ATE194389T1 - Verwendung bestimmter verbindungen als proben zum nachweis der antitubulinwirkung, sowie zur überwachung der resistenz - Google Patents
Verwendung bestimmter verbindungen als proben zum nachweis der antitubulinwirkung, sowie zur überwachung der resistenzInfo
- Publication number
- ATE194389T1 ATE194389T1 AT97308903T AT97308903T ATE194389T1 AT E194389 T1 ATE194389 T1 AT E194389T1 AT 97308903 T AT97308903 T AT 97308903T AT 97308903 T AT97308903 T AT 97308903T AT E194389 T1 ATE194389 T1 AT E194389T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrogen atom
- antitubulin
- samples
- haloalkynyl
- haloalkenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 238000012544 monitoring process Methods 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000004243 Tubulin Human genes 0.000 abstract 1
- 108090000704 Tubulin Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 cyano, thiocyano, isothiocyano Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000000159 protein binding assay Methods 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3092096P | 1996-11-14 | 1996-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE194389T1 true ATE194389T1 (de) | 2000-07-15 |
Family
ID=21856707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97308903T ATE194389T1 (de) | 1996-11-14 | 1997-11-06 | Verwendung bestimmter verbindungen als proben zum nachweis der antitubulinwirkung, sowie zur überwachung der resistenz |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0843018B1 (de) |
| JP (1) | JP3980727B2 (de) |
| KR (1) | KR19980042316A (de) |
| CN (1) | CN1136451C (de) |
| AT (1) | ATE194389T1 (de) |
| AU (1) | AU748274C (de) |
| CA (1) | CA2219872C (de) |
| DE (1) | DE69702433T2 (de) |
| ES (1) | ES2148906T3 (de) |
| IL (1) | IL122082A (de) |
| TW (1) | TW495609B (de) |
| ZA (1) | ZA979542B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1229037A1 (de) * | 1996-06-28 | 2002-08-07 | Dow AgroSciences LLC | Heterocyclische N-Acetonylbenzamide und ihre Verwendung als Fungizide |
| US6500405B1 (en) * | 1996-11-14 | 2002-12-31 | Dow Agrosciences Llc | Use of certain amides as probes for detection of antitubulin activity and resistance monitoring |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| CN114835584B (zh) * | 2022-06-07 | 2024-08-09 | 浙江金立源药业有限公司 | 3-甲基-4-硝基苯甲酸与醇酯化反应后处理的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863940A (en) * | 1984-07-26 | 1989-09-05 | Rohm And Haas | N-acetonyl-substituted amides and phytopathogenic fungicidal use thereof |
| ATE165168T1 (de) * | 1994-03-29 | 1998-05-15 | Lepetit Spa | Festphasenimmunoassay zum nachweis von inhibitoren von einem proteolytischen enzym |
| WO1996011398A1 (en) * | 1994-10-07 | 1996-04-18 | Merck & Co., Inc. | Process for assessing tubulin protein polymerization |
-
1997
- 1997-10-24 ZA ZA9709542A patent/ZA979542B/xx unknown
- 1997-10-31 IL IL12208297A patent/IL122082A/xx not_active IP Right Cessation
- 1997-10-31 AU AU43654/97A patent/AU748274C/en not_active Ceased
- 1997-10-31 CA CA002219872A patent/CA2219872C/en not_active Expired - Fee Related
- 1997-11-04 TW TW086116369A patent/TW495609B/zh not_active IP Right Cessation
- 1997-11-06 DE DE69702433T patent/DE69702433T2/de not_active Expired - Lifetime
- 1997-11-06 ES ES97308903T patent/ES2148906T3/es not_active Expired - Lifetime
- 1997-11-06 AT AT97308903T patent/ATE194389T1/de not_active IP Right Cessation
- 1997-11-06 EP EP97308903A patent/EP0843018B1/de not_active Expired - Lifetime
- 1997-11-12 KR KR1019970059436A patent/KR19980042316A/ko not_active Ceased
- 1997-11-13 CN CNB971226911A patent/CN1136451C/zh not_active Expired - Fee Related
- 1997-11-14 JP JP33110397A patent/JP3980727B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA979542B (en) | 1998-05-12 |
| EP0843018A1 (de) | 1998-05-20 |
| CA2219872C (en) | 2007-09-25 |
| CN1211736A (zh) | 1999-03-24 |
| DE69702433T2 (de) | 2001-03-08 |
| CA2219872A1 (en) | 1998-05-14 |
| ES2148906T3 (es) | 2000-10-16 |
| CN1136451C (zh) | 2004-01-28 |
| AU4365497A (en) | 1998-05-21 |
| TW495609B (en) | 2002-07-21 |
| AU748274B2 (en) | 2002-05-30 |
| DE69702433D1 (de) | 2000-08-10 |
| IL122082A0 (en) | 1998-03-10 |
| AU748274C (en) | 2003-03-27 |
| KR19980042316A (ko) | 1998-08-17 |
| IL122082A (en) | 2000-10-31 |
| JPH10160732A (ja) | 1998-06-19 |
| EP0843018B1 (de) | 2000-07-05 |
| JP3980727B2 (ja) | 2007-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |