DK0882138T3 - Stereoselektiv fremstilling af 2-substituerede ravsyrederivater - Google Patents

Stereoselektiv fremstilling af 2-substituerede ravsyrederivater

Info

Publication number
DK0882138T3
DK0882138T3 DK96941546T DK96941546T DK0882138T3 DK 0882138 T3 DK0882138 T3 DK 0882138T3 DK 96941546 T DK96941546 T DK 96941546T DK 96941546 T DK96941546 T DK 96941546T DK 0882138 T3 DK0882138 T3 DK 0882138T3
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
compounds
substituted succinic
alk
Prior art date
Application number
DK96941546T
Other languages
English (en)
Inventor
Murray Douglas Bailey
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Application granted granted Critical
Publication of DK0882138T3 publication Critical patent/DK0882138T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00Separation of optically-active compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62Halogen-containing esters
    • C07C69/65Halogen-containing esters of unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/40Unsubstituted amino or imino radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96941546T 1995-12-22 1996-12-17 Stereoselektiv fremstilling af 2-substituerede ravsyrederivater DK0882138T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002165996A CA2165996C (en) 1995-12-22 1995-12-22 Stereoselective preparation of 2-substituted succinic derivatives
PCT/CA1996/000852 WO1997023641A1 (en) 1995-12-22 1996-12-17 Stereoselective preparation of 2-substituted succinic derivatives

Publications (1)

Publication Number Publication Date
DK0882138T3 true DK0882138T3 (da) 2000-11-20

Family

ID=4157228

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96941546T DK0882138T3 (da) 1995-12-22 1996-12-17 Stereoselektiv fremstilling af 2-substituerede ravsyrederivater

Country Status (12)

Country Link
US (1) US5808085A (da)
EP (1) EP0882138B1 (da)
JP (1) JP4030583B2 (da)
AT (1) ATE194388T1 (da)
CA (1) CA2165996C (da)
DE (1) DE69609202T2 (da)
DK (1) DK0882138T3 (da)
ES (1) ES2147944T3 (da)
GR (1) GR3034465T3 (da)
MX (1) MX9805061A (da)
PT (1) PT882138E (da)
WO (1) WO1997023641A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6232958B1 (en) 1998-12-29 2001-05-15 Microsoft Corporation Input device with multiplexed switches
CN111556872B (zh) 2017-11-01 2024-05-10 梅琳塔治疗公司 硼酸酯衍生物的合成及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5215918A (en) * 1992-06-19 1993-06-01 Bend Research, Inc. Enantiomeric enrichment of (R,S)-3-quinuclidinol
NZ255301A (en) * 1992-09-25 1997-05-26 Bio Mega Boehringer Ingelheim N-(2-amino-2-oxoethyl)butanediamide derivatives, preparation and pharmaceutical compositions thereof
US5420283A (en) * 1993-08-02 1995-05-30 Pfizer Inc. Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
US5508466A (en) * 1994-04-13 1996-04-16 G.D. Searle & Co. Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent

Also Published As

Publication number Publication date
DE69609202D1 (de) 2000-08-10
JP2000502259A (ja) 2000-02-29
GR3034465T3 (en) 2000-12-29
US5808085A (en) 1998-09-15
EP0882138B1 (en) 2000-07-05
WO1997023641A1 (en) 1997-07-03
ATE194388T1 (de) 2000-07-15
CA2165996A1 (en) 1997-06-23
PT882138E (pt) 2000-10-31
EP0882138A1 (en) 1998-12-09
CA2165996C (en) 2002-01-29
JP4030583B2 (ja) 2008-01-09
DE69609202T2 (de) 2001-03-01
MX9805061A (es) 1998-10-31
ES2147944T3 (es) 2000-10-01

Similar Documents

Publication Publication Date Title
TR200102957T2 (tr) Sitalopram hazırlanması için metod.
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
FI960751A0 (fi) Substituoidut atsaindolylideeniyhdisteet ja menetelmä niiden valmistamiseksi
IE801713L (en) N-(3-mercapto-2-alkyl-1-oxopropyl)-2,¹3-dihydro-1h-indole-2-carboxylic acids
ATE19513T1 (de) Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
DK116480A (da) Fremgangsmaade til fremstilling af substituerede chromoner
PT918776E (pt) Sintese total de acilfulvenos antitumorais
DK0868182T3 (da) Fremgangsmåde til fremstilling af piperidinderivater
DK0510003T3 (da) Piperidin-og pyrrolidinderivater
DK1021405T3 (da) Azetidinonderivater til behandling af HCMV-infektioner
AU1198897A (en) 1-benzenesulfonyl pyrrolidine derivatives as bradykinin receptor antagonists
ES2138623T3 (es) Derivados de pleuromutilina.
DK0882138T3 (da) Stereoselektiv fremstilling af 2-substituerede ravsyrederivater
JPS5750989A (en) Imidazole compound
NO940018D0 (no) Fremgangsmaate for fremstilling av svovelholdige imidazolderivater
DE69201184D1 (de) 5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.
NO950387L (no) Nye tiazin- eller tiomorfolinderivater
EA200101050A1 (ru) Замещенные бензолактамные соединения
KR960007560A (ko) 신규한 아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도
GB2005250A (en) (1-Alkylpyrrolyl-2)thio- acetamides
IL80525A (en) Preparation of indolines by cyclodehydrating 2-(2'-aminoethylphenyl)-ethanol in the presence of amorphous aluminium silicate catalyst
AU561149B2 (en) Cardiotonic 4-semicarbazide quindyolines
ATE185347T1 (de) Hydroxyschutzgruppe entfernung in penemen