ATE194288T1 - Proanthocyanidinpolymere mit antivirales aktivität und deren herstellungsverfahren - Google Patents
Proanthocyanidinpolymere mit antivirales aktivität und deren herstellungsverfahrenInfo
- Publication number
- ATE194288T1 ATE194288T1 AT91919754T AT91919754T ATE194288T1 AT E194288 T1 ATE194288 T1 AT E194288T1 AT 91919754 T AT91919754 T AT 91919754T AT 91919754 T AT91919754 T AT 91919754T AT E194288 T1 ATE194288 T1 AT E194288T1
- Authority
- AT
- Austria
- Prior art keywords
- polymers
- antiviral activity
- proanthocyanidine
- production process
- proanthocyanidin polymers
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 4
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 abstract 3
- 229920001991 Proanthocyanidin Polymers 0.000 abstract 3
- 241001246270 Calophyllum Species 0.000 abstract 1
- 241001448862 Croton Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59689390A | 1990-10-12 | 1990-10-12 | |
| US07/737,077 US5211944A (en) | 1990-10-12 | 1991-07-29 | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| PCT/US1991/007679 WO1992006695A1 (en) | 1990-10-12 | 1991-10-10 | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194288T1 true ATE194288T1 (de) | 2000-07-15 |
Family
ID=27082674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91919754T ATE194288T1 (de) | 1990-10-12 | 1991-10-10 | Proanthocyanidinpolymere mit antivirales aktivität und deren herstellungsverfahren |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5211944A (de) |
| EP (1) | EP0553253B1 (de) |
| JP (1) | JP3448052B2 (de) |
| KR (1) | KR100207949B1 (de) |
| AT (1) | ATE194288T1 (de) |
| AU (1) | AU660631B2 (de) |
| CA (1) | CA2093825C (de) |
| DE (1) | DE69132289D1 (de) |
| MX (1) | MX9101540A (de) |
| NZ (1) | NZ240200A (de) |
| SG (1) | SG52707A1 (de) |
| WO (1) | WO1992006695A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981163A (en) * | 1990-05-15 | 1999-11-09 | New York Blood Center, Inc. | Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions |
| WO1994028120A1 (en) * | 1991-05-10 | 1994-12-08 | New York Blood Center, Inc. | Process for the sterilization of biological compositions and the product produced thereby |
| US5591770A (en) * | 1992-03-31 | 1997-01-07 | The United States Of America As Represented By The Department Of Health And Human Services | Calanolide and related antiretroviral compounds, compositions, and uses thereof |
| US6774141B1 (en) | 1992-03-31 | 2004-08-10 | The United States Of America As Represented By The Secretary Of Health And Human Services | Calanolide and related antiviral compounds, compositions, and uses thereof |
| DK0633887T3 (da) * | 1992-03-31 | 1999-11-29 | Us Health | Antivirale calanolidforbindelser, præparater og anvendelser deraf |
| US5650432A (en) * | 1995-03-24 | 1997-07-22 | Jlb, Inc. | Method of treating or preventing non-viral microbial infection |
| US5646178A (en) * | 1992-10-09 | 1997-07-08 | Jlb, Inc. | Cranberry extract and biologically active compounds derived therefrom |
| US5892060A (en) * | 1994-08-03 | 1999-04-06 | Sarawak Medichem Pharmaceuticals, Inc. | Method for the preparation of (+)-calanolide a and analogues thereof |
| US5977385A (en) * | 1994-08-03 | 1999-11-02 | Sarawak Medichem Pharmaceuticals | Method for the preparation of (+)-calanolide A and analogues thereof |
| US6043271A (en) * | 1994-08-03 | 2000-03-28 | Sarawak Medichem Pharmaceuticals, Inc. | Method for the preparation of (±)-calanolide A and intermediates thereof |
| US6277879B1 (en) | 1994-08-03 | 2001-08-21 | Sarawak Medichem Pharmaceuticals, Inc. | Calanolide analogues and methods of their use |
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
| JPH1059846A (ja) * | 1996-06-10 | 1998-03-03 | Kikkoman Corp | 白内障の予防または治療薬剤 |
| EP2060183A3 (de) | 1996-10-16 | 2009-06-03 | Napo Pharmaceuticals, Inc. | Enteralformulierungen von Proanthocyanidin-Polymer-Zusammensetzungen gegen Diarrhöe |
| AU775330B2 (en) * | 1996-10-16 | 2004-07-29 | Napo Pharmaceuticals Inc. | Enteric formulations of proanthocyanidin polymer antidiarrheal compositions |
| US6197808B1 (en) * | 1996-11-18 | 2001-03-06 | Cancer Instititute (Hospital), Chinese Academy Of Medical Sciences | Methods for treating hyperplasia |
| US5968973A (en) * | 1996-11-18 | 1999-10-19 | Cancer Institute (Hospital), Chinese Academy Of Medical Sciences | Method for treating hyperplasia |
| JP3213557B2 (ja) * | 1996-11-18 | 2001-10-02 | 三井農林株式会社 | 茶カテキンを有効成分として含有する尖圭コンジローマ治療剤 |
| EP1014969B1 (de) * | 1997-09-09 | 2008-11-12 | Rutgers, The State University of New Jersey | Proanthocyanidinhaltiges pflanzenextrakt für die hemmung von p-type fimbriae-bakterieller adhäsion an oberflächen |
| US6060235A (en) * | 1997-09-19 | 2000-05-09 | Geltex Pharmaceuticals, Inc. | Antiviral polymers comprising acid functional groups and hydrophobic groups |
| WO2000047062A2 (en) * | 1999-02-01 | 2000-08-17 | Shaman Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same |
| US6369241B1 (en) | 1999-04-26 | 2002-04-09 | Sarawak Medichem Pharmaceuticals, Inc. | Methods for preparing antiviral calanolide compounds |
| US6555523B1 (en) | 1999-07-08 | 2003-04-29 | Patrick T. Prendergast | Use of cirsiliol and derivatives to treat infections |
| EP1143807A3 (de) * | 1999-08-13 | 2002-09-11 | Dry Creek Nutrition, Inc. | Neue polyphenolische polymerische zusammensetzungen, verfahren zu deren isolierung, und verfahren zur modifizierung und verbesserung der geschmacklichen merkmale eines essbaren produktes |
| US6210681B1 (en) | 1999-09-07 | 2001-04-03 | Jlb, Inc. | Plant proanthocyanidin extracts |
| JP4963338B2 (ja) * | 1999-10-20 | 2012-06-27 | 株式会社ダイセル | たばこ煙用エレメント及びその製造方法 |
| US6391330B1 (en) | 2000-05-11 | 2002-05-21 | Michael A. Ross | Proanthocyanidins and ascorbic acid composition for topical application to human respiratory and oral mucosa |
| US7306815B2 (en) * | 2000-08-31 | 2007-12-11 | Phenolics, Llc | Compositions enriched in phenolic compounds and methods for producing the same |
| WO2002017945A1 (en) * | 2000-08-31 | 2002-03-07 | Hauser, Inc. | Efficient method for producing compositions enriched in anthocyanins |
| US6960360B2 (en) * | 2000-08-31 | 2005-11-01 | Phenolics, Llc | Efficient method for producing compositions enriched in total phenols |
| EP1213025A1 (de) * | 2000-12-06 | 2002-06-12 | Laboratoires Serobiologiques(Societe Anonyme) | Kosmetische und/oder dermopharmazeutische Zubereitungen enthaltend Extrakte aus den Blättern der Pflanze Argania spinosa |
| US20050220753A1 (en) * | 2002-03-22 | 2005-10-06 | Beijing Jiankai Technology Co., Ltd | Hydrophilic polymers-flavoids conjugates and pharmaceutical compositions comprising them |
| WO2003092654A1 (en) | 2002-05-02 | 2003-11-13 | President And Fellows Of Harvard College | Formulations limiting spread of pulmonary infections |
| US7208183B2 (en) | 2002-10-05 | 2007-04-24 | Bobrowski Paul J | Methods and preparations of the latex from the croton species |
| US20040071793A1 (en) * | 2002-10-05 | 2004-04-15 | Bobrowski Paul J. | Oral rehydration methods and compositions |
| US8124141B2 (en) * | 2003-03-12 | 2012-02-28 | Mitsui Norin Co., Ltd. | Rapidly absorbing lipophilic skin compositions and uses therefor |
| FR2852842A1 (fr) * | 2003-03-31 | 2004-10-01 | Silab Sa | Procede de preparation d'un principe actif a partir d'exsudat de resine des fruits de daemonorops draco, compositions l'incluant et utilisations |
| US20050074510A1 (en) * | 2003-10-04 | 2005-04-07 | Bobrowski Paul J. | Topical preparations for use in treatment of anorectal disease |
| US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| JPWO2005089780A1 (ja) * | 2004-03-18 | 2008-01-31 | 有限会社梅田事務所 | 抗エイズウイルス性組成物及びウイルス感染細胞の選択的不活化方法 |
| JP2005314316A (ja) * | 2004-04-30 | 2005-11-10 | Kikkoman Corp | 抗sarsコロナウイルス剤 |
| US20070065486A1 (en) * | 2004-05-21 | 2007-03-22 | Migco Limited | Migraine remedy |
| ES2245610B1 (es) * | 2004-06-23 | 2007-03-16 | Investigacion Y Nutricion, S.L. | Producto de origen vegetal y su procedimiento de obtencion. |
| US20060073220A1 (en) * | 2004-07-08 | 2006-04-06 | Daugherty F J | Cinnamon extract enriched for polyphenols and methods of preparing same |
| US20080166426A1 (en) * | 2005-03-11 | 2008-07-10 | Gary Pekoe | Anitbacterial compositions and methods of treatment |
| US20090076132A1 (en) * | 2005-03-11 | 2009-03-19 | Gary Pekoe | Antiviral compositions and methods of treatment |
| US20060204600A1 (en) * | 2005-03-11 | 2006-09-14 | Paul Konz | Dragon's blood anti-viral materials and methods |
| SI2241318T1 (sl) * | 2006-05-01 | 2013-04-30 | Napo Pharmaceuticals, Inc. | Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| ES2616012T3 (es) | 2006-05-01 | 2017-06-09 | Napo Pharmaceuticals, Inc. | Composiciones para tratar o prevenir enfermedad inflamatoria del intestino |
| JP4892690B2 (ja) * | 2008-09-03 | 2012-03-07 | 財団法人宮崎県産業支援財団 | C型肝炎ウイルス産生抑制剤 |
| EP2391371B1 (de) | 2009-01-27 | 2014-11-26 | World Force Technologies, LLC | Virusbindendes und -hemmendes polysaccharid mit hohem molekulargewicht |
| WO2011024049A2 (en) | 2009-08-26 | 2011-03-03 | Glenmark Pharmaceuticals Ltd | Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations |
| JP5343016B2 (ja) * | 2010-01-22 | 2013-11-13 | 株式会社ロッテ | 抗インフルエンザウイルス剤及びこれを吸着、含浸、添加させてなるインフルエンザ感染抑制用品 |
| WO2012030645A1 (en) | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Respirably dry powder comprising calcium lactate, sodium chloride and leucine |
| CN103200938B (zh) | 2010-08-30 | 2018-07-31 | 普马特里克斯营业公司 | 干燥粉末配方及用于治疗肺部疾病的方法 |
| PT3470057T (pt) | 2010-09-29 | 2021-12-03 | Pulmatrix Operating Co Inc | Pós secos catiónicos compreendendo sais de magnésio |
| BR112013007304B1 (pt) | 2010-09-29 | 2021-12-14 | Pulmatrix, Inc. | Pós secos de cátion de metal monovalente para inalação |
| CN107595836A (zh) | 2010-10-31 | 2018-01-19 | 纳珀制药公司 | 用于治疗hiv相关性腹泻的方法和组合物 |
| WO2012101008A1 (en) | 2011-01-27 | 2012-08-02 | Glenmark Pharmaceuticals Limited | Process for the production of proanthocyanidin polymeric composition |
| CN107596518B (zh) | 2012-02-29 | 2021-04-23 | 普马特里克斯营业公司 | 可吸入干粉剂 |
| US20150050373A1 (en) * | 2012-03-13 | 2015-02-19 | Piramal Enterprises Limited | Herbal composition for the treatment of metabolic disorders |
| KR101349609B1 (ko) * | 2012-06-08 | 2014-01-09 | 순천향대학교 산학협력단 | 어류의 백신분석을 위한 indicator 및 이를 이용한 어류용 백신 분석방법 |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| US11857510B2 (en) | 2017-05-31 | 2024-01-02 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating congenital diarrhea disorder |
| JP7328153B2 (ja) | 2017-05-31 | 2023-08-16 | ナポ ファーマシューティカルズ インク. | 胆汁酸性下痢、小腸切除又は胆嚢除去及び短腸症候群に関連する下痢を治療するための方法及び組成物 |
| KR20210145207A (ko) * | 2019-03-29 | 2021-12-01 | 에보니크 오퍼레이션즈 게엠베하 | 헤르페스비리다에에 의해 유발된 바이러스 감염의 예방 및/또는 치료에 사용하기 위한 베리 추출물을 함유하는 제제 |
| CN114624367B (zh) * | 2020-12-14 | 2023-05-09 | 四川大学 | 一种采用固态氧鎓盐无溶剂加压提取竹叶黄酮的方法 |
| US20230060934A1 (en) * | 2021-08-25 | 2023-03-02 | Michael Wayne Dockery | Botanical antiviral nutritional supplement |
| US20250387369A1 (en) | 2022-06-10 | 2025-12-25 | Tohoku University | Antiviral Agent |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2226185A1 (en) * | 1973-04-20 | 1974-11-15 | Vincent Yves | Therapeutically active tannin fractions prepd. - from Cupressus sempervirens fruits by extracting with solvents |
| CA1086651A (en) * | 1977-12-12 | 1980-09-30 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health And Welfare Canada | Compositions for, and treatment of, herpes viral infections |
| US4335110A (en) * | 1979-08-23 | 1982-06-15 | Orewa Inc. | Pharmaceutical compositions of sanguinaria galangal and zinc chloride |
| JPS59196884A (ja) * | 1983-04-20 | 1984-11-08 | Nippon Shinyaku Co Ltd | 新規なるタンニン |
| JPS61205272A (ja) * | 1985-03-08 | 1986-09-11 | Tsumura Juntendo Inc | 新規なタンニン |
| US4698360B1 (en) * | 1985-04-09 | 1997-11-04 | D Investigations Pharmacologiq | Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof |
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| JPH0231074B2 (ja) * | 1986-08-26 | 1990-07-11 | Nippon Shinyaku Co Ltd | Shintannin |
| CA2001898A1 (en) * | 1988-10-31 | 1990-04-30 | Kuo-Hsiung Lee | Inhibition of human retroviruses |
| CA2057023A1 (fr) * | 1989-05-12 | 1990-11-13 | Leon Cariel | Composition a base de proanthocyanidols, leur application pharmacologique |
-
1991
- 1991-07-29 US US07/737,077 patent/US5211944A/en not_active Expired - Lifetime
- 1991-10-10 SG SG1996008125A patent/SG52707A1/en unknown
- 1991-10-10 AT AT91919754T patent/ATE194288T1/de not_active IP Right Cessation
- 1991-10-10 AU AU88780/91A patent/AU660631B2/en not_active Expired
- 1991-10-10 EP EP91919754A patent/EP0553253B1/de not_active Expired - Lifetime
- 1991-10-10 CA CA002093825A patent/CA2093825C/en not_active Expired - Lifetime
- 1991-10-10 DE DE69132289T patent/DE69132289D1/de not_active Expired - Lifetime
- 1991-10-10 WO PCT/US1991/007679 patent/WO1992006695A1/en not_active Ceased
- 1991-10-10 JP JP51851291A patent/JP3448052B2/ja not_active Expired - Lifetime
- 1991-10-11 NZ NZ240200A patent/NZ240200A/en unknown
- 1991-10-11 MX MX9101540A patent/MX9101540A/es unknown
-
1994
- 1994-02-09 US US08/194,779 patent/US5494661A/en not_active Expired - Lifetime
-
1999
- 1999-11-01 KR KR1019930701100A patent/KR100207949B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| MX9101540A (es) | 1992-06-05 |
| CA2093825C (en) | 2003-01-07 |
| EP0553253A1 (de) | 1993-08-04 |
| AU660631B2 (en) | 1995-07-06 |
| EP0553253B1 (de) | 2000-07-05 |
| US5211944A (en) | 1993-05-18 |
| WO1992006695A1 (en) | 1992-04-30 |
| KR100207949B1 (ko) | 1999-07-15 |
| NZ240200A (en) | 1994-04-27 |
| DE69132289D1 (de) | 2000-08-10 |
| KR930702010A (ko) | 1993-09-08 |
| AU8878091A (en) | 1992-05-20 |
| EP0553253A4 (en) | 1993-09-15 |
| JP3448052B2 (ja) | 2003-09-16 |
| US5494661A (en) | 1996-02-27 |
| CA2093825A1 (en) | 1992-04-13 |
| JPH06502413A (ja) | 1994-03-17 |
| SG52707A1 (en) | 1998-09-28 |
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