DK0882138T3 - Stereoselektiv fremstilling af 2-substituerede ravsyrederivater - Google Patents

Stereoselektiv fremstilling af 2-substituerede ravsyrederivater

Info

Publication number
DK0882138T3
DK0882138T3 DK96941546T DK96941546T DK0882138T3 DK 0882138 T3 DK0882138 T3 DK 0882138T3 DK 96941546 T DK96941546 T DK 96941546T DK 96941546 T DK96941546 T DK 96941546T DK 0882138 T3 DK0882138 T3 DK 0882138T3
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
compounds
substituted succinic
alk
Prior art date
Application number
DK96941546T
Other languages
English (en)
Inventor
Murray Douglas Bailey
Original Assignee
Boehringer Ingelheim Ca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Ca Ltd filed Critical Boehringer Ingelheim Ca Ltd
Application granted granted Critical
Publication of DK0882138T3 publication Critical patent/DK0882138T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK96941546T 1995-12-22 1996-12-17 Stereoselektiv fremstilling af 2-substituerede ravsyrederivater DK0882138T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002165996A CA2165996C (en) 1995-12-22 1995-12-22 Stereoselective preparation of 2-substituted succinic derivatives
PCT/CA1996/000852 WO1997023641A1 (en) 1995-12-22 1996-12-17 Stereoselective preparation of 2-substituted succinic derivatives

Publications (1)

Publication Number Publication Date
DK0882138T3 true DK0882138T3 (da) 2000-11-20

Family

ID=4157228

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96941546T DK0882138T3 (da) 1995-12-22 1996-12-17 Stereoselektiv fremstilling af 2-substituerede ravsyrederivater

Country Status (12)

Country Link
US (1) US5808085A (da)
EP (1) EP0882138B1 (da)
JP (1) JP4030583B2 (da)
AT (1) ATE194388T1 (da)
CA (1) CA2165996C (da)
DE (1) DE69609202T2 (da)
DK (1) DK0882138T3 (da)
ES (1) ES2147944T3 (da)
GR (1) GR3034465T3 (da)
MX (1) MX9805061A (da)
PT (1) PT882138E (da)
WO (1) WO1997023641A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6232958B1 (en) 1998-12-29 2001-05-15 Microsoft Corporation Input device with multiplexed switches
US11999757B2 (en) 2017-11-01 2024-06-04 Melinta Subsidiary Corp. Synthesis of boronate ester derivatives and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5215918A (en) * 1992-06-19 1993-06-01 Bend Research, Inc. Enantiomeric enrichment of (R,S)-3-quinuclidinol
RU95113586A (ru) * 1992-09-25 1997-01-10 Био-Мега/Берингер Ингельхейм Рисерч Инк. (CA) Производные n-/2-амино-2-оксоэтил/бугандиамида или их кислотноаддитивные соли и фармацевтическая композиция со свойствами ингибитора ренина
US5420283A (en) * 1993-08-02 1995-05-30 Pfizer Inc. Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
US5508466A (en) * 1994-04-13 1996-04-16 G.D. Searle & Co. Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent

Also Published As

Publication number Publication date
US5808085A (en) 1998-09-15
WO1997023641A1 (en) 1997-07-03
ES2147944T3 (es) 2000-10-01
DE69609202T2 (de) 2001-03-01
EP0882138A1 (en) 1998-12-09
JP4030583B2 (ja) 2008-01-09
DE69609202D1 (de) 2000-08-10
CA2165996C (en) 2002-01-29
ATE194388T1 (de) 2000-07-15
CA2165996A1 (en) 1997-06-23
PT882138E (pt) 2000-10-31
JP2000502259A (ja) 2000-02-29
MX9805061A (es) 1998-10-31
GR3034465T3 (en) 2000-12-29
EP0882138B1 (en) 2000-07-05

Similar Documents

Publication Publication Date Title
TR200102957T2 (tr) Sitalopram hazırlanması için metod.
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
FI960751A0 (fi) Substituoidut atsaindolylideeniyhdisteet ja menetelmä niiden valmistamiseksi
IE801713L (en) N-(3-mercapto-2-alkyl-1-oxopropyl)-2,¹3-dihydro-1h-indole-2-carboxylic acids
ATE19513T1 (de) Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel.
DK116480A (da) Fremgangsmaade til fremstilling af substituerede chromoner
PT918776E (pt) Sintese total de acilfulvenos antitumorais
DK0868182T3 (da) Fremgangsmåde til fremstilling af piperidinderivater
DK0510003T3 (da) Piperidin-og pyrrolidinderivater
DK1021405T3 (da) Azetidinonderivater til behandling af HCMV-infektioner
AU6179886A (en) Angiotensin converting enzyme inhibitors
DK0711291T3 (da) N-(Piperidinyl-1-alkyl)-substituerede cyclohexancarboxylsyreamider som 5-HT1A-receptorantagonister
US4772694A (en) Chiral 3-(1,2,5-trisubstituted imidazolidinone) azetidinone antibiotic intermediates
ATE206418T1 (de) 1-benzolsulfonylpyrrolidinderivate als bradykinin rezeptor antagonisten
ES2138623T3 (es) Derivados de pleuromutilina.
JPS5750989A (en) Imidazole compound
GR3034465T3 (en) Stereoselective preparation of 2-substituted succinic derivatives
NO940018D0 (no) Fremgangsmaate for fremstilling av svovelholdige imidazolderivater
DE69201184D1 (de) 5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.
NO950387L (no) Nye tiazin- eller tiomorfolinderivater
EA200101050A1 (ru) Замещенные бензолактамные соединения
KR960007560A (ko) 신규한 아민 유도체, 그의 제조방법 및 항부정맥제로서의 용도
AU561149B2 (en) Cardiotonic 4-semicarbazide quindyolines
GB2005250A (en) (1-Alkylpyrrolyl-2)thio- acetamides
IL80525A (en) Preparation of indolines by cyclodehydrating 2-(2'-aminoethylphenyl)-ethanol in the presence of amorphous aluminium silicate catalyst