton, Dickinson And Company Method for analysis of subpopulations of cells
ES2112833T3 (es) * 1988-12-06 1998-04-16 Flinders Technologies Pty Ltd Aislamiento de celulas fetales a partir de sangre materna para permitir el diagnostico prenatal.
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method

Also Published As

Publication number Publication date
ES2149760T3 (es) 2000-11-16
AU7471691A (en) 1991-10-21
SG79188A1 (en) 2001-03-20
ZA912317B (en) 1991-12-24
NZ237589A (en) 1992-04-28
AU649027B2 (en) 1994-05-12
JPH05506144A (ja) 1993-09-16
EP0521909B1 (de) 2000-06-28
DE69132269T2 (de) 2001-03-15
GR3034487T3 (en) 2000-12-29
DE69132269D1 (de) 2000-08-03
WO1991014768A1 (en) 1991-10-03
EP0521909A4 (en) 1993-11-18
IE910996A1 (en) 1991-10-09
CA2059554A1 (en) 1991-09-28
EP0521909A1 (de) 1993-01-13
IL97677A (en) 1996-07-23
IL97677A0 (en) 1992-06-21
US5153117A (en) 1992-10-06
JP2965699B2 (ja) 1999-10-18
DK0521909T3 (da) 2000-10-30
CA2059554C (en) 2004-06-22
US5447842A (en) 1995-09-05

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