ZA912317B - Fetal cell recovery method - Google Patents

Fetal cell recovery method

Info

Publication number
ZA912317B
ZA912317B ZA912317A ZA912317A ZA912317B ZA 912317 B ZA912317 B ZA 912317B ZA 912317 A ZA912317 A ZA 912317A ZA 912317 A ZA912317 A ZA 912317A ZA 912317 B ZA912317 B ZA 912317B
Authority
ZA
South Africa
Prior art keywords
cells
pct
cell surface
maternal
fetal
Prior art date
Application number
ZA912317A
Other languages
English (en)
Inventor
Malcolm J Simons
J Simons Malcolm
Original Assignee
Gene Type A G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Type A G filed Critical Gene Type A G
Publication of ZA912317B publication Critical patent/ZA912317B/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
ZA912317A 1990-03-27 1991-03-27 Fetal cell recovery method ZA912317B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/499,932 US5153117A (en) 1990-03-27 1990-03-27 Fetal cell recovery method

Publications (1)

Publication Number Publication Date
ZA912317B true ZA912317B (en) 1991-12-24

Family

ID=23987348

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA912317A ZA912317B (en) 1990-03-27 1991-03-27 Fetal cell recovery method

Country Status (16)

Country Link
US (2) US5153117A (de)
EP (1) EP0521909B1 (de)
JP (1) JP2965699B2 (de)
AT (1) ATE194166T1 (de)
AU (1) AU649027B2 (de)
CA (1) CA2059554C (de)
DE (1) DE69132269T2 (de)
DK (1) DK0521909T3 (de)
ES (1) ES2149760T3 (de)
GR (1) GR3034487T3 (de)
IE (1) IE910996A1 (de)
IL (1) IL97677A (de)
NZ (1) NZ237589A (de)
SG (1) SG79188A1 (de)
WO (1) WO1991014768A1 (de)
ZA (1) ZA912317B (de)

Families Citing this family (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0791659A3 (de) * 1989-11-13 1997-09-17 Children's Medical Center Corporation Antigen spezifischer Trennung von nukleierten fetalen Zellen bei nichtinvasiver Nachweis von fetaler DNA
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5627029A (en) * 1991-05-03 1997-05-06 Genzyme Corporation Method for obtaining informative cells
WO1993021342A1 (en) * 1992-04-09 1993-10-28 Ig Laboratories, Inc. Probes for detecting common liveborn chromosomal aneuploidies
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
JPH07509136A (ja) * 1992-07-17 1995-10-12 バイシス，インク． インサイチュ（ｉｎ　ｓｉｔｕ）・ハイブリダイゼーションのための母体血液中の胎児細胞の富化と同定
US5275933A (en) * 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood
WO1994016102A1 (en) * 1993-01-06 1994-07-21 Boehringer Mannheim Corporation Fluorescent detection of nonviable cells
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
WO1995009245A1 (en) * 1993-09-27 1995-04-06 Oncor, Inc. Methods for detecting and analyzing individual rare cells in a population
US5352613A (en) * 1993-10-07 1994-10-04 Tafas Triantafillos P Cytological screening method
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
GB9422504D0 (en) * 1994-11-08 1995-01-04 Robertson Patricia M B Blood testing
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US5639669A (en) * 1995-06-07 1997-06-17 Ledley; Robert Separation of fetal cells from maternal blood
WO1997038313A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
JP4323571B2 (ja) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド 光学装置
CA2283416A1 (en) 1997-03-08 1998-09-17 The University Of Dundee Prenatal diagnostic methods
US6890755B1 (en) * 1997-12-08 2005-05-10 The Trustees Of Columbia University In The City Of New York Recovery of fetal cells from maternal blood using chaotic advection
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6210889B1 (en) * 1998-01-28 2001-04-03 The Universite Laval Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities
US6733967B1 (en) 1998-04-21 2004-05-11 Interleukin Genetics, Inc. Fetal testing for prediction of low birth weight
ES2296398T3 (es) 1998-07-30 2008-04-16 Xy, Inc. Sistema de inseminacion equina artificial no quirurgica.
EP1163502A1 (de) * 1999-02-18 2001-12-19 Bio-View Ltd Vorrichtung und verfahren zum identifizieren und analysieren von seltenen zellarten in einem gemischten zellverband
WO2000071987A2 (en) * 1999-05-25 2000-11-30 John Philip Isolation and culturing of fetal cells
WO2001033228A2 (en) * 1999-11-03 2001-05-10 Oncotech, Inc. Cancer diagnosis employing cell-sorting and gene-profiles
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
WO2001072392A2 (en) * 2000-03-14 2001-10-04 Exiqon A/S New methods for separation and isolation of subpopulations of cells in biological samples
EP2258173A3 (de) 2000-05-09 2012-06-13 Xy, Llc Hochreines X-Chromosom-Lager und Y-Chromosom-Lagerpopulationen von Spermatozoiden
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2822983C (en) 2000-11-29 2017-05-09 Xy, Llc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002074055A2 (en) * 2001-03-19 2002-09-26 Ikonisys, Inc. Epifluorecence microscope with improved image contrast
US20040214314A1 (en) * 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
WO2003040064A2 (en) * 2001-11-07 2003-05-15 Bioview Ltd. Kits and methods for preparing cell samples optimized for dual staining
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
NZ535044A (en) * 2002-03-01 2008-12-24 Ravgen Inc Non-invasive method to determine the genetic sequence of foetal DNA from a sample from a pregnant female thereby detecting any alternation in gene sequence as compared with the wild type sequence
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
EP1532453B1 (de) * 2002-05-31 2013-08-21 Genetic Technologies Limited Maternale antikörper als marker für fötale zellen zur identifizierung und anreicherung fötaler zellen aus maternalem blut
EP1533616A4 (de) * 2002-06-07 2007-01-17 Towa Kagaku Co Ltd Detektionskitt, darin zu verwendende assay-platte, detektionsverfahren, auswertungsverfahren, polyklonalantikörper von frosch-vitellogenin und prozess zur herstellung davon
AU2003243475A1 (en) * 2002-06-13 2003-12-31 New York University Early noninvasive prenatal test for aneuploidies and heritable conditions
US8211629B2 (en) 2002-08-01 2012-07-03 Xy, Llc Low pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CA2534394C (en) 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
CA2500392C (en) 2002-09-27 2012-11-27 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
ES2784011T3 (es) 2002-10-16 2020-09-21 Streck Inc Procedimiento y dispositivo para recoger y preservar las células para su análisis
WO2004078999A1 (en) * 2003-03-05 2004-09-16 Genetic Technologies Limited Identification of fetal dna and fetal cell markers in maternal plasma or serum
DK2959774T3 (da) 2003-03-28 2019-05-13 Inguran Llc Fremgangsmåde til kryokonservering af sædceller
WO2004104178A2 (en) 2003-05-15 2004-12-02 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
EP2260854A1 (de) 2004-03-29 2010-12-15 Inguran, LLC Spermasuspensionen zur Sortierung in X- oder Y-Chromosomen-tragende angereicherte Populationen
AU2005266930B2 (en) 2004-07-22 2010-09-16 Inguran, Llc Process for enriching a population of sperm cells
US7527978B2 (en) * 2004-10-07 2009-05-05 Children's Hospital & Research Center At Oakland Flow cytometry based micronucleus assays and kits
US7439062B2 (en) * 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
EP1874920A4 (de) * 2005-04-05 2009-11-04 Cellpoint Diagnostics Vorrichtungen und verfahren zur anreicherung und veränderung zirkulierender tumorzellen und anderer partikel
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
GB0509500D0 (en) * 2005-05-10 2005-06-15 Revealcyte Method of fetal cell enrichment
WO2006119569A1 (en) * 2005-05-11 2006-11-16 Genetic Technologies Limtied Methods of enriching fetal cells
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US7618770B2 (en) 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US10083273B2 (en) 2005-07-29 2018-09-25 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
WO2007062486A1 (en) * 2005-12-02 2007-06-07 Simons Haplomics Limited Methods for gene mapping and haplotyping
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2029779A4 (de) 2006-06-14 2010-01-20 Living Microsystems Inc Verwendung hoch paralleler snp-genotypisierung zur fötalen diagnose
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
GB0616045D0 (en) * 2006-08-11 2006-09-20 Univ Bristol Blood cell separation
DE102006062619B4 (de) * 2006-12-29 2012-04-26 Medion Diagnostics Ag Verfahren zur Bestimmung von minoren Zellpopulationen in heterogenen Zellpopulationen
EP2250497B1 (de) * 2008-02-18 2014-09-10 Genetic Technologies Limited Zellprozessierungs- und/oder -anreicherungsverfahren
US20120149587A1 (en) * 2008-03-12 2012-06-14 University Of Virginia Patent Foundation Method for detecting nucleated cells
KR20100135797A (ko) 2008-03-12 2010-12-27 유니버시티 오브 버지니아 페이턴트 파운데이션 중합체 분석물의 검출
US20110178719A1 (en) 2008-08-04 2011-07-21 Gene Security Network, Inc. Methods for Allele Calling and Ploidy Calling
ES2620012T3 (es) 2008-09-20 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
US20100167271A1 (en) * 2008-12-30 2010-07-01 Streck, Inc. Method for screening blood using a preservative that may be in a substantially solid state form
US11634747B2 (en) 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
DE202010018561U1 (de) 2009-01-21 2017-08-28 Streck Inc. Blutsammelröhrchen
EP3290530B1 (de) 2009-02-18 2020-09-02 Streck Inc. Konservierung von zellfreien nukleinsäuren
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
EP2473638B1 (de) 2009-09-30 2017-08-09 Natera, Inc. Verfahren zur nichtinvasiven pränatalen ploidiezuordnung
CA2780536C (en) * 2009-11-09 2018-01-02 Streck, Inc. Stabilization of rna in and extracting from intact cells within a blood sample
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
EP2656263B1 (de) 2010-12-22 2019-11-06 Natera, Inc. Verfahren für nichtinvasiven pränatalen vaterschaftstest
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
EP4136972A1 (de) 2013-07-24 2023-02-22 Streck, Inc. Zusammensetzungen und verfahren zur stabilisierung zirkulierender tumorzellen
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
CN113774132A (zh) 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
CA2984884A1 (en) * 2014-05-15 2015-11-19 Kellbenx Incorporated Preparation of fetal nucleated red blood cells (nrbcs) for diagnostic testing
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
DK3294906T3 (en) 2015-05-11 2024-08-05 Natera Inc Methods for determining ploidy
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
WO2018022991A1 (en) 2016-07-29 2018-02-01 Streck, Inc. Suspension composition for hematology analysis control
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US12378543B2 (en) 2017-10-19 2025-08-05 Streck Llc Compositions for hemolysis and coagulation regulation and stabilization of extracellular vesicles
DK3781714T3 (da) 2018-04-14 2026-03-30 Natera Inc Fremgangsmåder til cancerpåvisning og -overvågning ved personlig påvisning af cirkulerende tumor-dna
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3980559A1 (de) 2019-06-06 2022-04-13 Natera, Inc. Verfahren zur detektion von immunzellen-dna und zur überwachung des immunsystems

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675286A (en) * 1985-01-28 1987-06-23 Aspen Diagnostics, Inc. Fetal cell separation and testing
US4835098A (en) * 1985-09-04 1989-05-30 Regents Of University Of Minnesota Characterization of HLA alleles with locus-specific DNA probes
US4987086A (en) * 1987-11-30 1991-01-22 Becton, Dickinson And Company Method for analysis of subpopulations of cells
ATE161960T1 (de) * 1988-12-06 1998-01-15 Flinders Technologies Pty Ltd Isolierung von fetalen zellen aus mütterlichem blut zur ausführung von pränataler diagnostik
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method

Also Published As

Publication number Publication date
SG79188A1 (en) 2001-03-20
WO1991014768A1 (en) 1991-10-03
DE69132269D1 (de) 2000-08-03
JP2965699B2 (ja) 1999-10-18
ES2149760T3 (es) 2000-11-16
AU7471691A (en) 1991-10-21
EP0521909A1 (de) 1993-01-13
DK0521909T3 (da) 2000-10-30
CA2059554C (en) 2004-06-22
US5153117A (en) 1992-10-06
CA2059554A1 (en) 1991-09-28
NZ237589A (en) 1992-04-28
EP0521909B1 (de) 2000-06-28
IL97677A0 (en) 1992-06-21
JPH05506144A (ja) 1993-09-16
GR3034487T3 (en) 2000-12-29
AU649027B2 (en) 1994-05-12
IE910996A1 (en) 1991-10-09
IL97677A (en) 1996-07-23
ATE194166T1 (de) 2000-07-15
US5447842A (en) 1995-09-05
DE69132269T2 (de) 2001-03-15
EP0521909A4 (en) 1993-11-18

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