ATE194976T1 - Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen - Google Patents

Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen

Info

Publication number: ATE194976T1
Authority: AT; Austria
Prior art keywords: beta; amidinophenyl; producing; pyrrolidine; substituted ureas
Prior art date: 1994-12-05

Application number

AT95940016T

Other languages

English (en)

Inventor

Norman Anthony Abood

Daniel Lee Flynn

Scott Anthony Laneman

Roger Nosal

Lori Ann Schretzman

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-05

Filing date

1995-12-04

Publication date

2000-08-15

1995-12-04 Application filed by Searle & Co filed Critical Searle & Co

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE194976T1 publication Critical patent/ATE194976T1/de

Links

229940000635 beta-alanine Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000003672 ureas Chemical class 0.000 title 1
-1 trimethylsulfonium halide Chemical class 0.000 abstract 4
DSJRMYGLIXGHHM-UHFFFAOYSA-N 3-aminopropanoic acid;urea Chemical class NC(N)=O.NCCC(O)=O DSJRMYGLIXGHHM-UHFFFAOYSA-N 0.000 abstract 2
150000002742 methionines Chemical class 0.000 abstract 2
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
229960004676 antithrombotic agent Drugs 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000003951 lactams Chemical class 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

AT95940016T 1994-12-05 1995-12-04 Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen ATE194976T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/349,333 US5610296A (en)	1994-12-05	1994-12-05	Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs
PCT/US1995/014948 WO1996017827A1 (en)	1994-12-05	1995-12-04	PROCESS FOR THE PREPARATION OF AMIDINO PHENYL PYRROLIDINE β-ALANINE UREA ANALOGS

Publications (1)

Publication Number	Publication Date
ATE194976T1 true ATE194976T1 (de)	2000-08-15

Family

ID=23371935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95940016T ATE194976T1 (de)	1994-12-05	1995-12-04	Verfahren zur herstellung von n-(amidinophenyl pyrrolidin)-n'-beta-alanin-substituierten harnstoffen

Country Status (11)

Country	Link
US (4)	US5610296A (de)
EP (1)	EP0796245B1 (de)
JP (1)	JPH10509960A (de)
AT (1)	ATE194976T1 (de)
AU (1)	AU4163696A (de)
DE (1)	DE69518164T2 (de)
DK (1)	DK0796245T3 (de)
ES (1)	ES2150592T3 (de)
GR (1)	GR3034516T3 (de)
PT (1)	PT796245E (de)
WO (1)	WO1996017827A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL125859A0 (en) *	1996-03-28	1999-04-11	Glaxo Group Ltd	Pyrrolopyrrolone derivatives useful as inhibitors of neutrophil elastase
ZA988469B (en) *	1997-09-17	1999-03-17	Biocryst Pharm Inc	Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors
ZA988735B (en)	1997-10-06	2000-03-23	Du Pont Pharm Co	An efficient method for the conversion of nitriles to amidines.
US5986107A (en) *	1998-04-08	1999-11-16	G. D. Searle & Co.	Process for the preparation of a 2-oxopyrrolidine compound
US6025358A (en) *	1998-06-11	2000-02-15	G. D. Searle & Co.	Double prodrugs of potent GP IIb/IIIa antagonists
DE19841895A1 (de) *	1998-09-11	2000-03-23	Degussa	Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
US6723711B2 (en)	1999-05-07	2004-04-20	Texas Biotechnology Corporation	Propanoic acid derivatives that inhibit the binding of integrins to their receptors
RU2263109C2 (ru) *	1999-05-07	2005-10-27	Тексэс Байотекнолоджи Копэрейшн	ПРОИЗВОДНЫЕ КАРБОНОВЫХ КИСЛОТ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СЕЛЕКТИВНОГО ИНГИБИРОВАНИЯ СВЯЗЫВАНИЯ α4β1 ИНТЕГРИНА У МЛЕКОПИТАЮЩЕГО
US6972296B2 (en) *	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
RU2195447C1 (ru) *	2001-07-31	2002-12-27	Кубанский государственный технологический университет	1-(4-нитрофенил)-4-n-x-аминопирролидоны-2, проявляющие рострегулирующую и антистрессовую активность, и способ их получения
SI21096B (sl) *	2001-10-09	2012-05-31	Encysive Pharmaceuticals Inc	Derivati karboksilne kisline ki inhibirajo vezavo integrinov na njihove receptorje
AU2002365132A1 (en)	2001-10-17	2003-07-15	Bristol-Myers Squibb Company	BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-Alpha CONVERTING ENZYME (TACE)
EP2192905A4 (de)	2007-08-29	2010-11-10	Adam Lubin	Verfahren zur selektiven behandlung von erkrankungen
ES2690315T3 (es)	2012-06-15	2018-11-20	Mitsubishi Tanabe Pharma Corporation	Compuestos de imidazol y triazol como inhibidores de DGAT-1
CN111440149A (zh) *	2020-03-31	2020-07-24	浙江美诺华药物化学有限公司	一种达比加群酯中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL55573A0 (en) *	1977-10-03	1978-12-17	Erba Carlo Spa	Substituted n-(ss-alkoxy-ethyl)-n-(4-phenoxybenzyl)-dichloroacetamides and process for their preparation
US5239113A (en) *	1991-10-15	1993-08-24	Monsanto Company	Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
DE69425431T2 (de) *	1993-03-31	2001-02-08	G.D. Searle & Co., Chicago	1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren

1994
- 1994-12-05 US US08/349,333 patent/US5610296A/en not_active Expired - Fee Related
1995
- 1995-06-05 US US08/465,212 patent/US5576447A/en not_active Expired - Fee Related
- 1995-06-05 US US08/463,657 patent/US5484946A/en not_active Expired - Fee Related
- 1995-06-06 US US08/467,417 patent/US5659063A/en not_active Expired - Fee Related
- 1995-12-04 AU AU41636/96A patent/AU4163696A/en not_active Abandoned
- 1995-12-04 ES ES95940016T patent/ES2150592T3/es not_active Expired - Lifetime
- 1995-12-04 JP JP8517599A patent/JPH10509960A/ja not_active Abandoned
- 1995-12-04 DE DE69518164T patent/DE69518164T2/de not_active Expired - Fee Related
- 1995-12-04 AT AT95940016T patent/ATE194976T1/de not_active IP Right Cessation
- 1995-12-04 WO PCT/US1995/014948 patent/WO1996017827A1/en not_active Ceased
- 1995-12-04 EP EP95940016A patent/EP0796245B1/de not_active Expired - Lifetime
- 1995-12-04 DK DK95940016T patent/DK0796245T3/da active
- 1995-12-04 PT PT95940016T patent/PT796245E/pt unknown
2000
- 2000-09-29 GR GR20000402206T patent/GR3034516T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0796245B1 (de)	2000-07-26
JPH10509960A (ja)	1998-09-29
US5610296A (en)	1997-03-11
DE69518164T2 (de)	2001-03-22
GR3034516T3 (en)	2000-12-29
EP0796245A1 (de)	1997-09-24
AU4163696A (en)	1996-06-26
PT796245E (pt)	2000-12-29
US5576447A (en)	1996-11-19
WO1996017827A1 (en)	1996-06-13
US5659063A (en)	1997-08-19
US5484946A (en)	1996-01-16
ES2150592T3 (es)	2000-12-01
DK0796245T3 (da)	2000-09-11
DE69518164D1 (de)	2000-08-31

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Legal Events

Date	Code	Title	Description
2007-09-15	REN	Ceased due to non-payment of the annual fee