ATE194388T1 - Stereoselektive herstellung von 2-substituierten succinatderivaten - Google Patents
Stereoselektive herstellung von 2-substituierten succinatderivatenInfo
- Publication number
- ATE194388T1 ATE194388T1 AT96941546T AT96941546T ATE194388T1 AT E194388 T1 ATE194388 T1 AT E194388T1 AT 96941546 T AT96941546 T AT 96941546T AT 96941546 T AT96941546 T AT 96941546T AT E194388 T1 ATE194388 T1 AT E194388T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- compounds
- alk
- thiazolyl
- Prior art date
Links
- 230000000707 stereoselective effect Effects 0.000 title 1
- 150000003890 succinate salts Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- -1 2-amino-4-thiazolyl Chemical group 0.000 abstract 1
- KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/40—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002165996A CA2165996C (en) | 1995-12-22 | 1995-12-22 | Stereoselective preparation of 2-substituted succinic derivatives |
| PCT/CA1996/000852 WO1997023641A1 (en) | 1995-12-22 | 1996-12-17 | Stereoselective preparation of 2-substituted succinic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194388T1 true ATE194388T1 (de) | 2000-07-15 |
Family
ID=4157228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96941546T ATE194388T1 (de) | 1995-12-22 | 1996-12-17 | Stereoselektive herstellung von 2-substituierten succinatderivaten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5808085A (de) |
| EP (1) | EP0882138B1 (de) |
| JP (1) | JP4030583B2 (de) |
| AT (1) | ATE194388T1 (de) |
| CA (1) | CA2165996C (de) |
| DE (1) | DE69609202T2 (de) |
| DK (1) | DK0882138T3 (de) |
| ES (1) | ES2147944T3 (de) |
| GR (1) | GR3034465T3 (de) |
| MX (1) | MX9805061A (de) |
| PT (1) | PT882138E (de) |
| WO (1) | WO1997023641A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6232958B1 (en) | 1998-12-29 | 2001-05-15 | Microsoft Corporation | Input device with multiplexed switches |
| US11999757B2 (en) | 2017-11-01 | 2024-06-04 | Melinta Subsidiary Corp. | Synthesis of boronate ester derivatives and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5275950A (en) * | 1990-05-11 | 1994-01-04 | Abbott Laboratories | Process for the preparation of a renin inhibiting compound |
| US5215918A (en) * | 1992-06-19 | 1993-06-01 | Bend Research, Inc. | Enantiomeric enrichment of (R,S)-3-quinuclidinol |
| RU95113586A (ru) * | 1992-09-25 | 1997-01-10 | Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA) | Производные n-/2-амино-2-оксоэтил/бугандиамида или их кислотноаддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина |
| US5420283A (en) * | 1993-08-02 | 1995-05-30 | Pfizer Inc. | Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide |
| US5508466A (en) * | 1994-04-13 | 1996-04-16 | G.D. Searle & Co. | Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent |
-
1995
- 1995-12-22 CA CA002165996A patent/CA2165996C/en not_active Expired - Fee Related
-
1996
- 1996-12-17 US US08/767,917 patent/US5808085A/en not_active Expired - Lifetime
- 1996-12-17 PT PT96941546T patent/PT882138E/pt unknown
- 1996-12-17 DE DE69609202T patent/DE69609202T2/de not_active Expired - Lifetime
- 1996-12-17 DK DK96941546T patent/DK0882138T3/da active
- 1996-12-17 EP EP96941546A patent/EP0882138B1/de not_active Expired - Lifetime
- 1996-12-17 AT AT96941546T patent/ATE194388T1/de active
- 1996-12-17 ES ES96941546T patent/ES2147944T3/es not_active Expired - Lifetime
- 1996-12-17 WO PCT/CA1996/000852 patent/WO1997023641A1/en not_active Ceased
- 1996-12-17 JP JP52317097A patent/JP4030583B2/ja not_active Expired - Fee Related
-
1998
- 1998-06-22 MX MX9805061A patent/MX9805061A/es not_active IP Right Cessation
-
2000
- 2000-09-21 GR GR20000402154T patent/GR3034465T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5808085A (en) | 1998-09-15 |
| DK0882138T3 (da) | 2000-11-20 |
| WO1997023641A1 (en) | 1997-07-03 |
| ES2147944T3 (es) | 2000-10-01 |
| DE69609202T2 (de) | 2001-03-01 |
| EP0882138A1 (de) | 1998-12-09 |
| JP4030583B2 (ja) | 2008-01-09 |
| DE69609202D1 (de) | 2000-08-10 |
| CA2165996C (en) | 2002-01-29 |
| CA2165996A1 (en) | 1997-06-23 |
| PT882138E (pt) | 2000-10-31 |
| JP2000502259A (ja) | 2000-02-29 |
| MX9805061A (es) | 1998-10-31 |
| GR3034465T3 (en) | 2000-12-29 |
| EP0882138B1 (de) | 2000-07-05 |
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