ATE195118T1 - 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen - Google Patents

1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen

Info

Publication number
ATE195118T1
ATE195118T1 AT95902445T AT95902445T ATE195118T1 AT E195118 T1 ATE195118 T1 AT E195118T1 AT 95902445 T AT95902445 T AT 95902445T AT 95902445 T AT95902445 T AT 95902445T AT E195118 T1 ATE195118 T1 AT E195118T1
Authority
AT
Austria
Prior art keywords
treatment
sulfamyl
acylamino
alkoxycarbonyl
halo
Prior art date
Application number
AT95902445T
Other languages
English (en)
Inventor
John J Talley
Donald J Rogier Jr
Thomas D Penning
Stella S Yu
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE195118T1 publication Critical patent/ATE195118T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT95902445T 1993-11-30 1994-11-14 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen ATE195118T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/160,517 US5434178A (en) 1993-11-30 1993-11-30 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
PCT/US1994/012722 WO1995015318A1 (en) 1993-11-30 1994-11-14 1,3,5-trisubstituted pyrazole compounds for treatment of inflammation

Publications (1)

Publication Number Publication Date
ATE195118T1 true ATE195118T1 (de) 2000-08-15

Family

ID=22577200

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95902445T ATE195118T1 (de) 1993-11-30 1994-11-14 1,3,5- trisubstituierte pyrazolverbindungen zur behandlung von entzündungen

Country Status (12)

Country Link
US (1) US5434178A (de)
EP (1) EP0731796B1 (de)
JP (1) JPH09505830A (de)
AT (1) ATE195118T1 (de)
AU (1) AU1171595A (de)
CA (1) CA2177574A1 (de)
DE (1) DE69425442T2 (de)
DK (1) DK0731796T3 (de)
ES (1) ES2150545T3 (de)
GR (1) GR3034515T3 (de)
PT (1) PT731796E (de)
WO (1) WO1995015318A1 (de)

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JPH09505830A (ja) 1997-06-10
DK0731796T3 (da) 2000-09-04
GR3034515T3 (en) 2000-12-29
AU1171595A (en) 1995-06-19
EP0731796A1 (de) 1996-09-18
DE69425442T2 (de) 2001-02-08
CA2177574A1 (en) 1995-06-08
DE69425442D1 (de) 2000-09-07
PT731796E (pt) 2001-01-31
US5434178A (en) 1995-07-18
EP0731796B1 (de) 2000-08-02
WO1995015318A1 (en) 1995-06-08
ES2150545T3 (es) 2000-12-01

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