NO951134L - N-(hydroksyletyl) butandiamed-derivater som renin-inhibitorer - Google Patents
N-(hydroksyletyl) butandiamed-derivater som renin-inhibitorerInfo
- Publication number
- NO951134L NO951134L NO951134A NO951134A NO951134L NO 951134 L NO951134 L NO 951134L NO 951134 A NO951134 A NO 951134A NO 951134 A NO951134 A NO 951134A NO 951134 L NO951134 L NO 951134L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- lower alkyl
- thiazolylmethyl
- cyclohexylmethyl
- phenyl
- Prior art date
Links
- -1 hydroxylethyl Chemical group 0.000 title abstract 5
- 239000002461 renin inhibitor Substances 0.000 title 1
- 229940086526 renin-inhibitors Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 abstract 1
- 102000004881 Angiotensinogen Human genes 0.000 abstract 1
- 108090001067 Angiotensinogen Proteins 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Det beskrives forbindelser med formel: A-NfRMCfOJCHjCHfR^CfOJ-B, hvor A er et oksygen-bærende radikal valgt fra gruppen bestående av: (a) HO-CH(R3)CH2 hvor R1 for eksempel er hydrogen, lavere alkyl, lavere cykloalkyl, fenyl eller en usubstituert fem- eller seks-leddet hetero- cyklisk ring som inneholder ett eller to heteroatomer valgt fra N, O eller S; (b) HO-CH2CH(R4) hvor R4 for eksempel er lavere alkyl eller fenyl(lavere)alkyl; og (c) HO-CR5(R6)CH2 hvor hver av R5 og Rs er lavere alkyl; eller R5 og Rs sammen med karbonatomet som de er tilknyttet, danner l,l-(lavere cyklo- alkandiyl), l,l-(4-hydroksycykloheksandiyl) eller l,l-(4- oksocykloheksandiyl); (d) (lavere alkoksyJCR^R^jCHj hvor hver av R5A og R6A er lavere alkyl; eller R5A og R" sammen med karbonatomet som de er tilknyttet, danner l,l-(lavere cyklo- alkandiyl); og (e) (lavere alkyl)C(0)CH2; R1 er for eksempel benzyl, alkyl, substituert alkyl som f.eks. cykloheksylmetyl eller R'R8NC(O)CH2, hvor R7 og R" er alkyl som f.eks. metyl eller etyl; R2 er for eksempel alkyl, cykloalkylmetyl, 1H- imidazol-4-ylmetyl, 4-tiazolylmetyl eller (2-amino-4- tiazolyljmetyl; og B er et reninsubstrat-overgangstilstands- mimetikum, for eksempel [l(S)-(cykloheksylmetyl)-2(R),3(S)- dihydroksy-5-metylheksyl]amino. Forbindelsene inhiberer renin- aktivitet og er indisert ved behandling av hypertensjon og kongestiv hjertesvikt.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95125092A | 1992-09-25 | 1992-09-25 | |
| PCT/CA1993/000379 WO1994007845A1 (en) | 1992-09-25 | 1993-09-15 | N-(hydroxyethyl)butanediamide derivatives as renin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO951134D0 NO951134D0 (no) | 1995-03-24 |
| NO951134L true NO951134L (no) | 1995-03-24 |
Family
ID=25683065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO951134A NO951134L (no) | 1992-09-25 | 1995-03-24 | N-(hydroksyletyl) butandiamed-derivater som renin-inhibitorer |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO951134L (no) |
-
1995
- 1995-03-24 NO NO951134A patent/NO951134L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO951134D0 (no) | 1995-03-24 |
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