DK0796245T3 - Fremgangsmåde til fremstilling af amidinophenyl-pyrrolidin-betaalanin-urinstof-analoge - Google Patents

Fremgangsmåde til fremstilling af amidinophenyl-pyrrolidin-betaalanin-urinstof-analoge

Info

Publication number
DK0796245T3
DK0796245T3 DK95940016T DK95940016T DK0796245T3 DK 0796245 T3 DK0796245 T3 DK 0796245T3 DK 95940016 T DK95940016 T DK 95940016T DK 95940016 T DK95940016 T DK 95940016T DK 0796245 T3 DK0796245 T3 DK 0796245T3
Authority
DK
Denmark
Prior art keywords
beta
amidinophenyl
preparation
uranium
pyrrolidine
Prior art date
Application number
DK95940016T
Other languages
English (en)
Inventor
Roger Nosal
Norman Anthony Abood
Daniel Lee Flynn
Scott Anthony Laneman
Lori Ann Schretzman
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0796245T3 publication Critical patent/DK0796245T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK95940016T 1994-12-05 1995-12-04 Fremgangsmåde til fremstilling af amidinophenyl-pyrrolidin-betaalanin-urinstof-analoge DK0796245T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/349,333 US5610296A (en) 1994-12-05 1994-12-05 Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs
PCT/US1995/014948 WO1996017827A1 (en) 1994-12-05 1995-12-04 PROCESS FOR THE PREPARATION OF AMIDINO PHENYL PYRROLIDINE β-ALANINE UREA ANALOGS

Publications (1)

Publication Number Publication Date
DK0796245T3 true DK0796245T3 (da) 2000-09-11

Family

ID=23371935

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95940016T DK0796245T3 (da) 1994-12-05 1995-12-04 Fremgangsmåde til fremstilling af amidinophenyl-pyrrolidin-betaalanin-urinstof-analoge

Country Status (11)

Country Link
US (4) US5610296A (da)
EP (1) EP0796245B1 (da)
JP (1) JPH10509960A (da)
AT (1) ATE194976T1 (da)
AU (1) AU4163696A (da)
DE (1) DE69518164T2 (da)
DK (1) DK0796245T3 (da)
ES (1) ES2150592T3 (da)
GR (1) GR3034516T3 (da)
PT (1) PT796245E (da)
WO (1) WO1996017827A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL125859A0 (en) * 1996-03-28 1999-04-11 Glaxo Group Ltd Pyrrolopyrrolone derivatives useful as inhibitors of neutrophil elastase
ZA988469B (en) * 1997-09-17 1999-03-17 Biocryst Pharm Inc Pyrrolidin-2-one compounds and their use as neuraminidase inhibitors
ZA988735B (en) 1997-10-06 2000-03-23 Du Pont Pharm Co An efficient method for the conversion of nitriles to amidines.
US5986107A (en) * 1998-04-08 1999-11-16 G. D. Searle & Co. Process for the preparation of a 2-oxopyrrolidine compound
US6025358A (en) * 1998-06-11 2000-02-15 G. D. Searle & Co. Double prodrugs of potent GP IIb/IIIa antagonists
DE19841895A1 (de) * 1998-09-11 2000-03-23 Degussa Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
US6723711B2 (en) 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
RU2263109C2 (ru) * 1999-05-07 2005-10-27 Тексэс Байотекнолоджи Копэрейшн ПРОИЗВОДНЫЕ КАРБОНОВЫХ КИСЛОТ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СЕЛЕКТИВНОГО ИНГИБИРОВАНИЯ СВЯЗЫВАНИЯ α4β1 ИНТЕГРИНА У МЛЕКОПИТАЮЩЕГО
US6972296B2 (en) * 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
RU2195447C1 (ru) * 2001-07-31 2002-12-27 Кубанский государственный технологический университет 1-(4-нитрофенил)-4-n-x-аминопирролидоны-2, проявляющие рострегулирующую и антистрессовую активность, и способ их получения
SI21096B (sl) * 2001-10-09 2012-05-31 Encysive Pharmaceuticals Inc Derivati karboksilne kisline ki inhibirajo vezavo integrinov na njihove receptorje
AU2002365132A1 (en) 2001-10-17 2003-07-15 Bristol-Myers Squibb Company BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-Alpha CONVERTING ENZYME (TACE)
EP2192905A4 (en) 2007-08-29 2010-11-10 Adam Lubin METHOD FOR SELECTIVE THERAPY OF DISEASE
ES2690315T3 (es) 2012-06-15 2018-11-20 Mitsubishi Tanabe Pharma Corporation Compuestos de imidazol y triazol como inhibidores de DGAT-1
CN111440149A (zh) * 2020-03-31 2020-07-24 浙江美诺华药物化学有限公司 一种达比加群酯中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL55573A0 (en) * 1977-10-03 1978-12-17 Erba Carlo Spa Substituted n-(ss-alkoxy-ethyl)-n-(4-phenoxybenzyl)-dichloroacetamides and process for their preparation
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
DE69425431T2 (de) * 1993-03-31 2001-02-08 G.D. Searle & Co., Chicago 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren

Also Published As

Publication number Publication date
EP0796245B1 (en) 2000-07-26
JPH10509960A (ja) 1998-09-29
US5610296A (en) 1997-03-11
DE69518164T2 (de) 2001-03-22
GR3034516T3 (en) 2000-12-29
EP0796245A1 (en) 1997-09-24
ATE194976T1 (de) 2000-08-15
AU4163696A (en) 1996-06-26
PT796245E (pt) 2000-12-29
US5576447A (en) 1996-11-19
WO1996017827A1 (en) 1996-06-13
US5659063A (en) 1997-08-19
US5484946A (en) 1996-01-16
ES2150592T3 (es) 2000-12-01
DE69518164D1 (de) 2000-08-31

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