ATE195344T1 - Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen - Google Patents

Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen

Info

Publication number
ATE195344T1
ATE195344T1 AT91201769T AT91201769T ATE195344T1 AT E195344 T1 ATE195344 T1 AT E195344T1 AT 91201769 T AT91201769 T AT 91201769T AT 91201769 T AT91201769 T AT 91201769T AT E195344 T1 ATE195344 T1 AT E195344T1
Authority
AT
Austria
Prior art keywords
interleukin
new
production
dna
expression
Prior art date
Application number
AT91201769T
Other languages
English (en)
Inventor
Douglas P Cerretti
Iii Paul J Conlon
David J Cosman
Kenneth H Grabstein
Thomas P Hopp
Shirley R Kronheim
Alf D Larsen
Carl J March
Virgina L Price
Original Assignee
Cistron Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE195344(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/676,533 external-priority patent/US5484887A/en
Application filed by Cistron Biotechnology Inc filed Critical Cistron Biotechnology Inc
Application granted granted Critical
Publication of ATE195344T1 publication Critical patent/ATE195344T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT91201769T 1984-06-19 1985-03-13 Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen ATE195344T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62220184A 1984-06-19 1984-06-19
US63500684A 1984-07-27 1984-07-27
US67455584A 1984-11-26 1984-11-26
US06/676,533 US5484887A (en) 1984-06-19 1984-11-30 Homogeneous interleukin 1
US68764684A 1984-12-31 1984-12-31

Publications (1)

Publication Number Publication Date
ATE195344T1 true ATE195344T1 (de) 2000-08-15

Family

ID=27542003

Family Applications (2)

Application Number Title Priority Date Filing Date
AT91201769T ATE195344T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1 und für interleukin-1 kodierende dns und deren herstellung, solche dns enthaltende vektoren und deren herstellung und verwendung zum transformieren von wirten, die die expression von interleukin-1 zulassen
AT85301752T ATE84547T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT85301752T ATE84547T1 (de) 1984-06-19 1985-03-13 Gereinigtes interleukin-1.

Country Status (10)

Country Link
EP (2) EP0456332B1 (de)
JP (3) JP3217698B2 (de)
AT (2) ATE195344T1 (de)
AU (1) AU579142B2 (de)
CA (2) CA1341433C (de)
DE (2) DE3588224T2 (de)
DK (2) DK168048B1 (de)
IE (1) IE61353B1 (de)
MX (1) MX9203654A (de)
NZ (1) NZ211386A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0569687B1 (de) * 1984-05-18 2002-08-21 New England Medical Center Hospitals, Inc. Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5998578A (en) * 1984-05-18 1999-12-07 New England Medical Center Hospitals, Inc. Biologically active fragments of IL-1β
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
DE3587605T2 (de) * 1984-12-25 1994-03-17 Dainippon Pharmaceutical Co Interleukin-1 und dessen Derivat.
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene
DE3683186D1 (de) * 1985-04-25 1992-02-13 Hoffmann La Roche Rekombinantes humaninterleukin-1.
US5831022A (en) * 1986-02-18 1998-11-03 Hoffmann-La Roche Inc. Purification of recombinant human IL-1α
US5008374A (en) * 1986-03-14 1991-04-16 Otsuka Pharmaceutical Co., Ltd. IL-1α derivatives and drugs
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US5047505A (en) * 1987-01-27 1991-09-10 Du Pont Merck Pharmaceutical Company High level expression in E. coli of soluble mature HIL-1beta and derivatives with altered biological activity
US4894333A (en) * 1987-05-28 1990-01-16 Immunex Corporation Bovine interleukin-1α
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
GB9010356D0 (en) * 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
WO2003049602A2 (en) * 2001-12-11 2003-06-19 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
RU2302460C1 (ru) * 2005-11-02 2007-07-10 Институт цитологии и генетики Сибирского отделения Российской академии наук (СО РАН) РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBi101-IL18, КОДИРУЮЩАЯ СИНТЕЗ ИНТЕРЛЕЙКИНА-18 ЧЕЛОВЕКА В ТРАНСГЕННЫХ РАСТЕНИЯХ
KR20090052355A (ko) * 2006-08-14 2009-05-25 시코르, 인크. 순도가 높은 페메트렉세드 이산 및 이의 제조 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE37564T1 (de) * 1982-04-20 1988-10-15 Sloan Kettering Inst Cancer Reinigung von interleukin-2.
DE3588241T2 (de) * 1984-05-18 2002-12-05 Massachusetts Institute Of Technology, Cambridge Menschliche IL-1 cDNS-Sequenzen die für biologisch aktive menschliche IL-1-Proteine kodieren
DK172052B1 (da) * 1984-12-21 1997-09-29 Otsuka Pharma Co Ltd Antitumor-aktivt stof, fremgangsmåde til dets fremstilling, lægemiddel indeholdende stoffet, gen kodende for stoffet, vektor indeholdende genet samt rekombinant mikroorganisme transformet med en sådan vektor
AU577856B2 (en) * 1985-01-17 1988-10-06 Immunex Corporation Cloning and characterization of the human interleukin 1 gene

Also Published As

Publication number Publication date
CA1341433C (en) 2003-06-24
EP0165654B1 (de) 1993-01-13
EP0456332A1 (de) 1991-11-13
JP3217698B2 (ja) 2001-10-09
DE3588224T2 (de) 2001-10-25
JP3009381B2 (ja) 2000-02-14
DE3586972D1 (de) 1993-02-25
IE850614L (en) 1986-09-08
DK37293D0 (da) 1993-03-30
DE3588224D1 (de) 2000-09-14
CA1340978C (en) 2000-05-02
DE3586972T2 (de) 1993-07-08
MX9203654A (es) 1992-07-01
EP0165654A2 (de) 1985-12-27
DK110485D0 (da) 1985-03-11
EP0456332B1 (de) 2000-08-09
DK168048B1 (da) 1994-01-24
IE61353B1 (en) 1994-11-02
AU3986385A (en) 1986-01-02
ATE84547T1 (de) 1993-01-15
DK37293A (da) 1993-03-30
DK110485A (da) 1985-12-20
AU579142B2 (en) 1988-11-17
JPH10279598A (ja) 1998-10-20
EP0165654A3 (en) 1988-05-04
JPH09118697A (ja) 1997-05-06
NZ211386A (en) 1989-04-26
JP2000060577A (ja) 2000-02-29

Similar Documents

Publication Publication Date Title
DE3588224D1 (de) Gereinigtes Interleukin-1 und für Interleukin-1 kodierende DNS und deren Herstellung, solche DNS enthaltende Vektoren und deren Herstellung und Verwendung zum Transformieren von Wirten, die die Expression von Interleukin-1 zulassen
Yoshimura et al. Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants.
Clark-Lewis et al. Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2
Allen et al. A family of structural genes for human lymphoblastoid (leukocyte-type) interferon
Cameron et al. Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1.
Kikumoto et al. Purification and characterization of recombinant human interleukin-1β produced in Escherichia coli
US5401651A (en) DNA encoding ENA-78, a neutrophil activating factor
KR890003802A (ko) 재조합 dna 기술에 의해 제조된 소의 췌장 트립신 억제제, 그 제조 방법, 발현 벡터 및 재조합 숙주 및 그의 제약적 용도
Cameron et al. Purification to homogeneity and amino acid sequence analysis of two anionic species of human interleukin 1.
Bond et al. A mouse T cell product that preferentially enhances IgA production. II. Physicochemical characterization.
Travis et al. The amino acid sequence of ferredoxin from the sulfate reducing bacterium, Desulfovibrio gigas
Wetzel et al. Properties of a human alpha-interferon purified from E. coli extracts
Schmelzer et al. Biochemical characterization of recombinant human nerve growth factor
Ohmori et al. Identification of a platelet Mr 22,000 GTP-binding protein as the novel smg-21 gene product having the same putative effector domain as the ras gene products
Simpson et al. Structural characterization of a murine myeloid leukaemia inhibitory factor
Byrne et al. Human granulocyte-macrophage colony-stimulating factor purified from a Hodgkin's tumor cell line
ACKLIN et al. Recombinant human brain‐derived neurotrophic factor (rHuBDNF) Disulfide structure and characterization of BDNF expressed in CHO cells
DE59109085D1 (de) Epididymis-spezifische Polypeptide und deren Verwendung
Kato et al. Purification and partial sequence analysis of human interleukin-2 derived from peripheral blood leukocytes
Lauren et al. Covalent dimerization of recombinant human interferon-γ
EP0147175A3 (de) Basische-Polypeptiden und Verfahren zu deren Herstellung
Nishikawa et al. 27 amino acid residues can be deleted from the N‐terminus of human lymphotoxin without impairment of its cytotoxic activity
Tsuji et al. Structural and biological identity of recombinant EDF (erythroid differentiation factor) with natural EDF
TH39847A (th) ยีนโปรตีนเนื้อเยื่อของสัตว์เลี้ยงลูกด้วยนมที่ถูกแยกออกมา สารเคมีที่เกี่ยวข้อง
Linder et al. Separation of human pancreatic carboxypeptidase A isoenzymes by high performance liquid chromatography

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee